Karen Oegema Ludwig Institute for Cancer Research, San Diego Biography Publications Institution JoVE Articles Karen Oegema has not added a biography. If you are Karen Oegema and would like to personalize this page please email our Author Liaison for assistance. Publications The G2-to-M Transition Is Ensured by a Dual Mechanism That Protects Cyclin B from Degradation by Cdc20-Activated APC/C Developmental Cell. Oct, 2019 | Pubmed ID: 31588029 Ancestral Roles of the Fam20C Family of Secreted Protein Kinases Revealed in The Journal of Cell Biology. Sep, 2019 | Pubmed ID: 31541016 Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity Current Biology : CB. Sep, 2019 | Pubmed ID: 31495582 The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis Developmental Cell. 03, 2019 | Pubmed ID: 30827898 The ARP2/3 Complex Prevents Excessive Formin Activity During Cytokinesis Molecular Biology of the Cell. 01, 2019 | Pubmed ID: 30403552 CFI-400945 is Not a Selective Cellular PLK4 Inhibitor Proceedings of the National Academy of Sciences of the United States of America. 11, 2018 | Pubmed ID: 30377272 CYK-4 Functions Independently of Its Centralspindlin Partner ZEN-4 to Cellularize Oocytes in Germline Syncytia ELife. 07, 2018 | Pubmed ID: 29989548 A Positive-feedback-based Mechanism for Constriction Rate Acceleration During Cytokinesis in ELife. 07, 2018 | Pubmed ID: 29963981 Employing the One-cell C. Elegans Embryo to Study Cell Division Processes Methods in Cell Biology. 2018 | Pubmed ID: 29804670 TPXL-1 Activates Aurora A to Clear Contractile Ring Components from the Polar Cortex During Cytokinesis The Journal of Cell Biology. 03, 2018 | Pubmed ID: 29311228 Kinetochores Accelerate or Delay APC/C Activation by Directing Cdc20 to Opposing Fates Genes & Development. 06, 2017 | Pubmed ID: 28698300 A Toolkit for GFP-mediated Tissue-specific Protein Degradation in Development (Cambridge, England). 07, 2017 | Pubmed ID: 28619826 Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments Via the Ska Complex Developmental Cell. 05, 2017 | Pubmed ID: 28535376 How Centrioles Acquire the Ability to Reproduce ELife. 03, 2017 | Pubmed ID: 28271993 GOLPH3 Drives Cell Migration by Promoting Golgi Reorientation and Directional Trafficking to the Leading Edge Molecular Biology of the Cell. 12, 2016 | Pubmed ID: 27708138 A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly Developmental Cell. 09, 2016 | Pubmed ID: 27623381 Polo-like Kinase Phosphorylation Determines Caenorhabditis Elegans Centrosome Size and Density by Biasing SPD-5 Toward an Assembly-competent Conformation Biology Open. Oct, 2016 | Pubmed ID: 27591191 53BP1 and USP28 Mediate P53 Activation and G1 Arrest After Centrosome Loss or Extended Mitotic Duration The Journal of Cell Biology. 07, 2016 | Pubmed ID: 27432897 A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions Cell. Apr, 2016 | Pubmed ID: 27020753 Non-centrosomal Epidermal Microtubules Act in Parallel to LET-502/ROCK to Promote C. Elegans Elongation Development (Cambridge, England). Jan, 2016 | Pubmed ID: 26586219 NOCA-1 Functions with γ-tubulin and in Parallel to Patronin to Assemble Non-centrosomal Microtubule Arrays in C. Elegans ELife. Sep, 2015 | Pubmed ID: 26371552 Centrosomes. Regulated Assembly of a Supramolecular Centrosome Scaffold in Vitro Science (New York, N.Y.). May, 2015 | Pubmed ID: 25977552 Cell Biology. Reversible Centriole Depletion with an Inhibitor of Polo-like Kinase 4 Science (New York, N.Y.). Jun, 2015 | Pubmed ID: 25931445 Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. Elegans PloS One. 2015 | Pubmed ID: 25919583 The CENP-A N-tail Confers Epigenetic Stability to Centromeres Via the CENP-T Branch of the CCAN in Fission Yeast Current Biology : CB. Feb, 2015 | Pubmed