Articles by Kazuki Ikura in JoVE
Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model Yuka Kato1, Takanori Iwata2, Kaoru Washio2, Toshiyuki Yoshida2, Hozue Kuroda2, Shunichi Morikawa3, Mariko Hamada1, Kazuki Ikura1, Nobuyuki Kaibuchi2, Masayuki Yamato2, Teruo Okano2, Yasuko Uchigata1 1 Adipose-derived stem cells (ASCs) are easily isolated and harvested from the fat of normal rats. ASC sheets can be created using cell-sheet engineering and can be transplanted into Zucker diabetic fatty rats exhibiting full-thickness skin defects with exposed bone and then covered with a bilayer of artificial skin.
Other articles by Kazuki Ikura on PubMed
HDL Cholesterol As a Predictor for the Incidence of Lower Extremity Amputation and Wound-related Death in Patients with Diabetic Foot Ulcers Atherosclerosis. Apr, 2015 | Pubmed ID: 25697577 We examined whether HDL cholesterol levels are a predictor for an incidence of lower-extremity amputation (LEA) and wound-related death in patients with diabetic foot ulcers (DFUs).
Brachial-ankle Pulse Wave Velocity, but Not Ankle-brachial Index, Predicts All-cause Mortality in Patients with Diabetes After Lower Extremity Amputation Journal of Diabetes Investigation. Mar, 2017 | Pubmed ID: 27422213 We examined whether brachial-ankle pulse wave velocity (baPWV) and ankle-brachial pressure index (ABI) are predictors for mortality in diabetic patients after lower extremity amputation. This was an observational historical cohort study of 102 Japanese diabetic patients after first non-traumatic lower extremity amputation, with a mean age of 63 years (standard deviation 12 years). The end-point was all-cause mortality. During the mean follow-up period of 3.3 years, 44 patients reached the end-point. In both univariate and multivariate analyses, baPWV (m/s) (hazard ratio [HR] 1.05 and 1.04, both P < 0.01, respectively), but not ABI (HR 0.38 and 0.89, P = 0.08 and 0.86, respectively), was a significant predictor for the end-point. When baPWV (above or below the median [21.8 m/s]) and ABI (normal [0.9-1.4] or not) were analyzed as categorical variables, the results were similar. In conclusion, baPWV, but not ABI, might be a predictor for all-cause mortality in diabetic patients after lower extremity amputation.