Karen Duff Department of Pathology Columbia University Biography Publications Institution JoVE Articles Karen Duff has not added a biography. If you are Karen Duff and would like to personalize this page please email our Author Liaison for assistance. Publications Trans-synaptic Spread of Tau Pathology in Vivo PloS One. 2012 | Pubmed ID: 22312444 Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease The Journal of Biological Chemistry. Jan, 2012 | Pubmed ID: 22134919 Microarray Analysis of CA1 Pyramidal Neurons in a Mouse Model of Tauopathy Reveals Progressive Synaptic Dysfunction Neurobiology of Disease. Feb, 2012 | Pubmed ID: 22079237 Age and α-synuclein Expression Interact to Reveal a Dependence of Dopaminergic Axons on Endogenous Akt/PKB Signaling Neurobiology of Disease. Nov, 2011 | Pubmed ID: 21782946 Modulation of ABCA1 by an LXR Agonist Reduces β-amyloid Levels and Improves Outcome After Traumatic Brain Injury Journal of Neurotrauma. Feb, 2011 | Pubmed ID: 21175399 The Phospholipase D1 Pathway Modulates Macroautophagy Nature Communications. 2010 | Pubmed ID: 21266992 Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-linked Synaptic Dysfunction and Cognitive Deficits The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2010 | Pubmed ID: 21147981 Phenothiazine-mediated Rescue of Cognition in Tau Transgenic Mice Requires Neuroprotection and Reduced Soluble Tau Burden Molecular Neurodegeneration. 2010 | Pubmed ID: 21040568 Lowering Beta-amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model PloS One. 2010 | Pubmed ID: 20532168 Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19834068 Age-dependent Impairment of Cognitive and Synaptic Function in the Htau Mouse Model of Tau Pathology The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2009 | Pubmed ID: 19710325 Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric Alpha-synuclein The American Journal of Pathology. Aug, 2009 | Pubmed ID: 19628769 Inhibition of Tau Polymerization with a Cyanine Dye in Two Distinct Model Systems The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19478088 Structure-activity Relationship of Cyanine Tau Aggregation Inhibitors Journal of Medicinal Chemistry. Jun, 2009 | Pubmed ID: 19432420 Acceleration and Persistence of Neurofibrillary Pathology in a Mouse Model of Tauopathy Following Anesthesia FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2009 | Pubmed ID: 19279139 Optical Visualization of Alzheimer's Pathology Via Multiphoton-excited Intrinsic Fluorescence and Second Harmonic Generation Optics Express. Mar, 2009 | Pubmed ID: 19259208 Noninvasive and Transient Blood-brain Barrier Opening in the Hippocampus of Alzheimer's Double Transgenic Mice Using Focused Ultrasound Ultrasonic Imaging. Jul, 2008 | Pubmed ID: 19149463 Linking Abeta and Tau in Late-onset Alzheimer's Disease: a Dual Pathway Hypothesis Neuron. Nov, 2008 | Pubmed ID: 19038212 Anesthesia-induced Hyperphosphorylation Detaches 3-repeat Tau from Microtubules Without Affecting Their Stability in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2008 | Pubmed ID: 19036972 Is Tau Aggregation Toxic or Protective? Journal of Alzheimer's Disease : JAD. Aug, 2008 | Pubmed ID: 18688098 New Directions for Frontotemporal Dementia Drug Discovery Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2008 | Pubmed ID: 18631953 A Transgenic Rat That Develops Alzheimer's Disease-like Amyloid Pathology, Deficits in Synaptic Plasticity and Cognitive Impairment Neurobiology of Disease. Jul, 2008 | Pubmed ID: 18504134 Females Exhibit More Extensive Amyloid, but Not Tau, Pathology in an Alzheimer Transgenic Model Brain Research. Jun, 2008 | Pubmed ID: 18486110 Retromer Deficiency Observed in Alzheimer's Disease Causes Hippocampal Dysfunction, Neurodegeneration, and Abeta Accumulation Proceedings of the National Academy of Sciences of the United States