John F. Hancock Department of Integrative Biology and Pharmacology, McGovern Medical School University of Texas Health Science Center Biography Publications Institution JoVE Articles John F. Hancock has not added a biography. If you are John F. Hancock and would like to personalize this page please email our Author Liaison for assistance. Publications Lipidomic Atlas of Mammalian Cell Membranes Reveals Hierarchical Variation Induced by Culture Conditions, Subcellular Membranes, and Cell Lineages Soft Matter. May, 2020 | Pubmed ID: 32451522 Corrigendum: Fingolimod Augments Monomethylfumarate Killing of GBM Cells Frontiers in Oncology. 2020 | Pubmed ID: 32426288 Fingolimod Augments Monomethylfumarate Killing of GBM Cells Frontiers in Oncology. 2020 | Pubmed ID: 32047722 (Curcumin+sildenafil) Enhances the Efficacy of 5FU and Anti-PD1 Therapies in Vivo Journal of Cellular Physiology. Oct, 2020 | Pubmed ID: 31985048 Neratinib Degrades MST4 Via Autophagy That Reduces Membrane Stiffness and is Essential for the Inactivation of PI3K, ERK1/2, and YAP/TAZ Signaling Journal of Cellular Physiology. Nov, 2020 | Pubmed ID: 31912905 Enhanced Signaling Via ERBB3/PI3K Plays a Compensatory Survival Role in Pancreatic Tumor Cells Exposed to [neratinib + Valproate] Cellular Signalling. 04, 2020 | Pubmed ID: 31911180 A Novel Prenyl-polybasic Domain Code Determines Lipid-binding Specificity of the K-Ras Membrane Anchor Small GTPases. May, 2020 | Pubmed ID: 29239694 Distinct Binding Preferences Between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling Molecular Cell. 12, 2019 | Pubmed ID: 31606273 Signaling Alterations Caused by Drugs and Autophagy Cellular Signalling. Dec, 2019 | Pubmed ID: 31520735 Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic KRAS Function Life Science Alliance. 10, 2019 | Pubmed ID: 31451509 Acylpeptide Hydrolase is a Novel Regulator of KRAS Plasma Membrane Localization and Function Journal of Cell Science. 07, 2019 | Pubmed ID: 31266814 Neratinib Inhibits Hippo/YAP Signaling, Reduces Mutant K-RAS Expression, and Kills Pancreatic and Blood Cancer Cells Oncogene. 07, 2019 | Pubmed ID: 31253872 Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding ACS Omega. Feb, 2019 | Pubmed ID: 30842983 HRAS-driven Cancer Cells Are Vulnerable to TRPML1 Inhibition EMBO Reports. Feb, 2019 | Pubmed ID: 30787043 Three Distinct Regions of CRaf Kinase Domain Interact with Membrane Scientific Reports. 02, 2019 | Pubmed ID: 30765804 Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs Biophysical Journal. 01, 2019 | Pubmed ID: 30616834 Neratinib and Entinostat Combine to Rapidly Reduce the Expression of K-RAS, N-RAS, Gα and Gα and Kill Uveal Melanoma Cells Cancer Biology & Therapy. 2019 | Pubmed ID: 30571927 Neratinib Augments the Lethality of [regorafenib + sildenafil] Journal of Cellular Physiology. 04, 2019 | Pubmed ID: 30203445 Electron Microscopy Combined with Spatial Analysis: Quantitative Mapping of the Nano-assemblies of Plasma Membrane-associating Proteins and Lipids Biophysics Reports. 2018 | Pubmed ID: 30596140 An Oxanthroquinone Derivative That Disrupts RAS Plasma Membrane Localization Inhibits Cancer Cell Growth The Journal of Biological Chemistry. 08, 2018 | Pubmed ID: 29970615 Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor Molecular and Cellular Biology. 09, 2018 | Pubmed ID: 29967243 Ras and the Plasma Membrane: A Complicated Relationship Cold Spring Harbor Perspectives in Medicine. 10, 2018 | Pubmed ID: 29229665 Clustering of Rac1: Selective Lipid Sorting Drives Signaling Trends in Biochemical Sciences. 02, 2018 | Pubmed ID: 29198968 Sphingomyelin Metabolism Is a Regulator of K-Ras Function Molecular and Cellular Biology. Feb, 2018 | Pubmed ID: 29158292 Deciphering Lipid Codes: K-Ras As a Paradigm Traffic (Copenhagen, Denmark). 03, 2018 | Pubmed ID: 29120102 ω-3 Polyunsaturated Fatty Acids Direct Differentiation of the Membrane Phenotype in Mesenchymal Stem Cells to Potentiate Osteogenesis Science Advances. 11, 2017 | Pubmed ID: 29134198 Lipid Sorting and the Activity of Arf Signaling Complexes Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 29073041 Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes Journal of the American Chemical Society. 