Ken Mackie Department of Psychological and Brain Sciences, Gill Center for Biomolecular Research Indiana University Biography Publications Institution JoVE Articles Ken Mackie has not added a biography. If you are Ken Mackie and would like to personalize this page please email our Author Liaison for assistance. Publications Components of Endocannabinoid Signaling System Are Expressed in the Perinatal Mouse Cerebellum and Required for Its Normal Development ENeuro. Mar, 2020 | Pubmed ID: 32179579 A Glial-Neuronal Circuit in the Median Eminence Regulates Thyrotropin-Releasing Hormone-Release Via the Endocannabinoid System IScience. Mar, 2020 | Pubmed ID: 32143135 Endocannabinoid Genetic Variation Enhances Vulnerability to THC Reward in Adolescent Female Mice Science Advances. 02, 2020 | Pubmed ID: 32095523 One-Stop Microfluidic Assembly of Human Brain Organoids To Model Prenatal Cannabis Exposure Analytical Chemistry. Mar, 2020 | Pubmed ID: 32070103 Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening Neuron. Mar, 2020 | Pubmed ID: 31948734 C-Jun N Terminal Kinase Signaling Pathways Mediate Cannabinoid Tolerance in an Agonist-specific Manner Neuropharmacology. 03, 2020 | Pubmed ID: 31758947 Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators Journal of Medicinal Chemistry. Jan, 2020 | Pubmed ID: 31756109 Life-long Epigenetic Programming of Cortical Architecture by Maternal 'Western' Diet During Pregnancy Molecular Psychiatry. 01, 2020 | Pubmed ID: 31735910 Cannabinoid Exposure Via Lactation in Rats Disrupts Perinatal Programming of the Gamma-Aminobutyric Acid Trajectory and Select Early-Life Behaviors Biological Psychiatry. Apr, 2020 | Pubmed ID: 31653479 Chronic Adolescent Exposure to ∆9-tetrahydrocannabinol Decreases NMDA Current and Extrasynaptic Plasmalemmal Density of NMDA GluN1 Subunits in the Prelimbic Cortex of Adult Male Mice Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 01, 2020 | Pubmed ID: 31323660 Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos International Journal of Molecular Sciences. Dec, 2019 | Pubmed ID: 31881740 Inhibitory Control Deficits Associated with Upregulation of CBR in the HIV-1 Tat Transgenic Mouse Model of Hand Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Dec, 2019 | Pubmed ID: 31372820 Cannabinoid Receptor-mediated Modulation of Inhibitory Inputs to Mitral Cells in the Main Olfactory Bulb Journal of Neurophysiology. 08, 2019 | Pubmed ID: 31215302 Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype Frontiers in Molecular Neuroscience. 2019 | Pubmed ID: 31213981 Self-administration of Edible Δ-tetrahydrocannabinol and Associated Behavioral Effects in Mice Drug and Alcohol Dependence. 06, 2019 | Pubmed ID: 31029878 Ultrastructural Localization of Cannabinoid CB1 and MGluR5 Receptors in the Prefrontal Cortex and Amygdala The Journal of Comparative Neurology. Nov, 2019 | Pubmed ID: 31008528 Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea Cornea. Jul, 2019 | Pubmed ID: 30969262 Protective Effect of N-Arachidonoyl Glycine-GPR18 Signaling After Excitotoxical Lesion in Murine Organotypic Hippocampal Slice Cultures International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30871175 GPR55 Controls Functional Differentiation of Self-renewing Epithelial Progenitors for Salivation JCI Insight. 02, 2019 | Pubmed ID: 30830860 Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal Molecular Pharmacology. 02, 2019 | Pubmed ID: 30504240 Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains Frontiers in Molecular Neuroscience. 