Kevin D. Costa Cardiovascular Research Institute Icahn School of Medicine at Mount Sinai Biography Publications Institution JoVE Articles Kevin D. Costa has not added a biography. If you are Kevin D. Costa and would like to personalize this page please email our Author Liaison for assistance. Publications Single-cell RNA Sequencing Reveals Maturation Trajectory in Human Pluripotent Stem Cell-derived Cardiomyocytes in Engineered Tissues IScience. Apr, 2023 | Pubmed ID: 36950112 Computational Design of Custom Therapeutic Cells to Correct Failing Human Cardiomyocytes Frontiers in Systems Biology. 2023 | Pubmed ID: 36743445 Age and Blood Pressure Contribute to Aortic Cell and Tissue Stiffness Through Distinct Mechanisms Hypertension (Dallas, Tex. : 1979). Aug, 2022 | Pubmed ID: 35766034 Generation of Human Induced Pluripotent Stem Cell (iPSC) Lines Derived from Five Patients Carrying the Pathogenic Phospholamban-R14del (PLN-R14del) Variant and Three Non-carrier Family Members Stem Cell Research. Apr, 2022 | Pubmed ID: 35247838 Gene Editing Reverses Arrhythmia Susceptibility in Humanized PLN-R14del Mice: Modelling a European Cardiomyopathy with Global Impact Cardiovascular Research. Dec, 2022 | Pubmed ID: 35191471 Cell Therapy Model Restores Failing Human Myocyte Electrophysiology and Calcium Cycling in Fibrotic Myocardium Frontiers in Physiology. 2021 | Pubmed ID: 35046835 Adverse Effects of Hydroxychloroquine and Azithromycin on Contractility and Arrhythmogenicity Revealed by Human Engineered Cardiac Tissues Journal of Molecular and Cellular Cardiology. Apr, 2021 | Pubmed ID: 33373642 High-resolution Integrated Piezoresistive Sensors for Microfluidic Monitoring Lab on a Chip. Jan, 2021 | Pubmed ID: 33300516 Combinatorial Treatment of Human Cardiac Engineered Tissues With Biomimetic Cues Induces Functional Maturation As Revealed by Optical Mapping of Action Potentials and Calcium Transients Frontiers in Physiology. 2020 | Pubmed ID: 32226389 Adult Human Cardiac Stem Cell Supplementation Effectively Increases Contractile Function and Maturation in Human Engineered Cardiac Tissues Stem Cell Research & Therapy. Dec, 2019 | Pubmed ID: 31801634 Sarco/endoplasmic Reticulum Ca-ATPase is a More Effective Calcium Remover Than Sodium-calcium Exchanger in Human Embryonic Stem Cell-derived Cardiomyocytes American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2019 | Pubmed ID: 31347915 Modulation of Chromatin Remodeling Proteins SMYD1 and SMARCD1 Promotes Contractile Function of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocyte in 3D-engineered Cardiac Tissues Scientific Reports. May, 2019 | Pubmed ID: 31097748 Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells As a Two-Tiered Assay for Inotropic Responses Clinical Pharmacology and Therapeutics. Aug, 2019 | Pubmed ID: 30723889 3D Printing a Mechanically-Tunable Acrylate Resin on a Commercial DLP-SLA Printer Additive Manufacturing. Oct, 2018 | Pubmed ID: 31106119 Cardiac Tissue Engineering Models of Inherited and Acquired Cardiomyopathies Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29987817 An Introduction to Computational Modeling of Cardiac Electrophysiology and Arrhythmogenicity Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29987808 Dehomogenized Elastic Properties of Heterogeneous Layered Materials in AFM Indentation Experiments Biophysical Journal. Jun, 2018 | Pubmed ID: 29874620 Functional and Transcriptomic Insights into Pathogenesis of R9C Phospholamban Mutation Using Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Journal of Molecular and Cellular Cardiology. Jun, 2018 | Pubmed ID: 29752948 Bioengineering an Electro-mechanically Functional Miniature Ventricular Heart Chamber from Human Pluripotent Stem Cells Biomaterials. May, 2018 | Pubmed ID: 29459321 Exosomal MicroRNA-21-5p Mediates Mesenchymal Stem Cell Paracrine Effects on Human Cardiac Tissue Contractility Circulation Research. 03, 2018 | Pubmed ID: 29449318 Physiologic, Pathologic, and Therapeutic Paracrine Modulation of Cardiac Excitation-Contraction Coupling Circulation Research. Jan, 2018 | Pubmed ID: 29301848 Coronary Capillary Blood Flow in a Rat Model of Congestive Heart Failure Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2018 | Pubmed ID: 29051335 Rho Kinase Regulates Aortic Vascular Smooth Muscle Cell Stiffness Via Actin/SRF/Myocardin in Hypertension Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2017 | Pubmed ID: 29169155 Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification Stem Cell Reports. Nov, 2017 | Pubmed ID: 29033305 CXCR4 and CXCR7 Play Distinct Roles in Cardiac Lineage Specification and Pharmacologic β-adrenergic Response Stem Cell Research. 