Jian Jin Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Jian Jin has not added a biography. If you are Jian Jin and would like to personalize this page please email our Author Liaison for assistance. Publications Influenza Virus Infection Causes Global RNAPII Termination Defects Nature Structural & Molecular Biology. Sep, 2018 | Pubmed ID: 30177761 Structural Determinants of 5-HT Receptor Activation and Biased Agonism Nature Structural & Molecular Biology. Sep, 2018 | Pubmed ID: 30127358 Proteolysis Targeting Chimeras (PROTACs) of Anaplastic Lymphoma Kinase (ALK) European Journal of Medicinal Chemistry. May, 2018 | Pubmed ID: 29627725 Inhibition of the G9a/GLP Histone Methyltransferase Complex Modulates Anxiety-related Behavior in Mice Acta Pharmacologica Sinica. May, 2018 | Pubmed ID: 29417943 Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) Journal of Medicinal Chemistry. Feb, 2018 | Pubmed ID: 29320176 Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3) Journal of Medicinal Chemistry. Feb, 2018 | Pubmed ID: 29244490 VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression Circulation Research. Jan, 2018 | Pubmed ID: 29233846 Structure-inspired Design of β-arrestin-biased Ligands for Aminergic GPCRs Nature Chemical Biology. Feb, 2018 | Pubmed ID: 29227473 Targeted Gene Repression Using Novel Bifunctional Molecules to Harness Endogenous Histone Deacetylation Activity ACS Synthetic Biology. 01, 2018 | Pubmed ID: 29073761 Inhibitors of Protein Methyltransferases and Demethylases Chemical Reviews. Feb, 2018 | Pubmed ID: 28338320 The Polycomb Group Protein BMI-1 Inhibitor PTC-209 is a Potent Anti-myeloma Agent Alone or in Combination with Epigenetic Inhibitors Targeting EZH2 and the BET Bromodomains Oncotarget. Nov, 2017 | Pubmed ID: 29262596 Report and Application of a Tool Compound Data Set Journal of Chemical Information and Modeling. 11, 2017 | Pubmed ID: 29035535 Structure-activity Relationship Studies of G9a-like Protein (GLP) Inhibitors Bioorganic & Medicinal Chemistry. 08, 2017 | Pubmed ID: 28662962 Recent Progress in Developing Selective Inhibitors of Protein Methyltransferases Current Opinion in Chemical Biology. Aug, 2017 | Pubmed ID: 28662389 Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2017 | Pubmed ID: 28490465 Development of a S-adenosylmethionine Analog That Intrudes the RNA-cap Binding Site of Zika Methyltransferase Scientific Reports. May, 2017 | Pubmed ID: 28487506 In Silico Design of Novel Probes for the Atypical Opioid Receptor MRGPRX2 Nature Chemical Biology. 05, 2017 | Pubmed ID: 28288109 An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity JACC. Basic to Translational Science. Feb, 2017 | Pubmed ID: 28286875 Hsp90 Inhibition Destabilizes Ezh2 Protein in Alloreactive T Cells and Reduces Graft-versus-host Disease in Mice Blood. 05, 2017 | Pubmed ID: 28246193 Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase Journal of Medicinal Chemistry. Mar, 2017 | Pubmed ID: 28135087 Epigenetic SiRNA and Chemical Screens Identify SETD8 Inhibition As a Therapeutic Strategy for P53 Activation in High-Risk Neuroblastoma Cancer Cell. 01, 2017 | Pubmed ID: 28073004 EZH2 Inhibition in Multiple Myeloma Downregulates Myeloma Associated Oncogenes and Upregulates MicroRNAs with Potential Tumor Suppressor Functions Oncotarget. Feb, 2017 | Pubmed ID: 28052011 Targeting the Histone Methyltransferase G9a Activates Imprinted Genes and Improves Survival of a Mouse Model of Prader-Willi Syndrome Nature Medicine. Feb, 2017 | Pubmed ID: 28024084 Distinct Cortical and Striatal Actions of a β-arrestin-biased Dopamine D2 Receptor Ligand Reveal Unique Antipsychotic-like Properties Proceedings of the National Academy of Sciences of the United States of America. 12, 2016 | Pubmed ID: 27911814 Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists Journal of Medicinal Chemistry. 12, 2016 | Pubmed ID: 27805392 Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase Journal of Medicinal Chemistry. 