John F. Hancock

Publications

• Lipidomic Atlas of Mammalian Cell Membranes Reveals Hierarchical Variation Induced by Culture Conditions, Subcellular Membranes, and Cell Lineages
  Soft Matter. May, 2020  |   Pubmed ID: 32451522
• Corrigendum: Fingolimod Augments Monomethylfumarate Killing of GBM Cells
  Frontiers in Oncology. 2020  |   Pubmed ID: 32426288
• Fingolimod Augments Monomethylfumarate Killing of GBM Cells
  Frontiers in Oncology. 2020  |   Pubmed ID: 32047722
• (Curcumin+sildenafil) Enhances the Efficacy of 5FU and Anti-PD1 Therapies in Vivo
  Journal of Cellular Physiology. Oct, 2020  |   Pubmed ID: 31985048
• Neratinib Degrades MST4 Via Autophagy That Reduces Membrane Stiffness and is Essential for the Inactivation of PI3K, ERK1/2, and YAP/TAZ Signaling
  Journal of Cellular Physiology. Nov, 2020  |   Pubmed ID: 31912905
• Enhanced Signaling Via ERBB3/PI3K Plays a Compensatory Survival Role in Pancreatic Tumor Cells Exposed to [neratinib + Valproate]
  Cellular Signalling. 04, 2020  |   Pubmed ID: 31911180
• A Novel Prenyl-polybasic Domain Code Determines Lipid-binding Specificity of the K-Ras Membrane Anchor
  Small GTPases. May, 2020  |   Pubmed ID: 29239694
• Distinct Binding Preferences Between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
  Molecular Cell. 12, 2019  |   Pubmed ID: 31606273
• Signaling Alterations Caused by Drugs and Autophagy
  Cellular Signalling. Dec, 2019  |   Pubmed ID: 31520735
• Targeting Plasma Membrane Phosphatidylserine Content to Inhibit Oncogenic KRAS Function
  Life Science Alliance. 10, 2019  |   Pubmed ID: 31451509
• Acylpeptide Hydrolase is a Novel Regulator of KRAS Plasma Membrane Localization and Function
  Journal of Cell Science. 07, 2019  |   Pubmed ID: 31266814
• Neratinib Inhibits Hippo/YAP Signaling, Reduces Mutant K-RAS Expression, and Kills Pancreatic and Blood Cancer Cells
  Oncogene. 07, 2019  |   Pubmed ID: 31253872
• Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding
  ACS Omega. Feb, 2019  |   Pubmed ID: 30842983
• HRAS-driven Cancer Cells Are Vulnerable to TRPML1 Inhibition
  EMBO Reports. Feb, 2019  |   Pubmed ID: 30787043
• Three Distinct Regions of CRaf Kinase Domain Interact with Membrane
  Scientific Reports. 02, 2019  |   Pubmed ID: 30765804
• Dynamics of Membrane-Bound G12V-KRAS from Simulations and Single-Molecule FRET in Native Nanodiscs
  Biophysical Journal. 01, 2019  |   Pubmed ID: 30616834
• Neratinib and Entinostat Combine to Rapidly Reduce the Expression of K-RAS, N-RAS, Gα and Gα and Kill Uveal Melanoma Cells
  Cancer Biology & Therapy. 2019  |   Pubmed ID: 30571927
• Neratinib Augments the Lethality of [regorafenib + sildenafil]
  Journal of Cellular Physiology. 04, 2019  |   Pubmed ID: 30203445
• Electron Microscopy Combined with Spatial Analysis: Quantitative Mapping of the Nano-assemblies of Plasma Membrane-associating Proteins and Lipids
  Biophysics Reports. 2018  |   Pubmed ID: 30596140
• An Oxanthroquinone Derivative That Disrupts RAS Plasma Membrane Localization Inhibits Cancer Cell Growth
  The Journal of Biological Chemistry. 08, 2018  |   Pubmed ID: 29970615
• Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor
  Molecular and Cellular Biology. 09, 2018  |   Pubmed ID: 29967243
• Ras and the Plasma Membrane: A Complicated Relationship
  Cold Spring Harbor Perspectives in Medicine. 10, 2018  |   Pubmed ID: 29229665
• Clustering of Rac1: Selective Lipid Sorting Drives Signaling
  Trends in Biochemical Sciences. 02, 2018  |   Pubmed ID: 29198968
• Sphingomyelin Metabolism Is a Regulator of K-Ras Function
  Molecular and Cellular Biology. Feb, 2018  |   Pubmed ID: 29158292
• Deciphering Lipid Codes: K-Ras As a Paradigm
  Traffic (Copenhagen, Denmark). 03, 2018  |   Pubmed ID: 29120102
• ω-3 Polyunsaturated Fatty Acids Direct Differentiation of the Membrane Phenotype in Mesenchymal Stem Cells to Potentiate Osteogenesis
  Science Advances. 11, 2017  |   Pubmed ID: 29134198
• Lipid Sorting and the Activity of Arf Signaling Complexes
  Proceedings of the National Academy of Sciences of the United States of America. 10, 2017  |   Pubmed ID: 29073041
• Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes
  Journal of the American Chemical Society. 09, 2017  |   Pubmed ID: 28863262
• Computational and Biochemical Characterization of Two Partially Overlapping Interfaces and Multiple Weak-affinity K-Ras Dimers
  Scientific Reports. Jan, 2017  |   Pubmed ID: 28067274
• Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output
  Cell. Jan, 2017  |   Pubmed ID: 28041850
• Corrigendum to "Ras Nanoclusters: Versatile Lipid-based Signaling Platforms" [Biochim. Biophys. Acta 1853/4 (2015) 841-849]
  Biochimica Et Biophysica Acta. Molecular Cell Research. Feb, 2017  |   Pubmed ID: 27875678
• Epac1 Interacts with Importin β1 and Controls Neurite Outgrowth Independently of CAMP and Rap1
  Scientific Reports. 11, 2016  |   Pubmed ID: 27808165
• AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions Via Cyclic GMP-Dependent Protein Kinase 2
  Molecular and Cellular Biology. 12, 2016  |   Pubmed ID: 27697864
• VPS35 Binds Farnesylated N-Ras in the Cytosol to Regulate N-Ras Trafficking
  The Journal of Cell Biology. Aug, 2016  |   Pubmed ID: 27502489
• Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization Through an Effector Binding Surface Suggests Limited Functional Role
  The Journal of Physical Chemistry. B. 08, 2016  |   Pubmed ID: 27072779
• Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis
  Biophysical Journal. Mar, 2016  |   Pubmed ID: 26958889
• Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane
  Molecular and Cellular Biology. 01, 2016  |   Pubmed ID: 26572827
• Grb2 Depletion Under Non-stimulated Conditions Inhibits PTEN, Promotes Akt-induced Tumor Formation and Contributes to Poor Prognosis in Ovarian Cancer
  Oncogene. 04, 2016  |   Pubmed ID: 26212011
• SIGNAL TRANSDUCTION. Membrane Potential Modulates Plasma Membrane Phospholipid Dynamics and K-Ras Signaling
  Science (New York, N.Y.). Aug, 2015  |   Pubmed ID: 26293964
• Specific Cancer-associated Mutations in the Switch III Region of Ras Increase Tumorigenicity by Nanocluster Augmentation
  ELife. Aug, 2015  |   Pubmed ID: 26274561
• Binding Hotspots on K-ras: Consensus Ligand Binding Sites and Other Reactive Regions from Probe-based Molecular Dynamics Analysis
  Proteins. May, 2015  |   Pubmed ID: 25740554
• Ras Nanoclusters: Versatile Lipid-based Signaling Platforms
  Biochimica Et Biophysica Acta. 04, 2015  |   Pubmed ID: 25234412
• Signal Integration by Lipid-mediated Spatial Cross Talk Between Ras Nanoclusters
  Molecular and Cellular Biology. Mar, 2014  |   Pubmed ID: 24366544
• Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-regulated Kinase Signaling in Cancer Cells
  Molecular and Cellular Biology. Jan, 2014  |   Pubmed ID: 24164897
• Inhibitors of K-Ras Plasma Membrane Localization
  The Enzymes. 2013  |   Pubmed ID: 25033808
• Another Surprise from Metformin: Novel Mechanism of Action Via K-Ras Influences Endometrial Cancer Response to Therapy
  Molecular Cancer Therapeutics. Dec, 2013  |   Pubmed ID: 24077915
• Andrographolide Derivatives Inhibit Guanine Nucleotide Exchange and Abrogate Oncogenic Ras Function
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013  |   Pubmed ID: 23737504
• Structure-based Reassessment of the Caveolin Signaling Model: Do Caveolae Regulate Signaling Through Caveolin-protein Interactions?
  Developmental Cell. Jul, 2012  |   Pubmed ID: 22814599
• Organization, Dynamics, and Segregation of Ras Nanoclusters in Membrane Domains
  Proceedings of the National Academy of Sciences of the United States of America. May, 2012  |   Pubmed ID: 22562795
• Nonsteroidal Anti-inflammatory Drugs Alter the Spatiotemporal Organization of Ras Proteins on the Plasma Membrane
  The Journal of Biological Chemistry. May, 2012  |   Pubmed ID: 22433858
• H-Ras Nanocluster Stability Regulates the Magnitude of MAPK Signal Output
  PloS One. Aug, 2010  |   Pubmed ID: 20700538
• Mathematical Modeling of K-Ras Nanocluster Formation on the Plasma Membrane
  Biophysical Journal. Jul, 2010  |   Pubmed ID: 20643072
• Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment to Induce Nanocluster Formation
  Molecular and Cellular Biology. Aug, 2010  |   Pubmed ID: 20516214
• Ras Membrane Orientation and Nanodomain Localization Generate Isoform Diversity
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010  |   Pubmed ID: 20080631
• On the Use of Ripley's K-function and Its Derivatives to Analyze Domain Size
  Biophysical Journal. Aug, 2009  |   Pubmed ID: 19686657
• Nucleophosmin and Nucleolin Regulate K-Ras Plasma Membrane Interactions and MAPK Signal Transduction
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19661056
• Ras Acylation, Compartmentalization and Signaling Nanoclusters (Review)
  Molecular Membrane Biology. Jan, 2009  |   Pubmed ID: 19115142