Karen S. Wilcox Department of Pharmacology and Toxicology University of Utah Biography Publications Institution JoVE Articles Karen S. Wilcox has not added a biography. If you are Karen S. Wilcox and would like to personalize this page please email our Author Liaison for assistance. Publications Spontaneous Recurrent Seizures in an Intra-amygdala Kainate Microinjection Model of Temporal Lobe Epilepsy Are Differentially Sensitive to Antiseizure Drugs Experimental Neurology. 03, 2022 | Pubmed ID: 34922908 Screening of Prototype Antiseizure and Anti-inflammatory Compounds in the Theiler's Murine Encephalomyelitis Virus Model of Epilepsy Epilepsia Open. 03, 2022 | Pubmed ID: 34668659 Inflammation Unleashed in Viral-Induced Epileptogenesis Epilepsy Currents. Nov-Dec, 2021 | Pubmed ID: 34924851 Development of an Antiepileptogenesis Drug Screening Platform: Effects of Everolimus and Phenobarbital Epilepsia. 07, 2021 | Pubmed ID: 34080183 Antiepileptogenesis and Disease Modification: Progress, Challenges, and the Path Forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored Antiepileptogenesis and Disease Modification Workshop Epilepsia Open. 06, 2021 | Pubmed ID: 34033232 Development of an Antiseizure Drug Screening Platform for Dravet Syndrome at the NINDS Contract Site for the Epilepsy Therapy Screening Program Epilepsia. 07, 2021 | Pubmed ID: 34002394 Response: Usefulness of the Post-kainate Spontaneous Recurrent Seizure Model for Screening for Antiseizure and for Neuroprotective Effects Epilepsia. 05, 2021 | Pubmed ID: 33778946 Identification of Clinically Relevant Biomarkers of Epileptogenesis - a Strategic Roadmap Nature Reviews. Neurology. 04, 2021 | Pubmed ID: 33594276 Reactivity and Increased Proliferation of NG2 Cells Following Central Nervous System Infection with Theiler's Murine Encephalomyelitis Virus Journal of Neuroinflammation. Dec, 2020 | Pubmed ID: 33272299 Accurate Detection of Spontaneous Seizures Using a Generalized Linear Model with External Validation Epilepsia. 09, 2020 | Pubmed ID: 32761902 Evaluation of Subchronic Administration of Antiseizure Drugs in Spontaneously Seizing Rats Epilepsia. 06, 2020 | Pubmed ID: 32420627 Discovery of the First Vitamin K Analogue As a Potential Treatment of Pharmacoresistant Seizures Journal of Medicinal Chemistry. 06, 2020 | Pubmed ID: 32390424 Ultrastructural and Functional Changes at the Tripartite Synapse During Epileptogenesis in a Model of Temporal Lobe Epilepsy Experimental Neurology. 04, 2020 | Pubmed ID: 31935368 The Current Approach of the Epilepsy Therapy Screening Program Contract Site for Identifying Improved Therapies for the Treatment of Pharmacoresistant Seizures in Epilepsy Neuropharmacology. 04, 2020 | Pubmed ID: 31790717 Evaluation of Antiseizure Drug Efficacy and Tolerability in the Rat Lamotrigine-resistant Amygdala Kindling Model Epilepsia Open. Sep, 2019 | Pubmed ID: 31440726 Cannabidiol Reduces Seizures Following CNS Infection with Theiler's Murine Encephalomyelitis Virus Epilepsia Open. Sep, 2019 | Pubmed ID: 31440724 Genetic and Pharmacological Manipulation of Glial Glutamate Transporters Does Not Alter Infection-induced Seizure Activity Experimental Neurology. 08, 2019 | Pubmed ID: 31022385 Conditional Knock-out of MGluR5 from Astrocytes During Epilepsy Development Impairs High-Frequency Glutamate Uptake The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 01, 2019 | Pubmed ID: 30504280 Recurrent Epileptiform Discharges in the Medial Entorhinal Cortex of Kainate-treated Rats Are Differentially Sensitive to Antiseizure Drugs Epilepsia. 