08, 2017 | Pubmed ID: 28711757 Experimental and Computational Insight Into Human Mesenchymal Stem Cell Paracrine Signaling and Heterocellular Coupling Effects on Cardiac Contractility and Arrhythmogenicity Circulation Research. Aug, 2017 | Pubmed ID: 28642329 Inhibition of SRF/myocardin Reduces Aortic Stiffness by Targeting Vascular Smooth Muscle Cell Stiffening in Hypertension Cardiovascular Research. Feb, 2017 | Pubmed ID: 28003268 Lipidoid MRNA Nanoparticles for Myocardial Delivery in Rodents Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27910047 Modeling Electrophysiological Coupling and Fusion Between Human Mesenchymal Stem Cells and Cardiomyocytes PLoS Computational Biology. Jul, 2016 | Pubmed ID: 27454812 Genomic Correction of Familial Cardiomyopathy in Human Engineered Cardiac Tissues European Heart Journal. Nov, 2016 | Pubmed ID: 27450564 Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome Annals of Biomedical Engineering. Oct, 2016 | Pubmed ID: 27090893 Decellularized Scaffold Hydrogel Materials for MI Treatment: Could "The Matrix" Really Be the Future? Journal of the American College of Cardiology. Mar, 2016 | Pubmed ID: 26940930 Direct Hydrogel Encapsulation of Pluripotent Stem Cells Enables Ontomimetic Differentiation and Growth of Engineered Human Heart Tissues Biomaterials. Mar, 2016 | Pubmed ID: 26826618 Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2016 | Pubmed ID: 26791211 Human Engineered Cardiac Tissues Created Using Induced Pluripotent Stem Cells Reveal Functional Characteristics of BRAF-Mediated Hypertrophic Cardiomyopathy PloS One. 2016 | Pubmed ID: 26784941 Myocardial Delivery of Lipidoid Nanoparticle Carrying ModRNA Induces Rapid and Transient Expression Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2016 | Pubmed ID: 26471463 An Update on the Etiology of Abdominal Aortic Aneurysms: Implications for Future Diagnostic Testing Expert Review of Cardiovascular Therapy. Oct, 2015 | Pubmed ID: 26401919 An Evolving Understanding of the Genetic Causes of Abdominal Aortic Aneurysm Disease Surgical Technology International. May, 2015 | Pubmed ID: 26055010 Phospholamban As a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-derived Ventricular Cardiomyocytes and Engineered 3-dimensional Tissue Constructs Circulation. Arrhythmia and Electrophysiology. Feb, 2015 | Pubmed ID: 25504561 Stem Cell Factor Gene Transfer Improves Cardiac Function After Myocardial Infarction in Swine Circulation. Heart Failure. Jan, 2015 | Pubmed ID: 25342737 Physical Developmental Cues for the Maturation of Human Pluripotent Stem Cell-derived Cardiomyocytes Stem Cell Research & Therapy. Oct, 2014 | Pubmed ID: 25688759 Abnormal Muscle Mechanosignaling Triggers Cardiomyopathy in Mice with Marfan Syndrome The Journal of Clinical Investigation. Mar, 2014 | Pubmed ID: 24531548 Advancing Functional Engineered Cardiac Tissues Toward a Preclinical Model of Human Myocardium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2014 | Pubmed ID: 24174427 Shear Stress Triggers Insertion of Voltage-gated Potassium Channels from Intracellular Compartments in Atrial Myocytes Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24065831 Synthesis and in Vitro Evaluation of a Multifunctional and Surface-switchable Nanoemulsion Platform Chemical Communications (Cambridge, England). Oct, 2013 | Pubmed ID: 23877789 Myocyte-depleted Engineered Cardiac Tissues Support Therapeutic Potential of Mesenchymal Stem Cells Tissue Engineering. Part A. Jul, 2012 | Pubmed ID: 22500611 Biomedical Model Fitting and Error Analysis Science Signaling. Sep, 2011 | Pubmed ID: 21954296 공학적 심장 조직의 데이터 수집 및 모델 처리량을 개선하기 위한 바이오리액터 설계 Camille C. van Neste1, Karlo A. Wiley1, Serena W. Chang1, Joseph Borrello1, Irene C. Turnbull1, Kevin D. Costa1 1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai JoVE 64368 Bioengineering 정의 인간 공학 심장 조직의 건설 심장 세포 치료의 메커니즘을 연구하는 Timothy J. Cashman1, Rebecca Josowitz2, Bruce D. Gelb2, Ronald A. Li1,3, Nicole C. Dubois2, Kevin D. Costa1 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 3Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong Bioengineering
공학적 심장 조직의 데이터 수집 및 모델 처리량을 개선하기 위한 바이오리액터 설계 Camille C. van Neste1, Karlo A. Wiley1, Serena W. Chang1, Joseph Borrello1, Irene C. Turnbull1, Kevin D. Costa1 1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai JoVE 64368 Bioengineering
정의 인간 공학 심장 조직의 건설 심장 세포 치료의 메커니즘을 연구하는 Timothy J. Cashman1, Rebecca Josowitz2, Bruce D. Gelb2, Ronald A. Li1,3, Nicole C. Dubois2, Kevin D. Costa1 1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 3Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong Bioengineering
