John S. Condeelis Department of Anatomy and Structural Biology Albert Einstein College of Medicine Biography Publications Institution JoVE Articles John S. Condeelis has not added a biography. If you are John S. Condeelis and would like to personalize this page please email our Author Liaison for assistance. Publications Ribosome Biogenesis During Cell Cycle Arrest Fuels EMT in Development and Disease Nature Communications. 05, 2019 | Pubmed ID: 31068593 Optimizing Leading Edge F-actin Labeling Using Multiple Actin Probes, Fixation Methods and Imaging Modalities BioTechniques. Mar, 2019 | Pubmed ID: 30869550 The Emerging Roles of Macrophages in Cancer Metastasis and Response to Chemotherapy Journal of Leukocyte Biology. Feb, 2019 | Pubmed ID: 30720887 Homophilic CD44 Interactions Mediate Tumor Cell Aggregation and Polyclonal Metastasis in Patient-Derived Breast Cancer Models Cancer Discovery. 01, 2019 | Pubmed ID: 30361447 Loss of Amphiregulin Reduces Myoepithelial Cell Coverage of Mammary Ducts and Alters Breast Tumor Growth Breast Cancer Research : BCR. 10, 2018 | Pubmed ID: 30367629 Black Race and Distant Recurrence After Neoadjuvant or Adjuvant Chemotherapy in Breast Cancer Clinical & Experimental Metastasis. 10, 2018 | Pubmed ID: 30136072 The Different Routes to Metastasis Via Hypoxia-Regulated Programs Trends in Cell Biology. 11, 2018 | Pubmed ID: 30041830 Myosin-IIA Heavy Chain Phosphorylation on S1943 Regulates Tumor Metastasis Experimental Cell Research. Sep, 2018 | Pubmed ID: 29953877 Targeting Invadopodia-mediated Breast Cancer Metastasis by Using ABL Kinase Inhibitors Oncotarget. Apr, 2018 | Pubmed ID: 29774130 A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation Cell Reports. May, 2018 | Pubmed ID: 29719241 A Novel Neuregulin - Jagged1 Paracrine Loop in Breast Cancer Transendothelial Migration Breast Cancer Research : BCR. 04, 2018 | Pubmed ID: 29636067 Chemotherapy-induced Metastasis: Mechanisms and Translational Opportunities Clinical & Experimental Metastasis. 04, 2018 | Pubmed ID: 29307118 Pyk2 and FAK Differentially Regulate Invadopodia Formation and Function in Breast Cancer Cells The Journal of Cell Biology. 01, 2018 | Pubmed ID: 29133485 Chemotherapy-induced Metastasis in Breast Cancer Oncotarget. Dec, 2017 | Pubmed ID: 29340008 Rac3 Regulates Breast Cancer Invasion and Metastasis by Controlling Adhesion and Matrix Degradation The Journal of Cell Biology. 12, 2017 | Pubmed ID: 29061650 The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2 Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors Molecular Cancer Therapeutics. 11, 2017 | Pubmed ID: 28838996 Neoadjuvant Chemotherapy Induces Breast Cancer Metastasis Through a TMEM-mediated Mechanism Science Translational Medicine. Jul, 2017 | Pubmed ID: 28679654 Tumor Cell Invadopodia: Invasive Protrusions That Orchestrate Metastasis Trends in Cell Biology. 08, 2017 | Pubmed ID: 28412099 Macrophage-dependent Tumor Cell Transendothelial Migration is Mediated by Notch1/Mena(INV)-initiated Invadopodium Formation Scientific Reports. Nov, 2016 | Pubmed ID: 27901093 Mena Dysregulates Cortactin Phosphorylation to Promote Invadopodium Maturation Scientific Reports. 11, 2016 | Pubmed ID: 27824079 Validation of a Device for the Active Manipulation of the Tumor Microenvironment During Intravital Imaging Intravital. 2016 | Pubmed ID: 27790386 The Alternatively-included 11a Sequence Modifies the Effects of Mena on Actin Cytoskeletal Organization and Cell Behavior Scientific Reports. Oct, 2016 | Pubmed ID: 27748415 Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells EBioMedicine. 11, 2016 | Pubmed ID: 27743905 Signatures of Breast Cancer Metastasis at a Glance Journal of Cell Science. May, 2016 | Pubmed ID: 27084578 GPCR Signaling Mediates Tumor Metastasis Via PI3Kβ Cancer Research. May, 2016 | Pubmed ID: 27013201 3-D Individual Cell Based Computational Modeling of Tumor Cell-macrophage Paracrine Signaling Mediated by EGF and CSF-1 Gradients Integrative Biology : Quantitative Biosciences from Nano to Macro. Jan, 2016 | Pubmed ID: 26686751 Characterization of the Expression of the Pro-metastatic Mena(INV) Isoform During Breast Tumor Progression Clinical & Experimental Metastasis. Mar, 2016 | Pubmed ID: 26680363 PTP1B-dependent Regulation of Receptor Tyrosine Kinase Signaling by the Actin-binding Protein Mena Molecular Biology of the Cell. Nov, 2015 | Pubmed ID: 26337385 Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA Cancer Discovery. Sep, 2015 | Pubmed ID: 26269515 Menacalc, a Quantitative Method of Metastasis Assessment, As a Prognostic Marker for Axillary Node-negative Breast Cancer BMC Cancer. 