Jonathan M. Gibbins

Publications

• G Protein-coupled Receptor Kinase 5 Regulates Thrombin Signaling in Platelets Via PAR-1
  Blood Advances. Sep, 2021  |   Pubmed ID: 34581777
• Multi-parameter Phenotyping of Platelet Reactivity for Stratification of Human Cohorts
  Blood Advances. Sep, 2021  |   Pubmed ID: 34474473
• Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors
  Biomolecules. 07, 2021  |   Pubmed ID: 34356607
• The Voltage-gated K Channel Kv1.3 Modulates Platelet Motility and αβ Integrin-dependent Adhesion to Collagen
  Platelets. Aug, 2021  |   Pubmed ID: 34348571
• Aberrant Glycosylation of Anti-SARS-CoV-2 IgG is a Pro-thrombotic Stimulus for Platelets
  Blood. Jul, 2021  |   Pubmed ID: 34315173
• The Protein Disulphide Isomerase Inhibitor CxxCpep Modulates Oxidative Burst and Mitochondrial Function in Platelets
  Free Radical Biology & Medicine. 08, 2021  |   Pubmed ID: 34252541
• Thiol Isomerases Orchestrate Thrombosis and Hemostasis
  Antioxidants & Redox Signaling. Jun, 2021  |   Pubmed ID: 33940944
• Mind the Gap: Connexins and Pannexins in Platelet Function
  Platelets. Oct, 2021  |   Pubmed ID: 33818243
• Protein Disulphide Isomerase and NADPH Oxidase 1 Cooperate to Control Platelet Function and Are Associated with Cardiometabolic Disease Risk Factors
  Antioxidants (Basel, Switzerland). Mar, 2021  |   Pubmed ID: 33806982
• Targeting Platelet Inhibition Receptors for Novel Therapies: PECAM-1 and G6b-B
  Platelets. Aug, 2021  |   Pubmed ID: 33646086
• Platelet-derived Extracellular Vesicles Express NADPH Oxidase-1 (Nox-1), Generate Superoxide and Modulate Platelet Function
  Free Radical Biology & Medicine. 03, 2021  |   Pubmed ID: 33548451
• Maternal and Offspring High-fat Diet Leads to Platelet Hyperactivation in Male Mice Offspring
  Scientific Reports. 01, 2021  |   Pubmed ID: 33446734
• Zafirlukast is a Broad-spectrum Thiol Isomerase Inhibitor That Inhibits Thrombosis Without Altering Bleeding Times
  British Journal of Pharmacology. 02, 2021  |   Pubmed ID: 33080041
• Structural, Functional, and Mechanistic Insights Uncover the Fundamental Role of Orphan Connexin-62 in Platelets
  Blood. 02, 2021  |   Pubmed ID: 32822477
• Antiplatelet Properties of Pim Kinase Inhibition Are Mediated Through Disruption of Thromboxane A2 Receptor Signaling
  Haematologica. 07, 2021  |   Pubmed ID: 32467143
• A Model of the PI Cycle Reveals the Regulating Roles of Lipid-binding Proteins and Pitfalls of Using Mosaic Biological Data
  Scientific Reports. 08, 2020  |   Pubmed ID: 32764630
• Control of Platelet CLEC-2-Mediated Activation by Receptor Clustering and Tyrosine Kinase Signaling
  Biophysical Journal. 06, 2020  |   Pubmed ID: 32396849
• Ca Waves Coordinate Purinergic Receptor-evoked Integrin Activation and Polarization
  Science Signaling. 01, 2020  |   Pubmed ID: 31964805
• Platelet α-granules Contribute to Organ-specific Pathologies in a Mouse Model of Severe Malaria
  Blood Advances. 01, 2020  |   Pubmed ID: 31891656
• Interspecies Differences in Protein Expression Do Not Impact the Spatiotemporal Regulation of Glycoprotein VI Mediated Activation
  Journal of Thrombosis and Haemostasis : JTH. 02, 2020  |   Pubmed ID: 31680418
• Myricetin, the Main Flavonoid in Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5
  Frontiers in Pharmacology. 2019  |   Pubmed ID: 32116678
• Non-genomic Effects of the Pregnane X Receptor Negatively Regulate Platelet Functions, Thrombosis and Haemostasis
  Scientific Reports. 11, 2019  |   Pubmed ID: 31748641
• The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects
  TH Open : Companion Journal to Thrombosis and Haemostasis. Jul, 2019  |   Pubmed ID: 31367693
• The Formyl Peptide FMLF Primes Platelet Activation and Augments Thrombus Formation
  Journal of Thrombosis and Haemostasis : JTH. 07, 2019  |   Pubmed ID: 31033193