2018 | Pubmed ID: 30542263 Cannabidiol's Upregulation of -acyl Ethanolamines in the Central Nervous System Requires -acyl Phosphatidyl Ethanolamine-Specific Phospholipase D Cannabis and Cannabinoid Research. 2018 | Pubmed ID: 30515459 Median Nerve Stimulation Induces Analgesia Via Orexin-initiated Endocannabinoid Disinhibition in the Periaqueductal Gray Proceedings of the National Academy of Sciences of the United States of America. 11, 2018 | Pubmed ID: 30348772 Sex-dependent Effects of in Utero Cannabinoid Exposure on Cortical Function ELife. 09, 2018 | Pubmed ID: 30201092 ( R)- N-(1-Methyl-2-hydroxyethyl)-13-( S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes Journal of Medicinal Chemistry. 10, 2018 | Pubmed ID: 30196704 Neuroprotective Effects of Fatty Acid Amide Hydrolase Catabolic Enzyme Inhibition in a HIV-1 Tat Model of NeuroAIDS Neuropharmacology. 10, 2018 | Pubmed ID: 30114402 Synthetic Peripherally-restricted Cannabinoid Suppresses Chemotherapy-induced Peripheral Neuropathy Pain Symptoms by CB1 Receptor Activation Neuropharmacology. 09, 2018 | Pubmed ID: 29981335 Analysis of Endocannabinoid System in Rat Testis During the First Spermatogenetic Wave Frontiers in Endocrinology. 2018 | Pubmed ID: 29896156 Controlled-Deactivation CB1 Receptor Ligands As a Novel Strategy to Lower Intraocular Pressure Pharmaceuticals (Basel, Switzerland). May, 2018 | Pubmed ID: 29786643 Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons Molecular Pharmacology. 07, 2018 | Pubmed ID: 29669714 Short-Term Genetic Selection for Adolescent Locomotor Sensitivity to Delta9-Tetrahydrocannabinol (THC) Behavior Genetics. 05, 2018 | Pubmed ID: 29550900 Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior Biological Psychiatry. 08, 2018 | Pubmed ID: 29458998 Δ-Tetrahydrocannabinol Changes the Brain Lipidome and Transcriptome Differentially in the Adolescent and the Adult Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. May, 2018 | Pubmed ID: 29408467 Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 01, 2018 | Pubmed ID: 29192125 Slowly Signaling G Protein-Biased CB Cannabinoid Receptor Agonist LY2828360 Suppresses Neuropathic Pain with Sustained Efficacy and Attenuates Morphine Tolerance and Dependence Molecular Pharmacology. 02, 2018 | Pubmed ID: 29192123 Enantiomer-specific Positive Allosteric Modulation of CB Signaling in Autaptic Hippocampal Neurons Pharmacological Research. 03, 2018 | Pubmed ID: 29158048 Cannabinoid-1 Receptor Deletion in Podocytes Mitigates Both Glomerular and Tubular Dysfunction in a Mouse Model of Diabetic Nephropathy Diabetes, Obesity & Metabolism. 03, 2018 | Pubmed ID: 29106063 Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence Biological Psychiatry. 11, 2018 | Pubmed ID: 28823711 GPR55 Regulates Intraepithelial Lymphocyte Migration Dynamics and Susceptibility to Intestinal Damage Science Immunology. 12, 2017 | Pubmed ID: 29222090 Synthesis of Photoswitchable Δ-Tetrahydrocannabinol Derivatives Enables Optical Control of Cannabinoid Receptor 1 Signaling Journal of the American Chemical Society. 12, 2017 | Pubmed ID: 29161035 Chronic Adolescent Δ-Tetrahydrocannabinol Treatment of Male Mice Leads to Long-Term Cognitive and Behavioral Dysfunction, Which Are Prevented by Concurrent Cannabidiol Treatment Cannabis and Cannabinoid Research. 2017 | Pubmed ID: 29098186 Discovery and Characterization of Two Novel CB1 Receptor Splice Variants with Modified N-termini in Mouse Journal of Neurochemistry. 