Judith Klumperman Center for Molecular Medicine-Cell Biology, University Medical Center Utrecht Utrecht University Biography Publications Institution JoVE Articles Judith Klumperman has not added a biography. If you are Judith Klumperman and would like to personalize this page please email our Author Liaison for assistance. Publications Small Molecules to Regulate the GH/IGF1 Axis by Inhibiting the Growth Hormone Receptor Synthesis Frontiers in Endocrinology. 2022 | Pubmed ID: 35966052 Bimodal Endocytic Probe for Three-dimensional Correlative Light and Electron Microscopy Cell Reports Methods. May, 2022 | Pubmed ID: 35637912 Correlative Organelle Microscopy: Fluorescence Guided Volume Electron Microscopy of Intracellular Processes Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35478966 An Optimized Protocol for Immuno-electron Microscopy of Endogenous LC3 Autophagy. Apr, 2022 | Pubmed ID: 35387562 FER Regulates Endosomal Recycling and is a Predictor for Adjuvant Taxane Benefit in Breast Cancer Cell Reports. Apr, 2022 | Pubmed ID: 35385742 High Resolution Proteomic Analysis of Subcellular Fractionated Boar Spermatozoa Provides Comprehensive Insights Into Perinuclear Theca-Residing Proteins Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35252197 Quantitative Correlative Microscopy Reveals the Ultrastructural Distribution of Endogenous Endosomal Proteins The Journal of Cell Biology. Jan, 2022 | Pubmed ID: 34817533 The Potential and Limitations of Intrahepatic Cholangiocyte Organoids to Study Inborn Errors of Metabolism Journal of Inherited Metabolic Disease. Mar, 2022 | Pubmed ID: 34671987 Author Correction: Vps3 and Vps8 Control Integrin Trafficking from Early to Recycling Endosomes and Regulate Integrin-dependent Functions Nature Communications. Sep, 2021 | Pubmed ID: 34588435 ER - lysosome Contacts at a Pre-axonal Region Regulate Axonal Lysosome Availability Nature Communications. Jul, 2021 | Pubmed ID: 34301956 α-Synuclein Fibrils Subvert Lysosome Structure and Function for the Propagation of Protein Misfolding Between Cells Through Tunneling Nanotubes PLoS Biology. Jul, 2021 | Pubmed ID: 34283825 Understanding Membrane Traffic from Molecular Ensemble, Energetics, and the Cell Biology of Participant Components Current Opinion in Cell Biology. Aug, 2021 | Pubmed ID: 34219001 Cysteamine-bicalutamide Combination Therapy Corrects Proximal Tubule Phenotype in Cystinosis EMBO Molecular Medicine. Jul, 2021 | Pubmed ID: 34165243 Neurodegenerative VPS41 Variants Inhibit HOPS Function and MTORC1-dependent TFEB/TFE3 Regulation EMBO Molecular Medicine. May, 2021 | Pubmed ID: 33851776 Pancreatic β-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion Diabetes. Feb, 2021 | Pubmed ID: 33168621 Apolipoprotein L1-Specific Antibodies Detect Endogenous APOL1 Inside the Endoplasmic Reticulum and on the Plasma Membrane of Podocytes Journal of the American Society of Nephrology : JASN. 09, 2020 | Pubmed ID: 32764142 Wiskott-Aldrich Syndrome Protein Restricts CGAS/STING Activation by DsDNA Immune Complexes JCI Insight. Sep, 2020 | Pubmed ID: 32721945 Quantifying Lymphocyte Vacuolization Serves As a Measure of CLN3 Disease Severity JIMD Reports. Jul, 2020 | Pubmed ID: 32685355 A Paralog-specific Role of COPI Vesicles in the Neuronal Differentiation of Mouse Pluripotent Cells Life Science Alliance. Sep, 2020 | Pubmed ID: 32665377 Integrated Super Resolution Fluorescence Microscopy and Transmission Electron Microscopy Ultramicroscopy. Aug, 2020 | Pubmed ID: 32470633 Combining Supervised and Unsupervised Machine Learning Methods for Phenotypic Functional Genomics Screening SLAS Discovery : Advancing Life Sciences R & D. Jul, 2020 | Pubmed ID: 32400262 Single-cell Analysis Uncovers That Metabolic Reprogramming by ErbB2 Signaling is Essential for Cardiomyocyte Proliferation in the Regenerating Heart ELife. Dec, 2019 | Pubmed ID: 31868166 The Ubiquitin-conjugating Enzyme UBE2QL1 Coordinates Lysophagy in Response to Endolysosomal Damage EMBO Reports. Oct, 2019 | Pubmed ID: 31432621 DGAT2 Partially Compensates for Lipid-induced ER Stress in Human DGAT1-deficient Intestinal Stem Cells Journal of Lipid Research. Oct, 2019 | Pubmed ID: 31315900 The Hepatic WASH Complex is Required for Efficient Plasma LDL and HDL Cholesterol Clearance JCI Insight. Jun, 2019 | Pubmed ID: 31167970 CORVET, CHEVI and HOPS - Multisubunit Tethers of the Endo-lysosomal System in Health and Disease Journal of Cell Science. May, 2019 | Pubmed ID: 31092635 Visualizing the Cellular Route of Entry of a Cystine-knot Peptide with Xfect Transfection Reagent by Electron Microscopy Scientific Reports. May, 