• Flow Cytometry for Near-patient Testing in Premature Neonates Reveals Variation in Platelet Function: a Novel Approach to Guide Platelet Transfusion
  Pediatric Research. 05, 2019  |   Pubmed ID: 30742030
• Gradient-dependent Inhibition of Stimulatory Signaling from Platelet G Protein-coupled Receptors
  Haematologica. 07, 2019  |   Pubmed ID: 30630981
• Cobimetinib and Trametinib Inhibit Platelet MEK but Do Not Cause Platelet Dysfunction
  Platelets. 2019  |   Pubmed ID: 30252580
• The Endogenous Antimicrobial Cathelicidin LL37 Induces Platelet Activation and Augments Thrombus Formation
  Blood Advances. 11, 2018  |   Pubmed ID: 30413433
• Mathematical Techniques for Understanding Platelet Regulation and the Development of New Pharmacological Approaches
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 30171583
• Screening and High-Throughput Platelet Assays
  Methods in Molecular Biology (Clifton, N.J.). 2018  |   Pubmed ID: 30171573
• Functional Redundancy Between RAP1 Isoforms in Murine Platelet Production and Function
  Blood. 11, 2018  |   Pubmed ID: 30131434
• Talin is a Substrate for SUMOylation in Migrating Cancer Cells
  Experimental Cell Research. 09, 2018  |   Pubmed ID: 30003879
• Connexins and Pannexins in Vascular Function and Disease
  International Journal of Molecular Sciences. Jun, 2018  |   Pubmed ID: 29874791
• NADPH Oxidase 2 (NOX2): A Key Target of Oxidative Stress-mediated Platelet Activation and Thrombosis
  Trends in Cardiovascular Medicine. 10, 2018  |   Pubmed ID: 29661712
• Modeling Thrombosis in Silico: Frontiers, Challenges, Unresolved Problems and Milestones
  Physics of Life Reviews. 11, 2018  |   Pubmed ID: 29550179
• Severe Platelet Dysfunction in NHL Patients Receiving Ibrutinib is Absent in Patients Receiving Acalabrutinib
  Blood Advances. 12, 2017  |   Pubmed ID: 29296914
• Lipopolysaccharide Potentiates Platelet Responses Via Toll-like Receptor 4-stimulated Akt-Erk-PLA2 Signalling
  PloS One. 2017  |   Pubmed ID: 29136006
• Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets
  Arteriosclerosis, Thrombosis, and Vascular Biology. 08, 2017  |   Pubmed ID: 28619996
• Evidence for Shear-mediated Ca Entry Through Mechanosensitive Cation Channels in Human Platelets and a Megakaryocytic Cell Line
  The Journal of Biological Chemistry. 06, 2017  |   Pubmed ID: 28416610
• RXR Ligands Negatively Regulate Thrombosis and Hemostasis
  Arteriosclerosis, Thrombosis, and Vascular Biology. 05, 2017  |   Pubmed ID: 28254816
• Challenges in Diagnosing and Treating Snakebites in a Rural Population of Tamil Nadu, India: The Views of Clinicians
  Toxicon : Official Journal of the International Society on Toxinology. May, 2017  |   Pubmed ID: 28238804
• Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets
  Arteriosclerosis, Thrombosis, and Vascular Biology. 12, 2016  |   Pubmed ID: 27758768
• Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases
  Arteriosclerosis, Thrombosis, and Vascular Biology. 06, 2016  |   Pubmed ID: 27079884
• Platelets Stop Us Leaking
  Blood. Mar, 2016  |   Pubmed ID: 27013214
• Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
  PLoS Computational Biology. Nov, 2015  |   Pubmed ID: 26584182
• Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function
  PloS One. 2015  |   Pubmed ID: 26551971
• Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2015  |   Pubmed ID: 26359510
• GRID and Docking Analyses Reveal a Molecular Basis for Flavonoid Inhibition of Src Family Kinase Activity
  The Journal of Nutritional Biochemistry. Nov, 2015  |   Pubmed ID: 26140983
• Gap Junctions and Connexin Hemichannels in the Regulation of Haemostasis and Thrombosis
  Biochemical Society Transactions. Jun, 2015  |   Pubmed ID: 26009196
• Pharmacological Actions of Nobiletin in the Modulation of Platelet Function
  British Journal of Pharmacology. Aug, 2015  |   Pubmed ID: 25988959