11, 2018 | Pubmed ID: 30328622 Epilepsy As a Network Disorder (2): What Can We Learn from Other Network Disorders Such As Dementia and Schizophrenia, and What Are the Implications for Translational Research? Epilepsy & Behavior : E&B. 01, 2018 | Pubmed ID: 29097123 Novel Targets for Developing Antiseizure And, Potentially, Antiepileptogenic Drugs Epilepsy Currents. Sep-Oct, 2017 | Pubmed ID: 29225544 Corneal Kindled C57BL/6 Mice Exhibit Saturated Dentate Gyrus Long-term Potentiation and Associated Memory Deficits in the Absence of Overt Neuron Loss Neurobiology of Disease. Sep, 2017 | Pubmed ID: 28624414 Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, And/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain Neurochemical Research. Jul, 2017 | Pubmed ID: 28508174 Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy ENeuro. Mar-Apr, 2017 | Pubmed ID: 28497109 Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP) Neurochemical Research. Jul, 2017 | Pubmed ID: 28478594 Development and Pharmacologic Characterization of the Rat 6 Hz Model of Partial Seizures Epilepsia. 06, 2017 | Pubmed ID: 28449218 Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy Neurochemical Research. Jul, 2017 | Pubmed ID: 28303498 Acute Treatment with Minocycline, but Not Valproic Acid, Improves Long-term Behavioral Outcomes in the Theiler's Virus Model of Temporal Lobe Epilepsy Epilepsia. 12, 2016 | Pubmed ID: 27739576 NBQX, a Highly Selective Competitive Antagonist of AMPA and KA Ionotropic Glutamate Receptors, Increases Seizures and Mortality Following Picornavirus Infection Experimental Neurology. 06, 2016 | Pubmed ID: 27072529 Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy Journal of Neuropathology and Experimental Neurology. Apr, 2016 | Pubmed ID: 26945036 Repeated Low-dose Kainate Administration in C57BL/6J Mice Produces Temporal Lobe Epilepsy Pathology but Infrequent Spontaneous Seizures Experimental Neurology. May, 2016 | Pubmed ID: 26896834 Altered Structure and Function of Astrocytes Following Status Epilepticus Epilepsy & Behavior : E&B. Aug, 2015 | Pubmed ID: 26219575 Oxidative Stress in Murine Theiler's Virus-induced Temporal Lobe Epilepsy Experimental Neurology. Sep, 2015 | Pubmed ID: 26079647 Imaging Activity in Astrocytes and Neurons with Genetically Encoded Calcium Indicators Following in Utero Electroporation Frontiers in Molecular Neuroscience. 2015 | Pubmed ID: 25926768 Evaluating an Etiologically Relevant Platform for Therapy Development for Temporal Lobe Epilepsy: Effects of Carbamazepine and Valproic Acid on Acute Seizures and Chronic Behavioral Comorbidities in the Theiler's Murine Encephalomyelitis Virus Mouse Model The Journal of Pharmacology and Experimental Therapeutics. May, 2015 | Pubmed ID: 25755209 Imaging Activity in Neurons and Glia with a Polr2a-based and Cre-dependent GCaMP5G-IRES-tdTomato Reporter Mouse Neuron. Sep, 2014 | Pubmed ID: 25155958 The Challenge and Promise of Anti-epileptic Therapy Development in Animal Models The Lancet. Neurology. Sep, 2014 | Pubmed ID: 25127174 Does Brain Inflammation Mediate Pathological Outcomes in Epilepsy? Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 25012376 Antiseizure Drugs Differentially Modulate θ-burst Induced Long-term Potentiation in C57BL/6 Mice Epilepsia. Feb, 2014 | Pubmed ID: 24447124 Impaired Cognitive Ability and Anxiety-like Behavior Following Acute Seizures in the Theiler's Virus Model of Temporal Lobe Epilepsy Neurobiology of Disease. Apr, 2014 | Pubmed ID: 24412221 Novel, Broad-spectrum Anticonvulsants Containing a Sulfamide Group: Pharmacological Properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112) Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24205976 The Expression of Kainate Receptor Subunits in Hippocampal Astrocytes After Experimentally Induced Status Epilepticus Journal of Neuropathology and Experimental Neurology. Oct, 2013 | Pubmed ID: 24042195 Issues Related to Development of New Antiseizure Treatments Epilepsia. Aug, 2013 | Pubmed ID: 23909851 Rapid Loss of Efficacy to the Antiseizure Drugs Lamotrigine and Carbamazepine: a Novel Experimental Model of Pharmacoresistant Epilepsy Epilepsia. Jul, 2013 | Pubmed ID: 23750799 The Activity Within the CA3 Excitatory Network During Theiler's Virus Encephalitis is Distinct from That Observed During Chronic Epilepsy Journal of Neurovirology. Feb, 2012 | Pubmed ID: 22328242 A New Derivative of Valproic Acid Amide Possesses a Broad-spectrum Antiseizure Profile and Unique Activity Against Status Epilepticus and Organophosphate Neuronal Damage Epilepsia. Jan, 2012 | Pubmed ID: 22150444 Altered Learning and Arc-regulated Consolidation of Learning in Striatum by Methamphetamine-induced Neurotoxicity Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Mar, 2012 | Pubmed ID: 22071872 Once Initiated, Viral Encephalitis-induced Seizures Are Consistent No Matter the Treatment or Lack of Interleukin-6 Journal of Neurovirology. Oct, 2011 | Pubmed ID: 21833798 Lack of Correlation of Central Nervous System Inflammation and Neuropathology with the Development of Seizures Following Acute Virus Infection Journal of Virology. Aug, 2011 | Pubmed ID: 21680509 CAMP-dependent Protein Kinase A Activity Modulates Topiramate Potentiation of GABA(A) Receptors Epilepsy Research. Sep, 2011 | Pubmed ID: 21665439 Interleukin-6, Produced by Resident Cells of the Central Nervous System and Infiltrating Cells, Contributes to the Development of Seizures Following Viral Infection Journal of Virology. Jul, 2011 | Pubmed ID: 21543484 Topiramate Modulation of β(1)- and β(3)-homomeric GABA(A) Receptors Pharmacological Research. Jul, 2011 | Pubmed ID: 21421049 CGX-1007 Prevents Excitotoxic Cell Death Via Actions at Multiple Types of NMDA Receptors Neurotoxicology. Aug, 2011 | Pubmed ID: 21396956 Development of Postinfection Epilepsy After Theiler's Virus Infection of C57BL/6 Mice Journal of Neuropathology and Experimental Neurology. Dec, 2010 | Pubmed ID: 21107134 Role for Complement in the Development of Seizures Following Acute Viral Infection Journal of Virology. Jul, 2010 | Pubmed ID: 20427530 Theiler's Virus Infection Chronically Alters Seizure Susceptibility Epilepsia. Aug, 2010 | Pubmed ID: 20002148 Innate but Not Adaptive Immune Responses Contribute to Behavioral Seizures Following Viral Infection Epilepsia. Mar, 2010 | Pubmed ID: 19845729 Electroconvulsive Seizure Thresholds and Kindling Acquisition Rates Are Altered in Mouse Models of Human KCNQ2 and KCNQ3 Mutations for Benign Familial Neonatal Convulsions Epilepsia. Jul, 2009 | Pubmed ID: 19453707 Differences in Excitatory Transmission Between Thalamic and Cortical Afferents to Single Spiny Efferent Neurons of Rat Dorsal Striatum The European Journal of Neuroscience. Nov, 2008 | Pubmed ID: 19046385 Mouse Models of Human KCNQ2 and KCNQ3 Mutations for Benign Familial Neonatal Convulsions Show Seizures and Neuronal Plasticity Without Synaptic Reorganization The Journal of Physiology. Jul, 2008 | Pubmed ID: 18483067 Seizures Following Picornavirus Infection Epilepsia. Jun, 2008 | Pubmed ID: 18325012 Inhibition of the Betaine-GABA Transporter (mGAT2/BGT-1) Modulates Spontaneous Electrographic Bursting in the Medial Entorhinal Cortex (mEC) Epilepsy Research. Mar, 2008 | Pubmed ID: 18262393 Mechanisms of Action of Antiepileptic Drugs International Review of Neurobiology. 