Juan Iovanna Aix-Marseille Univ, INSERM, CNRS Institut Paoli-Calmettes, CRCM Biography Publications Institution JoVE Articles Juan Iovanna has not added a biography. If you are Juan Iovanna and would like to personalize this page please email our Author Liaison for assistance. Publications PML Hyposumoylation is Responsible for the Resistance of Pancreatic Cancer FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2019 | Pubmed ID: 31557059 Designing and Repurposing Drugs to Target Intrinsically Disordered Proteins for Cancer Treatment: Using NUPR1 As a Paradigm Molecular & Cellular Oncology. 2019 | Pubmed ID: 31528692 Emerging Epigenomic Landscapes of Pancreatic Cancer in the Era of Precision Medicine Nature Communications. Aug, 2019 | Pubmed ID: 31462645 Dynamics of the Intrinsically Disordered Protein NUPR1 in Isolation and in Its Fuzzy Complexes with DNA and Prothymosin α Biochimica Et Biophysica Acta. Proteins and Proteomics. Nov, 2019 | Pubmed ID: 31325636 Flavonoid-alkylphospholipid Conjugates Elicit Dual Inhibition of Cancer Cell Growth and Lipid Accumulation Chemical Communications (Cambridge, England). Aug, 2019 | Pubmed ID: 31270526 Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi) Frontiers in Oncology. 2019 | Pubmed ID: 31231611 Can the Plasma PD-1 Levels Predict the Presence and Efficiency of Tumor-infiltrating Lymphocytes in Patients with Metastatic Melanoma? Therapeutic Advances in Medical Oncology. 2019 | Pubmed ID: 31205506 Dendrimers As Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1 Biomacromolecules. Jul, 2019 | Pubmed ID: 31181156 Aurora Kinase B-phosphorylated HP1α Functions in Chromosomal Instability Cell Cycle (Georgetown, Tex.). Jun, 2019 | Pubmed ID: 31130069 Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome Frontiers in Oncology. 2019 | Pubmed ID: 31024848 Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas Upon Combined Inhibition of EGFR and C-RAF Cancer Cell. Apr, 2019 | Pubmed ID: 30975481 Ligand-based Design Identifies a Potent NUPR1 Inhibitor Exerting Anticancer Activity Via Necroptosis The Journal of Clinical Investigation. 03, 2019 | Pubmed ID: 30920390 Prognostic Significance of Circulating PD-1, PD-L1, Pan-BTN3As, BTN3A1 and BTLA in Patients with Pancreatic Adenocarcinoma Oncoimmunology. 2019 | Pubmed ID: 30906655 Pancreatic Cancer Chemo-resistance is Driven by Tumor Phenotype Rather Than Tumor Genotype Heliyon. Dec, 2018 | Pubmed ID: 30582059 Ribonuclease MCPiP1 Contributes to the Loss of Micro-RNA-200 Family Members in Pancreatic Cancer Cells Oncotarget. Nov, 2018 | Pubmed ID: 30542509 Inactivation of NUPR1 Promotes Cell Death by Coupling ER-stress Responses with Necrosis Scientific Reports. 11, 2018 | Pubmed ID: 30451898 Self-assembling Supramolecular Dendrimer Nanosystem for PET Imaging of Tumors Proceedings of the National Academy of Sciences of the United States of America. 11, 2018 | Pubmed ID: 30348798 Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway Scientific Reports. 10, 2018 | Pubmed ID: 30305677 Chloroquine Plays a Cell-dependent Role in the Response to Treatment of Pancreatic Adenocarcinoma Oncotarget. Jul, 2018 | Pubmed ID: 30112111 Epigenetics of Gastrointestinal Diseases: Notes from a Workshop Epigenetics. 2018 | Pubmed ID: 30056798 α-lipoic Acid Reduces Postreperfusion Syndrome in Human Liver Transplantation - a Pilot Study Transplant International : Official Journal of the European Society for Organ Transplantation. 12, 2018 | Pubmed ID: 29974521 The Chromatin Nuclear Protein NUPR1L is Intrinsically Disordered and Binds to the Same Proteins As Its Paralogue The Biochemical Journal. 07, 2018 | Pubmed ID: 29925531 [Multi-omic Approaches Reveal New Therapeutic Targets for the Treatment of Pancreatic Cancer] Medecine Sciences : M/S. May, 2018 | Pubmed ID: 29900832 Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment Frontiers in Immunology. 