2019 | Pubmed ID: 31061420 High Accuracy, Fiducial Marker-based Image Registration of Correlative Microscopy Images Scientific Reports. Mar, 2019 | Pubmed ID: 30824844 The 2018 Correlative Microscopy Techniques Roadmap Journal of Physics D: Applied Physics. Nov, 2018 | Pubmed ID: 30799880 Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies Neuron. Dec, 2018 | Pubmed ID: 30392797 Fluorescently Labelled Silica Coated Gold Nanoparticles As Fiducial Markers for Correlative Light and Electron Microscopy Scientific Reports. Sep, 2018 | Pubmed ID: 30206379 Vps3 and Vps8 Control Integrin Trafficking from Early to Recycling Endosomes and Regulate Integrin-dependent Functions Nature Communications. Feb, 2018 | Pubmed ID: 29476049 Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration Theranostics. 2018 | Pubmed ID: 29463990 Single Organelle Dynamics Linked to 3D Structure by Correlative Live-cell Imaging and 3D Electron Microscopy Traffic (Copenhagen, Denmark). May, 2018 | Pubmed ID: 29451726 Ultrastructural Characterization of Membrane Rearrangements Induced by Porcine Epidemic Diarrhea Virus Infection Viruses. Sep, 2017 | Pubmed ID: 28872588 Improving Comprehension Efficiency of High Content Screening Data Through Interactive Visualizations Assay and Drug Development Technologies. 2017 | Pubmed ID: 28837357 EB1 and EB3 Regulate Microtubule Minus End Organization and Golgi Morphology The Journal of Cell Biology. Oct, 2017 | Pubmed ID: 28814570 Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform Assay and Drug Development Technologies. Oct, 2016 | Pubmed ID: 27732064 Molecular Pathway of Microtubule Organization at the Golgi Apparatus Developmental Cell. Oct, 2016 | Pubmed ID: 27666745 HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets Assay and Drug Development Technologies. Oct, 2016 | Pubmed ID: 27636821 Architecture of the Mammalian Golgi Cold Spring Harbor Perspectives in Biology. Jul, 2011 | Pubmed ID: 21502307 A Flippase-independent Function of ATP8B1, the Protein Affected in Familial Intrahepatic Cholestasis Type 1, is Required for Apical Protein Expression and Microvillus Formation in Polarized Epithelial Cells Hepatology (Baltimore, Md.). Jun, 2010 | Pubmed ID: 20512993 Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes PLoS Biology. Jan, 2010 | Pubmed ID: 20098723 Efficient IgM Assembly and Secretion Require the Plasma Cell Induced Endoplasmic Reticulum Protein PERp1 Proceedings of the National Academy of Sciences of the United States of America. Oct, 2009 | Pubmed ID: 19805154 Glycolipid-dependent Sorting of Melanosomal from Lysosomal Membrane Proteins by Lumenal Determinants Traffic (Copenhagen, Denmark). Jun, 2008 | Pubmed ID: 18373728 Pre- and Post-Golgi Translocation of Glucosylceramide in Glycosphingolipid Synthesis The Journal of Cell Biology. Oct, 2007 | Pubmed ID: 17923531 Involvement of a Golgi-resident GPI-anchored Protein in Maintenance of the Golgi Structure Molecular Biology of the Cell. Apr, 2007 | Pubmed ID: 17251550 Short-chain Ubiquitination Mediates the Regulated Endocytosis of the Aquaporin-2 Water Channel Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17101973 Aberrant Receptor-mediated Endocytosis of Schistosoma Mansoni Glycoproteins on Host Lipoproteins PLoS Medicine. Aug, 2006 | Pubmed ID: 16942390 Presenilin-1 Exists in Both Pre- and Post-Golgi Compartments and Recycles Via COPI-coated Membranes Traffic (Copenhagen, Denmark). Aug, 2003 | Pubmed ID: 12839498 A Phosphorylation Site Regulates Sorting of the Vesicular Acetylcholine Transporter to Dense Core Vesicles The Journal of Cell Biology. Apr, 2000 | Pubmed ID: 10769030 Synaptic Vesicles Form by Budding from Tubular Extensions of Sorting Endosomes in PC12 Cells Molecular Biology of the Cell. Dec, 1999 | Pubmed ID: 10588650 Dynamic Kinetochore Size Regulation Promotes Microtubule Capture and Chromosome Biorientation in Mitosis Nature Cell Biology. | Pubmed ID: 29915359 Localização ultraestrutural da CL3 endógena por microscopia óptica-eletrônica correlativa em seção Jan van der Beek1, Tineke Veenendaal1, Cecilia de Heus1, Suzanne van Dijk1, Corlinda ten Brink1, Nalan Liv1, Judith Klumperman1 1Center for Molecular Medicine-Cell Biology, University Medical Center Utrecht, Utrecht University JoVE 65067 Biology
Localização ultraestrutural da CL3 endógena por microscopia óptica-eletrônica correlativa em seção Jan van der Beek1, Tineke Veenendaal1, Cecilia de Heus1, Suzanne van Dijk1, Corlinda ten Brink1, Nalan Liv1, Judith Klumperman1 1Center for Molecular Medicine-Cell Biology, University Medical Center Utrecht, Utrecht University JoVE 65067 Biology