ID: 25619765 The Microtubule Minus-end-binding Protein Patronin/PTRN-1 is Required for Axon Regeneration in C. Elegans Cell Reports. Nov, 2014 | Pubmed ID: 25437544 The Caenorhabditis Elegans Pericentriolar Material Components SPD-2 and SPD-5 Are Monomeric in the Cytoplasm Before Incorporation into the PCM Matrix Molecular Biology of the Cell. Oct, 2014 | Pubmed ID: 25103243 Structure of the C. Elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases Structure (London, England : 1993). Aug, 2014 | Pubmed ID: 24980795 A Bub1-Mad1 Interaction Targets the Mad1-Mad2 Complex to Unattached Kinetochores to Initiate the Spindle Checkpoint The Journal of Cell Biology. Mar, 2014 | Pubmed ID: 24567362 Spatial Control of Phospholipid Flux Restricts Endoplasmic Reticulum Sheet Formation to Allow Nuclear Envelope Breakdown Genes & Development. Jan, 2014 | Pubmed ID: 24449268 Meiotic Double-strand Breaks Uncover and Protect Against Mitotic Errors in the C. Elegans Germline Current Biology : CB. Dec, 2013 | Pubmed ID: 24239117 Crosstalk Between Microtubule Attachment Complexes Ensures Accurate Chromosome Segregation Science (New York, N.Y.). Dec, 2013 | Pubmed ID: 24231804 The Midbody Ring Scaffolds the Abscission Machinery in the Absence of Midbody Microtubules The Journal of Cell Biology. Nov, 2013 | Pubmed ID: 24217623 A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA During Cytokinesis Developmental Cell. Sep, 2013 | Pubmed ID: 24012485 Direct Binding of SAS-6 to ZYG-1 Recruits SAS-6 to the Mother Centriole for Cartwheel Assembly Developmental Cell. May, 2013 | Pubmed ID: 23673331 Hierarchical Assembly of the Eggshell and Permeability Barrier in C. Elegans The Journal of Cell Biology. Aug, 2012 | Pubmed ID: 22908315 Cytokinesis in Animal Cells Annual Review of Cell and Developmental Biology. 2012 | Pubmed ID: 22804577 An Inverse Relationship to Germline Transcription Defines Centromeric Chromatin in C. Elegans Nature. Apr, 2012 | Pubmed ID: 22495302 Microtubule Binding by KNL-1 Contributes to Spindle Checkpoint Silencing at the Kinetochore The Journal of Cell Biology. Feb, 2012 | Pubmed ID: 22331849 Affinity Purification of Protein Complexes in C. Elegans Methods in Cell Biology. 2011 | Pubmed ID: 22118282 Rapid De Novo Centromere Formation Occurs Independently of Heterochromatin Protein 1 in C. Elegans Embryos Current Biology : CB. Nov, 2011 | Pubmed ID: 22018540 Acute Drug Treatment in the Early C. Elegans Embryo PloS One. 2011 | Pubmed ID: 21935434 Uncoordinated Loss of Chromatid Cohesion is a Common Outcome of Extended Metaphase Arrest PloS One. 2011 | Pubmed ID: 21829677 A High-resolution C. Elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue Cell. Apr, 2011 | Pubmed ID: 21529718 The Chromosomal Passenger Complex and Centralspindlin Independently Contribute to Contractile Ring Assembly The Journal of Cell Biology. Apr, 2011 | Pubmed ID: 21464231 A Kinetochore-independent Mechanism Drives Anaphase Chromosome Separation During Acentrosomal Meiosis Nature Cell Biology. Sep, 2010 | Pubmed ID: 20729837 Removal of Spindly from Microtubule-attached Kinetochores Controls Spindle Checkpoint Silencing in Human Cells Genes & Development. May, 2010 | Pubmed ID: 20439434 Analyzing the Effects of Delaying Aster Separation on Furrow Formation During Cytokinesis in the Caenorhabditis Elegans Embryo Molecular Biology of the Cell. Jan, 2010 | Pubmed ID: 19889842 The Hydrolethalus Syndrome Protein HYLS-1 Links Core Centriole Structure to Cilia Formation Genes & Development. Sep, 2009 | Pubmed ID: 19656802 Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size Cell. May, 2009 | Pubmed ID: 19490897 Systematic Analysis in Caenorhabditis Elegans Reveals That the Spindle Checkpoint is Composed of Two Largely Independent