Jonathan Chernoff Fox Chase Cancer Center Biography Publications Institution JoVE Articles Jonathan Chernoff has not added a biography. If you are Jonathan Chernoff and would like to personalize this page please email our Author Liaison for assistance. Publications How to Get and Keep Your Lab Funded Molecular Biology of the Cell. Oct, 2018 | Pubmed ID: 30325287 Group I Paks Are Essential for Epithelial- Mesenchymal Transition in an Apc-driven Model of Colorectal Cancer Nature Communications. Aug, 2018 | Pubmed ID: 30150766 A New Concept in NF2 Pharmacotherapy: Targeting Fatty Acid Synthesis Oncoscience. May, 2018 | Pubmed ID: 30035161 PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells Cancer Discovery. Jul, 2018 | Pubmed ID: 29572236 Suppression of RAC1-driven Malignant Melanoma by Group A PAK Inhibitors Oncogene. Feb, 2018 | Pubmed ID: 29059171 Hras Helps Hippo Heterodimerize to Evade Tumor Suppression Small GTPases. 07, 2018 | Pubmed ID: 27560370 Pak2 Regulates Myeloid-derived Suppressor Cell Development in Mice Blood Advances. Oct, 2017 | Pubmed ID: 29296839 Pak1 Mediates the Stimulatory Effect of Insulin and Curcumin on Hepatic ChREBP Expression Journal of Molecular Cell Biology. Oct, 2017 | Pubmed ID: 28992163 PAK Signalling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAF-mutant Melanomas Nature. 10, 2017 | Pubmed ID: 28953887 Targeting MYC Sensitizes Malignant Mesothelioma Cells to PAK Blockage-induced Cytotoxicity American Journal of Cancer Research. 2017 | Pubmed ID: 28861328 An Essential Role for the Tumor-Suppressor Merlin in Regulating Fatty Acid Synthesis Cancer Research. 09, 2017 | Pubmed ID: 28729415 Recent Advances in Methods to Assess the Activity of the Kinome F1000Research. 2017 | Pubmed ID: 28713564 Targeting Group I P21-activated Kinases to Control Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis Oncogene. 09, 2017 | Pubmed ID: 28534510 Targeting PAK1 Biochemical Society Transactions. 02, 2017 | Pubmed ID: 28202661 Alfred G. Knudson Jr, MD, PhD: In Memoriam (1922-2016) Cancer Research. 02, 2017 | Pubmed ID: 28202462 Medium Throughput Biochemical Compound Screening Identifies Novel Agents for Pharmacotherapy of Neurofibromatosis Type 1 Biochimie. Apr, 2017 | Pubmed ID: 28065690 Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro Molecular and Cellular Biology. 02, 2017 | Pubmed ID: 27920252 The Group I Pak Inhibitor Frax-1036 Sensitizes 11q13-amplified Ovarian Cancer Cells to the Cytotoxic Effects of Rottlerin Small GTPases. 10, 2017 | Pubmed ID: 27427770 Reduced PAK1 Activity Sensitizes FA/BRCA-proficient Breast Cancer Cells to PARP Inhibition Oncotarget. 11, 2016 | Pubmed ID: 27740936 Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP PLoS Genetics. 09, 2016 | Pubmed ID: 27583434 Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer Cell Reports. 08, 2016 | Pubmed ID: 27452461 H-ras Inhibits the Hippo Pathway by Promoting Mst1/Mst2 Heterodimerization Current Biology : CB. 06, 2016 | Pubmed ID: 27238285 P21-activated Kinase 2 Regulates HSPC Cytoskeleton, Migration, and Homing Via CDC42 Activation and Interaction with β-Pix Blood. Apr, 2016 | Pubmed ID: 26932803 Effects of P21-activated Kinase 1 Inhibition on 11q13-amplified Ovarian Cancer Cells Oncogene. 