K. Sandy Pang Department of Pharmaceutical Sciences University of Toronto Biography Publications Institution JoVE Articles K. Sandy Pang has not added a biography. If you are K. Sandy Pang and would like to personalize this page please email our Author Liaison for assistance. Publications Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming, and Humorous Pharmaceutical Scientist Journal of Pharmaceutical Sciences. Sep, 2017 | Pubmed ID: 28479350 Revisiting the Role of Gut Wall in the Fate of Orally Administered Drugs: Why Now and to What Effect? Biopharmaceutics & Drug Disposition. 03, 2017 | Pubmed ID: 28317174 Comparing Early Liver Graft Function from Heart Beating and Living-donors: A Pilot Study Aiming to Identify New Biomarkers of Liver Injury Biopharmaceutics & Drug Disposition. Jul, 2017 | Pubmed ID: 28102538 Unequivocal Evidence Supporting the Segregated Flow Intestinal Model That Discriminates Intestine Versus Liver First-pass Removal with PBPK Modeling Biopharmaceutics & Drug Disposition. Apr, 2017 | Pubmed ID: 27977852 Physiologically Based Pharmacokinetic Modeling Revealed Minimal Codeine Intestinal Metabolism in First-pass Removal in Rats Biopharmaceutics & Drug Disposition. Jan, 2017 | Pubmed ID: 27925239 Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models The Journal of Pharmacology and Experimental Therapeutics. Jan, 2017 | Pubmed ID: 27789682 Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2016 | Pubmed ID: 27342868 Metabolite Kinetics: The Segregated Flow Model for Intestinal and Whole Body Physiologically Based Pharmacokinetic Modeling to Describe Intestinal and Hepatic Glucuronidation of Morphine in Rats In Vivo Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2016 | Pubmed ID: 27098743 Polymer-lipid Hybrid Nanoparticles Synchronize Pharmacokinetics of Co-encapsulated Doxorubicin-mitomycin C and Enable Their Spatiotemporal Co-delivery and Local Bioavailability in Breast Tumor Nanomedicine : Nanotechnology, Biology, and Medicine. Jul, 2016 | Pubmed ID: 26772427 Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice Drug Metabolism and Disposition: the Biological Fate of Chemicals. Feb, 2016 | Pubmed ID: 26586377 Response to Letter to the Editor on "fractional Clearance for Verapamil N-demethylation in the Isolated Rat Liver Preparation" Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jul, 2015 | Pubmed ID: 25964425 PKPD Modelling to Predict Altered Disposition of 1α,25-dihydroxyvitamin D3 in Mice Due to Dose-dependent Regulation of CYP27B1 on Synthesis and CYP24A1 on Degradation British Journal of Pharmacology. Jul, 2015 | Pubmed ID: 25829051 Pharmacokinetic Modeling of Tranexamic Acid for Patients Undergoing Cardiac Surgery with Normal Renal Function and Model Simulations for Patients with Renal Impairment Biopharmaceutics & Drug Disposition. Jul, 2015 | Pubmed ID: 25704361 PBPK Modeling to Unravel Nonlinear Pharmacokinetics of Verapamil to Estimate the Fractional Clearance for Verapamil N-demethylation in the Recirculating Rat Liver Preparation Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2015 | Pubmed ID: 25650380 Dealing with the Complex Drug-drug Interactions: Towards Mechanistic Models Biopharmaceutics & Drug Disposition. Mar, 2015 | Pubmed ID: 25545151 Vitamin D Receptor Activation Induces P-glycoprotein and Increases Brain Efflux of Quinidine: an Intracerebral Microdialysis Study in Conscious Rats Pharmaceutical Research. Mar, 2015 | Pubmed ID: 25319098 Effects of 1α,25-dihydroxyvitamin D3 , the Natural Vitamin D Receptor Ligand, on the Pharmacokinetics of Cefdinir and Cefadroxil, Organic Anion Transporter Substrates, in Rat Journal of Pharmaceutical Sciences. Nov, 2014 | Pubmed ID: 25266751 1α,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2014 | Pubmed ID: 24849345 Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol Gastroenterology. Apr, 2014 | Pubmed ID: 24365583 Comparative Effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on Transporters and Enzymes in Fxr(+/+) and Fxr(-/-) Mice Biopharmaceutics & Drug Disposition. Oct, 2013 | Pubmed ID: 23897575 Temporal Changes in Tissue 1α,25-dihydroxyvitamin D3, Vitamin D Receptor Target Genes, and Calcium and PTH Levels After 1,25(OH)2D3 Treatment in Mice American Journal of Physiology. Endocrinology and Metabolism. May, 2013 | Pubmed ID: 23482451 Why We Need Proper PBPK Models to Examine Intestine and Liver Oral Drug Absorption Current Drug Metabolism. Jan, 2013 | Pubmed ID: 22935069 1α,25-Dihydroxyvitamin D3-liganded Vitamin D Receptor Increases Expression and Transport Activity of P-glycoprotein in Isolated Rat Brain Capillaries and Human and Rat Brain Microvessel Endothelial Cells Journal of Neurochemistry. Dec, 2012 | Pubmed ID: 23035695 Commentary: Theoretical Predictions of Flow Effects on Intestinal and Systemic Availability in Physiologically Based Pharmacokinetic Intestine Models: the Traditional Model, Segregated Flow Model, and QGut Model Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2012 | Pubmed ID: 22745334 Effects of 1α,25-dihydroxyvitamin D3 on Transport and Metabolism of Adefovir Dipivoxil and Its Metabolites in Caco-2 Cells European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jun, 2012 | Pubmed ID: 22387228 Physiologically Based Pharmacokinetic (PBPK) Modeling: It is Here to Stay! Biopharmaceutics & Drug Disposition. Mar, 2012 | Pubmed ID: 22351594 Utility of a Physiologically-based Pharmacokinetic (PBPK) Modeling Approach to Quantitatively Predict a Complex Drug-drug-disease Interaction Scenario for Rivaroxaban During the Drug Review Process: Implications for Clinical Practice Biopharmaceutics & Drug Disposition. Mar, 2012 | Pubmed ID: 22270945 Evaluation of Exposure Change of Nonrenally Eliminated Drugs in Patients with Chronic Kidney Disease Using Physiologically Based Pharmacokinetic Modeling and Simulation Journal of Clinical Pharmacology. Jan, 2012 | Pubmed ID: 22232759 Fraction Absorbed (Fabs ): Different Connotations and Confusion for the Literature? Biopharmaceutics & Drug Disposition. 07, 2011 | Pubmed ID: 21630284 1Alpha,25-dihydroxyvitamin D3 Up-regulates P-glycoprotein Via the Vitamin D Receptor and Not Farnesoid X Receptor in Both Fxr(-/-) and Fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice in Vivo The Journal of Pharmacology and Experimental Therapeutics. Jun, 2011 | Pubmed ID: 21421739 1α,25-dihydroxyvitamin D3 on Intestinal Transporter Function: Studies with the Rat Everted Intestinal Sac Biopharmaceutics & Drug Disposition. Mar, 2011 | Pubmed ID: 21341280 Comparative Effects of Doxercalciferol (1α-hydroxyvitamin D₂) Versus Calcitriol (1α,25-dihydroxyvitamin D₃) on the Expression of Transporters and Enzymes in the Rat in Vivo Journal of Pharmaceutical Sciences. Apr, 2011 | Pubmed ID: 20967888 The Role of Lithocholic Acid in the Regulation of Bile Acid Detoxication, Synthesis, and Transport Proteins in Rat and Human Intestine and Liver Slices Toxicology in Vitro : an International Journal Published in Association with BIBRA. Feb, 2011 | Pubmed ID: 20888898 PBPK Modeling of Intestinal and Liver Enzymes and Transporters in Drug Absorption and Sequential Metabolism Current Drug Metabolism. Nov, 2010 | Pubmed ID: 21189137 Physiologically-based Pharmacokinetic Modeling for Absorption, Transport, Metabolism and Excretion Journal of Pharmacokinetics and Pharmacodynamics. Dec, 2010 | Pubmed ID: 21153869 Interplay of Transporters and Enzymes in the Caco-2 Cell Monolayer: I. Effect of Altered Apical Secretion Biopharmaceutics & Drug