Joseph A. Madri Department of Pathology Yale University School of Medicine Biography Publications Institution JoVE Articles Joseph A. Madri has not added a biography. If you are Joseph A. Madri and would like to personalize this page please email our Author Liaison for assistance. Publications Somatic PRKAR1A Mutation in Sporadic Atrial Myxoma with Cerebral Parenchymal Metastases: a Case Report Journal of Medical Case Reports. Dec, 2019 | Pubmed ID: 31874650 Minocycline Mitigates the Effect of Neonatal Hypoxic Insult on Human Brain Organoids Cell Death & Disease. 04, 2019 | Pubmed ID: 30975982 MMP-2: A Modulator of Neuronal Precursor Activity and Cognitive and Motor Behaviors Behavioural Brain Research. 08, 2017 | Pubmed ID: 28666838 CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation Arteriosclerosis, Thrombosis, and Vascular Biology. 06, 2017 | Pubmed ID: 28450292 As Human Lung Microvascular Endothelia Achieve Confluence, Src Family Kinases Are Activated, and Tyrosine-phosphorylated P120 Catenin Physically Couples NEU1 Sialidase to CD31 Cellular Signalling. 07, 2017 | Pubmed ID: 28343945 The Role of Endothelial HIF-1 αin the Response to Sublethal Hypoxia in C57BL/6 Mouse Pups Laboratory Investigation; a Journal of Technical Methods and Pathology. 04, 2017 | Pubmed ID: 28092362 -NOD Mice Having a Lyn Tyrosine Kinase Mutation Exhibit Abnormal Neutrophil Chemotaxis Journal of Cellular Physiology. Jul, 2017 | Pubmed ID: 27591397 Targeted Proteomics Effectively Quantifies Differences Between Native Lung and Detergent-decellularized Lung Extracellular Matrices Acta Biomaterialia. Dec, 2016 | Pubmed ID: 27693690 CD44 Influences Fibroblast Behaviors Via Modulation of Cell-Cell and Cell-Matrix Interactions, Affecting Survivin and Hippo Pathways Journal of Cellular Physiology. Mar, 2016 | Pubmed ID: 26248063 ENPP1-Fc Prevents Mortality and Vascular Calcifications in Rodent Model of Generalized Arterial Calcification of Infancy Nature Communications. Dec, 2015 | Pubmed ID: 26624227 Modulation of Sox10, HIF-1α, Survivin, and YAP by Minocycline in the Treatment of Neurodevelopmental Handicaps Following Hypoxic Insult The American Journal of Pathology. Sep, 2015 | Pubmed ID: 26209807 A Hydrogel-endothelial Cell Implant Mimics Infantile Hemangioma: Modulation by Survivin and the Hippo Pathway Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2015 | Pubmed ID: 25961170 Disturbed Shear Stress Reduces Klf2 Expression in Arterial-venous Fistulae In vivo Physiological Reports. Mar, 2015 | Pubmed ID: 25780089 Temporal Regulation of Venous Extracellular Matrix Components During Arteriovenous Fistula Maturation The Journal of Vascular Access. Mar-Apr, 2015 | Pubmed ID: 25262757 Adhesion Molecule-mediated Hippo Pathway Modulates Hemangioendothelioma Cell Behavior Molecular and Cellular Biology. Dec, 2014 | Pubmed ID: 25266662 NEU1 Sialidase Regulates the Sialylation State of CD31 and Disrupts CD31-driven Capillary-like Tube Formation in Human Lung Microvascular Endothelia The Journal of Biological Chemistry. Mar, 2014 | Pubmed ID: 24550400 Stratified Control of IGF-I Expression by Hypoxia and Stress Hormones in Osteoblasts Gene. Apr, 2014 | Pubmed ID: 24440782 CD44 Regulation of Endothelial Cell Proliferation and Apoptosis Via Modulation of CD31 and VE-cadherin Expression The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24425872 Modeling the Neurovascular Niche: Unbiased Transcriptome Analysis of the Murine Subventricular Zone in Response to Hypoxic Insult PloS One. 2013 | Pubmed ID: 24146847 The Mouse Aortocaval Fistula Recapitulates Human Arteriovenous Fistula Maturation American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2013 | Pubmed ID: 24097429 CD44 Regulates Vascular Endothelial Barrier Integrity Via a PECAM-1 Dependent Mechanism Angiogenesis. Jul, 2013 | Pubmed ID: 23504212 CD44 Deficiency Contributes to Enhanced Experimental Autoimmune Encephalomyelitis: a Role in Immune Cells and Vascular Cells of the Blood-brain Barrier The American Journal of Pathology. Apr, 2013 | Pubmed ID: 23416161 Brain Regional Angiogenic Potential at the Neurovascular Unit During Normal Aging Neurobiology of Aging. May, 2012 | Pubmed ID: 22019053 Characterization of the Natural History of Extracellular Matrix Production in Tissue-engineered Vascular Grafts During Neovessel Formation Cells, Tissues, Organs. 