• EphB2 Regulates Contact-dependent and Contact-independent Signaling to Control Platelet Function
  Blood. Jan, 2015  |   Pubmed ID: 25370417
• Discovery of Novel GPVI Receptor Antagonists by Structure-based Repurposing
  PloS One. 2014  |   Pubmed ID: 24971515
• Platelet Endothelial Cell Adhesion Molecule-1 Inhibits Platelet Response to Thrombin and Von Willebrand Factor by Regulating the Internalization of Glycoprotein Ib Via AKT/glycogen Synthase Kinase-3/dynamin and Integrin αIIbβ3
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2014  |   Pubmed ID: 24969778
• Ibuprofen Inhibits Migration and Proliferation of Human Coronary Artery Smooth Muscle Cells by Inducing a Differentiated Phenotype: Role of Peroxisome Proliferator-activated Receptor γ
  The Journal of Pharmacy and Pharmacology. Jun, 2014  |   Pubmed ID: 24438071
• Snakebite and Its Socio-economic Impact on the Rural Population of Tamil Nadu, India
  PloS One. 2013  |   Pubmed ID: 24278244
• Platelets Using Proteins Creatively
  Blood. Nov, 2013  |   Pubmed ID: 24263955
• Tangeretin Regulates Platelet Function Through Inhibition of Phosphoinositide 3-kinase and Cyclic Nucleotide Signaling
  Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2013  |   Pubmed ID: 24135020
• Flavonoid Inhibitory Pharmacodynamics on Platelet Function in Physiological Environments
  Food & Function. Dec, 2013  |   Pubmed ID: 24121953
• Connexin40 Regulates Platelet Function
  Nature Communications. 2013  |   Pubmed ID: 24096827
• Antithrombotic Actions of Statins Involve PECAM-1 Signaling
  Blood. Oct, 2013  |   Pubmed ID: 24030383
• Staphylococcus Aureus Lipoteichoic Acid Inhibits Platelet Activation and Thrombus Formation Via the Paf Receptor
  The Journal of Infectious Diseases. Dec, 2013  |   Pubmed ID: 23911710
• Platelet Protein Disulfide Isomerase is Required for Thrombus Formation but Not for Hemostasis in Mice
  Blood. Aug, 2013  |   Pubmed ID: 23788140
• The Integration of Proteomics and Systems Approaches to Map Regulatory Mechanisms Underpinning Platelet Function
  Proteomics. Clinical Applications. Jan, 2013  |   Pubmed ID: 23184887
• Insights into Dietary Flavonoids As Molecular Templates for the Design of Anti-platelet Drugs
  Cardiovascular Research. Jan, 2013  |   Pubmed ID: 23024269
• Sequence and Phylogenetic Analysis of Viper Venom Serine Proteases
  Bioinformation. 2012  |   Pubmed ID: 23055627
• Rhinocetin, a Venom-derived Integrin-specific Antagonist Inhibits Collagen-induced Platelet and Endothelial Cell Functions
  The Journal of Biological Chemistry. Jul, 2012  |   Pubmed ID: 22689571
• Gap Junctions and Connexin Hemichannels Underpin Hemostasis and Thrombosis
  Circulation. May, 2012  |   Pubmed ID: 22528526
• JAMming the Signals
  Blood. Apr, 2012  |   Pubmed ID: 22493215
• Endogenous Inhibitory Mechanisms and the Regulation of Platelet Function
  Methods in Molecular Biology (Clifton, N.J.). 2012  |   Pubmed ID: 22130718
• Clot Retraction
  Methods in Molecular Biology (Clifton, N.J.). 2012  |   Pubmed ID: 22130703
• Regulation of Platelet Biology by Platelet Endothelial Cell Adhesion Molecule-1
  Platelets. 2012  |   Pubmed ID: 22035359
• Analysis of Protein Networks in Resting and Collagen Receptor (GPVI)-stimulated Platelet Sub-proteomes
  Proteomics. Dec, 2011  |   Pubmed ID: 22114104
• Evolutionary Analysis of Novel Serine Proteases in the Venom Gland Transcriptome of Bitis Gabonica Rhinoceros
  PloS One. 2011  |   Pubmed ID: 21731776
• LXR As a Novel Antithrombotic Target
  Blood. May, 2011  |   Pubmed ID: 21411760
• Purification and Functional Characterisation of Rhiminopeptidase A, a Novel Aminopeptidase from the Venom of Bitis Gabonica Rhinoceros
  PLoS Neglected Tropical Diseases. Aug, 2010  |   Pubmed ID: 20706583
• Platelet-mediated Metabolism of the Common Dietary Flavonoid, Quercetin
  PloS One. Mar, 2010  |   Pubmed ID: 20300638