08, 2017 | Pubmed ID: 28608535 A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner Investigative Ophthalmology & Visual Science. 06, 2017 | Pubmed ID: 28593245 Cannabinoid CB Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain Through a CB Mechanism That is Independent of CB Receptors in Mice The Journal of Pharmacology and Experimental Therapeutics. 08, 2017 | Pubmed ID: 28592614 Modulation of CB1 Cannabinoid Receptor by Allosteric Ligands: Pharmacology and Therapeutic Opportunities Neuropharmacology. Sep, 2017 | Pubmed ID: 28527758 Endocannabinoid Signaling in Hypothalamic Circuits Regulates Arousal from General Anesthesia in Mice The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463228 Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice Scientific Reports. 04, 2017 | Pubmed ID: 28428628 Mice Expressing a "hyper-sensitive" Form of the CB1 Cannabinoid Receptor (CB1) Show Modestly Enhanced Alcohol Preference and Consumption PloS One. 2017 | Pubmed ID: 28426670 Cannabinoid CB1 Receptor Overactivity Contributes to the Pathogenesis of Idiopathic Pulmonary Fibrosis JCI Insight. Apr, 2017 | Pubmed ID: 28422760 Endocannabinoid Signalling Modulates Susceptibility to Traumatic Stress Exposure Nature Communications. 03, 2017 | Pubmed ID: 28348378 Inflammation of Peripheral Tissues and Injury to Peripheral Nerves Induce Differing Effects in the Expression of the Calcium-sensitive N-arachydonoylethanolamine-synthesizing Enzyme and Related Molecules in Rat Primary Sensory Neurons The Journal of Comparative Neurology. Jun, 2017 | Pubmed ID: 27997038 Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists The Journal of Pharmacology and Experimental Therapeutics. Feb, 2017 | Pubmed ID: 27927913 Novel Indole-based Compounds That Differentiate Alkylindole-sensitive Receptors from Cannabinoid Receptors and Microtubules: Characterization of Their Activity on Glioma Cell Migration Pharmacological Research. 01, 2017 | Pubmed ID: 27832960 Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk Scientific Reports. Sep, 2016 | Pubmed ID: 27653550 A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation ENeuro. Jul-Aug, 2016 | Pubmed ID: 27517090 Mice Expressing a "Hyper-Sensitive" Form of the Cannabinoid Receptor 1 (CB1) Are Neither Obese Nor Diabetic PloS One. 2016 | Pubmed ID: 27501235 Orexins Contribute to Restraint Stress-induced Cocaine Relapse by Endocannabinoid-mediated Disinhibition of Dopaminergic Neurons Nature Communications. 07, 2016 | Pubmed ID: 27448020 Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27245911 Western Blotting of the Endocannabinoid System Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27245910 Hierarchical Glucocorticoid-endocannabinoid Interplay Regulates the Activation of the Nucleus Accumbens by Insulin Brain Research Bulletin. Jun, 2016 | Pubmed ID: 27208730 Functional Selectivity of CB2 Cannabinoid Receptor Ligands at a Canonical and Noncanonical Pathway The Journal of Pharmacology and Experimental Therapeutics. 08, 2016 | Pubmed ID: 27194477 A Pro-nociceptive Phenotype Unmasked in Mice Lacking Fatty-acid Amide Hydrolase Molecular Pain. 2016 | Pubmed ID: 27178246 Where's My Entourage? The Curious Case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol Pharmacological Research. 08, 2016 | Pubmed ID: 27117667 Broad Impact of Deleting Endogenous Cannabinoid Hydrolyzing Enzymes and the CB1 Cannabinoid Receptor on the Endogenous Cannabinoid-related Lipidome in Eight Regions of the Mouse Brain Pharmacological Research. 