of America. May, 2008 | Pubmed ID: 18480253 Transcriptional Regulation of Beta-secretase by P25/cdk5 Leads to Enhanced Amyloidogenic Processing Neuron. Mar, 2008 | Pubmed ID: 18341989 Interplay Between Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 Beta Mediated by Neuregulin Signaling Leads to Differential Effects on Tau Phosphorylation and Amyloid Precursor Protein Processing The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2008 | Pubmed ID: 18322105 Axonal Transport Rates in Vivo Are Unaffected by Tau Deletion or Overexpression in Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2008 | Pubmed ID: 18272688 Increased Dopaminergic Neuron Sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Transgenic Mice Expressing Mutant A53T Alpha-synuclein Neurochemical Research. May, 2008 | Pubmed ID: 17999181 Insulin Dysfunction Induces in Vivo Tau Hyperphosphorylation Through Distinct Mechanisms The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2007 | Pubmed ID: 18077675 Collapsin Response Mediator Protein-2 Hyperphosphorylation is an Early Event in Alzheimer's Disease Progression Journal of Neurochemistry. Nov, 2007 | Pubmed ID: 17683481 Anesthesia Leads to Tau Hyperphosphorylation Through Inhibition of Phosphatase Activity by Hypothermia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2007 | Pubmed ID: 17376970 Antibody Against C-terminal Abeta Selectively Elevates Plasma Abeta Neuroreport. Feb, 2007 | Pubmed ID: 17314674 Normal and Abnormal Tau Neurobiology Alzheimer Disease and Associated Disorders. Oct-Dec, 2006 | Pubmed ID: 17132962 Cholesterol Distribution, Not Total Levels, Correlate with Altered Amyloid Precursor Protein Processing in Statin-treated Mice Neuromolecular Medicine. 2006 | Pubmed ID: 16775383 The Effects of ABCA1 on Cholesterol Efflux and Abeta Levels in Vitro and in Vivo Journal of Neurochemistry. Aug, 2006 | Pubmed ID: 16771834 The Amyloid Pathology Progresses in a Neurotransmitter-specific Manner Neurobiology of Aging. Nov, 2006 | Pubmed ID: 16271419 Using Proteomics and Network Analysis to Elucidate the Consequences of Synaptic Protein Oxidation in a PS1 + AbetaPP Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Dec, 2005 | Pubmed ID: 16340081 Macroautophagy--a Novel Beta-amyloid Peptide-generating Pathway Activated in Alzheimer's Disease The Journal of Cell Biology. Oct, 2005 | Pubmed ID: 16203860 Untangling Memory Deficits Nature Medicine. Aug, 2005 | Pubmed ID: 16079873 Dense-core Plaques in Tg2576 and PSAPP Mouse Models of Alzheimer's Disease Are Centered on Vessel Walls The American Journal of Pathology. Aug, 2005 | Pubmed ID: 16049337 An Abeta Sequestration Approach Using Non-antibody Abeta Binding Agents Current Alzheimer Research. Apr, 2005 | Pubmed ID: 15974928 Cell-cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005 | Pubmed ID: 15930395 Histological Co-localization of Iron in Abeta Plaques of PS/APP Transgenic Mice Neurochemical Research. Feb, 2005 | Pubmed ID: 15895823 Inhibition of Glycogen Synthase Kinase-3 by Lithium Correlates with Reduced Tauopathy and Degeneration in Vivo Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15867159 Fibrillar Amyloid Deposition Leads to Local Synaptic Abnormalities and Breakage of Neuronal Branches Nature Neuroscience. Nov, 2004 | Pubmed ID: 15475950 Visualization of Beta-amyloid Plaques in a Transgenic Mouse Model of Alzheimer's Disease Using MR Microscopy Without Contrast Reagents Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Sep, 2004 | Pubmed ID: 15334572 Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology Journal of Neuropathology and Experimental Neurology. Aug, 2004 | Pubmed ID: 15330337 Brain on Steroids Resists Neurodegeneration Nature Medicine. Jul, 2004 | Pubmed ID: 15229510 Mostly Separate Distributions of CLAC- Versus Abeta40- or Thioflavin S-reactivities in Senile Plaques Reveal Two