09, 2017 | Pubmed ID: 28863262 Computational and Biochemical Characterization of Two Partially Overlapping Interfaces and Multiple Weak-affinity K-Ras Dimers Scientific Reports. Jan, 2017 | Pubmed ID: 28067274 Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output Cell. Jan, 2017 | Pubmed ID: 28041850 Corrigendum to "Ras Nanoclusters: Versatile Lipid-based Signaling Platforms" [Biochim. Biophys. Acta 1853/4 (2015) 841-849] Biochimica Et Biophysica Acta. Molecular Cell Research. Feb, 2017 | Pubmed ID: 27875678 Epac1 Interacts with Importin β1 and Controls Neurite Outgrowth Independently of CAMP and Rap1 Scientific Reports. 11, 2016 | Pubmed ID: 27808165 AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions Via Cyclic GMP-Dependent Protein Kinase 2 Molecular and Cellular Biology. 12, 2016 | Pubmed ID: 27697864 VPS35 Binds Farnesylated N-Ras in the Cytosol to Regulate N-Ras Trafficking The Journal of Cell Biology. Aug, 2016 | Pubmed ID: 27502489 Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization Through an Effector Binding Surface Suggests Limited Functional Role The Journal of Physical Chemistry. B. 08, 2016 | Pubmed ID: 27072779 Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis Biophysical Journal. Mar, 2016 | Pubmed ID: 26958889 Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane Molecular and Cellular Biology. 01, 2016 | Pubmed ID: 26572827 Grb2 Depletion Under Non-stimulated Conditions Inhibits PTEN, Promotes Akt-induced Tumor Formation and Contributes to Poor Prognosis in Ovarian Cancer Oncogene. 04, 2016 | Pubmed ID: 26212011 SIGNAL TRANSDUCTION. Membrane Potential Modulates Plasma Membrane Phospholipid Dynamics and K-Ras Signaling Science (New York, N.Y.). Aug, 2015 | Pubmed ID: 26293964 Specific Cancer-associated Mutations in the Switch III Region of Ras Increase Tumorigenicity by Nanocluster Augmentation ELife. Aug, 2015 | Pubmed ID: 26274561 Binding Hotspots on K-ras: Consensus Ligand Binding Sites and Other Reactive Regions from Probe-based Molecular Dynamics Analysis Proteins. May, 2015 | Pubmed ID: 25740554 Ras Nanoclusters: Versatile Lipid-based Signaling Platforms Biochimica Et Biophysica Acta. 04, 2015 | Pubmed ID: 25234412 Signal Integration by Lipid-mediated Spatial Cross Talk Between Ras Nanoclusters Molecular and Cellular Biology. Mar, 2014 | Pubmed ID: 24366544 Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-regulated Kinase Signaling in Cancer Cells Molecular and Cellular Biology. Jan, 2014 | Pubmed ID: 24164897 Inhibitors of K-Ras Plasma Membrane Localization The Enzymes. 2013 | Pubmed ID: 25033808 Another Surprise from Metformin: Novel Mechanism of Action Via K-Ras Influences Endometrial Cancer Response to Therapy Molecular Cancer Therapeutics. Dec, 2013 | Pubmed ID: 24077915 Andrographolide Derivatives Inhibit Guanine Nucleotide Exchange and Abrogate Oncogenic Ras Function Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23737504 Structure-based Reassessment of the Caveolin Signaling Model: Do Caveolae Regulate Signaling Through Caveolin-protein Interactions? Developmental Cell. Jul, 2012 | Pubmed ID: 22814599 Organization, Dynamics, and Segregation of Ras Nanoclusters in Membrane Domains Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22562795 Nonsteroidal Anti-inflammatory Drugs Alter the Spatiotemporal Organization of Ras Proteins on the Plasma Membrane The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22433858 H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output PloS One. Aug, 2010 | Pubmed ID: 20700538 Mathematical Modeling of K-Ras Nanocluster Formation on the Plasma Membrane Biophysical Journal. Jul, 2010 | Pubmed ID: 20643072 Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment to Induce Nanocluster Formation Molecular and Cellular Biology. Aug, 2010 | Pubmed ID: 20516214 Ras Membrane Orientation and Nanodomain Localization Generate Isoform Diversity Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010 | Pubmed ID: 20080631 On the Use of Ripley's K-function and Its Derivatives to Analyze Domain Size Biophysical Journal. Aug, 2009 | Pubmed ID: 19686657 Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19661056 Ras Acylation, Compartmentalization and Signaling Nanoclusters (Review) Molecular Membrane Biology. Jan, 2009 | Pubmed ID: 19115142 تحديد مثبطات EGFR و RAS باستخدام إليجانات Caenorhabditis Dharini van der Hoeven1,2, Thuy Nhu L. Truong1, Ali Naji1, Sabita Thapa1, John F. Hancock2, Ransome van der Hoeven1 1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center JoVE 61788 Cancer Research
تحديد مثبطات EGFR و RAS باستخدام إليجانات Caenorhabditis Dharini van der Hoeven1,2, Thuy Nhu L. Truong1, Ali Naji1, Sabita Thapa1, John F. Hancock2, Ransome van der Hoeven1 1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center JoVE 61788 Cancer Research
