John H. Sampson Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery Duke University Biography Publications Institution JoVE Articles John H. Sampson has not added a biography. If you are John H. Sampson and would like to personalize this page please email our Author Liaison for assistance. Publications Proteomic Profiling of Patient-derived Glioblastoma Xenografts Identifies a Subset with Activated EGFR: Implications for Drug Development Journal of Neurochemistry. Jan, 2015 | Pubmed ID: 25598002 A Phase II, Multicenter Trial of Rindopepimut (CDX-110) in Newly Diagnosed Glioblastoma: the ACT III Study Neuro-oncology. Jan, 2015 | Pubmed ID: 25586468 Increased Proportion of FoxP3+ Regulatory T Cells in Tumor Infiltrating Lymphocytes is Associated with Tumor Recurrence and Reduced Survival in Patients with Glioblastoma Cancer Immunology, Immunotherapy : CII. Jan, 2015 | Pubmed ID: 25555571 Enhancing Dendritic Cell-based Vaccination for Highly Aggressive Glioblastoma Expert Opinion on Biological Therapy. Jan, 2015 | Pubmed ID: 25327832 Chimeric Antigen Receptor Engineered T Cells Can Eliminate Brain Tumors and Initiate Long-term Protection Against Recurrence Oncoimmunology. 2014 | Pubmed ID: 25610729 Leveraging Chemotherapy-induced Lymphopenia to Potentiate Cancer Immunotherapy Oncoimmunology. 2014 | Pubmed ID: 25610727 Peptide Vaccines for the Treatment of Glioblastoma Journal of Neuro-oncology. Dec, 2014 | Pubmed ID: 25491947 Defining the Optimal Planning Target Volume in Image-Guided Stereotactic Radiosurgery of Brain Metastases: Results of a Randomized Trial International Journal of Radiation Oncology, Biology, Physics. Oct, 2014 | Pubmed ID: 25442342 Immunotherapy for Primary Brain Tumors: No Longer a Matter of Privilege Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2014 | Pubmed ID: 25398845 Severe Adverse Immunologic Reaction in a Patient with Glioblastoma Receiving Autologous Dendritic Cell Vaccines Combined with GM-CSF and Dose-Intensified Temozolomide Cancer Immunology Research. Nov, 2014 | Pubmed ID: 25387895 Targeting MiR-23a in CD8+ Cytotoxic T Lymphocytes Prevents Tumor-dependent Immunosuppression The Journal of Clinical Investigation. Dec, 2014 | Pubmed ID: 25347474 Epidermal Growth Factor Receptor and Variant III Targeted Immunotherapy Neuro-oncology. Oct, 2014 | Pubmed ID: 25342601 Recurrent Malignant Gliomas Seminars in Radiation Oncology. Oct, 2014 | Pubmed ID: 25219814 Immunotherapy Advances for Glioblastoma Neuro-oncology. Nov, 2014 | Pubmed ID: 25190673 Rindopepimut: a Promising Immunotherapeutic for the Treatment of Glioblastoma Multiforme Immunotherapy. Jun, 2014 | Pubmed ID: 25186601 Antibody-based Immunotherapy for Malignant Glioma Seminars in Oncology. Aug, 2014 | Pubmed ID: 25173142 Standard of Care and Future Pharmacological Treatment Options for Malignant Glioma: an Urgent Need for Screening and Identification of Novel Tumor-specific Antigens Expert Opinion on Pharmacotherapy. Oct, 2014 | Pubmed ID: 25139628 Immunological Targeting of Cytomegalovirus for Glioblastoma Therapy Oncoimmunology. 2014 | Pubmed ID: 25101224 A Novel, Reproducible, and Objective Method for Volumetric Magnetic Resonance Imaging Assessment of Enhancing Glioblastoma Journal of Neurosurgery. Sep, 2014 | Pubmed ID: 25036205 Oncolytic Polio Virotherapy of Cancer Cancer. Nov, 2014 | Pubmed ID: 24939611 Worse Outcomes for Patients Undergoing Brain Tumor and Cerebrovascular Procedures Following the ACGME Resident Duty-hour Restrictions Journal of Neurosurgery. Aug, 2014 | Pubmed ID: 24926647 Response Journal of Neurosurgery. Mar, 2014 | Pubmed ID: 24724172 EGFRvIII-specific Chimeric Antigen Receptor T Cells Migrate