Jean D. Beggs

Publications

• Spt5 Modulates Co-transcriptional Spliceosome Assembly in
  RNA (New York, N.Y.). Jul, 2019  |   Pubmed ID: 31289129
• Mutagenesis of Snu114 Domain IV Identifies a Developmental Role in Meiotic Splicing
  RNA Biology. 02, 2019  |   Pubmed ID: 30672374
• A Fast and Tuneable Auxin-inducible Degron for Depletion of Target Proteins in Budding Yeast
  Yeast (Chichester, England). 01, 2019  |   Pubmed ID: 30375036
• A Nuclear Export Block Triggers the Decay of Newly Synthesized Polyadenylated RNA
  Cell Reports. Aug, 2018  |   Pubmed ID: 30157437
• Transcription Rate Strongly Affects Splicing Fidelity and Cotranscriptionality in Budding Yeast
  Genome Research. 02, 2018  |   Pubmed ID: 29254943
• RNA Polymerase II Stalling at Pre-mRNA Splice Sites is Enforced by Ubiquitination of the Catalytic Subunit
  ELife. 10, 2017  |   Pubmed ID: 29027900
• Extremely Fast and Incredibly Close: Cotranscriptional Splicing in Budding Yeast
  RNA (New York, N.Y.). 05, 2017  |   Pubmed ID: 28153948
• Transcriptome-wide RNA Processing Kinetics Revealed Using Extremely Short 4tU Labeling
  Genome Biology. Dec, 2015  |   Pubmed ID: 26679539
• Cwc21p Promotes the Second Step Conformation of the Spliceosome and Modulates 3' Splice Site Selection
  Nucleic Acids Research. Mar, 2015  |   Pubmed ID: 25740649
• Brr2p Carboxy-terminal Sec63 Domain Modulates Prp16 Splicing RNA Helicase
  Nucleic Acids Research. Dec, 2014  |   Pubmed ID: 25428373
• A Splicing-dependent Transcriptional Checkpoint Associated with Prespliceosome Formation
  Molecular Cell. Mar, 2014  |   Pubmed ID: 24560925
• A Rule-based Kinetic Model of RNA Polymerase II C-terminal Domain Phosphorylation
  Journal of the Royal Society, Interface. Sep, 2013  |   Pubmed ID: 23804443
• Structural Basis for Dual Roles of Aar2p in U5 SnRNP Assembly
  Genes & Development. Mar, 2013  |   Pubmed ID: 23442228
• RNA Helicases in Splicing
  RNA Biology. Jan, 2013  |   Pubmed ID: 23229095
• Brr2p-mediated Conformational Rearrangements in the Spliceosome During Activation and Substrate Repositioning
  Genes & Development. Nov, 2012  |   Pubmed ID: 23124065
• Kinetic Analysis of Pre-ribosome Structure in Vivo
  RNA (New York, N.Y.). Dec, 2012  |   Pubmed ID: 23093724
• Structure, Function and Regulation of Spliceosomal RNA Helicases
  Current Opinion in Cell Biology. Jun, 2012  |   Pubmed ID: 22464735
• Modelling Reveals Kinetic Advantages of Co-transcriptional Splicing
  PLoS Computational Biology. Oct, 2011  |   Pubmed ID: 22022255
• Mechanism for Aar2p Function As a U5 SnRNP Assembly Factor
  Genes & Development. Aug, 2011  |   Pubmed ID: 21764848
• Cross-linking, Ligation, and Sequencing of Hybrids Reveals RNA-RNA Interactions in Yeast
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011  |   Pubmed ID: 21610164
• Splicing-dependent RNA Polymerase Pausing in Yeast
  Molecular Cell. Nov, 2010  |   Pubmed ID: 21095588
• RiboSys, a High-resolution, Quantitative Approach to Measure the in Vivo Kinetics of Pre-mRNA Splicing and 3'-end Processing in Saccharomyces Cerevisiae
  RNA (New York, N.Y.). Dec, 2010  |   Pubmed ID: 20974745
• Cross-talk in Transcription, Splicing and Chromatin: Who Makes the First Call?