11, 2016 | Pubmed ID: 27804297 Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6 Journal of Medicinal Chemistry. 10, 2016 | Pubmed ID: 27584694 Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase MedChemComm. May, 2016 | Pubmed ID: 27547295 Structure-Activity Relationship Studies for Enhancer of Zeste Homologue 2 (EZH2) and Enhancer of Zeste Homologue 1 (EZH1) Inhibitors Journal of Medicinal Chemistry. 08, 2016 | Pubmed ID: 27468126 Topoisomerase 1 Inhibition Suppresses Inflammatory Genes and Protects from Death by Inflammation Science (New York, N.Y.). May, 2016 | Pubmed ID: 27127234 Novel Therapeutics Targeting Epigenetics: New Molecules, New Methods ACS Medicinal Chemistry Letters. Feb, 2016 | Pubmed ID: 26985299 Identification of a Small-molecule Ligand of the Epigenetic Reader Protein Spindlin1 Via a Versatile Screening Platform Nucleic Acids Research. 05, 2016 | Pubmed ID: 26893353 Genome-wide Profiling of Histone H3 Lysine 27 and Lysine 4 Trimethylation in Multiple Myeloma Reveals the Importance of Polycomb Gene Targeting and Highlights EZH2 As a Potential Therapeutic Target Oncotarget. Feb, 2016 | Pubmed ID: 26755663 A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases ACS Chemical Biology. Mar, 2016 | Pubmed ID: 26598975 Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Feb, 2016 | Pubmed ID: 26129680 A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26338712 The Promise and Peril of Chemical Probes Nature Chemical Biology. Aug, 2015 | Pubmed ID: 26196764 Non-canonical Bromodomain Within DNA-PKcs Promotes DNA Damage Response and Radioresistance Through Recognizing an IR-Induced Acetyl-Lysine on H2AX Chemistry & Biology. Jul, 2015 | Pubmed ID: 26119999 Targeting EZH2 and PRC2 Dependence As Novel Anticancer Therapy Experimental Hematology. Aug, 2015 | Pubmed ID: 26027790 A Potent, Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3) Angewandte Chemie (International Ed. in English). Apr, 2015 | Pubmed ID: 25728001 The First Structure-activity Relationship Studies for Designer Receptors Exclusively Activated by Designer Drugs ACS Chemical Neuroscience. Mar, 2015 | Pubmed ID: 25587888 Chemical Probes of Histone Lysine Methyltransferases ACS Chemical Biology. Jan, 2015 | Pubmed ID: 25423077 Selective Inhibitors of Protein Methyltransferases Journal of Medicinal Chemistry. Feb, 2015 | Pubmed ID: 25406853 Selective Inhibition of EZH2 and EZH1 Enzymatic Activity by a Small Molecule Suppresses MLL-rearranged Leukemia Blood. Jan, 2015 | Pubmed ID: 25395428 Structure-activity Relationship Studies of SETD8 Inhibitors MedChemComm. Dec, 2014 | Pubmed ID: 25554733 EZH2 Inhibition Enhances the Efficacy of an EGFR Inhibitor in Suppressing Colon Cancer Cells Cancer Biology & Therapy. 2014 | Pubmed ID: 25535899 A Chromatin Activity-based Chemoproteomic Approach Reveals a Transcriptional Repressome for Gene-specific Silencing Nature Communications. Dec, 2014 | Pubmed ID: 25502336 Репрессии транскрипции гена, перенаправив клеточными с химической эпигеномные модификаторы Anna M. Chiarella1, Tiffany A. Wang2, Kyle V. Butler3, Jian Jin3, Nathaniel A. Hathaway4 1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina JoVE 58222 Bioengineering
Репрессии транскрипции гена, перенаправив клеточными с химической эпигеномные модификаторы Anna M. Chiarella1, Tiffany A. Wang2, Kyle V. Butler3, Jian Jin3, Nathaniel A. Hathaway4 1Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, University of North Carolina, 2College of Arts and Sciences, Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, 3Chemical Biology and Drug Discovery, Pharmacological Sciences and Oncological Sciences, Icahn School of Medicine at Mount Sinai, 4Chemical Biology and Medicinal Chemistry, Center for Integrative Chemical Biology and Drug Discovery, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina JoVE 58222 Bioengineering