04, 2016 | Pubmed ID: 26257058 P21-Activated Kinase 2 Regulates Endothelial Development and Function Through the Bmk1/Erk5 Pathway Molecular and Cellular Biology. Dec, 2015 | Pubmed ID: 26391956 PAK1 is a Therapeutic Target in Acute Myeloid Leukemia and Myelodysplastic Syndrome Blood. Aug, 2015 | Pubmed ID: 26170031 Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance Journal of Immunology (Baltimore, Md. : 1950). Aug, 2015 | Pubmed ID: 26157175 Disruption of P21-activated Kinase 1 Gene Diminishes Atherosclerosis in Apolipoprotein E-deficient Mice Nature Communications. Jun, 2015 | Pubmed ID: 26104863 Small Molecule Inhibition of Group I P21-activated Kinases in Breast Cancer Induces Apoptosis and Potentiates the Activity of Microtubule Stabilizing Agents Breast Cancer Research : BCR. Apr, 2015 | Pubmed ID: 25902869 Pak2 Restrains Endomitosis During Megakaryopoiesis and Alters Cytoskeleton Organization Blood. May, 2015 | Pubmed ID: 25824689 Regulation of Mammalian Ste20 (Mst) Kinases Trends in Biochemical Sciences. Mar, 2015 | Pubmed ID: 25665457 Group I Paks As Therapeutic Targets in NF2-deficient Meningioma Oncotarget. Feb, 2015 | Pubmed ID: 25596744 Pak2 Regulates Hematopoietic Progenitor Cell Proliferation, Survival, and Differentiation Stem Cells (Dayton, Ohio). May, 2015 | Pubmed ID: 25586960 Molecular Pathways: Targeting the Kinase Effectors of RHO-family GTPases Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2015 | Pubmed ID: 25336694 Gq-mediated Akt Translocation to the Membrane: a Novel PIP3-independent Mechanism in Platelets Blood. Jan, 2015 | Pubmed ID: 25331114 Potential Compensation Among Group I PAK Members in Hindlimb Ischemia and Wound Healing PloS One. 2014 | Pubmed ID: 25379771 Molecular Pathways: Targeting RAC-p21-activated Serine-threonine Kinase Signaling in RAS-driven Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2014 | Pubmed ID: 25225063 Pak2 is Required for Actin Cytoskeleton Remodeling, TCR Signaling, and Normal Thymocyte Development and Maturation ELife. May, 2014 | Pubmed ID: 24843022 A Pak1/Erk Signaling Module Acts Through Gata6 to Regulate Cardiovascular Development in Zebrafish Developmental Cell. May, 2014 | Pubmed ID: 24823378 Activation of CAMP Signaling Attenuates Impaired Hepatic Glucose Disposal in Aged Male P21-activated Protein Kinase-1 Knockout Mice Endocrinology. Jun, 2014 | Pubmed ID: 24684301 PAK Signalling During the Development and Progression of Cancer Nature Reviews. Cancer. Jan, 2014 | Pubmed ID: 24505617 Analysis of PTP1B Sumoylation Methods (San Diego, Calif.). Jan, 2014 | Pubmed ID: 24076082 P21-activated Kinase Inhibitors The Enzymes. 