  Biochemical Society Transactions. Oct, 2010  |   Pubmed ID: 20863294
• Brr2p RNA Helicase with a Split Personality: Insights into Structure and Function
  Biochemical Society Transactions. Aug, 2010  |   Pubmed ID: 20659012
• Processivity and Coupling in Messenger RNA Transcription
  PloS One. Jan, 2010  |   Pubmed ID: 20126621
• Physical and Genetic Interactions of Yeast Cwc21p, an Ortholog of Human SRm300/SRRM2, Suggest a Role at the Catalytic Center of the Spliceosome
  RNA (New York, N.Y.). Dec, 2009  |   Pubmed ID: 19854871
• Interaction of Yeast EIF4G with Spliceosome Components: Implications in Pre-mRNA Processing Events
  RNA Biology. Nov-Dec, 2009  |   Pubmed ID: 19838078
• Analysis of Lsm1p and Lsm8p Domains in the Cellular Localization of Lsm Complexes in Budding Yeast
  The FEBS Journal. Jul, 2009  |   Pubmed ID: 19490016
• Mutations in the U5 SnRNA Result in Altered Splicing of Subsets of Pre-mRNAs and Reduced Stability of Prp8
  RNA (New York, N.Y.). Jul, 2009  |   Pubmed ID: 19447917
• A Role for Q/N-rich Aggregation-prone Regions in P-body Localization
  Journal of Cell Science. Aug, 2008  |   Pubmed ID: 18611963
• Requirements for Nuclear Localization of the Lsm2-8p Complex and Competition Between Nuclear and Cytoplasmic Lsm Complexes
  Journal of Cell Science. Dec, 2007  |   Pubmed ID: 18029398
• Prp8 Mutations That Cause Human Retinitis Pigmentosa Lead to a U5 SnRNP Maturation Defect in Yeast
  Nature Structural & Molecular Biology. Nov, 2007  |   Pubmed ID: 17934474
• The Lsm2-8 Complex Determines Nuclear Localization of the Spliceosomal U6 SnRNA
  Nucleic Acids Research. 2007  |   Pubmed ID: 17251193
• Yeast Ntr1/spp382 Mediates Prp43 Function in Postspliceosomes
  Molecular and Cellular Biology. Aug, 2006  |   Pubmed ID: 16880513
• Prp8p Dissection Reveals Domain Structure and Protein Interaction Sites
  RNA (New York, N.Y.). Feb, 2006  |   Pubmed ID: 16373487
• Crosstalk Between RNA Metabolic Pathways: an RNOMICS Approach
  Nature Reviews. Molecular Cell Biology. May, 2005  |   Pubmed ID: 15956981
• Prp8 Protein: at the Heart of the Spliceosome
  RNA (New York, N.Y.). May, 2005  |   Pubmed ID: 15840809
• Interaction Between a G-patch Protein and a Spliceosomal DEXD/H-box ATPase That is Critical for Splicing
  Molecular and Cellular Biology. Dec, 2004  |   Pubmed ID: 15542821
• Nuclear Pre-mRNA Decapping and 5' Degradation in Yeast Require the Lsm2-8p Complex
  Molecular and Cellular Biology. Nov, 2004  |   Pubmed ID: 15485930
• Lsm Proteins Promote Regeneration of Pre-mRNA Splicing Activity
  Current Biology : CB. Aug, 2004  |   Pubmed ID: 15324666
• Splicing Goes Global
  Trends in Genetics : TIG. Jun, 2003  |   Pubmed ID: 12801718
• Identification and Characterization of Prp45p and Prp46p, Essential Pre-mRNA Splicing Factors
  RNA (New York, N.Y.). Jan, 2003  |   Pubmed ID: 12554883
• Lsm Proteins Are Required for Normal Processing of Pre-tRNAs and Their Efficient Association with La-homologous Protein Lhp1p
  Molecular and Cellular Biology. Jul, 2002  |   Pubmed ID: 12077351
• Dhr1p, a Putative DEAH-box RNA Helicase, is Associated with the Box C+D SnoRNP U3
  Molecular and Cellular Biology. Oct, 2000  |   Pubmed ID: 10982841
• Genome-wide Protein Interaction Screens Reveal Functional Networks Involving Sm-like Proteins
  Yeast (Chichester, England). Jun, 2000  |   Pubmed ID: 10900456