2012 | Pubmed ID: 21996715 Cyclic Strain Delays the Expression of Tissue Factor Induced by Thrombin in Human Umbilical Vein Endothelial Cells The International Journal of Angiology : Official Publication of the International College of Angiology, Inc. Sep, 2011 | Pubmed ID: 22942631 Varying Effects of Hemodynamic Forces on Tissue Factor RNA Expression in Human Endothelial Cells The Journal of Surgical Research. Sep, 2011 | Pubmed ID: 21592524 Laminar Shear, but Not Orbital Shear, Has a Synergistic Effect with Thrombin Stimulation on Tissue Factor Expression in Human Umbilical Vein Endothelial Cells Journal of Vascular Surgery. Aug, 2011 | Pubmed ID: 21367569 Pulsatile To-fro Flow Induces Greater and Sustained Expression of Tissue Factor RNA in HUVEC Than Unidirectional Laminar Flow American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2011 | Pubmed ID: 21257914 Myometrial Wound Healing Post-Cesarean Delivery in the MRL/MpJ Mouse Model of Uterine Scarring The American Journal of Pathology. Jul, 2010 | Pubmed ID: 20489145 An Implantable Vascularized Protein Gel Construct That Supports Human Fetal Hepatoblast Survival and Infection by Hepatitis C Virus in Mice PloS One. Apr, 2010 | Pubmed ID: 20376322 Modeling the Neurovascular Niche: Implications for Recovery from CNS Injury Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society. Oct, 2009 | Pubmed ID: 20083857 Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-renewal: Modeling the Neurovascular Niche The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19815710 VEGF A 和 Semaphorin3A: 调制器血管交感神经支配。 Developmental Biology. Oct, 2009 | Pubmed ID: 19631637 Using Proteomics in Perinatal and Neonatal Sepsis: Hopes and Challenges for the Future Current Opinion in Infectious Diseases. Jun, 2009 | Pubmed ID: 19395960 Bone Marrow Monocyte PECAM-1 Deficiency Elicits Increased Osteoclastogenesis Resulting in Trabecular Bone Loss Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234161 基质金属蛋白酶 9 便利西尼罗河病毒进入大脑。 Journal of Virology. Sep, 2008 | Pubmed ID: 18632868 Differential Effects of Shear Stress and Cyclic Strain on Sp1 Phosphorylation by Protein Kinase Czeta Modulates Membrane Type 1-matrix Metalloproteinase in Endothelial Cells Endothelium : Journal of Endothelial Cell Research. Jan-Feb, 2008 | Pubmed ID: 18568943 Targeted Imaging of Hypoxia-induced Integrin Activation in Myocardium Early After Infarction Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2008 | Pubmed ID: 18356482 Modeling the Neurovascular Niche: Murine Strain Differences Mimic the Range of Responses to Chronic Hypoxia in the Premature Newborn Journal of Neuroscience Research. May, 2008 | Pubmed ID: 18092360 PECAM-1: a Multifaceted Regulator of Megakaryocytopoiesis Blood. Aug, 2007 | Pubmed ID: 17412889 PECAM-1 Modulates Thrombin-induced Tissue Factor Expression on Endothelial Cells Journal of Cellular Physiology. Feb, 2007 | Pubmed ID: 17111362 PECAM-1 Affects GSK-3beta-mediated Beta-catenin Phosphorylation and Degradation The American Journal of Pathology. Jul, 2006 | Pubmed ID: 16816383 Noninvasive Imaging of Angiogenesis with a 99mTc-labeled Peptide Targeted at Alphavbeta3 Integrin After Murine Hindlimb Ischemia Circulation. Jun, 2005 | Pubmed ID: 15956134 Role of C5 in the Development of Airway Inflammation, Airway Hyperresponsiveness, and Ongoing Airway Response The Journal of Clinical Investigation. Jun, 2005 | Pubmed ID: 15902311 Identification of the Regions of PECAM-1 Involved in Beta- and Gamma-catenin Associations Biochemical and Biophysical Research Communications. Apr, 2005 | Pubmed ID: 15766557 MAPKs (ERK1/2, P38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15668248 Enhanced Susceptibility to Endotoxic Shock and Impaired STAT3 Signaling in CD31-deficient Mice The American Journal of Pathology. Jan, 2005 | Pubmed ID: 15632011 MMP-2 Null Mice Exhibit an Early Onset and Severe Experimental Autoimmune Encephalomyelitis Due