08, 2016 | Pubmed ID: 27109320 A Broad-based Study on Hyphenating New Ionization Technologies with MS/MS for PTMs and Tissue Characterization Proteomics. 06, 2016 | Pubmed ID: 27093917 Mechanisms of Biased β-Arrestin-Mediated Signaling Downstream from the Cannabinoid 1 Receptor Molecular Pharmacology. 06, 2016 | Pubmed ID: 27009233 Cannabinoids Occlude the HIV-1 Tat-Induced Decrease in GABAergic Neurotransmission in Prefrontal Cortex Slices Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. 06, 2016 | Pubmed ID: 26993829 Lipidomics Profile of a NAPE-PLD KO Mouse Provides Evidence of a Broader Role of This Enzyme in Lipid Metabolism in the Brain Biochimica Et Biophysica Acta. Jun, 2016 | Pubmed ID: 26956082 Matrix-Assisted Ionization on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials Analytical Chemistry. 11, 2016 | Pubmed ID: 26938428 Stress Induces Analgesia Via Orexin 1 Receptor-initiated Endocannabinoid/CB1 Signaling in the Mouse Periaqueductal Gray Neuropharmacology. 06, 2016 | Pubmed ID: 26907809 An Introduction to the Endogenous Cannabinoid System Biological Psychiatry. Apr, 2016 | Pubmed ID: 26698193 Role of GPR55 During Axon Growth and Target Innervation ENeuro. Sep-Oct, 2015 | Pubmed ID: 26730399 Distribution of the Endocannabinoid System in the Central Nervous System Handbook of Experimental Pharmacology. 2015 | Pubmed ID: 26408158 Drug Detection and Quantification Directly from Tissue Using Novel Ionization Methods for Mass Spectrometry European Journal of Mass Spectrometry (Chichester, England). 2015 | Pubmed ID: 26307700 Aiming for Allosterism: Evaluation of Allosteric Modulators of CB1 in a Neuronal Model Pharmacological Research. Sep, 2015 | Pubmed ID: 26211948 Ultrastructural Evidence for Synaptic Contacts Between Cortical Noradrenergic Afferents and Endocannabinoid-synthesizing Post-synaptic Neurons Neuroscience. Sep, 2015 | Pubmed ID: 26162236 Adolescent Cannabis Exposure Interacts with Mutant DISC1 to Produce Impaired Adult Emotional Memory Neurobiology of Disease. Oct, 2015 | Pubmed ID: 26093170 Tolerance to the Antinociceptive Effects of Chronic Morphine Requires C-Jun N-terminal Kinase Molecular Pain. Jun, 2015 | Pubmed ID: 26065412 Cannabinoid-induced Chemotaxis in Bovine Corneal Epithelial Cells Investigative Ophthalmology & Visual Science. May, 2015 | Pubmed ID: 26024113 An Animal Model of Female Adolescent Cannabinoid Exposure Elicits a Long-lasting Deficit in Presynaptic Long-term Plasticity Neuropharmacology. Dec, 2015 | Pubmed ID: 25979486 Molecular-interaction and Signaling Profiles of AM3677, a Novel Covalent Agonist Selective for the Cannabinoid 1 Receptor ACS Chemical Neuroscience. Aug, 2015 | Pubmed ID: 25978068 CB1 Knockout Mice Unveil Sustained CB2-Mediated Antiallodynic Effects of the Mixed CB1/CB2 Agonist CP55,940 in a Mouse Model of Paclitaxel-Induced Neuropathic Pain Molecular Pharmacology. Jul, 2015 | Pubmed ID: 25904556 Cannabinoid Receptor-interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation Molecular Pharmacology. Apr, 2015 | Pubmed ID: 25657338 Cannabinoid Receptor 1 Promotes Hepatocellular Carcinoma Initiation and Progression Through Multiple Mechanisms Hepatology (Baltimore, Md.). May, 2015 | Pubmed ID: 25580584 Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1-dependent Withdrawal Biological Psychiatry. Mar, 2015 | Pubmed ID: 24853387 Programming of Neural Cells by (endo)cannabinoids: from Physiological Rules to Emerging Therapies Nature Reviews. Neuroscience. Dec, 2014 | Pubmed ID: 25409697 CB2 Cannabinoid Receptors As a Therapeutic Target-what