Distinct Subpopulations of Beta-amyloid Deposits The American Journal of Pathology. Jul, 2004 | Pubmed ID: 15215182 Rat Transgenic Models with a Phenotype of Intracellular Abeta Accumulation in Hippocampus and Cortex Journal of Alzheimer's Disease : JAD. Jun, 2004 | Pubmed ID: 15201476 Amyloid-beta Deposition is Associated with Decreased Hippocampal Glucose Metabolism and Spatial Memory Impairment in APP/PS1 Mice Journal of Neuropathology and Experimental Neurology. May, 2004 | Pubmed ID: 15198121 Development of Abeta Terminal End-specific Antibodies and Sensitive ELISA for Abeta Variant Biochemical and Biophysical Research Communications. Jul, 2004 | Pubmed ID: 15184044 Links Between the Pathology of Alzheimer's Disease and Vascular Dementia Neurochemical Research. Jun, 2004 | Pubmed ID: 15176482 Transgenic Mouse Models of Alzheimer's Disease: How Useful Have They Been for Therapeutic Development? Briefings in Functional Genomics & Proteomics. Apr, 2004 | Pubmed ID: 15163359 Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-dependent Neurodegeneration Neuron. Apr, 2004 | Pubmed ID: 15066262 MRI Assessment of Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Apr, 2004 | Pubmed ID: 15065253 Rapid Neurofibrillary Tangle Formation After Localized Gene Transfer of Mutated Tau The American Journal of Pathology. Jan, 2004 | Pubmed ID: 14695347 Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol Journal of Molecular Neuroscience : MN. 2003 | Pubmed ID: 14501024 Evidence for Peripheral Clearance of Cerebral Abeta Protein Following Chronic, Active Abeta Immunization in PSAPP Mice Neurobiology of Disease. Oct, 2003 | Pubmed ID: 13678662 Detection of Alzheimer's Amyloid in Transgenic Mice Using Magnetic Resonance Microimaging Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. Aug, 2003 | Pubmed ID: 12876705 Hyperphosphorylation and Aggregation of Tau in Mice Expressing Normal Human Tau Isoforms Journal of Neurochemistry. Aug, 2003 | Pubmed ID: 12859672 Presenilin Redistribution Associated with Aberrant Cholesterol Transport Enhances Beta-amyloid Production in Vivo The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2003 | Pubmed ID: 12843267 Cdk5 is a Key Factor in Tau Aggregation and Tangle Formation in Vivo Neuron. May, 2003 | Pubmed ID: 12765608 Use of in Vivo Models to Study the Role of Cholesterol in the Etiology of Alzheimer's Disease Neurochemical Research. Jul, 2003 | Pubmed ID: 12737522 Brain Damage Results in Down-regulation of N-acetylaspartate As a Neuronal Osmolyte Neuromolecular Medicine. 2003 | Pubmed ID: 12728192 Co-localization of Cholesterol, Apolipoprotein E and Fibrillar Abeta in Amyloid Plaques Brain Research. Molecular Brain Research. Jan, 2003 | Pubmed ID: 12573540 Novel Therapeutic Approach for the Treatment of Alzheimer's Disease by Peripheral Administration of Agents with an Affinity to Beta-amyloid The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2003 | Pubmed ID: 12514198 Organotypic Slice Cultures from Transgenic Mice As Disease Model Systems Journal of Molecular Neuroscience : MN. Dec, 2002 | Pubmed ID: 12540058 Cholesterol in Alzheimer's Disease and Tauopathy Annals of the New York Academy of Sciences. Nov, 2002 | Pubmed ID: 12480774 Statin Therapy for Alzheimer's Disease: Will It Work? Journal of Molecular Neuroscience : MN. Aug-Oct, 2002 | Pubmed ID: 12212773 Imaging Brain Amyloid of Alzheimer Disease in Vivo in Transgenic Mice with an Abeta Peptide Radiopharmaceutical Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2002 | Pubmed ID: 11823720 A técnica de coleta de líquido cefalorraquidiano Serial da Cisterna Magna em rato Li Liu1, Karen Duff1 1Department of Pathology, Columbia University JoVE 960 Biology
A técnica de coleta de líquido cefalorraquidiano Serial da Cisterna Magna em rato Li Liu1, Karen Duff1 1Department of Pathology, Columbia University JoVE 960 Biology