• Purification and Functional Characterisation of Rhinocerase, a Novel Serine Protease from the Venom of Bitis Gabonica Rhinoceros
  PloS One. Mar, 2010  |   Pubmed ID: 20300193
• A Structural Basis for the Inhibition of Collagen-stimulated Platelet Function by Quercetin and Structurally Related Flavonoids
  British Journal of Pharmacology. Mar, 2010  |   Pubmed ID: 20148891
• Platelets Release Novel Thiol Isomerase Enzymes Which Are Recruited to the Cell Surface Following Activation
  British Journal of Haematology. Feb, 2010  |   Pubmed ID: 19995400
• PECAM-1 Expression and Activity Negatively Regulate Multiple Platelet Signaling Pathways
  FEBS Letters. Nov, 2009  |   Pubmed ID: 19850043
• Proteomic Analysis of Resting and Thrombin-stimulated Platelets Reveals the Translocation and Functional Relevance of HIP-55 in Platelets
  Proteomics. Sep, 2009  |   Pubmed ID: 19725075
• A Functional Proteomic Method for the Enrichment of Peripheral Membrane Proteins Reveals the Collagen Binding Protein Hsp47 is Exposed on the Surface of Activated Human Platelets
  Journal of Proteome Research. Jun, 2009  |   Pubmed ID: 19341245
• Tweaking the Gain on Platelet Regulation: the Tachykinin Connection
  Atherosclerosis. Sep, 2009  |   Pubmed ID: 19150714
• A Dual Role for Integrin-linked Kinase in Platelets: Regulating Integrin Function and Alpha-granule Secretion
  Blood. Dec, 2008  |   Pubmed ID: 18772455
• The Neurokinin 1 Receptor: a Potential New Target for Anti-platelet Therapy?
  Current Opinion in Pharmacology. Apr, 2008  |   Pubmed ID: 18296119
• Peripheral Tachykinins and the Neurokinin Receptor NK1 Are Required for Platelet Thrombus Formation
  Blood. Jan, 2008  |   Pubmed ID: 17895403
• In Vivo Selection for Metastasis Promoting Genes in the Mouse
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007  |   Pubmed ID: 17420453
• Nongenomic Signaling of the Retinoid X Receptor Through Binding and Inhibiting Gq in Human Platelets
  Blood. May, 2007  |   Pubmed ID: 17213293
• Ingestion of Onion Soup High in Quercetin Inhibits Platelet Aggregation and Essential Components of the Collagen-stimulated Platelet Activation Pathway in Man: a Pilot Study
  The British Journal of Nutrition. Sep, 2006  |   Pubmed ID: 16925853
• Extracellular Disulfide Exchange and the Regulation of Cellular Function
  Antioxidants & Redox Signaling. Mar-Apr, 2006  |   Pubmed ID: 16677077
• Platelet PECAM-1 Inhibits Thrombus Formation in Vivo
  Blood. Jan, 2006  |   Pubmed ID: 16166583
• A Role for the Thiol Isomerase Protein ERP5 in Platelet Function
  Blood. Feb, 2005  |   Pubmed ID: 15466936
• Study of Tyrosine Kinases and Protein Tyrosine Phosphorylation
  Methods in Molecular Biology (Clifton, N.J.). 2004  |   Pubmed ID: 15308800
• Techniques for Analysis of Proteins by SDS-polyacrylamide Gel Electrophoresis and Western Blotting
  Methods in Molecular Biology (Clifton, N.J.). 2004  |   Pubmed ID: 15308799
• Platelet Adhesion Signalling and the Regulation of Thrombus Formation
  Journal of Cell Science. Jul, 2004  |   Pubmed ID: 15252124
• Tachykinins Regulate the Function of Platelets
  Blood. Aug, 2004  |   Pubmed ID: 15130944
• Regulation of Glycogen Synthase Kinase 3 in Human Platelets: a Possible Role in Platelet Function?
  FEBS Letters. Oct, 2003  |   Pubmed ID: 14550568
• The Role of Polyphenolic Compounds in the Diet As Inhibitors of Platelet Function
  The Proceedings of the Nutrition Society. May, 2003  |   Pubmed ID: 14506895
• The Negative Regulation of Platelet Function: Extending the Role of the ITIM
  Trends in Cardiovascular Medicine. Jul, 2002  |   Pubmed ID: 12161075
• Protein Kinase B is Regulated in Platelets by the Collagen Receptor Glycoprotein VI
  The Journal of Biological Chemistry. Apr, 2002  |   Pubmed ID: 11825911
• Platelet Endothelial Cell Adhesion Molecule-1 Signaling Inhibits the Activation of Human Platelets
  Blood. Jan, 2002  |   Pubmed ID: 11756163