In JoVE (2)
Other Publications (2)
Articles by Jeremy Wu in JoVE
Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology Hao Chang1, Yanshu Wang1, Hao Wu1, Jeremy Nathans1,2,3 1Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 2Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 3Department of Ophthalmology, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine Mammalian skin contains a diverse array of structures - such as hair follicles and nerve endings - that exhibit distinctive patterns of spatial organization. Analyzing skin as a flat mount takes advantage of the 2-dimensional geometry of this tissue to produce full-thickness high-resolution images of skin structures.
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms Manav Korpal1, Jacob Feala1, Xiaoling Puyang1, Jian Zou1, Alex H. Ramos2, Jeremy Wu1, Timm Baumeister1, Lihua Yu1, Markus Warmuth1, Ping Zhu1 1H3 Biomedicine, 2Massachusetts General Hospital Drug resistance to targeted therapeutics is widespread and the need to identify mechanisms of resistance--prior to or following clinical onset--is critical for guiding alternative clinical management strategies. Here, we present a protocol to couple derivation of drug-resistant lines in vitro with sequencing to expedite discovery of these mechanisms.
Other articles by Jeremy Wu on PubMed
Design and Construction of Linear Laser Encoders That Possess High Tolerance of Mechanical Runout Applied Optics. Nov, 2004 | Pubmed ID: 15540432 A linearly diffracted laser encoder that has high tolerance of head-to-scale misalignment and a high signal-to-noise ratio is described. The preservation of parallelism between the incident and the diffracted beams, which can be attributed to a built-in folded 1x telescope, allows for the high alignment tolerance. It can be shown that, by coupling this newly developed circular polarization interferometer configuration with grating scale geometry optimization, one can eliminate the problems associated with signal distortion that arise from various efficiencies of the p- and the s-polarized light beams and obtain a high signal-to-noise ratio. Both theoretical and experimental results are presented to confirm the improved results and performance.