2015 | Pubmed ID: 26112005 Profilin1 Regulates Invadopodium Maturation in Human Breast Cancer Cells European Journal of Cell Biology. Feb, 2015 | Pubmed ID: 25613364 Autocrine CSF1R Signaling Mediates Switching Between Invasion and Proliferation Downstream of TGFβ in Claudin-low Breast Tumor Cells Oncogene. May, 2015 | Pubmed ID: 25088194 Invasive Breast Carcinoma Cells from Patients Exhibit MenaINV- and Macrophage-dependent Transendothelial Migration Science Signaling. Nov, 2014 | Pubmed ID: 25429076 Digging a Little Deeper: the Stages of Invadopodium Formation and Maturation European Journal of Cell Biology. Oct, 2014 | Pubmed ID: 25113547 An in Vitro One-dimensional Assay to Study Growth Factor-regulated Tumor Cell-macrophage Interaction Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24908299 Metastatic Cells: Moving Onco-targets Oncotarget. Jun, 2014 | Pubmed ID: 24907202 Tumor Microenvironment of Metastasis and Risk of Distant Metastasis of Breast Cancer Journal of the National Cancer Institute. Aug, 2014 | Pubmed ID: 24895374 Talin Regulates Moesin-NHE-1 Recruitment to Invadopodia and Promotes Mammary Tumor Metastasis The Journal of Cell Biology. Jun, 2014 | Pubmed ID: 24891603 Invadopodia in Context Cell Adhesion & Migration. 2014 | Pubmed ID: 24713806 Spatial Regulation of Tumor Cell Protrusions by RhoC Cell Adhesion & Migration. 2014 | Pubmed ID: 24642482 Filamin A Interacting Protein 1-like Inhibits WNT Signaling and MMP Expression to Suppress Cancer Cell Invasion and Metastasis International Journal of Cancer. Jul, 2014 | Pubmed ID: 24327474 Autocrine HBEGF Expression Promotes Breast Cancer Intravasation, Metastasis and Macrophage-independent Invasion in Vivo Oncogene. Jul, 2014 | Pubmed ID: 24013225 Intravital Multiphoton Imaging Reveals Multicellular Streaming As a Crucial Component of in Vivo Cell Migration in Human Breast Tumors Intravital. Apr, 2013 | Pubmed ID: 25013744 Wiskott-Aldrich Syndrome Protein Regulates Leukocyte-dependent Breast Cancer Metastasis Cell Reports. Aug, 2013 | Pubmed ID: 23911287 Dysregulation of PAD4-mediated Citrullination of Nuclear GSK3β Activates TGF-β Signaling and Induces Epithelial-to-mesenchymal Transition in Breast Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818587 Arg/Abl2 Promotes Invasion and Attenuates Proliferation of Breast Cancer in Vivo Oncogene. May, 2013 | Pubmed ID: 22777352 Development Path and Current Status of the NANIVID: a New Device for Cancer Cell Studies Journal of Micro/nanolithography, MEMS, and MOEMS : JM3. Mar, 2012 | Pubmed ID: 25419258 Reconstitution of in Vivo Macrophage-tumor Cell Pairing and Streaming Motility on One-dimensional Micro-patterned Substrates Intravital. Jul, 2012 | Pubmed ID: 24634804 Selective Gene-expression Profiling of Migratory Tumor Cells in Vivo Predicts Clinical Outcome in Breast Cancer Patients Breast Cancer Research : BCR. 2012 | Pubmed ID: 23113900 Quantitative Assessment of Invasive Mena Isoforms (Menacalc) As an Independent Prognostic Marker in Breast Cancer Breast Cancer Research : BCR. 2012 | Pubmed ID: 22971274 A FRET-facilitated Photoswitching Using an Orange Fluorescent Protein with the Fast Photoconversion Kinetics Journal of the American Chemical Society. Sep, 2012 | Pubmed ID: 22900938 Three-dimensional Microfluidic Model for Tumor Cell Intravasation and Endothelial Barrier Function Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869695 Correlated Immunohistochemical and Cytological Assays for the Prediction of Hematogenous Dissemination of Breast Cancer The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jan, 2012 | Pubmed ID: 22215635 