2018 | Pubmed ID: 29868007 E2F Signature is Predictive for the Pancreatic Adenocarcinoma Clinical Outcome and Sensitivity to E2F Inhibitors, but Not for the Response to Cytotoxic-based Treatments Scientific Reports. 05, 2018 | Pubmed ID: 29844366 Distinct Epigenetic Landscapes Underlie the Pathobiology of Pancreatic Cancer Subtypes Nature Communications. 05, 2018 | Pubmed ID: 29773832 Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma Cruzi Protein/Protein Interaction Inhibitors Molecular Biotechnology. May, 2018 | Pubmed ID: 29600316 Amphipathic Helical Peptides Hamper Protein-protein Interactions of the Intrinsically Disordered Chromatin Nuclear Protein 1 (NUPR1) Biochimica Et Biophysica Acta. General Subjects. 06, 2018 | Pubmed ID: 29530795 Cadherin-1 and Cadherin-3 Cooperation Determines the Aggressiveness of Pancreatic Ductal Adenocarcinoma British Journal of Cancer. 02, 2018 | Pubmed ID: 29161242 Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas Gastroenterology. 03, 2018 | Pubmed ID: 29158190 BTN3A is a Prognosis Marker and a Promising Target for Vγ9Vδ2 T Cells Based-immunotherapy in Pancreatic Ductal Adenocarcinoma (PDAC) Oncoimmunology. 2017 | Pubmed ID: 29296524 Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts Cell Reports. Nov, 2017 | Pubmed ID: 29186684 Factors Released by the Tumor Far Microenvironment Are Decisive for Pancreatic Adenocarcinoma Development and Progression Oncoimmunology. 2017 | Pubmed ID: 29147622 Speeding Towards Individualized Treatment for Pancreatic Cancer by Taking an Alternative Road Cancer Letters. 12, 2017 | Pubmed ID: 28947138 Collagen-derived Proline Promotes Pancreatic Ductal Adenocarcinoma Cell Survival Under Nutrient Limited Conditions Nature Communications. 07, 2017 | Pubmed ID: 28685754 REG3β Modifies Cell Tumor Function by Impairing Extracellular Vesicle Uptake Scientific Reports. 06, 2017 | Pubmed ID: 28600520 Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe Molecular Cancer Research : MCR. 08, 2017 | Pubmed ID: 28442587 [Autophagy Contributes to the Initiation of Pancreatic Cancer] Medecine Sciences : M/S. Mar, 2017 | Pubmed ID: 28367822 Gene Expression Profiling of Patient-derived Pancreatic Cancer Xenografts Predicts Sensitivity to the BET Bromodomain Inhibitor JQ1: Implications for Individualized Medicine Efforts EMBO Molecular Medicine. 04, 2017 | Pubmed ID: 28275007 Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma Scientific Reports. 01, 2017 | Pubmed ID: 28054562 GATA6 Regulates EMT and Tumour Dissemination, and is a Marker of Response to Adjuvant Chemotherapy in Pancreatic Cancer Gut. 09, 2017 | Pubmed ID: 27325420 Autophagy Induced During Pancreatitis Promotes -Dependent Transformation in the Pancreas Frontiers in Oncology. 2016 | Pubmed ID: 27833900 Stratification and Therapeutic Potential of PML in Metastatic Breast Cancer Nature Communications. 08, 2016 | Pubmed ID: 27553708 A Pancreatic Ductal Adenocarcinoma Subpopulation is Sensitive to FK866, an Inhibitor of NAMPT Oncotarget. Aug, 2016 | Pubmed ID: 27462772 The Promise of Epigenomic Therapeutics in Pancreatic Cancer Epigenomics. 06, 2016 | Pubmed ID: 27337224 Determinants of the PKa Values of Ionizable Residues in an Intrinsically Disordered Protein Archives of Biochemistry and Biophysics. 05, 2016 | Pubmed ID: 27046343 REG3β Plays a Key Role in IL17RA Protumoral Effect-Response Cancer Research. 04, 2016 | Pubmed ID: 26992425 α-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation Transplantation. Apr, 2016 | Pubmed ID: 26502371 Response to "Is the Reg3α (HIP/PAP) Protein Really an Obesogenic Factor?" Journal of Cellular Physiology. Jan, 2016 | Pubmed ID: 26280560 Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation Scientific Reports. Nov, 2015 | Pubmed ID: 26617245 A Mycobacterium Tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette-Guérin-vaccinated Individuals EBioMedicine. Aug, 2015 | Pubmed ID: 26425695 IL17 Functions Through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer Cancer Research. Nov, 2015 | Pubmed ID: 26404002 Targeting CD44 As a Novel Therapeutic Approach for Treating Pancreatic Cancer Recurrence Oncoscience. 