John B. Bruning

Publications

• Vanishing White Matter: Eukaryotic Initiation Factor 2B Model and the Impact of Missense Mutations
  Molecular Genetics & Genomic Medicine. Jan, 2021  |   Pubmed ID: 33432707
• Nucleoside Selectivity of Aspergillus Fumigatus Nucleoside-diphosphate Kinase
  The FEBS Journal. Oct, 2020  |   Pubmed ID: 33089641
• D-Alanine-d-alanine Ligase As a Model for the Activation of ATP-grasp Enzymes by Monovalent Cations
  The Journal of Biological Chemistry. 06, 2020  |   Pubmed ID: 32335509
• An Aldo-keto Reductase with 2-keto-l-gulonate Reductase Activity Functions in L-tartaric Acid Biosynthesis from Vitamin C in
  The Journal of Biological Chemistry. 11, 2019  |   Pubmed ID: 31488549
• Combining Random Microseed Matrix Screening and the Magic Triangle for the Efficient Structure Solution of a Potential Lysin from Bacteriophage P68
  Acta Crystallographica. Section D, Structural Biology. Jul, 2019  |   Pubmed ID: 31282476
• Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules
  Methods in Molecular Biology (Clifton, N.J.). 2019  |   Pubmed ID: 31041754
• Shooting Three Inflammatory Targets with a Single Bullet: Novel Multi-targeting Anti-inflammatory Glitazones
  European Journal of Medicinal Chemistry. Apr, 2019  |   Pubmed ID: 30818268
• Structure, Mechanism, and Inhibition of Thioredoxin Reductase
  Antimicrobial Agents and Chemotherapy. 03, 2019  |   Pubmed ID: 30642940
• Structural and Dynamic Elucidation of a Non-acid PPAR Partial Agonist: SR1988
  Nuclear Receptor Research. 2018  |   Pubmed ID: 30906767
• Precipitant-ligand Exchange Technique Reveals the ADP Binding Mode in Mycobacterium Tuberculosis Dethiobiotin Synthetase
  Acta Crystallographica. Section D, Structural Biology. Oct, 2018  |   Pubmed ID: 30289406
• Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism
  Structure (London, England : 1993). 11, 2018  |   Pubmed ID: 30146169
• PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix
  IScience. Feb, 2018  |   Pubmed ID: 30123887
• Rational Design of a 3 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp
  Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2018  |   Pubmed ID: 29917264
• HDX Reveals the Conformational Dynamics of DNA Sequence Specific VDR Co-activator Interactions
  Nature Communications. 10, 2017  |   Pubmed ID: 29030554
• X-ray Crystal Structure of Rivoglitazone Bound to PPARγ and PPAR Subtype Selectivity of TZDs
  Biochimica Et Biophysica Acta. General Subjects. Aug, 2017  |   Pubmed ID: 28499821
• Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics
  Journal of Medicinal Chemistry. 06, 2017  |   Pubmed ID: 28485590
• Structure of the Sliding Clamp from the Fungal Pathogen Aspergillus Fumigatus (AfumPCNA) and Interactions with Human P21
  The FEBS Journal. 03, 2017  |   Pubmed ID: 28165677
• SR2067 Reveals a Unique Kinetic and Structural Signature for PPARγ Partial Agonism
  ACS Chemical Biology. Jan, 2016  |   Pubmed ID: 26579553
• Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism
  PPAR Research. 2015  |   Pubmed ID: 26435709
• Structural Mechanism for Signal Transduction in RXR Nuclear Receptor Heterodimers
  Nature Communications. Aug, 2015  |   Pubmed ID: 26289479
• Pharmacological Repression of PPARγ Promotes Osteogenesis
  Nature Communications. Jun, 2015  |   Pubmed ID: 26068133
• New Insights into the Evolutionary History of Plant Sorbitol Dehydrogenase
  BMC Plant Biology. Apr, 2015  |   Pubmed ID: 25879735
• Macrocyclic Protease Inhibitors with Reduced Peptide Character
  Angewandte Chemie (International Ed. in English). Jul, 2014  |   Pubmed ID: 24903745
• Human Variants in the Neuronal Basic Helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function
  PloS One. 2014  |   Pubmed ID: 24465693