to an Increase in MMP-9 Expression and Activity FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2004 | Pubmed ID: 15522913 Noninvasive Imaging of Myocardial Angiogenesis Following Experimental Myocardial Infarction The Journal of Clinical Investigation. Jun, 2004 | Pubmed ID: 15199403 Paracrine and Autocrine Functions of Brain-derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) in Brain-derived Endothelial Cells The Journal of Biological Chemistry. Aug, 2004 | Pubmed ID: 15169782 Nitric Oxide Modulates Murine Yolk Sac Vasculogenesis and Rescues Glucose Induced Vasculopathy Development (Cambridge, England). May, 2004 | Pubmed ID: 15128676 组胺对进行血管舒张功能通过内皮源性抑制小鼠骨骼肌小动脉无生产。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769822 Maternal Diabetes: Effects on Embryonic Vascular Development--a Vascular Endothelial Growth Factor-A-mediated Process Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jul-Aug, 2003 | Pubmed ID: 14692647 Vascular Endothelial Growth Factor Expression, Beta-catenin Tyrosine Phosphorylation, and Endothelial Proliferative Behavior: a Pathway for Transformation? Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2003 | Pubmed ID: 12920240 Platelet Endothelial Cell Adhesion Molecule-1 Modulates Endothelial Cell Motility Through the Small G-protein Rho FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2003 | Pubmed ID: 12890700 The Evolving Roles of Cell Surface Proteases in Health and Disease: Implications for Developmental, Adaptive, Inflammatory, and Neoplastic Processes Current Topics in Developmental Biology. 2003 | Pubmed ID: 12696757 废除的小动脉扩张,但在 ENOS/小鼠对组胺提睾肌不收缩。 American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2003 | Pubmed ID: 12689855 PECAM-1 Promotes Beta-catenin Accumulation and Stimulates Endothelial Cell Proliferation Biochemical and Biophysical Research Communications. Mar, 2003 | Pubmed ID: 12646189 Lack of Platelet Endothelial Cell Adhesion Molecule-1 Attenuates Foreign Body Inflammation Because of Decreased Angiogenesis The American Journal of Pathology. Mar, 2003 | Pubmed ID: 12598328 Elevated Glucose Inhibits VEGF-A-mediated Endocardial Cushion Formation: Modulation by PECAM-1 and MMP-2 The Journal of Cell Biology. Feb, 2003 | Pubmed ID: 12591918 Platelet-endothelial Cell Adhesion Molecule-1 Modulates Endothelial Migration Through Its Immunoreceptor Tyrosine-based Inhibitory Motif Biochemical and Biophysical Research Communications. Jan, 2003 | Pubmed ID: 12535670 Disrupted Synaptic Development in the Hypoxic Newborn Brain Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12438650 Cyclic Strain Stimulates Early Growth Response Gene Product 1-mediated Expression of Membrane Type 1 Matrix Metalloproteinase in Endothelium Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2002 | Pubmed ID: 12118097 Transcription Factor Sp1 Phosphorylation Induced by Shear Stress Inhibits Membrane Type 1-matrix Metalloproteinase Expression in Endothelium The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12093818 Altered Vascular Permeability and Early Onset of Experimental Autoimmune Encephalomyelitis in PECAM-1-deficient Mice The Journal of Clinical Investigation. Feb, 2002 | Pubmed ID: 11827998 Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11777931 Hyperglycemia-induced Vasculopathy in the Murine Conceptus is Mediated Via Reductions of VEGF-A Expression and VEGF Receptor Activation The American Journal of Pathology. Apr, 2001 | Pubmed ID: 11290536 PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo The American Journal of Pathology. Jul, 2000 | Pubmed ID: 10880378 一种从人类胚胎干细胞中生成脑器官的静态自导方法 Erin M. Boisvert1, Robert E. Means1, Michael Michaud1, Jason J. Thomson2, Joseph A. Madri1, Samuel G. Katz1 1Department of Pathology, Yale University School of Medicine, 2Stem Cell Center, Yale University School of Medicine JoVE 60379 Developmental Biology
一种从人类胚胎干细胞中生成脑器官的静态自导方法 Erin M. Boisvert1, Robert E. Means1, Michael Michaud1, Jason J. Thomson2, Joseph A. Madri1, Samuel G. Katz1 1Department of Pathology, Yale University School of Medicine, 2Stem Cell Center, Yale University School of Medicine JoVE 60379 Developmental Biology