2013 | Pubmed ID: 25034104 P21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils PloS One. 2013 | Pubmed ID: 24019894 FRAX597, a Small Molecule Inhibitor of the P21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 23960073 Targeting Cdc42 in Cancer Expert Opinion on Therapeutic Targets. Nov, 2013 | Pubmed ID: 23957315 The PAK System Links Rho GTPase Signaling to Thrombin-mediated Platelet Activation American Journal of Physiology. Cell Physiology. Sep, 2013 | Pubmed ID: 23784547 ArhGAP15, a Rac-specific GTPase-activating Protein, Plays a Dual Role in Inhibiting Small GTPase Signaling The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23760270 Role of P21-activated Kinases in Cardiovascular Development and Function Cellular and Molecular Life Sciences : CMLS. Nov, 2013 | Pubmed ID: 23640572 P21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI-mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2013 | Pubmed ID: 23640496 Pak1 Kinase Links ErbB2 to β-catenin in Transformation of Breast Epithelial Cells Cancer Research. Jun, 2013 | Pubmed ID: 23576562 肿瘤抑癌 Mst1 促进磷酸化而失活过氧还蛋白-1 的细胞氧化还原状态的变化。 The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23386615 Rac 蛋白效应 P21 激活激酶是造血干/祖细胞迁移和植入状态的必要条件。 Blood. Jan, 2013 | Pubmed ID: 23335370 P 21 激活激酶 1 介导通过多个信号转导大肠黏膜胃泌素刺激扩散。 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2013 | Pubmed ID: 23306081 Pak2 激酶抑制肥大细胞 FcεRI 受体通过 Rho 蛋白鸟嘌呤核苷酸交换因子 (环境基金) 活动的调制信号。 The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23204526 P21 活化蛋白激酶 1 (Pak1) 介导相声胰岛素与 β-连环素对 Proglucagon 基因表达和其消融影响葡萄糖稳态的雄性 C57BL/6 小鼠。 Endocrinology. Jan, 2013 | Pubmed ID: 23183186 白沙函数的小鼠模型。 Cellular Logistics. Apr, 2012 | Pubmed ID: 23162740 P21 激活激酶 1 是高效肿瘤形成和进展介导 Ras 皮肤癌症模型中的所必需的。 Cancer Research. Nov, 2012 | Pubmed ID: 22983922 P21 激活激酶 (白石) 的抑制作用降低气道反应性体内和体外小鼠和人类的航空公司。 PloS One. 2012 | Pubmed ID: 22900031 第一组 P21 激活激酶 (资料袋) 促进肿瘤细胞增殖和存活 AKT1 和 Raf MAPK 途径。 Molecular Cancer Research : MCR. Sep, 2012 | Pubmed ID: 22798428 PKM2 进入 Morpheein 学院。 Molecular Cell. Mar, 2012 | Pubmed ID: 22405271 Sumoylated 蛋白酪氨酸磷酸酶 1B 本地化到内部的核膜,并调节酪氨酸磷酸化的 Emerin。 Journal of Cell Science. Jan, 2012 | Pubmed ID: 22266903 P21 激活激酶在缺血再灌注伴肌钙蛋白 T 和肌球蛋白轻链 2 磷酸化变化过程提高了心肌收缩力。 American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2012 | Pubmed ID: 22037191 P21 激活激酶-1 在小鼠中消融促进协会与激活 Erk1/2 蛋白磷酸酶 2A 抑制异丙肾上腺素致心肌肥厚。 Journal of Molecular and Cellular Cardiology. Dec, 2011 | Pubmed ID: 21971074 抑制或消融 P21 激活激酶 (PAK1) 扰乱体内的葡萄糖恒久机制。 The Journal of Biological Chemistry. Dec, 2011 | Pubmed ID: 21969371 Rac1 驱动器 Melanoblast 组织小鼠发育过程的策划 Pseudopod-驱动动力及细胞周期进程。 Developmental Cell. Oct, 2011 | Pubmed ID: 21924960 序贯磷酸化 SLP 76 在 173 酪氨酸是 T 和肥大细胞激活所需。 The EMBO Journal. Aug, 2011 | Pubmed ID: 21725281 Pak1 规管粘着强度 IIA 分布肌球蛋白和肌动蛋白动力学优化细胞迁移。 The Journal of Cell Biology. Jun, 2011 | Pubmed ID: 21708980 Rho 家族蛋白 生防护中心/RhoV 诱导 PC12 细胞的凋亡通过 JNK 激活。 Small GTPases. 1, 2011 | Pubmed ID: 21686277 非典型的 MAPK Erk3 的作为新型基质 P21 激活激酶 (白石) 活动的标识。 The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21317288 回到未来: 从 2010 年 NF 会议程序。 American Journal of Medical Genetics. Part A. Feb, 2011 | Pubmed ID: 21271647 获取有关 P21 激活激酶智能。 Molecular and Cellular Biology. Feb, 2011 | Pubmed ID: 21115726 MTOR 通路影响扩散和药敏试验的膀胱上皮癌细胞,是在人类膀胱癌症的一个子集。 BJU International. Jul, 2011 | Pubmed ID: 21050361 P21 激活激酶中 Erbb2 阳性乳腺癌: 一个新的治疗目标吗? Small GTPases. 