to and Kill Tumor Deposits Infiltrating the Brain Parenchyma in an Invasive Xenograft Model of Glioblastoma PloS One. 2014 | Pubmed ID: 24722266 Recognition and Killing of Autologous, Primary Glioblastoma Tumor Cells by Human Cytomegalovirus Pp65-specific Cytotoxic T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2014 | Pubmed ID: 24658154 Methodology and Reporting of Meta-analyses in the Neurosurgical Literature Journal of Neurosurgery. Apr, 2014 | Pubmed ID: 24460491 Editorial on "heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccination for Recurrent Glioblastoma: a Phase II, Single Arm Trial" Neuro-oncology. Jan, 2014 | Pubmed ID: 24443362 Impact of PhD Training on Scholarship in a Neurosurgical Career Journal of Neurosurgery. Mar, 2014 | Pubmed ID: 24359004 EGFRvIII MCAR-modified T-cell Therapy Cures Mice with Established Intracerebral Glioma and Generates Host Immunity Against Tumor-antigen Loss Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2014 | Pubmed ID: 24352643 SEER Insights Journal of Neurosurgery. Feb, 2014 | Pubmed ID: 24286150 Intracerebral Delivery of a Third Generation EGFRvIII-specific Chimeric Antigen Receptor is Efficacious Against Human Glioma Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Jan, 2014 | Pubmed ID: 24054399 Human Regulatory T Cells Kill Tumor Cells Through Granzyme-dependent Cytotoxicity Upon Retargeting with a Bispecific Antibody Cancer Immunology Research. Sep, 2013 | Pubmed ID: 24570975 Regulatory T Cells Are Redirected to Kill Glioblastoma by an EGFRvIII-targeted Bispecific Antibody Oncoimmunology. Dec, 2013 | Pubmed ID: 24475376 Enhanced Oncolytic Virotherapy Through Oxidative Stress Inhibition Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2013 | Pubmed ID: 24201213 A Cytokine Cocktail Directly Modulates the Phenotype of DC-enriched Anti-tumor T Cells to Convey Potent Anti-tumor Activities in a Murine Model Cancer Immunology, Immunotherapy : CII. Nov, 2013 | Pubmed ID: 23982483 An EGFRvIII-targeted Bispecific T-cell Engager Overcomes Limitations of the Standard of Care for Glioblastoma Expert Review of Clinical Pharmacology. Jul, 2013 | Pubmed ID: 23927666 Antibody, T-cell and Dendritic Cell Immunotherapy for Malignant Brain Tumors Future Oncology (London, England). Jul, 2013 | Pubmed ID: 23837761 Rational Design and Generation of Recombinant Control Reagents for Bispecific Antibodies Through CDR Mutagenesis Journal of Immunological Methods. Sep, 2013 | Pubmed ID: 23806556 Complete Response to Steroids in Dural Inflammatory Pseudotumor Associated with Still's Disease Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. Oct, 2013 | Pubmed ID: 23768965 An Update on Vaccine Therapy and Other Immunotherapeutic Approaches for Glioblastoma Expert Review of Vaccines. Jun, 2013 | Pubmed ID: 23750791 A Novel Bispecific Antibody Recruits T Cells to Eradicate Tumors in the "immunologically Privileged" Central Nervous System Oncoimmunology. Apr, 2013 | Pubmed ID: 23734318 Concurrent Stereotactic Radiosurgery and Bevacizumab in Recurrent Malignant Gliomas: a Prospective Trial International Journal of Radiation Oncology, Biology, Physics. Aug, 2013 | Pubmed ID: 23725997 Clinicopathological Characteristics and Treatment of Rhabdoid Glioblastoma Journal of Neurosurgery. Aug, 2013 | Pubmed ID: 23641829 Radiotherapy and Radiosurgery for Tumors of the Central Nervous System Surgical Oncology Clinics of North America. Jul, 2013 | Pubmed ID: 23622073 BLyS Levels Correlate with Vaccine-induced Antibody Titers in Patients with Glioblastoma Lymphodepleted by Therapeutic Temozolomide Cancer Immunology, Immunotherapy : CII. Jun, 2013 | Pubmed ID: 23591978 Isocitrate