2007 | Pubmed ID: 17433919 Phenytoin- and Carbamazepine-resistant Spontaneous Bursting in Rat Entorhinal Cortex is Blocked by Retigabine in Vitro Epilepsy Research. May, 2007 | Pubmed ID: 17395429 Differential Contribution of Kainate Receptors to Excitatory Postsynaptic Currents in Superficial Layer Neurons of the Rat Medial Entorhinal Cortex Neuroscience. May, 2007 | Pubmed ID: 17395391 Discovery of Antiepileptic Drugs Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2007 | Pubmed ID: 17199014 A Rat Brain Slice Preparation for Characterizing Both Thalamostriatal and Corticostriatal Afferents Journal of Neuroscience Methods. Jan, 2007 | Pubmed ID: 16899300 Felbamate is a Subunit Selective Modulator of Recombinant Gamma-aminobutyric Acid Type A Receptors Expressed in Xenopus Oocytes European Journal of Pharmacology. Dec, 2006 | Pubmed ID: 17056029 Effect of Conantokin G on NMDA Receptor-mediated Spontaneous EPSCs in Cultured Cortical Neurons Journal of Neurophysiology. Sep, 2006 | Pubmed ID: 16760339 Subunit Selectivity of Topiramate Modulation of Heteromeric GABA(A) Receptors Neuropharmacology. Jun, 2006 | Pubmed ID: 16490221 A Spontaneous Mutation Involving Kcnq2 (Kv7.2) Reduces M-current Density and Spike Frequency Adaptation in Mouse CA1 Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2006 | Pubmed ID: 16481438 Mice Carrying the Szt1 Mutation Exhibit Increased Seizure Susceptibility and Altered Sensitivity to Compounds Acting at the M-channel Epilepsia. Sep, 2004 | Pubmed ID: 15329063 The Effect of CGX-1007 and CI-1041, Novel NMDA Receptor Antagonists, on NMDA Receptor-mediated EPSCs Epilepsy Research. Mar, 2004 | Pubmed ID: 15135163 Characterization of the Anticonvulsant Profile and Enantioselective Pharmacokinetics of the Chiral Valproylamide Propylisopropyl Acetamide in Rodents British Journal of Pharmacology. Feb, 2003 | Pubmed ID: 12598414 Evidence for Functionally Distinct Synaptic NMDA Receptors in Ventromedial Versus Dorsolateral Striatum Journal of Neurophysiology. Jan, 2003 | Pubmed ID: 12522160 Effects of the Anticonvulsant Retigabine on Cultured Cortical Neurons: Changes in Electroresponsive Properties and Synaptic Transmission Molecular Pharmacology. Apr, 2002 | Pubmed ID: 11901232 थेइलर के मुराइन एन्सेफैलोमाइलाइटिस वायरस का उपयोग करके संक्रामक एटियलजि के मिर्गी के लिए एक मॉडल Gaelle Batot1, Cameron S. Metcalf1, Laura A. Bell1,2, Alberto Pauletti3, Karen S. Wilcox1,2, Sonja Bröer3 1Department of Pharmacology and Toxicology, University of Utah, 2Interdepartmental Program in Neuroscience, University of Utah, 3Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology, Freie Universität Berlin JoVE 63673 Neuroscience
थेइलर के मुराइन एन्सेफैलोमाइलाइटिस वायरस का उपयोग करके संक्रामक एटियलजि के मिर्गी के लिए एक मॉडल Gaelle Batot1, Cameron S. Metcalf1, Laura A. Bell1,2, Alberto Pauletti3, Karen S. Wilcox1,2, Sonja Bröer3 1Department of Pharmacology and Toxicology, University of Utah, 2Interdepartmental Program in Neuroscience, University of Utah, 3Faculty of Veterinary Medicine, Institute of Pharmacology and Toxicology, Freie Universität Berlin JoVE 63673 Neuroscience