2015 | Pubmed ID: 26244163 IER3 in Pancreatic Carcinogenesis Oncotarget. Jun, 2015 | Pubmed ID: 26158545 The Aurora A-HP1γ Pathway Regulates Gene Expression and Mitosis in Cells from the Sperm Lineage BMC Developmental Biology. May, 2015 | Pubmed ID: 26021315 Functional Characterization of Nupr1L, A Novel P53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1 Journal of Cellular Physiology. Dec, 2015 | Pubmed ID: 25899918 Defects in Mitophagy Promote Redox-driven Metabolic Syndrome in the Absence of TP53INP1 EMBO Molecular Medicine. Jun, 2015 | Pubmed ID: 25828351 Deciphering the Cellular Source of Tumor Relapse Identifies CD44 As a Major Therapeutic Target in Pancreatic Adenocarcinoma Oncotarget. Apr, 2015 | Pubmed ID: 25797268 Transcriptomic Analysis Predicts Survival and Sensitivity to Anticancer Drugs of Patients with a Pancreatic Adenocarcinoma The American Journal of Pathology. Apr, 2015 | Pubmed ID: 25765988 Methodological Aspects of the Molecular and Histological Study of Prostate Cancer: Focus on PTEN Methods (San Diego, Calif.). May, 2015 | Pubmed ID: 25697760 The Thymus-specific Serine Protease TSSP/PRSS16 is Crucial for the Antitumoral Role of CD4(+) T Cells Cell Reports. Jan, 2015 | Pubmed ID: 25543139 A Subgroup of Pancreatic Adenocarcinoma is Sensitive to the 5-aza-dC DNA Methyltransferase Inhibitor Oncotarget. Jan, 2015 | Pubmed ID: 25481873 P8 Deficiency Increases Cellular ROS and Induces HO-1 Archives of Biochemistry and Biophysics. Jan, 2015 | Pubmed ID: 25475530 Redox-sensitive TP53INP1 SUMOylation As an Oxidative Stress Sensor to Activate TP53 Molecular & Cellular Oncology. Jul-Sep, 2014 | Pubmed ID: 27308354 Pancreatitis Promotes Oncogenic Kras(G12D)-induced Pancreatic Transformation Through Activation of Nupr1 Molecular & Cellular Oncology. 2014 | Pubmed ID: 27308320 Further Characterization of HDAC and SIRT Gene Expression Patterns in Pancreatic Cancer and Their Relation to Disease Outcome PloS One. 2014 | Pubmed ID: 25275504 Pancreatic Cancer-induced Cachexia is Jak2-dependent in Mice Journal of Cellular Physiology. Oct, 2014 | Pubmed ID: 24648112 Oligomerization and Phosphorylation Dependent Regulation of ArgBP2 Adaptive Capabilities and Associated Functions PloS One. 2014 | Pubmed ID: 24475245 Pancreatitis-associated Protein Does Not Predict Disease Relapse in Inflammatory Bowel Disease Patients PloS One. 2014 | Pubmed ID: 24416322 Genetic Inactivation of Nupr1 Acts As a Dominant Suppressor Event in a Two-hit Model of Pancreatic Carcinogenesis Gut. Jun, 2014 | Pubmed ID: 24026351 PAP/HIP Protein is an Obesogenic Factor Journal of Cellular Physiology. Feb, 2014 | Pubmed ID: 23881718 Development of an ELISA Detecting Tumor Protein 53-Induced Nuclear Protein 1 in Serum of Prostate Cancer Patients Results in Immunology. 2013 | Pubmed ID: 24600558 Nuclear Protein 1 Promotes Pancreatic Cancer Development and Protects Cells from Stress by Inhibiting Apoptosis The Journal of Clinical Investigation. Jun, 2012 | Pubmed ID: 22565310 تنميط اوبيكويتين و اوبيكويتين-مثل التعديلات اللاحقة الانتقالية وتحديد التعديلات الهامه Mirna Swayden1, Aurélie Dobric1, Yolande Berthois1, Hugo Villalba1, Stéphane Audebert1, Luc Camoin1, Juan Iovanna1, Philippe Soubeyran1 1Aix-Marseille Univ, INSERM, CNRS, Institut Paoli-Calmettes, CRCM JoVE 60402 Biochemistry
تنميط اوبيكويتين و اوبيكويتين-مثل التعديلات اللاحقة الانتقالية وتحديد التعديلات الهامه Mirna Swayden1, Aurélie Dobric1, Yolande Berthois1, Hugo Villalba1, Stéphane Audebert1, Luc Camoin1, Juan Iovanna1, Philippe Soubeyran1 1Aix-Marseille Univ, INSERM, CNRS, Institut Paoli-Calmettes, CRCM JoVE 60402 Biochemistry