Does the Future Hold? Molecular Pharmacology. Oct, 2014 | Pubmed ID: 25106425 Ligand-specific Endocytic Dwell Times Control Functional Selectivity of the Cannabinoid Receptor 1 Nature Communications. Aug, 2014 | Pubmed ID: 25081814 Transmission Geometry Laserspray Ionization Vacuum Using an Atmospheric Pressure Inlet Analytical Chemistry. Jul, 2014 | Pubmed ID: 24896880 Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2014 | Pubmed ID: 24719095 Multiple Mechanistically Distinct Modes of Endocannabinoid Mobilization at Central Amygdala Glutamatergic Synapses Neuron. Mar, 2014 | Pubmed ID: 24607231 The Mismatch Negativity: a Translational Probe of Auditory Processing in Cannabis Users Biological Psychiatry. Mar, 2014 | Pubmed ID: 24560430 Gβ₂ Mimics Activation Kinetic Slowing of CaV2.2 Channels by Noradrenaline in Rat Sympathetic Neurons Biochemical and Biophysical Research Communications. Feb, 2014 | Pubmed ID: 24513289 Impaired Fear Memory Specificity Associated with Deficient Endocannabinoid-dependent Long-term Plasticity Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Jun, 2014 | Pubmed ID: 24457285 Mastering Tricyclic Ring Systems for Desirable Functional Cannabinoid Activity European Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24125850 CB1 Cannabinoid Receptors Couple to Focal Adhesion Kinase to Control Insulin Release The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24089517 Two Novel Mutations in ABHD12: Expansion of the Mutation Spectrum in PHARC and Assessment of Their Functional Effects Human Mutation. Dec, 2013 | Pubmed ID: 24027063 Diacylglycerol Lipaseα (DAGLα) and DAGLβ Cooperatively Regulate the Production of 2-arachidonoyl Glycerol in Autaptic Hippocampal Neurons Molecular Pharmacology. Aug, 2013 | Pubmed ID: 23748223 A Role for O-1602 and G Protein-coupled Receptor GPR55 in the Control of Colonic Motility in Mice Neuropharmacology. Aug, 2013 | Pubmed ID: 23603203 Fmr1 Deletion Enhances and Ultimately Desensitizes CB(1) Signaling in Autaptic Hippocampal Neurons Neurobiology of Disease. Aug, 2013 | Pubmed ID: 23578490 GPR55, a G-protein Coupled Receptor for Lysophosphatidylinositol, Plays a Role in Motor Coordination PloS One. 2013 | Pubmed ID: 23565223 Cannabinoid Receptors Are Widely Expressed in Goldfish: Molecular Cloning of a CB2-like Receptor and Evaluation of CB1 and CB2 MRNA Expression Profiles in Different Organs Fish Physiology and Biochemistry. Oct, 2013 | Pubmed ID: 23504102 CaMKII Regulates Diacylglycerol Lipase-α and Striatal Endocannabinoid Signaling Nature Neuroscience. Apr, 2013 | Pubmed ID: 23502535 Downregulation of Cannabinoid Receptor 1 from Neuropeptide Y Interneurons in the Basal Ganglia of Patients with Huntington's Disease and Mouse Models The European Journal of Neuroscience. Feb, 2013 | Pubmed ID: 23167744 Characterisation of Cannabinoid 1 Receptor Expression in the Perikarya, and Peripheral and Spinal Processes of Primary Sensory Neurons Brain Structure & Function. May, 2013 | Pubmed ID: 22618437 Endocannabinoid-mediated Long-term Depression of Afferent Excitatory Synapses in Hippocampal Pyramidal Cells and GABAergic Interneurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2012 | Pubmed ID: 23055515 Brain CB₁ Receptor Expression Following Lipopolysaccharide-induced Inflammation Neuroscience. Dec, 2012 | Pubmed ID: 23041513 Uncoupling of the Endocannabinoid Signalling Complex in a Mouse Model of Fragile X Syndrome Nature Communications. 