9, 2010 | Pubmed ID: 21686266 P21 激活激酶所需的转型神经纤维瘤病 2 型的基于单元格的模型。 PloS One. 2010 | Pubmed ID: 21072183 LOV 征服 (sm) 所有的酶。 F1000 Biology Reports. 2010 | Pubmed ID: 20948805 A Rac-Pak Signaling Pathway is Essential for ErbB2-mediated Transformation of Human Breast Epithelial Cancer Cells Oncogene. Oct, 2010 | Pubmed ID: 20711231 蛋白质组学酪氨酸屏幕标识多个酪氨酸激酶信号传导通路闭合在恶性间皮瘤中激活。 Genes & Cancer. May, 2010 | Pubmed ID: 20672017 Arpc1b,centrosomal 的蛋白质,是活化剂和极光 A.基板 The Journal of Cell Biology. Jul, 2010 | Pubmed ID: 20603326 PTP1B: 在代谢与发生双重间谍。 Trends in Biochemical Sciences. Aug, 2010 | Pubmed ID: 20381358 新兴 P21 激活激酶 (资料袋) 的病毒感染的作用。 Trends in Cell Biology. Mar, 2010 | Pubmed ID: 20071173 第一组 P21 激活激酶: 新出现的病毒发病机制及免疫功能的作用。 The International Journal of Biochemistry & Cell Biology. Jan, 2010 | Pubmed ID: 19747561 需要 Pak1 核导入与 LC8 的互动,对斑马鱼发展不可或缺。 PloS One. 2009 | Pubmed ID: 19557173 哺乳动物 Ste20 激酶的 DeMSTification。 Current Biology : CB. May, 2009 | Pubmed ID: 19467213 Src 的蛋白酪氨酸磷酸酶 1B 激活是必需的 ErbB2 人类乳腺上皮细胞转化。 Cancer Research. Jun, 2009 | Pubmed ID: 19435911 Alphaherpesvirus US3 介导的肌动蛋白细胞骨架的重组被介导组 A P21 激活激酶。 Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19435845 白沙激酶调节 Rac 蛋白和是在人类神经鞘瘤的潜在目标。 Experimental Neurology. Jul, 2009 | Pubmed ID: 19409384 P21 激活激酶调节肥大细胞脱颗粒通过对钙动员和细胞骨架动力学的影响。 Blood. Mar, 2009 | Pubmed ID: 19124833 ERK1/2 介导 PAK1 活化调节 Lamellipodial 动态。 Journal of Cell Science. Nov, 2008 | Pubmed ID: 18940914 Pak1 规定了多个 C 试剂盒介导的 Ras MAPK 增益中函数型 Nf1 + /-肥大细胞。 Blood. Dec, 2008 | Pubmed ID: 18768391 鼻息肉选择性、 小分子抑制剂的目标 P21 激活激酶的自动调节机制。 Chemistry & Biology. Apr, 2008 | Pubmed ID: 18420139 两个资料袋的故事。 Biology of the Cell / Under the Auspices of the European Cell Biology Organization. Feb, 2008 | Pubmed ID: 18199048 Akt/PKB 活性 P21 激活激酶在心肌细胞中的调节。 Journal of Molecular and Cellular Cardiology. Feb, 2008 | Pubmed ID: 18054038 Alpha6beta4 整合素激活 Rac 依赖性 P21 激活激酶 1 开车到 3D 乳腺腺泡细胞凋亡的依赖活化的 NF-抵抗。 Journal of Cell Science. Oct, 2007 | Pubmed ID: 17911169 特异性分析白沙激酶的允许新型磷酸化站点的标识。 The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17392278 蛋白酪氨酸磷酸酶 1B,sumoylation 的调节。 Nature Cell Biology. Jan, 2007 | Pubmed ID: 17159996 Src 转换很酷的方式。 Nature Cell Biology. Sep, 2006 | Pubmed ID: 16946737 自磷酸二聚激酶大会基础化中 P21 激活激酶。 Journal of Molecular Biology. Aug, 2006 | Pubmed ID: 16837009 胞核胞质连体穿梭的 Pak5 规管其抗细胞凋亡特性。 Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16581795 确定对象激活 Rac1 介导交换因子 β-Pix。 The Journal of Cell Biology. Feb, 2006 | Pubmed ID: 16492808 PTP1B 的催化活性的调节: 细胞粘附、 酪氨酸残留 66 和脯氨酸残留 309 和 310 的角色。 Experimental Cell Research. Dec, 2005 | Pubmed ID: 16289152 生产和使用的一种细胞渗透抑制剂组 A 资料袋 (达 PID) 来分析信号转导。 Methods (San Diego, Calif.). Oct, 2005 | Pubmed ID: 16288885 蛋白酪氨酸磷酸酶 1B 和胰岛素受体酪氨酸激酶之间复杂的晶体结构。 Structure (London, England : 1993). Nov, 2005 | Pubmed ID: 16271887 极光 A.到白沙控释片 Developmental Cell. Nov, 2005 | Pubmed ID: 16256730 组 A P21 激活激酶的胞外调节蛋白激酶的生长因子的激活作用。 The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16129686 CIB1 在调节 PAK1 激活和细胞迁移中的重要作用。 The Journal of Cell Biology. Aug, 2005 | Pubmed ID: 16061695 Visinin 样蛋白-1 是一种强效抑制剂细胞粘附和迁移的鳞癌细胞。 Oncogene. Mar, 2005 | Pubmed ID: 15735716 空间不同 Cdc42 PAK1 和 N 黄蜂在乳腺癌细胞中的绑定。 