Kevin R Brown Donnelly Centre University of Toronto Biography Publications Institution JoVE Articles Kevin R Brown has not added a biography. If you are Kevin R Brown and would like to personalize this page please email our Author Liaison for assistance. Publications CRISPR Screens Are Feasible in TP53 Wild-type Cells Molecular Systems Biology. Aug, 2019 | Pubmed ID: 31464370 Bmi1 Regulates Human Glioblastoma Stem Cells Through Activation of Differential Gene Networks in CD133+ Brain Tumor Initiating Cells Journal of Neuro-oncology. Jul, 2019 | Pubmed ID: 31115870 Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Reports. Apr, 2019 | Pubmed ID: 30970261 A Rapid in Vitro Methodology for Simultaneous Target Discovery and Antibody Generation Against Functional Cell Subpopulations Scientific Reports. Jan, 2019 | Pubmed ID: 30696911 Functional Genomic Characterization of a Synthetic Anti-HER3 Antibody Reveals a Role for Ubiquitination by RNF41 in the Anti-proliferative Response The Journal of Biological Chemistry. 01, 2019 | Pubmed ID: 30523157 Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma Cancer Research. Sep, 2018 | Pubmed ID: 29945963 RNAi Screen Identifies Essential Regulators of Human Brain Metastasis-initiating Cells Acta Neuropathologica. 12, 2017 | Pubmed ID: 28766011 Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens G3 (Bethesda, Md.). 08, 2017 | Pubmed ID: 28655737 Targeting the Centriolar Replication Factor STIL Synergizes with DNA Damaging Agents for Treatment of Ovarian Cancer Oncotarget. Apr, 2017 | Pubmed ID: 28423708 Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer Cell Reports. 03, 2017 | Pubmed ID: 28273451 Genome-wide CRISPR Screens Reveal a Wnt-FZD5 Signaling Circuit As a Druggable Vulnerability of RNF43-mutant Pancreatic Tumors Nature Medicine. Jan, 2017 | Pubmed ID: 27869803 An Oncogenic KRAS Transcription Program Activates the RHOGEF ARHGEF2 to Mediate Transformed Phenotypes in Pancreatic Cancer Oncotarget. Jan, 2017 | Pubmed ID: 27835861 Efficient Generation of Patient-matched Malignant and Normal Primary Cell Cultures from Clear Cell Renal Cell Carcinoma Patients: Clinically Relevant Models for Research and Personalized Medicine BMC Cancer. 07, 2016 | Pubmed ID: 27422173 System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes Molecular Cell. Apr, 2016 | Pubmed ID: 26949039 Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance Cell. Jan, 2016 | Pubmed ID: 26771497 High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities Cell. Dec, 2015 | Pubmed ID: 26627737 Genome-wide RNAi Analysis Reveals That Simultaneous Inhibition of Specific Mevalonate Pathway Genes Potentiates Tumor Cell Death Oncotarget. Sep, 2015 | Pubmed ID: 26353928 Identification of P450 Oxidoreductase As a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs Cancer Research. Oct, 2015 | Pubmed ID: 26297733 Measuring Error Rates in Genomic Perturbation Screens: Gold Standards for Human Functional Genomics Molecular Systems Biology. Jul, 2014 | Pubmed ID: 24987113 A Negative Genetic Interaction Map in Isogenic Cancer Cell Lines Reveals Cancer Cell Vulnerabilities Molecular Systems Biology. Oct, 2013 | Pubmed ID: 24104479 Integrated Genomic, Transcriptomic, and RNA-interference Analysis of Genes in Somatic Copy Number Gains in Pancreatic Ductal Adenocarcinoma Pancreas. Aug, 2013 | Pubmed ID: 23851435 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Identification of Novel ATP13A2 Interactors and Their Role in α-synuclein Misfolding and Toxicity Human Molecular Genetics. Sep, 2012 | Pubmed ID: 22645275 Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells Cancer Discovery. Feb, 2012 | Pubmed ID: 22585861 COLT-Cancer: Functional Genetic Screening Resource for Essential Genes in Human Cancer Cell Lines Nucleic Acids Research. Jan, 2012 | Pubmed ID: 22102578 A Comprehensive Platform for Highly Multiplexed Mammalian Functional Genetic Screens BMC Genomics. 2011 | Pubmed ID: 21548937 NAViGaTOR: Network Analysis, Visualization and Graphing Toronto Bioinformatics (Oxford, England). Dec, 2009 | Pubmed ID: 19837718 Unequal Evolutionary Conservation of Human Protein Interactions in Interologous Networks Genome Biology. 2007 | Pubmed ID: 17535438 Online Predicted Human Interaction Database Bioinformatics (Oxford, England). May, 2005 | Pubmed ID: 15657099 Samlede CRISPR-baserte genetiske skjermer i pattedyrceller Katherine Chan*1, Amy Hin Yan Tong*1, Kevin R Brown1, Patricia Mero1, Jason Moffat1,2,3 1Donnelly Centre, University of Toronto, 2Department of Molecular Genetics, University of Toronto, 3Institute for Biomaterials and Biomedical Engineering, University of Toronto JoVE 59780 Genetics
Samlede CRISPR-baserte genetiske skjermer i pattedyrceller Katherine Chan*1, Amy Hin Yan Tong*1, Kevin R Brown1, Patricia Mero1, Jason Moffat1,2,3 1Donnelly Centre, University of Toronto, 2Department of Molecular Genetics, University of Toronto, 3Institute for Biomaterials and Biomedical Engineering, University of Toronto JoVE 59780 Genetics