Keiji Itaka Graduate School of Medicine, Laboratory of Clinical Biotechnology The University of Tokyo Biography Publications Institution JoVE Articles Keiji Itaka has not added a biography. If you are Keiji Itaka and would like to personalize this page please email our Author Liaison for assistance. Publications Screening of MRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity Pharmaceutics. 2015 | Pubmed ID: 26213960 A Tadpole-shaped Gene Carrier with Distinct Phase Segregation in a Ternary Polymeric Micelle Soft Matter. Apr, 2015 | Pubmed ID: 25711768 Treatment of Neurological Disorders by Introducing MRNA in Vivo Using Polyplex Nanomicelles Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2015 | Pubmed ID: 25599855 Intrathecal Injection of a Therapeutic Gene-containing Polyplex to Treat Spinal Cord Injury Journal of Controlled Release : Official Journal of the Controlled Release Society. Jan, 2015 | Pubmed ID: 25449800 Modulated Protonation of Side Chain Aminoethylene Repeats in N-substituted Polyaspartamides Promotes MRNA Transfection Journal of the American Chemical Society. Sep, 2014 | Pubmed ID: 25133991 Optimized Rod Length of Polyplex Micelles for Maximizing Transfection Efficiency and Their Performance in Systemic Gene Therapy Against Stroma-rich Pancreatic Tumors Biomaterials. Jul, 2014 | Pubmed ID: 24720877 Muscle-targeted Hydrodynamic Gene Introduction of Insulin-like Growth Factor-1 Using Polyplex Nanomicelle to Treat Peripheral Nerve Injury Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2014 | Pubmed ID: 24657809 Targeted Gene Delivery by Polyplex Micelles with Crowded PEG Palisade and CRGD Moiety for Systemic Treatment of Pancreatic Tumors Biomaterials. Mar, 2014 | Pubmed ID: 24439417 An Injectable Spheroid System with Genetic Modification for Cell Transplantation Therapy Biomaterials. Mar, 2014 | Pubmed ID: 24388386 Glycogen Shortage During Fasting Triggers Liver-brain-adipose Neurocircuitry to Facilitate Fat Utilization Nature Communications. 2013 | Pubmed ID: 23939267 Block/homo Polyplex Micelle-based GM-CSF Gene Therapy Via Intraperitoneal Administration Elicits Antitumor Immunity Against Peritoneal Dissemination and Exhibits Safety Potentials in Mice and Cynomolgus Monkeys Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2013 | Pubmed ID: 23422727 In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle PloS One. 2013 | Pubmed ID: 23418537 Gene Transfection to Spheroid Culture System on Micropatterned Culture Plate by Polyplex Nanomicelle: a Novel Platform of Genetically-modified Cell Transplantation Drug Delivery and Translational Research. Oct, 2012 | Pubmed ID: 25787177 Effective Transgene Expression Without Toxicity by Intraperitoneal Administration of PEG-detachable Polyplex Micelles in Mice with Peritoneal Dissemination Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2012 | Pubmed ID: 22484197 Homo-catiomer Integration into PEGylated Polyplex Micelle from Block-catiomer for Systemic Anti-angiogenic Gene Therapy for Fibrotic Pancreatic Tumors Biomaterials. Jun, 2012 | Pubmed ID: 22444644 PEGylated Polyplex with Optimized PEG Shielding Enhances Gene Introduction in Lungs by Minimizing Inflammatory Responses Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2012 | Pubmed ID: 22334020 Enhanced Stability and Gene Silencing Ability of SiRNA-loaded Polyion Complexes Formulated from Polyaspartamide Derivatives with a Repetitive Array of Amino Groups in the Side Chain Biomaterials. Mar, 2012 | Pubmed ID: 22200535 Enhanced Gene Expression Promoted by the Quantized Folding of PDNA Within Polyplex Micelles Biomaterials. Jan, 2012 | Pubmed ID: 21993237 Progress and Prospects of Polyplex Nanomicelles for Plasmid DNA Delivery Current Gene Therapy. Dec, 2011 | Pubmed ID: 22023475 Odd-even