Molecular and Cellular Biology. Mar, 2005 | Pubmed ID: 15713627 Rho-蛋白: 新成员、 新的途径。 Journal of Cellular Biochemistry. Feb, 2005 | Pubmed ID: 15543593 遗传学研究白 Journal of Cell Science. Sep, 2004 | Pubmed ID: 15331659 细胞粘附跨 Rho'ds。 The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15133033 分析和操纵的细胞内信号转导叶栅。 Methods (San Diego, Calif.). Apr, 2004 | Pubmed ID: 15003596 Vav1 传感器通过 LAT、 Sos 和 RasGRP1 的 Ras/ERK 通路的激活 T 细胞受体信号。 The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14764585 蛋白酪氨酸磷酸酶 1B 为潜在药物靶点的肥胖。 Current Drug Targets. Immune, Endocrine and Metabolic Disorders. Dec, 2003 | Pubmed ID: 14683461 和-34/BCAR3,其过度表达赋予抗雌激素抵抗,国内生产总值交换因子激活 Rac、 PAK1 和细胞周期蛋白 D1 启动子。 Cancer Research. Oct, 2003 | Pubmed ID: 14583477 NF2: 梅林 Wizardry。 Genes, Chromosomes & Cancer. Dec, 2003 | Pubmed ID: 14566860 Pak1 和 PIX 上皮伤口愈合期间规范接触抑制。 The EMBO Journal. Aug, 2003 | Pubmed ID: 12912914 蛋白酪氨酸磷酸酶 1B 介导永生化成纤维细胞内的肌动蛋白细胞骨架对胰岛素的影响。 The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12902327 P21 激活激酶 5 (Pak5) 线粒体本地化和抑制细胞凋亡的磷酸化坏。 Molecular and Cellular Biology. Aug, 2003 | Pubmed ID: 12897128 P38 丝裂素活化蛋白激酶介导细胞死亡和 P21 激活激酶介导细胞存活期间化疗药物诱导有丝分裂的逮捕。 Molecular Biology of the Cell. May, 2003 | Pubmed ID: 12802076 凋亡磷酸化组蛋白 H2B 被介导哺乳动物不育二十激酶。 Cell. May, 2003 | Pubmed ID: 12757711 快速诱导的树突棘形态发生跨突触 EphrinB EphB 受体活化的 Rho-全球环境基金 Kalirin。 Neuron. Jan, 2003 | Pubmed ID: 12546821 Tuberin、 结节性硬化症复杂 2 肿瘤抑癌基因产物,规管 Rho 激活、 细胞粘附和迁移。 Oncogene. Dec, 2002 | Pubmed ID: 12466966 小蛋白的的高仲夏。 Trends in Cell Biology. Nov, 2002 | Pubmed ID: 12446103 多肽、 蛋白质和有选择性地进行交互蛋白质靶点的药物检测。 Genome Research. Nov, 2002 | Pubmed ID: 12421766 细胞周期调节的磷酸化 P21 激活激酶 1。 Current Biology : CB. Jul, 2002 | Pubmed ID: 12176333 P21 激活激酶 1 与交互和 Phosphorylates 组蛋白 H3 在乳腺癌细胞中。 EMBO Reports. Aug, 2002 | Pubmed ID: 12151336 与及其底物相互作用的蛋白酪氨酸磷酸酶 (PTP) 1B 被受两个不同的绑定域。 The Biochemical Journal. Jun, 2002 | Pubmed ID: 12023880 P21 激活激酶: 三更加入白 The International Journal of Biochemistry & Cell Biology. Jul, 2002 | Pubmed ID: 11950587 效应器下游 Cdc42 和 Rac 的进化历史。 Genome Biology. 2002 | Pubmed ID: 11864373 P21 激活激酶链接 Rac/Cdc42 信号到梅林。 The Journal of Biological Chemistry. Jan, 2002 | Pubmed ID: 11719502 Temporal and Spatial Distribution of Activated Pak1 in Fibroblasts The Journal of Cell Biology. Dec, 2000 | Pubmed ID: 11134074 Lentivirus Nef Specifically Activates Pak2 Journal of Virology. Dec, 2000 | Pubmed ID: 11070003 Regulation of Macropinocytosis by P21-activated Kinase-1 Molecular Biology of the Cell. Oct, 2000 | Pubmed ID: 11029040 P21-activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts The Journal of Cell Biology. May, 1999 | Pubmed ID: 10330410 Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand Molecular and Cellular Biology. Jan, 1998 | Pubmed ID: 9418872 原位近接结扎法检测蛋白异构体的 Heterodimerization Sofiia Karchugina1, Jonathan Chernoff1 1Fox Chase Cancer Center JoVE 57755 Biochemistry 一个 Maria Radu1, Jonathan Chernoff1 1Fox Chase Cancer Center JoVE 50062 Medicine
原位近接结扎法检测蛋白异构体的 Heterodimerization Sofiia Karchugina1, Jonathan Chernoff1 1Fox Chase Cancer Center JoVE 57755 Biochemistry