Disposition. May, 2010 | Pubmed ID: 20437461 Physiological Modeling to Understand the Impact of Enzymes and Transporters on Drug and Metabolite Data and Bioavailability Estimates Pharmaceutical Research. Jul, 2010 | Pubmed ID: 20372987 Interplay of Phase II Enzymes and Transporters in Futile Cycling: Influence of Multidrug Resistance-associated Protein 2-mediated Excretion of Estradiol 17beta-D-glucuronide and Its 3-sulfate Metabolite on Net Sulfation in Perfused TR(-) and Wistar Rat Liver Preparations Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2010 | Pubmed ID: 20124397 Effects of 1alpha,25-dihydroxyvitamin D3 on Transporters and Enzymes of the Rat Intestine and Kidney in Vivo Biopharmaceutics & Drug Disposition. Jan, 2010 | Pubmed ID: 20013813 Interplay of Transporters and Enzymes in Drug and Metabolite Processing Molecular Pharmaceutics. Nov-Dec, 2009 | Pubmed ID: 19891494 1alpha,25-Dihydroxyvitamin D(3) Triggered Vitamin D Receptor and Farnesoid X Receptor-like Effects in Rat Intestine and Liver in Vivo Biopharmaceutics & Drug Disposition. Nov, 2009 | Pubmed ID: 19753549 Expression and Regulation of the Bile Acid Transporter, OSTalpha-OSTbeta in Rat and Human Intestine and Liver Biopharmaceutics & Drug Disposition. Jul, 2009 | Pubmed ID: 19562681 Comparison of Effects of VDR Versus PXR, FXR and GR Ligands on the Regulation of CYP3A Isozymes in Rat and Human Intestine and Liver European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. May, 2009 | Pubmed ID: 19429418 Up-regulation of Transporters and Enzymes by the Vitamin D Receptor Ligands, 1alpha,25-dihydroxyvitamin D3 and Vitamin D Analogs, in the Caco-2 Cell Monolayer The Journal of Pharmacology and Experimental Therapeutics. Aug, 2009 | Pubmed ID: 19414624 Disparity in Intestine Disposition Between Formed and Preformed Metabolites and Implications: a Theoretical Study Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2009 | Pubmed ID: 18948379 Safety Testing of Metabolites: Expectations and Outcomes Chemico-biological Interactions. Apr, 2009 | Pubmed ID: 18926805 Formed and Preformed Metabolites: Facts and Comparisons The Journal of Pharmacy and Pharmacology. Oct, 2008 | Pubmed ID: 18812018 The Caco-2 Cell Monolayer: Usefulness and Limitations Expert Opinion on Drug Metabolism & Toxicology. Apr, 2008 | Pubmed ID: 18433344 A Catenary Model to Study Transport and Conjugation of Baicalein, a Bioactive Flavonoid, in the Caco-2 Cell Monolayer: Demonstration of Substrate Inhibition The Journal of Pharmacology and Experimental Therapeutics. Jul, 2008 | Pubmed ID: 18385448 Role of Haptoglobin on the Uptake of Native and Beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] Cross-linked Human Hemoglobins in Isolated Perfused Rat Livers Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2008 | Pubmed ID: 18276837 Permeability, Transport, and Metabolism of Solutes in Caco-2 Cell Monolayers: a Theoretical Study Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2008 | Pubmed ID: 17932224 Advanced Pharmacokinetic Models Based on Organ Clearance, Circulatory, and Fractal Concepts The AAPS Journal. Jun, 2007 | Pubmed ID: 17907768 Transporters, Enzymes, and Enalapril Removal in a Rat (CC531-induced) Liver Metastatic Model American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2007 | Pubmed ID: 17855765 Increased Estrogen Sulfation of Estradiol 17beta-D-glucuronide in Metastatic Tumor Rat Livers The Journal of Pharmacology and Experimental Therapeutics. Nov, 2006 | Pubmed ID: 16895976 An Integrated Approach to Model Hepatic Drug Clearance European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2006 | Pubmed ID: 16806855 P-glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16alpha-carbonitrile Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2006 | Pubmed ID: 16751264 Vectorial Transport of Enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in Rat and Human Livers The Journal of Pharmacology and Experimental Therapeutics. Jul, 2006 | Pubmed ID: 16627748 Transactivation of Rat Apical Sodium-dependent Bile Acid Transporter and Increased Bile Acid Transport by 1alpha,25-dihydroxyvitamin D3 Via the Vitamin D Receptor Molecular Pharmacology. Jun, 2006 | Pubmed ID: 16481392 Transport is Not Rate-limiting in Morphine Glucuronidation in the Single-pass Perfused Rat Liver Preparation The Journal of Pharmacology and Experimental Therapeutics. May, 2006 | Pubmed ID: 16464965 Vascular Binding, Blood Flow, Transporter, and Enzyme Interactions on the Processing of Digoxin in Rat Liver The Journal of Pharmacology and Experimental Therapeutics. Oct, 2005 | Pubmed ID: 15994370 Binding of Acellular, Native and Cross-linked Human Hemoglobins to Haptoglobin: Enhanced Distribution and Clearance in the Rat American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2005 | Pubmed ID: 15890714 Comparative Pharmacophore Modeling of Organic Anion Transporting Polypeptides: a Meta-analysis of Rat Oatp1a1 and Human OATP1B1 The Journal of Pharmacology and Experimental Therapeutics. Aug, 2005 | Pubmed ID: 15845861 The Roles of Transporters and Enzymes in Hepatic Drug Processing Drug Metabolism and Disposition: the Biological Fate of Chemicals. Jan, 2005 | Pubmed ID: 15466164 Modeling of Intestinal Drug Absorption: Roles of Transporters and Metabolic Enzymes (for the Gillette Review Series) Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2003 | Pubmed ID: 14625347 Influence of P-glycoprotein, Transfer Clearances, and Drug Binding on Intestinal Metabolism in Caco-2 Cell Monolayers or Membrane Preparations: a Theoretical Analysis Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2003 | Pubmed ID: 12975330 Substrate Specificities of Rat Oatp1 and Ntcp: Implications for Hepatic Organic Anion Uptake American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2003 | Pubmed ID: 12842829 Moment Analysis of Metabolic Heterogeneity: Conjugation of Benzoate with Glycine in Rat Liver Studied by Multiple Indicator Dilution Technique The Journal of Pharmacology and Experimental Therapeutics. Apr, 2003 | Pubmed ID: 12649380 Retention of Transporter Activities in Cryopreserved, Isolated Rat Hepatocytes Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2003 | Pubmed ID: 12642471 Segmental Intestinal Transporters and Metabolic Enzymes on Intestinal Drug Absorption Drug Metabolism and Disposition: the Biological Fate of Chemicals. Apr, 2003 | Pubmed ID: 12642462 Transport of the Sulfated, Amidated Bile Acid, Sulfolithocholyltaurine, into Rat Hepatocytes is Mediated by Oatp1 and Oatp2 Hepatology (Baltimore, Md.). May, 2002 | Pubmed ID: 11981753 Esempio di estrazione e quantificazione simultanea cromatografica di doxorubicina e mitomicina C successivi alla consegna combinazione farmaco in nanoparticelle topi del tumore-cuscinetto Rui Xue Zhang1, Tian Zhang1, King Chen1, Ji Cheng1, Paris Lai1, Andrew M. Rauth2, K. Sandy Pang1, Xiao Yu Wu1 1Department of Pharmaceutical Sciences, University of Toronto, 2Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute, University Health Network JoVE 56159 Cancer Research
Esempio di estrazione e quantificazione simultanea cromatografica di doxorubicina e mitomicina C successivi alla consegna combinazione farmaco in nanoparticelle topi del tumore-cuscinetto Rui Xue Zhang1, Tian Zhang1, King Chen1, Ji Cheng1, Paris Lai1, Andrew M. Rauth2, K. Sandy Pang1, Xiao Yu Wu1 1Department of Pharmaceutical Sciences, University of Toronto, 2Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute, University Health Network JoVE 56159 Cancer Research