Dehydrogenase 1: What It Means to the Neurosurgeon: a Review Journal of Neurosurgery. Jun, 2013 | Pubmed ID: 23581583 Myeloablative Temozolomide Enhances CD8⁺ T-cell Responses to Vaccine and is Required for Efficacy Against Brain Tumors in Mice PloS One. 2013 | Pubmed ID: 23527092 Thickness of Subcutaneous Fat As a Risk Factor for Infection in Cervical Spine Fusion Surgery The Journal of Bone and Joint Surgery. American Volume. Feb, 2013 | Pubmed ID: 23426766 Systemic Administration of a Bispecific Antibody Targeting EGFRvIII Successfully Treats Intracerebral Glioma Proceedings of the National Academy of Sciences of the United States of America. Jan, 2013 | Pubmed ID: 23248284 Subarachnoid Hemorrhage Trials Journal of Neurosurgery. Jan, 2013 | Pubmed ID: 23039153 Contemporary Surgical Management of Vestibular Schwannomas: Analysis of Complications and Lessons Learned over the Past Decade Neurosurgery. Jun, 2013 | Pubmed ID: 23037828 Therapeutic Approaches for HER2-positive Brain Metastases: Circumventing the Blood-brain Barrier Cancer Treatment Reviews. May, 2013 | Pubmed ID: 22727691 The Limitations of Imaging Response Criteria The Lancet. Oncology. Nov, 2012 | Pubmed ID: 23116995 Regulatory T Cells Move in when Gliomas Say "I Do" Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2012 | Pubmed ID: 23052252 Enzyme Redesign Guided by Cancer-derived IDH1 Mutations Nature Chemical Biology. Nov, 2012 | Pubmed ID: 23001033 Editorial: Convection-enhanced Delivery Journal of Neurosurgery. Dec, 2012 | Pubmed ID: 22998062 Stereotactic Radiosurgery and Bevacizumab for Recurrent Glioblastoma Multiforme Journal of the National Comprehensive Cancer Network : JNCCN. Jun, 2012 | Pubmed ID: 22679114 The Use of Motor Mapping to Aid Resection of Eloquent Gliomas Neurosurgery Clinics of North America. Apr, 2012 | Pubmed ID: 22440865 Resection and Survival Journal of Neurosurgery. Jun, 2012 | Pubmed ID: 22424561 Phase 1 Trial of Dasatinib Plus Erlotinib in Adults with Recurrent Malignant Glioma Journal of Neuro-oncology. Jul, 2012 | Pubmed ID: 22407177 Toxin-based Targeted Therapy for Malignant Brain Tumors Clinical & Developmental Immunology. 2012 | Pubmed ID: 22400035 A Pilot Study of IL-2Rα Blockade During Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma PloS One. 2012 | Pubmed ID: 22383993 Convection Enhanced Delivery of Macromolecules for Brain Tumors Current Drug Discovery Technologies. Dec, 2012 | Pubmed ID: 22339074 Immunotherapy with Tumor Vaccines for the Treatment of Malignant Gliomas Current Drug Discovery Technologies. Dec, 2012 | Pubmed ID: 22339070 Clinical Data Simplified Journal of Neurosurgery. Feb, 2012 | Pubmed ID: 22054209 Avastin: More Questions Than Answers. . Journal of Neurosurgery. Feb, 2012 | Pubmed ID: 22035270 Phase II Study of Carboplatin, Irinotecan, and Bevacizumab for Bevacizumab Naïve, Recurrent Glioblastoma Journal of Neuro-oncology. Mar, 2012 | Pubmed ID: 21986722 Phase II Study of Gleevec® Plus Hydroxyurea (HU) in Adults with Progressive or Recurrent Meningioma Journal of Neuro-oncology. Jan, 2012 | Pubmed ID: 21938530 Disparities in Care Journal of Neurosurgery. Feb, 2012 | Pubmed ID: 21740120 Application of Novel Response/progression Measures for Surgically Delivered Therapies for Gliomas: Response Assessment in Neuro-Oncology (RANO) Working Group Neurosurgery. Jan, 2012 | Pubmed ID: 21593697 Safety and Efficacy of Stereotactic Radiosurgery and Adjuvant Bevacizumab in Patients with Recurrent Malignant Gliomas International Journal of Radiation Oncology, Biology, Physics. Apr, 2012 | Pubmed ID: 21489708 Imaging of Convection Enhanced Delivery of Toxins in Humans Toxins. Mar, 2011 | Pubmed ID: 22069706 Monitoring Radiographic Brain Tumor Progression Toxins. Mar, 2011 | Pubmed ID: 22069705 Bevacizumab-induced Reversible Posterior Leukoencephalopathy Syndrome and Successful Retreatment in a Patient with Glioblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2011 | Pubmed ID: 21900098 Monoclonal Antibody Blockade of IL-2 Receptor α During Lymphopenia Selectively Depletes Regulatory T Cells in Mice and Humans Blood. Sep, 2011 | Pubmed ID: 21768296 Is Cytomegalovirus a Therapeutic Target in Glioblastoma? Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2011 | Pubmed ID: 21632859 Convection-enhanced Delivery Journal of Neurosurgery. Sep, 2011 | Pubmed ID: 21619413 Phase 2 Study of Carboplatin, Irinotecan, and Bevacizumab for Recurrent Glioblastoma After Progression on Bevacizumab Therapy Cancer. Dec, 2011 | Pubmed ID: 21590689 Our Failure to Advance New Treatments for Glioma to Market Journal of Neurosurgery. Aug, 2011 | Pubmed ID: 21568655 The Addition of Bevacizumab to Standard Radiation Therapy and Temozolomide Followed by Bevacizumab, Temozolomide, and Irinotecan for Newly Diagnosed Glioblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2011 | Pubmed ID: 21531816 Epidemiology Journal of Neurosurgery. Aug, 2011 | Pubmed ID: 21529133 A Review of VEGF/VEGFR-targeted Therapeutics for Recurrent Glioblastoma Journal of the National Comprehensive Cancer Network : JNCCN. Apr, 2011 | Pubmed ID: 21464146 Bispecific Antibodies Engage T Cells for Antitumor Immunotherapy Expert Opinion on Biological Therapy. Jul, 2011 | Pubmed ID: 21449821 Colocalization of Gadolinium-diethylene Triamine Pentaacetic Acid with High-molecular-weight Molecules After Intracerebral Convection-enhanced Delivery in Humans Neurosurgery. Sep, 2011 | Pubmed ID: 21430586 Clinical Trial End Points for High-grade Glioma: the Evolving Landscape Neuro-oncology. Mar, 2011 | Pubmed ID: 21310734 A Novel Method for Volumetric MRI Response Assessment of Enhancing Brain Tumors PloS One. 2011 | Pubmed ID: 21298088 Resection of Vestibular Schwannomas Journal of Neurosurgery. May, 2011 | Pubmed ID: 21250806 Greater Chemotherapy-induced Lymphopenia Enhances Tumor-specific Immune Responses That Eliminate EGFRvIII-expressing Tumor Cells in Patients with Glioblastoma Neuro-oncology. Mar, 2011 | Pubmed ID: 21149254 Immunotherapy Coming of Age: What Will It Take to Make It Standard of Care for Glioblastoma? Neuro-oncology. Jan, 2011 | Pubmed ID: 21149252 A Comprehensive Outlook on Intracerebral Therapy of Malignant Gliomas Critical Reviews in Oncology/hematology. Oct, 2011 | Pubmed ID: 20888252 Low-grade Glioma Journal of Neurosurgery. Mar, 2011 | Pubmed ID: 20635855 Effect of Imaging and Catheter Characteristics on Clinical Outcome for Patients in the PRECISE Study Journal of Neuro-oncology. Jan, 2011 | Pubmed ID: 20563833 Effect of CYP3A-inducing Anti-epileptics on Sorafenib Exposure: Results of a Phase II Study of Sorafenib Plus Daily Temozolomide in Adults with Recurrent Glioblastoma Journal of Neuro-oncology. Jan, 2011 | Pubmed ID: 20443129 Immunologic Escape After Prolonged Progression-free Survival with Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients with Newly Diagnosed Glioblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2010 | Pubmed ID: 20921459 Stereotactic Radiosurgery in the Treatment of a Dural Carotid-cavernous Fistula Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. Jun, 2010 | Pubmed ID: 20431489 Immunotherapy Approaches for Malignant Glioma from 2007 to 2009 Current Neurology and Neuroscience Reports. Jul, 2010 | Pubmed ID: 20424975 Long-term Safety of Combined Intracerebral Delivery of Free Gadolinium and