Jong-Ik Hwang

Publications

• Spexin-Based Galanin Receptor Type 2 Agonist for Comorbid Mood Disorders and Abnormal Body Weight
  Frontiers in Neuroscience. 2019  |   Pubmed ID: 31057364
• SP-8356, a (1S)-(-)-verbenone Derivative, Exerts in Vitro and in Vivo Anti-breast Cancer Effects by Inhibiting NF-κB Signaling
  Scientific Reports. Apr, 2019  |   Pubmed ID: 31036845
• Generation by Somatic Cell Nuclear Transfer of GGTA1 Knockout Pigs Expressing Soluble Human TNFRI-Fc and Human HO-1
  Transgenic Research. 02, 2019  |   Pubmed ID: 30552552
• Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction Between Macrophages and Alveolar Epithelial Cells
  Scientific Reports. Dec, 2018  |   Pubmed ID: 30510259
• Conformational Signatures in β-arrestin2 Reveal Natural Biased Agonism at a G-protein-coupled Receptor
  Communications Biology. 2018  |   Pubmed ID: 30272007
• Nafamostat Mesilate Negatively Regulates the Metastasis of Triple-negative Breast Cancer Cells
  Archives of Pharmacal Research. Feb, 2018  |   Pubmed ID: 29196918
• Generation of CMAHKO/GTKO/shTNFRI-Fc/HO-1 Quadruple Gene Modified Pigs
  Transgenic Research. 08, 2017  |   Pubmed ID: 28553699
• The Accessory Proteins REEP5 and REEP6 Refine CXCR1-mediated Cellular Responses and Lung Cancer Progression
  Scientific Reports. 12, 2016  |   Pubmed ID: 27966653
• Human Antibody Reactivity Against Xenogeneic N-glycolylneuraminic Acid and Galactose-α-1,3-galactose Antigen
  Xenotransplantation. 07, 2016  |   Pubmed ID: 27373998
• Ninjurin1 Inhibits Colitis-mediated Colon Cancer Development and Growth by Suppression of Macrophage Infiltration Through Repression of FAK Signaling
  Oncotarget. May, 2016  |   Pubmed ID: 27127177
• Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling
  Molecules and Cells. May, 2016  |   Pubmed ID: 27094059
• Development of Spexin-based Human Galanin Receptor Type II-Specific Agonists with Increased Stability in Serum and Anxiolytic Effect in Mice
  Scientific Reports. Feb, 2016  |   Pubmed ID: 26907960
• Ninjurin1 Suppresses Metastatic Property of Lung Cancer Cells Through Inhibition of Interleukin 6 Signaling Pathway
  International Journal of Cancer. 07, 2016  |   Pubmed ID: 26815582
• Beneficial Effects of the Transgenic Expression of Human STNF-αR-Fc and HO-1 on Pig-to-mouse Islet Xenograft Survival
  Transplant Immunology. Feb, 2016  |   Pubmed ID: 26777482
• NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells
  Journal of Cellular Biochemistry. Jun, 2016  |   Pubmed ID: 26565392
• Prevertebrate Local Gene Duplication Facilitated Expansion of the Neuropeptide GPCR Superfamily
  Molecular Biology and Evolution. Nov, 2015  |   Pubmed ID: 26337547
• Dimer of Arfaptin 2 Regulates NF-κB Signaling by Interacting with IKKβ/NEMO and Inhibiting IKKβ Kinase Activity
  Cellular Signalling. Nov, 2015  |   Pubmed ID: 26296658
• Human Thrombomodulin Regulates Complement Activation As Well As the Coagulation Cascade in Xeno-immune Response
  Xenotransplantation. Jul-Aug, 2015  |   Pubmed ID: 26179123
• Ligand Binding Pocket Formed by Evolutionarily Conserved Residues in the Glucagon-like Peptide-1 (GLP-1) Receptor Core Domain
  The Journal of Biological Chemistry. Feb, 2015  |   Pubmed ID: 25561730
• A Novel Long-Acting Glucagon-Like Peptide-1 Agonist with Improved Efficacy in Insulin Secretion and β-Cell Growth
  Endocrinology and Metabolism (Seoul, Korea). Sep, 2014  |   Pubmed ID: 25309791
• Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family?
