Jeannie Chen

Publications

• Huntingtin Fibrils with Different Toxicity, Structure, and Seeding Potential Can Be Interconverted
  Nature Communications. 07, 2021  |   Pubmed ID: 34257293
• Biological Role of Arrestin-1 Oligomerization
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 10, 2020  |   Pubmed ID: 32948676
• Dark Noise and Retinal Degeneration from D190N-rhodopsin
  Proceedings of the National Academy of Sciences of the United States of America. 09, 2020  |   Pubmed ID: 32873651
• Diminished Cone Sensitivity in Cpfl3 Mice Is Caused by Defective Transducin Signaling
  Investigative Ophthalmology & Visual Science. 04, 2020  |   Pubmed ID: 32315379
• Isoelectric Focusing to Quantify Rhodopsin Phosphorylation in Mouse Retina
  Bio-protocol. Jul, 2019  |   Pubmed ID: 33654813
• Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 08, 2019  |   Pubmed ID: 31285302
• Elementary Response Triggered by Transducin in Retinal Rods
  Proceedings of the National Academy of Sciences of the United States of America. 03, 2019  |   Pubmed ID: 30796193
• The PDE6 Mutation in the Rd10 Retinal Degeneration Mouse Model Causes Protein Mislocalization and Instability and Promotes Cell Death Through Increased Ion Influx
  The Journal of Biological Chemistry. 10, 2018  |   Pubmed ID: 30126843
• Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1
  Frontiers in Molecular Neuroscience. 2018  |   Pubmed ID: 29973866
• Regulation of Calcium Homeostasis in the Outer Segments of Rod and Cone Photoreceptors
  Progress in Retinal and Eye Research. 11, 2018  |   Pubmed ID: 29883715
• Guanylate Cyclase-activating Protein 2 Contributes to Phototransduction and Light Adaptation in Mouse Cone Photoreceptors
  The Journal of Biological Chemistry. 05, 2018  |   Pubmed ID: 29549122
• Phenotypic Characterization of P23H and S334ter Rhodopsin Transgenic Rat Models of Inherited Retinal Degeneration
  Experimental Eye Research. 02, 2018  |   Pubmed ID: 29122605
• The Na/Ca, K Exchanger NCKX4 is Required for Efficient Cone-mediated Vision
  ELife. 06, 2017  |   Pubmed ID: 28650316
• Separation of Photoreceptor Cell Compartments in Mouse Retina for Protein Analysis
  Molecular Neurodegeneration. 04, 2017  |   Pubmed ID: 28399904
• Two Pathways of Rod Photoreceptor Cell Death Induced by Elevated CGMP
  Human Molecular Genetics. Jun, 2017  |   Pubmed ID: 28379353
• The GCaMP-R Family of Genetically Encoded Ratiometric Calcium Indicators
  ACS Chemical Biology. 04, 2017  |   Pubmed ID: 28195691
• Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice
  Scientific Reports. Feb, 2017  |   Pubmed ID: 28145503
• The Na(+)/Ca(2+), K(+) Exchanger 2 Modulates Mammalian Cone Phototransduction
  Scientific Reports. 09, 2016  |   Pubmed ID: 27580676
• Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 06, 2016  |   Pubmed ID: 27358455
• A New Mouse Model for Stationary Night Blindness with Mutant Slc24a1 Explains the Pathophysiology of the Associated Human Disease
  Human Molecular Genetics. Oct, 2015  |   Pubmed ID: 26246500
• C-terminal Threonines and Serines Play Distinct Roles in the Desensitization of Rhodopsin, a G Protein-coupled Receptor
  ELife. Apr, 2015  |   Pubmed ID: 25910054
• Regulation of Mammalian Cone Phototransduction by Recoverin and Rhodopsin Kinase
  The Journal of Biological Chemistry. Apr, 2015  |   Pubmed ID: 25673692
• Induction of the Unfolded Protein Response by Constitutive G-protein Signaling in Rod Photoreceptor Cells
  The Journal of Biological Chemistry. Oct, 2014  |   Pubmed ID: 25183010
• Functional EF-hands in Neuronal Calcium Sensor GCAP2 Determine Its Phosphorylation State and Subcellular Distribution in Vivo, and Are Essential for Photoreceptor Cell Integrity
  PLoS Genetics. Jul, 2014  |   Pubmed ID: 25058152
• The Physiological Roles of Arrestin-1 in Rod Photoreceptor Cells
  Handbook of Experimental Pharmacology. 2014  |   Pubmed ID: 24292825
• Rapid Degeneration of Rod Photoreceptors Expressing Self-association-deficient Arrestin-1 Mutant
  Cellular Signalling. Dec, 2013  |   Pubmed ID: 24012956
• Visual Arrestin Interaction with Clathrin Adaptor AP-2 Regulates Photoreceptor Survival in the Vertebrate Retina
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013  |   Pubmed ID: 23690606
• Functional Comparison of Rod and Cone Gα(t) on the Regulation of Light Sensitivity
  The Journal of Biological Chemistry. Feb, 2013  |   Pubmed ID: 23288843
• Diurnal, Localized Exposure of Phosphatidylserine by Rod Outer Segment Tips in Wild-type but Not Itgb5-/- or Mfge8-/- Mouse Retina
  Proceedings of the National Academy of Sciences of the United States of America. May, 2012  |   Pubmed ID: 22566632