Targeted Chemotherapeutic Agent PRX321 Neurological Research. Oct, 2010 | Pubmed ID: 20021739 Poor Drug Distribution As a Possible Explanation for the Results of the PRECISE Trial Journal of Neurosurgery. Aug, 2010 | Pubmed ID: 20020841 Bevacizumab Fails to Treat Temporal Paraganglioma: Discussion and Case Illustration Journal of Neuro-oncology. Jul, 2010 | Pubmed ID: 20020179 The Role of Tregs in Glioma-mediated Immunosuppression: Potential Target for Intervention Neurosurgery Clinics of North America. Jan, 2010 | Pubmed ID: 19944972 Clinical Applications of a Peptide-based Vaccine for Glioblastoma Neurosurgery Clinics of North America. Jan, 2010 | Pubmed ID: 19944970 Convection-enhanced Delivery of Free Gadolinium with the Recombinant Immunotoxin MR1-1 Journal of Neuro-oncology. May, 2010 | Pubmed ID: 19898744 Phase 2 Trial of Erlotinib Plus Sirolimus in Adults with Recurrent Glioblastoma Journal of Neuro-oncology. Jan, 2010 | Pubmed ID: 19562254 The Role of Tregs in Human Glioma Patients and Their Inhibition with a Novel STAT-3 Inhibitor Clinical Neurosurgery. 2009 | Pubmed ID: 20214040 An Epidermal Growth Factor Receptor Variant III-targeted Vaccine is Safe and Immunogenic in Patients with Glioblastoma Multiforme Molecular Cancer Therapeutics. Oct, 2009 | Pubmed ID: 19825799 EGFRvIII-targeted Vaccination Therapy of Malignant Glioma Brain Pathology (Zurich, Switzerland). Oct, 2009 | Pubmed ID: 19744042 Treatment of HER2-positive Breast Carcinomatous Meningitis with Intrathecal Administration of Alpha-particle-emitting (211)At-labeled Trastuzumab Nuclear Medicine and Biology. Aug, 2009 | Pubmed ID: 19647172 The PEPvIII-KLH (CDX-110) Vaccine in Glioblastoma Multiforme Patients Expert Opinion on Biological Therapy. Aug, 2009 | Pubmed ID: 19591631 Toward Effective Immunotherapy for the Treatment of Malignant Brain Tumors Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jul, 2009 | Pubmed ID: 19560742 Phase II Trial of Temozolomide (TMZ) Plus Irinotecan (CPT-11) in Adults with Newly Diagnosed Glioblastoma Multiforme Before Radiotherapy Journal of Neuro-oncology. Dec, 2009 | Pubmed ID: 19533023 A Constitutively Active Form of Neurokinin 1 Receptor and Neurokinin 1 Receptor-mediated Apoptosis in Glioblastomas Journal of Neurochemistry. May, 2009 | Pubmed ID: 19519779 Paraganglioma of the Head and Neck: Long-term Local Control with Radiotherapy American Journal of Clinical Oncology. Jun, 2009 | Pubmed ID: 19433962 IgE, Allergy, and Risk of Glioma: Update from the San Francisco Bay Area Adult Glioma Study in the Temozolomide Era International Journal of Cancer. Journal International Du Cancer. Aug, 2009 | Pubmed ID: 19408307 Phase 1 Trial of Temozolomide Plus Irinotecan Plus O6-benzylguanine in Adults with Recurrent Malignant Glioma Cancer. Jul, 2009 | Pubmed ID: 19402172 Phase I Trial of Temozolomide Plus O6-benzylguanine 5-day Regimen with Recurrent Malignant Glioma Neuro-oncology. Oct, 2009 | Pubmed ID: 19289491 Phase II Trial of Temozolomide Plus O6-benzylguanine in Adults with Recurrent, Temozolomide-resistant Malignant Glioma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2009 | Pubmed ID: 19204199 Phase II Trial of Gliadel Plus O6-benzylguanine in Adults with Recurrent Glioblastoma Multiforme Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2009 | Pubmed ID: 19188181 Proteomic and Immunologic Analyses of Brain Tumor Exosomes FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2009 | Pubmed ID: 19109410 Stereotactic Body Radiotherapy for Lesions of the Spine and Paraspinal Regions International Journal of Radiation Oncology, Biology, Physics. Apr, 2009 | Pubmed ID: 19004569 A Novel Inhibitor of Signal