2012 | Pubmed ID: 23011134 Laserspray Ionization Imaging of Multiply Charged Ions Using a Commercial Vacuum MALDI Ion Source Analytical Chemistry. Nov, 2012 | Pubmed ID: 23009673 Cannabinoid-1 Receptors in the Mouse Ventral Pallidum Are Targeted to Axonal Profiles Expressing Functionally Opposed Opioid Peptides and Contacting N-acylphosphatidylethanolamine-hydrolyzing Phospholipase D Terminals Neuroscience. Dec, 2012 | Pubmed ID: 22863674 Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-arachidonoylglycerol Formation and Endocannabinoid-mediated Analgesia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012 | Pubmed ID: 22787031 Presynaptic CB(1) Cannabinoid Receptors Control Frontocortical Serotonin and Glutamate Release--species Differences Neurochemistry International. Jul, 2012 | Pubmed ID: 22609378 CB₂ Cannabinoid Receptors Inhibit Synaptic Transmission when Expressed in Cultured Autaptic Neurons Neuropharmacology. Sep, 2012 | Pubmed ID: 22579668 Differential Distribution of Diacylglycerol Lipase-alpha and N-acylphosphatidylethanolamine-specific Phospholipase D Immunoreactivity in the Superficial Spinal Dorsal Horn of Rats Glia. May, 2012 | Pubmed ID: 22573306 Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy Diabetes. Mar, 2012 | Pubmed ID: 22315315 Plasticity of Mouse Enteric Synapses Mediated Through Endocannabinoid and Purinergic Signaling Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. Mar, 2012 | Pubmed ID: 22235973 CB₂: Therapeutic Target-in-waiting Progress in Neuro-psychopharmacology & Biological Psychiatry. Jul, 2012 | Pubmed ID: 22197668 Quinpirole Elicits Differential in Vivo Changes in the Pre- and Postsynaptic Distributions of Dopamine D₂ Receptors in Mouse Striatum: Relation to Cannabinoid-1 (CB₁) Receptor Targeting Psychopharmacology. May, 2012 | Pubmed ID: 22160162 Functional Selectivity in CB(2) Cannabinoid Receptor Signaling and Regulation: Implications for the Therapeutic Potential of CB(2) Ligands Molecular Pharmacology. Feb, 2012 | Pubmed ID: 22064678 Differential Signalling in Human Cannabinoid CB1 Receptors and Their Splice Variants in Autaptic Hippocampal Neurones British Journal of Pharmacology. Apr, 2012 | Pubmed ID: 22014238 The CB1 Cannabinoid Receptor C-terminus Regulates Receptor Desensitization in Autaptic Hippocampal Neurones British Journal of Pharmacology. Apr, 2012 | Pubmed ID: 22014214 Δ9-Tetrahydrocannabinol (Δ9-THC) Attenuates Mouse Sperm Motility and Male Fecundity British Journal of Pharmacology. Apr, 2012 | Pubmed ID: 21615727 Activation of Orexin 1 Receptors in the Periaqueductal Gray of Male Rats Leads to Antinociception Via Retrograde Endocannabinoid (2-arachidonoylglycerol)-induced Disinhibition The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2011 | Pubmed ID: 21994376 Recruitment of Prefrontal Cortical Endocannabinoid Signaling by Glucocorticoids Contributes to Termination of the Stress Response The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2011 | Pubmed ID: 21775596 Molecular Model of Cannabis Sensitivity in Developing Neuronal Circuits Trends in Pharmacological Sciences. Sep, 2011 | Pubmed ID: 21757242 The Atypical Cannabinoid O-1602 Protects Against Experimental Colitis and Inhibits Neutrophil Recruitment Inflammatory Bowel Diseases. Aug, 2011 | Pubmed ID: 21744421 Molecular Reorganization of Endocannabinoid Signalling in Alzheimer's Disease Brain : a Journal of Neurology. Apr, 2011 | Pubmed ID: 21459826 Imaging Mass Spectrometry in Transmission Geometry Rapid Communications in Mass Spectrometry : RCM. Mar, 2011 | Pubmed ID: 21337644 CP47, 497-C8 Und JWH073, Häufig