Phosphoinositide 3-kinase Signaling is Critical for ErbB3-driven Breast Cancer Cell Motility and Metastasis Oncogene. Feb, 2012 | Pubmed ID: 21725367 Opposing Roles of CXCR4 and CXCR7 in Breast Cancer Metastasis Breast Cancer Research : BCR. Dec, 2011 | Pubmed ID: 22152016 An EMT-driven Alternative Splicing Program Occurs in Human Breast Cancer and Modulates Cellular Phenotype PLoS Genetics. Aug, 2011 | Pubmed ID: 21876675 A Photoswitchable Orange-to-far-red Fluorescent Protein, PSmOrange Nature Methods. Sep, 2011 | Pubmed ID: 21804536 Chemotaxis in Cancer Nature Reviews. Cancer. Aug, 2011 | Pubmed ID: 21779009 Mena Invasive (MenaINV) Promotes Multicellular Streaming Motility and Transendothelial Migration in a Mouse Model of Breast Cancer Journal of Cell Science. Jul, 2011 | Pubmed ID: 21670198 Mena Invasive (Mena(INV)) and Mena11a Isoforms Play Distinct Roles in Breast Cancer Cell Cohesion and Association with TMEM Clinical & Experimental Metastasis. Aug, 2011 | Pubmed ID: 21484349 Mena Deficiency Delays Tumor Progression and Decreases Metastasis in Polyoma Middle-T Transgenic Mouse Mammary Tumors Breast Cancer Research : BCR. 2010 | Pubmed ID: 21108830 A New Chemotaxis Device for Cell Migration Studies Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20938544 AACR Special Conference on Epithelial-mesenchymal Transition and Cancer Progression and Treatment Cancer Research. Oct, 2010 | Pubmed ID: 20823151 Gene Expression Analysis of Macrophages That Facilitate Tumor Invasion Supports a Role for Wnt-signaling in Mediating Their Activity in Primary Mammary Tumors Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010 | Pubmed ID: 20018620 Invasion of Human Breast Cancer Cells in Vivo Requires Both Paracrine and Autocrine Loops Involving the Colony-stimulating Factor-1 Receptor Cancer Research. Dec, 2009 | Pubmed ID: 19934330 Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-kinase Cancer Research. Dec, 2009 | Pubmed ID: 19903845 Tumor Microenvironment of Metastasis in Human Breast Carcinoma: a Potential Prognostic Marker Linked to Hematogenous Dissemination Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2009 | Pubmed ID: 19318480 Identification of Invasion Specific Splice Variants of the Cytoskeletal Protein Mena Present in Mammary Tumor Cells During Invasion in Vivo Clinical & Experimental Metastasis. 2009 | Pubmed ID: 18985426 A Mena Invasion Isoform Potentiates EGF-induced Carcinoma Cell Invasion and Metastasis Developmental Cell. Dec, 2008 | Pubmed ID: 19081071 Mechanisms and Cellular Roles of Local Protein Synthesis in Mammalian Cells Current Opinion in Cell Biology. Apr, 2008 | Pubmed ID: 18378131 RhoA/ROCK-mediated Switching Between Cdc42- and Rac1-dependent Protrusion in MTLn3 Carcinoma Cells Experimental Cell Research. Apr, 2008 | Pubmed ID: 18316075 Imaging Real-time Gene Expression in Living Systems with Single-transcript Resolution: Construct Design and Imaging System Setup CSH Protocols. 2007 | Pubmed ID: 21356986 Imaging Real-Time Gene Expression in Living Systems with Single-Transcript Resolution: Single MRNA Particle Tracking with ImageJ-Based Analysis CSH Protocols. 2007 | Pubmed ID: 21356980 Imaging Real-time Gene Expression in Living Systems with Single-transcript Resolution: Image Analysis of Single MRNA Transcripts CSH Protocols. 2007 | Pubmed ID: 21356979 Imaging Real-time Gene Expression in Living Yeast CSH Protocols. 2007 | Pubmed ID: 21356978 Imaging Real-time Gene Expression in Mammalian Cells with Single-transcript Resolution CSH Protocols. 