• Effect of the ILE86TER Mutation in the γ Subunit of CGMP Phosphodiesterase (PDE6) on Rod Photoreceptor Signaling
  Cellular Signalling. Jan, 2012  |   Pubmed ID: 21920434
• Progressive Reduction of Its Expression in Rods Reveals Two Pools of Arrestin-1 in the Outer Segment with Different Roles in Photoresponse Recovery
  PloS One. 2011  |   Pubmed ID: 21818392
• Role of Guanylyl Cyclase Modulation in Mouse Cone Phototransduction
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011  |   Pubmed ID: 21632921
• Rod Outer Segment Retinol Formation is Independent of Abca4, Arrestin, Rhodopsin Kinase, and Rhodopsin Palmitylation
  Investigative Ophthalmology & Visual Science. May, 2011  |   Pubmed ID: 21398289
• Arrestin-1 Expression Level in Rods: Balancing Functional Performance and Photoreceptor Health
  Neuroscience. Feb, 2011  |   Pubmed ID: 21075174
• Channel Modulation and the Mechanism of Light Adaptation in Mouse Rods
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010  |   Pubmed ID: 21123569
• Monitoring Apoptosis and Neuronal Degeneration by Real-time Detection of Phosphatidylserine Externalization Using a Polarity-sensitive Indicator of Viability and Apoptosis
  Nature Protocols. Aug, 2010  |   Pubmed ID: 20671723
• Q344ter Mutation Causes Mislocalization of Rhodopsin Molecules That Are Catalytically Active: a Mouse Model of Q344ter-induced Retinal Degeneration
  PloS One. Jun, 2010  |   Pubmed ID: 20532191
• Engineering a Polarity-sensitive Biosensor for Time-lapse Imaging of Apoptotic Processes and Degeneration
  Nature Methods. Jan, 2010  |   Pubmed ID: 19966809
• Soluble and Mature Amyloid Fibrils in Drusen Deposits
  Investigative Ophthalmology & Visual Science. Mar, 2010  |   Pubmed ID: 19892876
• Enhanced Arrestin Facilitates Recovery and Protects Rods Lacking Rhodopsin Phosphorylation
  Current Biology : CB. Apr, 2009  |   Pubmed ID: 19361994
• Structure of Membrane-bound Alpha-synuclein from Site-directed Spin Labeling and Computational Refinement
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008  |   Pubmed ID: 19066219
• Formation of Soluble Amyloid Oligomers and Amyloid Fibrils by the Multifunctional Protein Vitronectin
  Molecular Neurodegeneration. Oct, 2008  |   Pubmed ID: 18939994
• Signaling Properties of a Short-wave Cone Visual Pigment and Its Role in Phototransduction
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2007  |   Pubmed ID: 17881515
• Investigation of Alpha-synuclein Fibril Structure by Site-directed Spin Labeling
  The Journal of Biological Chemistry. Aug, 2007  |   Pubmed ID: 17573347
• Functional Comparisons of Visual Arrestins in Rod Photoreceptors of Transgenic Mice
  Investigative Ophthalmology & Visual Science. May, 2007  |   Pubmed ID: 17460248
• Molecular Properties of Rhodopsin and Rod Function
  The Journal of Biological Chemistry. Mar, 2007  |   Pubmed ID: 17194706
• Stable Rhodopsin/arrestin Complex Leads to Retinal Degeneration in a Transgenic Mouse Model of Autosomal Dominant Retinitis Pigmentosa
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006  |   Pubmed ID: 17108167
• Drusen Deposits Associated with Aging and Age-related Macular Degeneration Contain Nonfibrillar Amyloid Oligomers
  The Journal of Clinical Investigation. Feb, 2006  |   Pubmed ID: 16453022
• Light-dependent Redistribution of Arrestin in Vertebrate Rods is an Energy-independent Process Governed by Protein-protein Interactions
  Neuron. May, 2005  |   Pubmed ID: 15944125
• Structure of Membrane-bound Alpha-synuclein Studied by Site-directed Spin Labeling
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004  |   Pubmed ID: 15155902
• Structural Organization of Alpha-synuclein Fibrils Studied by Site-directed Spin Labeling
  The Journal of Biological Chemistry. Sep, 2003  |   Pubmed ID: 12815044
• Mouse Models to Study GCAP Functions in Intact Photoreceptors
  Advances in Experimental Medicine and Biology. 2002  |   Pubmed ID: 12596933
• The Carboxyl-terminal Domain is Essential for Rhodopsin Transport in Rod Photoreceptors
  Vision Research. Feb, 2002  |   Pubmed ID: 11853757
• Role of Guanylate Cyclase-activating Proteins (GCAPs) in Setting the Flash Sensitivity of Rod Photoreceptors
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2001  |   Pubmed ID: 11493703
• Expression of Bcl-2 Protects Against Photoreceptor Degeneration in Retinal Degeneration Slow (rds) Mice
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2000  |   Pubmed ID: 10704489
• Abnormal Photoresponses and Light-induced Apoptosis in Rods Lacking Rhodopsin Kinase
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 1999  |   Pubmed ID: 10097103