  Frontiers in Endocrinology. 2014  |   Pubmed ID: 25165463
• Apoptotic Death of Prostate Cancer Cells by a Gonadotropin-releasing Hormone-II Antagonist
  PloS One. 2014  |   Pubmed ID: 24926857
• A Splicing Variant of NME1 Negatively Regulates NF-κB Signaling and Inhibits Cancer Metastasis by Interacting with IKKβ
  The Journal of Biological Chemistry. Jun, 2014  |   Pubmed ID: 24811176
• Coevolution of the Spexin/galanin/kisspeptin Family: Spexin Activates Galanin Receptor Type II and III
  Endocrinology. May, 2014  |   Pubmed ID: 24517231
• Local Duplication of Gonadotropin-releasing Hormone (GnRH) Receptor Before Two Rounds of Whole Genome Duplication and Origin of the Mammalian GnRH Receptor
  PloS One. 2014  |   Pubmed ID: 24498396
• Expression Analysis of Combinatorial Genes Using a Bi-cistronic T2A Expression System in Porcine Fibroblasts
  PloS One. 2013  |   Pubmed ID: 23922997
• A Novel Glucagon-related Peptide (GCRP) and Its Receptor GCRPR Account for Coevolution of Their Family Members in Vertebrates
  PloS One. 2013  |   Pubmed ID: 23776481
• Expansion of Secretin-like G Protein-coupled Receptors and Their Peptide Ligands Via Local Duplications Before and After Two Rounds of Whole-genome Duplication
  Molecular Biology and Evolution. May, 2013  |   Pubmed ID: 23427277
• CXCL14 Enhances Proliferation and Migration of NCI-H460 Human Lung Cancer Cells Overexpressing the Glycoproteins Containing Heparan Sulfate or Sialic Acid
  Journal of Cellular Biochemistry. May, 2013  |   Pubmed ID: 23161284
• Structural and Molecular Conservation of Glucagon-like Peptide-1 and Its Receptor Confers Selective Ligand-receptor Interaction
  Frontiers in Endocrinology. 2012  |   Pubmed ID: 23181056
• Generation and Characterization of Human Heme Oxygenase-1 Transgenic Pigs
  PloS One. 2012  |   Pubmed ID: 23071605
• Anti-cancer Activity of a Novel Small Molecule Compound That Simultaneously Activates P53 and Inhibits NF-κB Signaling
  PloS One. 2012  |   Pubmed ID: 23028510
• Spatiotemporal Expression and Functional Implication of CXCL14 in the Developing Mice Cerebellum
  Molecules and Cells. Sep, 2012  |   Pubmed ID: 22843118
• 分子神経ペプチド共進化性ゴナドトロピン放出ホルモンと Cognate G Protein-Coupled 受容体とキスペプチンニューロン。
  Frontiers in Neuroscience. 2012  |   Pubmed ID: 22291614
• Evolutionarily Conserved Residues at Glucagon-like Peptide-1 (GLP-1) Receptor Core Confer Ligand-induced Receptor Activation
  The Journal of Biological Chemistry. Feb, 2012  |   Pubmed ID: 22105074
• Insulin Contributes to Fine-tuning of the Pancreatic Beta-cell Response to Glucagon-like Peptide-1
  Molecules and Cells. Oct, 2011  |   Pubmed ID: 21904878
• Revisiting the Evolution of Gonadotropin-releasing Hormones and Their Receptors in Vertebrates: Secrets Hidden in Genomes
  General and Comparative Endocrinology. Jan, 2011  |   Pubmed ID: 21036176
• Regulation of IκB Kinase by GβL Through Recruitment of the Protein Phosphatases
  Molecules and Cells. Dec, 2010  |   Pubmed ID: 21110129
• Tyr1 and Ile7 of Glucose-dependent Insulinotropic Polypeptide (GIP) Confer Differential Ligand Selectivity Toward GIP and Glucagon-like Peptide-1 Receptors
  Molecules and Cells. Aug, 2010  |   Pubmed ID: 20799012
• Molecular Coevolution of Kisspeptins and Their Receptors from Fish to Mammals
  Annals of the New York Academy of Sciences. Jul, 2010  |   Pubmed ID: 20633134
• Suppression of NF-kappaB Signaling by KEAP1 Regulation of IKKbeta Activity Through Autophagic Degradation and Inhibition of Phosphorylation
  Cellular Signalling. Nov, 2010  |   Pubmed ID: 20600852
• Splicing Variants of the Orphan G-protein-coupled Receptor GPR56 Regulate the Activity of Transcription Factors Associated with Tumorigenesis
  Journal of Cancer Research and Clinical Oncology. Jan, 2010  |   Pubmed ID: 19572147
• Phylogenetic History, Pharmacological Features, and Signal Transduction of Neurotensin Receptors in Vertebrates
  Annals of the New York Academy of Sciences. Apr, 2009  |   Pubmed ID: 19456337
• A Gonadotropin-releasing Hormone-II Antagonist Induces Autophagy of Prostate Cancer Cells
  Cancer Research. Feb, 2009  |   Pubmed ID: 19176390
• Molecular Evolution of Multiple Forms of Kisspeptins and GPR54 Receptors in Vertebrates
  Endocrinology. Jun, 2009  |   Pubmed ID: 19164475
• Molecular Cloning of the Bullfrog Kisspeptin Receptor GPR54 with High Sensitivity to Xenopus Kisspeptin
  Peptides. Jan, 2009  |   Pubmed ID: 18550222
• Gene Expression Profiling of Light-induced Retinal Degeneration in Phototransduction Gene Knockout Mice
  Experimental & Molecular Medicine. Oct, 2008  |   Pubmed ID: 18985007
• GbetaL Regulates TNFalpha-induced NF-kappaB Signaling by Directly Inhibiting the Activation of IkappaB Kinase
  Cellular Signalling. Nov, 2008  |   Pubmed ID: 18755269
• Identification of Farnesyl Pyrophosphate and N-arachidonylglycine As Endogenous Ligands for GPR92
  The Journal of Biological Chemistry. Jul, 2008  |   Pubmed ID: 18499677
• Involvement of Amino Acids Flanking Glu7.32 of the Gonadotropin-releasing Hormone Receptor in the Selectivity of Antagonists
  Molecules and Cells. Feb, 2008  |   Pubmed ID: 18319619
• Extracellular Loop 3 (ECL3) and ECL3-proximal Transmembrane Domains VI and VII of the Mesotocin and Vasotocin Receptors Confer Differential Ligand Selectivity and Signaling Activity
  General and Comparative Endocrinology. Mar, 2008  |   Pubmed ID: 18158152
• Cloning and Activation of the Bullfrog Apelin Receptor: Gi/o Coupling and High Affinity for [Pro1]apelin-13
  Molecular and Cellular Endocrinology. Oct, 2007  |   Pubmed ID: 17825479
• Role of Galpha12 and Galpha13 As Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor
  Molecular and Cellular Biology. Sep, 2007  |   Pubmed ID: 17591699
• Molecular Cloning and Characterization of a Novel Phospholipase C, PLC-eta
  The Biochemical Journal. Jul, 2005  |   Pubmed ID: 15702972