Transducers and Activators of Transcription 3 Activation is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2008 | Pubmed ID: 18794085 Detection of Humoral Response in Patients with Glioblastoma Receiving EGFRvIII-KLH Vaccines Journal of Immunological Methods. Nov, 2008 | Pubmed ID: 18775433 Tumor-specific Immunotherapy Targeting the EGFRvIII Mutation in Patients with Malignant Glioma Seminars in Immunology. Oct, 2008 | Pubmed ID: 18539480 Combating Immunosuppression in Glioma Future Oncology (London, England). Jun, 2008 | Pubmed ID: 18518768 Immunotherapy Against Angiogenesis-associated Targets: Evidence and Implications for the Treatment of Malignant Glioma Expert Review of Anticancer Therapy. May, 2008 | Pubmed ID: 18471045 Selective Modification of Antigen-specific T Cells by RNA Electroporation Human Gene Therapy. May, 2008 | Pubmed ID: 18471037 Intracerebral Infusion of an EGFR-targeted Toxin in Recurrent Malignant Brain Tumors Neuro-oncology. Jun, 2008 | Pubmed ID: 18403491 Cryptococcal Meningitis in Patients with Glioma: a Report of Two Cases Journal of Neuro-oncology. Aug, 2008 | Pubmed ID: 18398572 Immunotherapy of Malignant Brain Tumors Immunological Reviews. Apr, 2008 | Pubmed ID: 18363995 Cholesterol Granuloma of the Lateral Ventricle. Case Report Journal of Neurosurgery. Feb, 2008 | Pubmed ID: 18240934 Immunological Responses in a Patient with Glioblastoma Multiforme Treated with Sequential Courses of Temozolomide and Immunotherapy: Case Study Neuro-oncology. Feb, 2008 | Pubmed ID: 18079360 Sensitive Detection of Human Cytomegalovirus in Tumors and Peripheral Blood of Patients Diagnosed with Glioblastoma Neuro-oncology. Feb, 2008 | Pubmed ID: 17951512 EGFRvIII-targeted Immunotoxin Induces Antitumor Immunity That is Inhibited in the Absence of CD4+ and CD8+ T Cells Cancer Immunology, Immunotherapy : CII. Jan, 2008 | Pubmed ID: 17634939 Convection-enhanced Delivery of Cintredekin Besudotox (interleukin-13-PE38QQR) Followed by Radiation Therapy with and Without Temozolomide in Newly Diagnosed Malignant Gliomas: Phase 1 Study of Final Safety Results Neurosurgery. Nov, 2007 | Pubmed ID: 18091279 Clinical Utility of a Patient-specific Algorithm for Simulating Intracerebral Drug Infusions Neuro-oncology. Jul, 2007 | Pubmed ID: 17435179 Viruses in the Treatment of Malignant Glioma Expert Review of Neurotherapeutics. Apr, 2007 | Pubmed ID: 17425484 Systemic CTLA-4 Blockade Ameliorates Glioma-induced Changes to the CD4+ T Cell Compartment Without Affecting Regulatory T-cell Function Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2007 | Pubmed ID: 17404100 Direct Intracerebral Delivery of Cintredekin Besudotox (IL13-PE38QQR) in Recurrent Malignant Glioma: a Report by the Cintredekin Besudotox Intraparenchymal Study Group Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2007 | Pubmed ID: 17327604 Induction of Hyperintense Signal on T2-weighted MR Images Correlates with Infusion Distribution from Intracerebral Convection-enhanced Delivery of a Tumor-targeted Cytotoxin AJR. American Journal of Roentgenology. Mar, 2007 | Pubmed ID: 17312057 Intracerebral Infusate Distribution by Convection-enhanced Delivery in Humans with Malignant Gliomas: Descriptive Effects of Target Anatomy and Catheter Positioning Neurosurgery. Feb, 2007 | Pubmed ID: 17297371 Phase II Study of Imatinib Mesylate and Hydroxyurea for Recurrent Grade III Malignant Gliomas Journal of Neuro-oncology. May, 2007 | Pubmed ID: 17245623 Genetic Analysis of Intracranial Tumors in a Murine Model of Glioma Demonstrate a Shift in Gene Expression in Response to Host Immunity Journal of Neuroimmunology. Jan, 2007 | Pubmed ID: 17137636 Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2006 | Pubmed ID: 17189402 Treatment of Neoplastic Meningitis with Intrathecal 9-nitro-camptothecin Neurologia Medico-chirurgica. Oct, 2006 | Pubmed ID: 17062987 Preoperative Functional MR Imaging Localization of Language and Motor Areas: Effect on Therapeutic Decision Making in Patients with Potentially Resectable Brain Tumors Radiology. Sep, 2006 | Pubmed ID: 16857981 Systemic Anti-CD25 Monoclonal Antibody Administration Safely Enhances Immunity in Murine Glioma Without Eliminating Regulatory T Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2006 | Pubmed ID: 16857805 Novel Human IgG2b/murine Chimeric Antitenascin Monoclonal Antibody Construct Radiolabeled with 131I and Administered into the Surgically Created Resection Cavity of Patients with Malignant Glioma: Phase I Trial Results Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jun, 2006 | Pubmed ID: 16741299 Safety of Intraparenchymal Convection-enhanced Delivery of Cintredekin Besudotox in Early-phase Studies Neurosurgical Focus. 2006 | Pubmed ID: 16709020 Comparison of Intratumoral Bolus Injection and Convection-enhanced Delivery of Radiolabeled Antitenascin Monoclonal Antibodies Neurosurgical Focus. 2006 | Pubmed ID: 16709019 Convection-enhanced Delivery of Therapeutics for Brain Disease, and Its Optimization Neurosurgical Focus. 2006 | Pubmed ID: 16709017 Increased Regulatory T-cell Fraction Amidst a Diminished CD4 Compartment Explains Cellular Immune Defects in Patients with Malignant Glioma Cancer Research. Mar, 2006 | Pubmed ID: 16540683 Targeted Therapy for Glioblastoma Multiforme Neoplastic Meningitis with Intrathecal Delivery of an Oncolytic Recombinant Poliovirus Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2006 | Pubmed ID: 16489093 Phase 1 Trial of Gefitinib Plus Sirolimus in Adults with Recurrent Malignant Glioma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2006 | Pubmed ID: 16467100 Phase II Study of Imatinib Mesylate Plus Hydroxyurea in Adults with Recurrent Glioblastoma Multiforme Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2005 | Pubmed ID: 16361636 Phase I Trial of Temozolomide Plus O6-benzylguanine for Patients with Recurrent or Progressive Malignant Glioma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2005 | Pubmed ID: 16192602 Surgical Management of Petroclival Meningiomas: Defining Resection Goals Based on Risk of Neurological Morbidity and Tumor Recurrence Rates in 137 Patients Neurosurgery. Mar, 2005 | Pubmed ID: 15730581 Sustained Radiographic and Clinical Response in Patient with Bifrontal Recurrent Glioblastoma Multiforme with Intracerebral Infusion of the Recombinant Targeted Toxin TP-38: Case Study Neuro-oncology. Jan, 2005 | Pubmed ID: 15701286 Poliovirus Receptor CD155-targeted Oncolysis of Glioma Neuro-oncology. Jul, 2004 | Pubmed ID: 15279713 Treatment of Intracerebral Neoplasia and Neoplastic Meningitis with Regional Delivery of Oncolytic Recombinant Poliovirus Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2004 | Pubmed ID: 15269159 Phase 1 Trial of Irinotecan Plus BCNU in Patients with Progressive or Recurrent Malignant Glioma Neuro-oncology. Apr, 2004 | Pubmed ID: 15134629 Phase 2 Trial of BCNU Plus Irinotecan in Adults with Malignant Glioma Neuro-oncology. Apr, 2004 | Pubmed ID: 15134628 Resistance to Tyrosine Kinase Inhibition by Mutant Epidermal Growth Factor Receptor Variant III Contributes to the Neoplastic Phenotype of Glioblastoma Multiforme Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2004 | Pubmed ID: 15131063 Microvascular Decompression for Glossopharyngeal Neuralgia: Long-term Effectiveness and Complication Avoidance Neurosurgery. Apr, 