Gefunden in 'Gewürz' Kräutermischungen, Sind Starke Und Wirkungsvolle CB1 Cannabinoid Rezeptor-Agonisten European Journal of Pharmacology. Jun, 2011 | Pubmed ID: 21333643 Expression of G Protein-coupled Receptors and Related Proteins in HEK293, AtT20, BV2, and N18 Cell Lines As Revealed by Microarray Analysis BMC Genomics. Jan, 2011 | Pubmed ID: 21214938 Presynaptic CB1 Receptors Regulate Synaptic Plasticity at Cerebellar Parallel Fiber Synapses Journal of Neurophysiology. Feb, 2011 | Pubmed ID: 21084685 WNT Signaling in Activated Microglia is Proinflammatory Glia. Jan, 2011 | Pubmed ID: 20967887 Laserspray Ionization, a New Method for Protein Analysis Directly from Tissue at Atmospheric Pressure with Ultrahigh Mass Resolution and Electron Transfer Dissociation Molecular & Cellular Proteomics : MCP. Feb, 2011 | Pubmed ID: 20855542 Requirement of Cannabinoid CB(1) Receptors in Cortical Pyramidal Neurons for Appropriate Development of Corticothalamic and Thalamocortical Projections The European Journal of Neuroscience. Sep, 2010 | Pubmed ID: 21050275 Differenzielle Subzellulare Rekrutierung Von Monoacylglycerol Lipase Erzeugt Räumliche Spezifität Des 2-Arachidonoylglycerol Signalisierung Während Axonale Pathfinding The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2010 | Pubmed ID: 20962221 Endocannabinoid Involvement in Endometriosis Pain. Dec, 2010 | Pubmed ID: 20833475 Die Serin-Hydrolase ABHD6 Steuert Die Ansammlung Und Die Wirksamkeit Des 2-AG an Cannabinoidrezeptoren Nature Neuroscience. Aug, 2010 | Pubmed ID: 20657592 Architecture of Cannabinoid Signaling in Mouse Retina The Journal of Comparative Neurology. Sep, 2010 | Pubmed ID: 20653038 Dynamic Changes of CB1-receptor Expression in Hippocampi of Epileptic Mice and Humans Epilepsia. Jul, 2010 | Pubmed ID: 20618415 CB2: a Cannabinoid Receptor with an Identity Crisis British Journal of Pharmacology. Jun, 2010 | Pubmed ID: 20590558 Alterations in the Hippocampal Endocannabinoid System in Diet-induced Obese Mice The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20445053 Transcriptional Regulation of Cannabinoid Receptor-1 Expression in the Liver by Retinoic Acid Acting Via Retinoic Acid Receptor-gamma The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20410309 Differential Effects of CB(1) Neutral Antagonists and Inverse Agonists on Gastrointestinal Motility in Mice Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. Jul, 2010 | Pubmed ID: 20180825 JWH018, a Common Constituent of 'Spice' Herbal Blends, is a Potent and Efficacious Cannabinoid CB Receptor Agonist British Journal of Pharmacology. Jun, 2010 | Pubmed ID: 20100276 Loss of Cannabinoid CB1 Receptor Expression in the 6-hydroxydopamine-induced Nigrostriatal Terminal Lesion Model of Parkinson's Disease in the Rat Brain Research Bulletin. Apr, 2010 | Pubmed ID: 20097273 CB1 Cannabinoid Receptors Promote Oxidative Stress and Cell Death in Murine Models of Doxorubicin-induced Cardiomyopathy and in Human Cardiomyocytes Cardiovascular Research. Mar, 2010 | Pubmed ID: 19942623 Regulation of MAP Kinase-directed Mitogenic and Protein Kinase B-mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells Diabetes. Feb, 2010 | Pubmed ID: 19933999 Characterization of Cannabinoid-1 Receptors in the Locus Coeruleus: Relationship with Mu-opioid Receptors Brain Research. Feb, 2010 | Pubmed ID: 19931229 The Putative Cannabinoid Receptor GPR55 Affects Osteoclast Function in Vitro and Bone Mass in Vivo Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805329 