Branches Molecular Biology of the Cell. Feb, 2009 | Pubmed ID: 19109417 A New Mechanism Controlling Kinetochore-microtubule Interactions Revealed by Comparison of Two Dynein-targeting Components: SPDL-1 and the Rod/Zwilch/Zw10 Complex Genes & Development. Sep, 2008 | Pubmed ID: 18765790 SAS-4 is Recruited to a Dynamic Structure in Newly Forming Centrioles That is Stabilized by the Gamma-tubulin-mediated Addition of Centriolar Microtubules The Journal of Cell Biology. Feb, 2008 | Pubmed ID: 18299348 Expression and Imaging of Fluorescent Proteins in the C. Elegans Gonad and Early Embryo Methods in Cell Biology. 2008 | Pubmed ID: 18155464 MVB-12, a Fourth Subunit of Metazoan ESCRT-I, Functions in Receptor Downregulation PloS One. Sep, 2007 | Pubmed ID: 17895996 A Role for Rab5 in Structuring the Endoplasmic Reticulum The Journal of Cell Biology. Jul, 2007 | Pubmed ID: 17591921 Functional Genomics Identifies a Myb Domain-containing Protein Family Required for Assembly of CENP-A Chromatin The Journal of Cell Biology. Mar, 2007 | Pubmed ID: 17339379 Cell Division WormBook : the Online Review of C. Elegans Biology. Jan, 2006 | Pubmed ID: 18050484 A Bir1-Sli15 Complex Connects Centromeres to Microtubules and is Required to Sense Kinetochore Tension Cell. Dec, 2006 | Pubmed ID: 17174893 Molecular Analysis of Mitotic Chromosome Condensation Using a Quantitative Time-resolved Fluorescence Microscopy Assay Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17005720 A Complex Containing the Sm Protein CAR-1 and the RNA Helicase CGH-1 is Required for Embryonic Cytokinesis in Caenorhabditis Elegans The Journal of Cell Biology. Oct, 2005 | Pubmed ID: 16247027 Distinct Roles for Two C. Elegans Anillins in the Gonad and Early Embryo Development (Cambridge, England). Jun, 2005 | Pubmed ID: 15930113 The CENP-F-like Proteins HCP-1 and HCP-2 Target CLASP to Kinetochores to Mediate Chromosome Segregation Current Biology : CB. Apr, 2005 | Pubmed ID: 15854912 Centriole Assembly Requires Both Centriolar and Pericentriolar Material Proteins Developmental Cell. Dec, 2004 | Pubmed ID: 15572125 The Minus End in Sight Current Biology : CB. Aug, 2003 | Pubmed ID: 12906817 Closing the GAP: a Role for a RhoA GAP in Cytokinesis Molecular Cell. Apr, 2003 | Pubmed ID: 12718869 C. elegans Embriyonik Gelişimi Analiz Etmek Için Yarı-yüksek-throughput Görüntüleme Yöntemi ve Veri Görselleştirme Araç Seti Renat N. Khaliullin1,2,3, Jeffrey M. Hendel1,2, Adina Gerson-Gurwitz1,2, Shaohe Wang1,4,5, Stacy D. Ochoa1,6, Zhiling Zhao1,7, Arshad Desai1,2, Karen Oegema1,2, Rebecca A. Green1,2 1Ludwig Institute for Cancer Research, San Diego, 2Department of Cellular and Molecular Medicine, University of California, San Diego, 3Recursion Pharmaceuticals, 4Biomedical Sciences Graduate Program, University of California, San Diego, 5Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 6Department of Biology, San Diego State University, 7Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco JoVE 60362 Developmental Biology
C. elegans Embriyonik Gelişimi Analiz Etmek Için Yarı-yüksek-throughput Görüntüleme Yöntemi ve Veri Görselleştirme Araç Seti Renat N. Khaliullin1,2,3, Jeffrey M. Hendel1,2, Adina Gerson-Gurwitz1,2, Shaohe Wang1,4,5, Stacy D. Ochoa1,6, Zhiling Zhao1,7, Arshad Desai1,2, Karen Oegema1,2, Rebecca A. Green1,2 1Ludwig Institute for Cancer Research, San Diego, 2Department of Cellular and Molecular Medicine, University of California, San Diego, 3Recursion Pharmaceuticals, 4Biomedical Sciences Graduate Program, University of California, San Diego, 5Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 6Department of Biology, San Diego State University, 7Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco JoVE 60362 Developmental Biology