2004 | Pubmed ID: 15046654 Immunotherapy of Surgical Malignancies Current Problems in Surgery. Jan, 2004 | Pubmed ID: 14749625 Phase II Trial of Gefitinib in Recurrent Glioblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2004 | Pubmed ID: 14638850 Efficacy of Intracerebral Microinfusion of Trastuzumab in an Athymic Rat Model of Intracerebral Metastatic Breast Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2003 | Pubmed ID: 14654531 Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-alpha and a Mutated Form of the Pseudomonas Exotoxin Termed PE-38 (TP-38) for the Treatment of Malignant Brain Tumors Journal of Neuro-oncology. Oct, 2003 | Pubmed ID: 14649883 Epidermal Growth Factor Receptor VIII Peptide Vaccination is Efficacious Against Established Intracerebral Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2003 | Pubmed ID: 14519652 Adoptive Immunotherapy for Malignant Glioma Cancer Journal (Sudbury, Mass.). May-Jun, 2003 | Pubmed ID: 12952301 The History, Evolution, and Clinical Use of Dendritic Cell-based Immunization Strategies in the Therapy of Brain Tumors Journal of Neuro-oncology. Aug-Sep, 2003 | Pubmed ID: 12952297 Phase II Trial of Temozolomide in Patients with Progressive Low-grade Glioma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2003 | Pubmed ID: 12586801 Clinical Immunotherapy for Brain Tumors Neuroimaging Clinics of North America. Nov, 2002 | Pubmed ID: 12687917 Viruses in the Treatment of Brain Tumors Neuroimaging Clinics of North America. Nov, 2002 | Pubmed ID: 12687911 Brain Tumors in Mice Are Susceptible to Blockade of Epidermal Growth Factor Receptor (EGFR) with the Oral, Specific, EGFR-tyrosine Kinase Inhibitor ZD1839 (iressa) Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2002 | Pubmed ID: 12429640 Intracanalicular Meningioma Mimicking Vestibular Schwannoma AJNR. American Journal of Neuroradiology. Oct, 2002 | Pubmed ID: 12372737 Mutant Epidermal Growth Factor Receptor Up-regulates Molecular Effectors of Tumor Invasion Cancer Research. Jun, 2002 | Pubmed ID: 12067969 Phase II Trial of Carmustine Plus O(6)-benzylguanine for Patients with Nitrosourea-resistant Recurrent or Progressive Malignant Glioma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2002 | Pubmed ID: 11980998 Phase II Trial of Murine (131)I-labeled Antitenascin Monoclonal Antibody 81C6 Administered into Surgically Created Resection Cavities of Patients with Newly Diagnosed Malignant Gliomas Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2002 | Pubmed ID: 11870184 Generation of Anti-idiotypic Reagents in the EGFRvIII Tumor-associated Antigen System Cancer Immunology, Immunotherapy : CII. Feb, 2002 | Pubmed ID: 11862416 Dendritic Cells Pulsed with a Tumor-specific Peptide Induce Long-lasting Immunity and Are Effective Against Murine Intracerebral Melanoma Neurosurgery. Jan, 2002 | Pubmed ID: 11844246 Bakım Glioblastoma Standardı Kapsamında Adoptif Tedavisi için CAR T hücrelerinin üretilmesi Katherine Riccione1,2, Carter M. Suryadevara1,3, David Snyder1, Xiuyu Cui1, John H. Sampson1,2,3, Luis Sanchez-Perez1 1Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University, 2Department of Biomedical Engineering, Duke University, 3Department of Pathology, Duke University Immunology and Infection
Bakım Glioblastoma Standardı Kapsamında Adoptif Tedavisi için CAR T hücrelerinin üretilmesi Katherine Riccione1,2, Carter M. Suryadevara1,3, David Snyder1, Xiuyu Cui1, John H. Sampson1,2,3, Luis Sanchez-Perez1 1Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University, 2Department of Biomedical Engineering, Duke University, 3Department of Pathology, Duke University Immunology and Infection