Monoacylglycerol Lipase Limits the Duration of Endocannabinoid-mediated Depolarization-induced Suppression of Excitation in Autaptic Hippocampal Neurons Molecular Pharmacology. Dec, 2009 | Pubmed ID: 19767452 Get Stoned in GABAergic Synapses Nature Neuroscience. Sep, 2009 | Pubmed ID: 19710646 Wiederholte Homotypischen Stress 2-Arachidonylglycerol Ebenen Erhöht Und Verbessert Die Kurzfristige Endocannabinoid Bei Hemmenden Synapsen in Basolateraler Amygdala Signalisieren Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Dec, 2009 | Pubmed ID: 19675536 Cannabinoid Signaling in Inhibitory Autaptic Hippocampal Neurons Neuroscience. Sep, 2009 | Pubmed ID: 19501632 Cannabinoid CB1 Receptor-dependent Long-term Depression in Autaptic Excitatory Neurons Journal of Neurophysiology. Aug, 2009 | Pubmed ID: 19494194 Molecular Architecture of Endocannabinoid Signaling at Nociceptive Synapses Mediating Analgesia The European Journal of Neuroscience. May, 2009 | Pubmed ID: 19453631 Building a New Conceptual Framework for Receptor Heteromers Nature Chemical Biology. Mar, 2009 | Pubmed ID: 19219011 Wiring and Firing Neuronal Networks: Endocannabinoids Take Center Stage Current Opinion in Neurobiology. Jun, 2008 | Pubmed ID: 18801434 Endocannabinoid Signaling Controls Pyramidal Cell Specification and Long-range Axon Patterning Proceedings of the National Academy of Sciences of the United States of America. Jun, 2008 | Pubmed ID: 18562289 Cannabinoid CB2 Receptors in the Enteric Nervous System Modulate Gastrointestinal Contractility in Lipopolysaccharide-treated Rats American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2008 | Pubmed ID: 18483180 Cannabinoid Receptors: Where They Are and What They Do Journal of Neuroendocrinology. May, 2008 | Pubmed ID: 18426493 Signaling Via CNS Cannabinoid Receptors Molecular and Cellular Endocrinology. Apr, 2008 | Pubmed ID: 18336996 Regulation of CB1 Cannabinoid Receptor Internalization by a Promiscuous Phosphorylation-dependent Mechanism Journal of Neurochemistry. Jul, 2008 | Pubmed ID: 18331587 Enzymatic Machinery for Endocannabinoid Biosynthesis Associated with Calcium Stores in Glutamatergic Axon Terminals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2008 | Pubmed ID: 18234884 Identification of the Sites of 2-arachidonoylglycerol Synthesis and Action Imply Retrograde Endocannabinoid Signaling at Both GABAergic and Glutamatergic Synapses in the Ventral Tegmental Area Neuropharmacology. Jan, 2008 | Pubmed ID: 17655884 Understanding Cannabinoid Psychoactivity with Mouse Genetic Models PLoS Biology. Oct, 2007 | Pubmed ID: 17927451 From Active Ingredients to the Discovery of the Targets: the Cannabinoid Receptors Chemistry & Biodiversity. Aug, 2007 | Pubmed ID: 17712815 CB2-receptor Stimulation Attenuates TNF-alpha-induced Human Endothelial Cell Activation, Transendothelial Migration of Monocytes, and Monocyte-endothelial Adhesion American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2007 | Pubmed ID: 17660390 Sammlung von gefrorenen Nagetier-Hirnregionen für Downstream-Analysen Jim Wager-Miller1, Michelle Murphy Green1, Hana Shafique1, Ken Mackie1 1Department of Psychological and Brain Sciences, Gill Center for Biomolecular Research, Indiana University JoVE 60474 Neuroscience
Sammlung von gefrorenen Nagetier-Hirnregionen für Downstream-Analysen Jim Wager-Miller1, Michelle Murphy Green1, Hana Shafique1, Ken Mackie1 1Department of Psychological and Brain Sciences, Gill Center for Biomolecular Research, Indiana University JoVE 60474 Neuroscience