Effect of Repeating Aminoethylene Units in the Side Chain of N-substituted Polyaspartamides on Gene Transfection Profiles Journal of the American Chemical Society. Oct, 2011 | Pubmed ID: 21879762 Combination of Chondroitin Sulfate and Polyplex Micelles from Poly(ethylene Glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} Block Copolymer for Prolonged in Vivo Gene Transfection with Reduced Toxicity Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2011 | Pubmed ID: 21571018 Enhanced Transfection with Silica-coated Polyplexes Loading Plasmid DNA Biomaterials. Jun, 2010 | Pubmed ID: 20304483 Efficient Delivery of Bioactive Antibodies into the Cytoplasm of Living Cells by Charge-conversional Polyion Complex Micelles Angewandte Chemie (International Ed. in English). Mar, 2010 | Pubmed ID: 20209539 Antiangiogenic Gene Therapy of Solid Tumor by Systemic Injection of Polyplex Micelles Loading Plasmid DNA Encoding Soluble Flt-1 Molecular Pharmaceutics. Apr, 2010 | Pubmed ID: 20178335 Biodegradable Polyamino Acid-based Polycations As Safe and Effective Gene Carrier Minimizing Cumulative Toxicity Biomaterials. May, 2010 | Pubmed ID: 20153891 Polyunsaturated Fatty Acids Selectively Suppress Sterol Regulatory Element-binding Protein-1 Through Proteolytic Processing and Autoloop Regulatory Circuit The Journal of Biological Chemistry. Apr, 2010 | Pubmed ID: 20145241 Polyplex Nanomicelle Promotes Hydrodynamic Gene Introduction to Skeletal Muscle Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2010 | Pubmed ID: 20043959 A Nanoparticle System Specifically Designed to Deliver Short Interfering RNA Inhibits Tumor Growth in Vivo Cancer Research. Aug, 2009 | Pubmed ID: 19654315 Intranuclear Fluorescence Resonance Energy Transfer Analysis of Plasmid DNA Decondensation from Nonviral Gene Carriers The Journal of Gene Medicine. Jul, 2009 | Pubmed ID: 19396931 Intratracheal Gene Transfer of Adrenomedullin Using Polyplex Nanomicelles Attenuates Monocrotaline-induced Pulmonary Hypertension in Rats Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2009 | Pubmed ID: 19337232 3D Spheroid Culture System on Micropatterned Substrates for Improved Differentiation Efficiency of Multipotent Mesenchymal Stem Cells Biomaterials. May, 2009 | Pubmed ID: 19215979 Recent Development of Nonviral Gene Delivery Systems with Virus-like Structures and Mechanisms European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Mar, 2009 | Pubmed ID: 18955136 Polyplex Micelles with Cyclic RGD Peptide Ligands and Disulfide Cross-links Directing to the Enhanced Transfection Via Controlled Intracellular Trafficking Molecular Pharmaceutics. Nov-Dec, 2008 | Pubmed ID: 19434856 Gentransfektion in Richtung Spheroid Zellen auf mikrostrukturierten Kulturplatten für genetisch veränderte Zelltransplantation Keiji Itaka1, Satoshi Uchida1, Akitsugu Matsui1, Kayoko Yanagihara1, Masaru Ikegami1, Taisuke Endo2, Takehiko Ishii3, Kazunori Kataoka2 1Graduate School of Medicine, Laboratory of Clinical Biotechnology, The University of Tokyo, 2Graduate School of Engineering, Department of Materials Engineering, The University of Tokyo, 3Graduate School of Engineering, Department of Bioengineering, The University of Tokyo Bioengineering
Gentransfektion in Richtung Spheroid Zellen auf mikrostrukturierten Kulturplatten für genetisch veränderte Zelltransplantation Keiji Itaka1, Satoshi Uchida1, Akitsugu Matsui1, Kayoko Yanagihara1, Masaru Ikegami1, Taisuke Endo2, Takehiko Ishii3, Kazunori Kataoka2 1Graduate School of Medicine, Laboratory of Clinical Biotechnology, The University of Tokyo, 2Graduate School of Engineering, Department of Materials Engineering, The University of Tokyo, 3Graduate School of Engineering, Department of Bioengineering, The University of Tokyo Bioengineering