2007 | Pubmed ID: 21356977 EGF-induced PIP2 Hydrolysis Releases and Activates Cofilin Locally in Carcinoma Cells The Journal of Cell Biology. Dec, 2007 | Pubmed ID: 18086920 ZBP1 Enhances Cell Polarity and Reduces Chemotaxis Journal of Cell Science. Sep, 2007 | Pubmed ID: 17878234 Cdc42 is Required for EGF-stimulated Protrusion and Motility in MTLn3 Carcinoma Cells Journal of Cell Science. Oct, 2007 | Pubmed ID: 17855387 The Distinct Roles of Ras and Rac in PI 3-kinase-dependent Protrusion During EGF-stimulated Cell Migration Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698922 Coordinated Regulation of Pathways for Enhanced Cell Motility and Chemotaxis is Conserved in Rat and Mouse Mammary Tumors Cancer Research. Apr, 2007 | Pubmed ID: 17440055 Molecular Cloning of HMena (ENAH) and Its Splice Variant HMena+11a: Epidermal Growth Factor Increases Their Expression and Stimulates HMena+11a Phosphorylation in Breast Cancer Cell Lines Cancer Research. Mar, 2007 | Pubmed ID: 17363586 ROCK- and Myosin-dependent Matrix Deformation Enables Protease-independent Tumor-cell Invasion in Vivo Current Biology : CB. Aug, 2006 | Pubmed ID: 16890527 Initiation of Cofilin Activity in Response to EGF is Uncoupled from Cofilin Phosphorylation and Dephosphorylation in Carcinoma Cells Journal of Cell Science. Jul, 2006 | Pubmed ID: 16803871 The Activity Status of Cofilin is Directly Related to Invasion, Intravasation, and Metastasis of Mammary Tumors The Journal of Cell Biology. May, 2006 | Pubmed ID: 16651380 Macrophages Promote the Invasion of Breast Carcinoma Cells Via a Colony-stimulating Factor-1/epidermal Growth Factor Paracrine Loop Cancer Research. Jun, 2005 | Pubmed ID: 15958574 Tumor Cells Caught in the Act of Invading: Their Strategy for Enhanced Cell Motility Trends in Cell Biology. Mar, 2005 | Pubmed ID: 15752977 Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells Within Primary Mammary Tumors Cancer Research. Dec, 2004 | Pubmed ID: 15574765 Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy Cancer Research. Nov, 2004 | Pubmed ID: 15520165 Over-expression of the P110beta but Not P110alpha Isoform of PI 3-kinase Inhibits Motility in Breast Cancer Cells Cell Motility and the Cytoskeleton. Nov, 2004 | Pubmed ID: 15468162 Cofilin Promotes Actin Polymerization and Defines the Direction of Cell Motility Science (New York, N.Y.). Apr, 2004 | Pubmed ID: 15118165 Gene Expression Analysis on Small Numbers of Invasive Cells Collected by Chemotaxis from Primary Mammary Tumors of the Mouse BMC Biotechnology. Aug, 2003 | Pubmed ID: 12914671 GFP Expression in the Mammary Gland for Imaging of Mammary Tumor Cells in Transgenic Mice Cancer Research. Dec, 2002 | Pubmed ID: 12499251 Single Cell Behavior in Metastatic Primary Mammary Tumors Correlated with Gene Expression Patterns Revealed by Molecular Profiling Cancer Research. Nov, 2002 | Pubmed ID: 12414658 A New Strategy for Caging Proteins Regulated by Kinases Journal of the American Chemical Society. Mar, 2002 | Pubmed ID: 11890784 Protein Tyrosine Phosphatase Phi Regulates Paxillin Tyrosine Phosphorylation and Mediates Colony-stimulating Factor 1-induced Morphological Changes in Macrophages Molecular and Cellular Biology. Mar, 2001 | Pubmed ID: 11238916 Phosphorylation of ADF/cofilin Abolishes EGF-induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension The Journal of Cell Biology. Nov, 2000 | Pubmed ID: 11086013 Role of Cofilin in Epidermal Growth Factor-stimulated Actin Polymerization and Lamellipod Protrusion The Journal of Cell Biology. Feb, 2000 | Pubmed ID: 10662778 Relationship Between Arp2/3 Complex and the Barbed Ends of Actin Filaments at the Leading Edge of Carcinoma Cells After Epidermal Growth Factor Stimulation The Journal of Cell Biology. Apr, 1999 | Pubmed ID: 10209028 Оценка опухолевой микросреды метастазов Doorway-Mediated Сосудистая проницаемость, связанная с распространением раковых клеток с помощью интравитального изображения и фиксированного анализа тканей George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 Cancer Research
Оценка опухолевой микросреды метастазов Doorway-Mediated Сосудистая проницаемость, связанная с распространением раковых клеток с помощью интравитального изображения и фиксированного анализа тканей George S. Karagiannis1,2,3, Jessica M. Pastoriza1,2,4, Lucia Borriello1,2, Rojin Jafari1,2, Anouchka Coste1,2,4, John S. Condeelis1,2,3,4, Maja H. Oktay1,2,3,5, David Entenberg1,2,3 1Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 2Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine, 3Integrated Imaging Program, Albert Einstein College of Medicine, 4Department of Surgery, Montefiore Medical Center, 5Department of Pathology, Montefiore Medical Center JoVE 59633 Cancer Research
