Jeffrey D. Varner

Publications

• Improving Designer Glycan Production in Through Model-guided Metabolic Engineering
  Metabolic Engineering Communications. Dec, 2019  |   Pubmed ID: 31008057
• Analysis of the Role of Thrombomodulin in All-trans Retinoic Acid Treatment of Coagulation Disorders in Cancer Patients
  Theoretical Biology & Medical Modelling. 02, 2019  |   Pubmed ID: 30764845
• Retinoic Acid and 6-formylindolo(3,2-b)carbazole (FICZ) Combination Therapy Reveals Putative Targets for Enhancing Response in Non-APL AML
  Leukemia & Lymphoma. Jul, 2019  |   Pubmed ID: 30570341
• Multi-scale Computational Study of the Warburg Effect, Reverse Warburg Effect and Glutamine Addiction in Solid Tumors
  PLoS Computational Biology. 12, 2018  |   Pubmed ID: 30532226
• Dynamic Optimization with Particle Swarms (DOPS): a Meta-heuristic for Parameter Estimation in Biochemical Models
  BMC Systems Biology. 10, 2018  |   Pubmed ID: 30314484
• Sequence Specific Modeling of E. Coli Cell-Free Protein Synthesis
  ACS Synthetic Biology. 08, 2018  |   Pubmed ID: 29944340
• Src Family Kinase Inhibitor Bosutinib Enhances Retinoic Acid-induced Differentiation of HL-60 Leukemia Cells
  Leukemia & Lymphoma. 12, 2018  |   Pubmed ID: 29569971
• Potential for Subsets of Wt-NPM1 Primary AML Blasts to Respond to Retinoic Acid Treatment
  Oncotarget. Jan, 2018  |   Pubmed ID: 29423110
• Reduced Order Modeling and Analysis of the Human Complement System
  PloS One. 2017  |   Pubmed ID: 29155837
• An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program
  Scientific Reports. 10, 2017  |   Pubmed ID: 29085021
• JuPOETs: a Constrained Multiobjective Optimization Approach to Estimate Biochemical Model Ensembles in the Julia Programming Language
  BMC Systems Biology. 01, 2017  |   Pubmed ID: 28122561
• Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1
  PLoS Computational Biology. Dec, 2016  |   Pubmed ID: 28027307
• Induced Myelomonocytic Differentiation in Leukemia Cells is Accompanied by Noncanonical Transcription Factor Expression
  FEBS Open Bio. 2015  |   Pubmed ID: 26566473
• 6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells
  PloS One. 2015  |   Pubmed ID: 26287494
• Generating Effective Models and Parameters for RNA Genetic Circuits
  ACS Synthetic Biology. Aug, 2015  |   Pubmed ID: 26046393
• GW5074 and PP2 Kinase Inhibitors Implicate Nontraditional C-Raf and Lyn Function As Drivers of Retinoic Acid-induced Maturation
  Cellular Signalling. Aug, 2015  |   Pubmed ID: 25817574
• Retinoic Acid Therapy Resistance Progresses from Unilineage to Bilineage in HL-60 Leukemic Blasts
  PloS One. 2014  |   Pubmed ID: 24922062
• Ubiquibodies, Synthetic E3 Ubiquitin Ligases Endowed with Unnatural Substrate Specificity for Targeted Protein Silencing
  The Journal of Biological Chemistry. Mar, 2014  |   Pubmed ID: 24474696
• Physicochemical Regulation of Endothelial Sprouting in a 3D Microfluidic Angiogenesis Model
  Journal of Biomedical Materials Research. Part A. Oct, 2013  |   Pubmed ID: 23559519
• The Src-family Kinase Inhibitor PP2 Rescues Inducible Differentiation Events in Emergent Retinoic Acid-resistant Myeloblastic Leukemia Cells
  PloS One. 2013  |   Pubmed ID: 23554907
• Hierarchical Approaches for Systems Modeling in Cardiac Development
  Wiley Interdisciplinary Reviews. Systems Biology and Medicine. May-Jun, 2013  |   Pubmed ID: 23463736
• Multiscale Models of Breast Cancer Progression
  Annals of Biomedical Engineering. Nov, 2012  |   Pubmed ID: 23008097
• Modellazione Computazionale E Analisi Di Insulina Indotto Iniziazione Traduzione Negli Eucarioti
  PLoS Computational Biology. Nov, 2011  |   Pubmed ID: 22102801
• A Review of the Mammalian Unfolded Protein Response
  Biotechnology and Bioengineering. Dec, 2011  |   Pubmed ID: 21809331
• Interferon Regulatory Factor-1 Binds C-Cbl, Enhances Mitogen Activated Protein Kinase Signaling and Promotes Retinoic Acid-induced Differentiation of HL-60 Human Myelo-monoblastic Leukemia Cells
  Leukemia & Lymphoma. Dec, 2011  |   Pubmed ID: 21740303
• Modeling and Analysis of Retinoic Acid Induced Differentiation of Uncommitted Precursor Cells
  Integrative Biology : Quantitative Biosciences from Nano to Macro. May, 2011  |   Pubmed ID: 21437295
• Ensembles of Uncertain Mathematical Models Can Identify Network Response to Therapeutic Interventions
  Molecular BioSystems. Nov, 2010  |   Pubmed ID: 20844798
• Ensembles of Signal Transduction Models Using Pareto Optimal Ensemble Techniques (POETs)
  Biotechnology Journal. Jul, 2010  |   Pubmed ID: 20665647
• Arsenic Trioxide Cooperates with All Trans Retinoic Acid to Enhance Mitogen-activated Protein Kinase Activation and Differentiation in PML-RARalpha Negative Human Myeloblastic Leukemia Cells
  Leukemia & Lymphoma. Sep, 2010  |   Pubmed ID: 20615082
• Analysis of the Molecular Networks in Androgen Dependent and Independent Prostate Cancer Revealed Fragile and Robust Subsystems
  PloS One. Jan, 2010  |   Pubmed ID: 20126616
• Engineering the Spatial Organization of Metabolic Enzymes: Mimicking Nature's Synergy
  Current Opinion in Biotechnology. Oct, 2008  |   Pubmed ID: 18725290
• A Test of Highly Optimized Tolerance Reveals Fragile Cell-cycle Mechanisms Are Molecular Targets in Clinical Cancer Trials
  PloS One. Apr, 2008  |   Pubmed ID: 18431497
• Computationally Derived Points of Fragility of a Human Cascade Are Consistent with Current Therapeutic Strategies
  PLoS Computational Biology. Jul, 2007  |   Pubmed ID: 17658944
• Stochastic Reaction-diffusion Simulation of Enzyme Compartmentalization Reveals Improved Catalytic Efficiency for a Synthetic Metabolic Pathway
  Metabolic Engineering. Jul, 2007  |   Pubmed ID: 17601761
• Systems Biology and the Mathematical Modelling of Antibody-directed Enzyme Prodrug Therapy (ADEPT)
  Systems Biology. Dec, 2005  |   Pubmed ID: 16986273