Klaus Elenius Medicity Research Laboratories and Institute of Biomedicine University of Turku Biography Publications Institution JoVE Articles Klaus Elenius has not added a biography. If you are Klaus Elenius and would like to personalize this page please email our Author Liaison for assistance. Publications Genetic and Functional Implications of an Exonic TRIM55 Variant in Heart Failure Journal of Molecular and Cellular Cardiology. Jan, 2020 | Pubmed ID: 31866377 Structural Characterization of EGFR Exon 19 Deletion Mutation Using Molecular Dynamics Simulation PloS One. 2019 | Pubmed ID: 31536605 Decorin Expression in Human Vulva Carcinoma: Oncosuppressive Effect of Decorin CDNA Transduction on Carcinoma Cells The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jul, 2019 | Pubmed ID: 31009269 An Unbiased Screen for Activating Epidermal Growth Factor Receptor Mutations The Journal of Biological Chemistry. 06, 2019 | Pubmed ID: 30952700 Endothelial Cells Regulate Physiological Cardiomyocyte Growth Via VEGFR2-Mediated Paracrine Signaling Circulation. May, 2019 | Pubmed ID: 30922063 ErbB4 Tyrosine Kinase Inhibition Impairs Neuromuscular Development in Zebrafish Embryos Molecular Biology of the Cell. 01, 2019 | Pubmed ID: 30462579 Gamma-secretase-dependent Signaling of Receptor Tyrosine Kinases Oncogene. 01, 2019 | Pubmed ID: 30166589 Different Responses of Colorectal Cancer Cells to Alternative Sequences of Cetuximab and Oxaliplatin Scientific Reports. 11, 2018 | Pubmed ID: 30410004 Receptor Tyrosine Kinase Profiling of Ischemic Heart Identifies ROR1 As a Potential Therapeutic Target BMC Cardiovascular Disorders. 10, 2018 | Pubmed ID: 30342492 SUMOylation Regulates Nuclear Accumulation and Signaling Activity of the Soluble Intracellular Domain of the ErbB4 Receptor Tyrosine Kinase The Journal of Biological Chemistry. 12, 2017 | Pubmed ID: 28974580 Genome-wide Screen of Gamma-secretase-mediated Intramembrane Cleavage of Receptor Tyrosine Kinases Molecular Biology of the Cell. Nov, 2017 | Pubmed ID: 28904208 Human Metaplastic Breast Carcinoma and Decorin Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society. Dec, 2017 | Pubmed ID: 28653173 Overexpression of ERBB4 JM-a CYT-1 and CYT-2 Isoforms in Transgenic Mice Reveals Isoform-specific Roles in Mammary Gland Development and Carcinogenesis Breast Cancer Research : BCR. Dec, 2014 | Pubmed ID: 25516216 ErbB4, a Receptor Tyrosine Kinase, Coordinates Organization of the Seminiferous Tubules in the Developing Testis Molecular Endocrinology (Baltimore, Md.). Sep, 2014 | Pubmed ID: 25058600 ERBB4 Promoter Polymorphism is Associated with Poor Distant Disease-free Survival in High-risk Early Breast Cancer PloS One. 2014 | Pubmed ID: 25036186 Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24966332 High Frequency of BRAF V600E Mutations in Ameloblastoma The Journal of Pathology. Apr, 2014 | Pubmed ID: 24374844 ERBB4 Mutations That Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19 American Journal of Human Genetics. Nov, 2013 | Pubmed ID: 24119685 CYT-1 Isoform of ErbB4 is an Independent Prognostic Factor in Serous Ovarian Cancer and Selectively Promotes Ovarian Cancer Cell Growth in Vitro Gynecologic Oncology. Apr, 2013 | Pubmed ID: 23313737 Systemic Analysis of Gene Expression Profiles Identifies ErbB3 As a Potential Drug Target in Pediatric Alveolar Rhabdomyosarcoma PloS One. 2012 | Pubmed ID: 23227212 Translation of a Research-based Genetic Test on a Rare Syndrome into Clinical Service Testing, with Sotos Syndrome As an Example Genetic Testing and Molecular Biomarkers. Oct, 2012 | Pubmed ID: 22924495 Proteolytic Processing of ErbB4 in Breast Cancer PloS One. 2012 | Pubmed ID: 22761786 Protein Inhibitor of Activated STAT3 (PIAS3) Protein Promotes SUMOylation and Nuclear Sequestration of the Intracellular Domain of ErbB4 Protein The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22584572 Interaction with ErbB4 Promotes Hypoxia-inducible Factor-1α Signaling The Journal of Biological Chemistry. Mar, 2012 | Pubmed ID: 22308027 ErbB4 Modulates Tubular Cell Polarity and Lumen Diameter During Kidney Development Journal of the American Society of Nephrology : JASN. Jan, 2012 | Pubmed ID: 22076439 Function of ERBB4 is Determined by Alternative Splicing Cell Cycle (Georgetown, Tex.). Aug, 2011 | Pubmed ID: 21811097 Cell Death or Survival Promoted by Alternative Isoforms of ErbB4 Molecular Biology of the Cell. Dec, 2010 | Pubmed ID: 20943952 EGFR Targeting Drugs in the Treatment of Head and Neck Squamous Cell Carcinoma Expert Opinion on Emerging Drugs. Jun, 2010 | Pubmed ID: 20415599 Retention of Prolyl Hydroxylase PHD2 in the Cytoplasm Prevents PHD2-induced Anchorage-independent Carcinoma Cell Growth Experimental Cell Research. Apr, 2010 | Pubmed ID: 20156434 Potential of ErbB4 Antibodies for Cancer Therapy Future Oncology (London, England). Jan, 2010 | Pubmed ID: 20021208 ErbB4 Splice Variants Cyt1 and Cyt2 Differ by 16 Amino Acids and Exert Opposing Effects on the Mammary Epithelium in Vivo Molecular and Cellular Biology. Sep, 2009 | Pubmed ID: 19596786 The EGFR Inhibitor Gefitinib Suppresses Recruitment of Pericytes and Bone Marrow-derived Perivascular Cells into Tumor Vessels Microvascular Research. Dec, 2009 | Pubmed ID: 19596357 Pim-1 Kinase Expression Predicts Radiation Response in Squamocellular Carcinoma of Head and Neck and is Under the Control of Epidermal Growth Factor Receptor Neoplasia (New York, N.Y.). Jul, 2009 | Pubmed ID: 19568408 Removal of Cell Surface Heparan Sulfate Increases TACE Activity and Cleavage of ErbB4 Receptor BMC Cell Biology. Jan, 2009 | Pubmed ID: 19171023 Somatic Mutations of ErbB4: Selective Loss-of-function Phenotype Affecting Signal Transduction Pathways in Cancer The Journal of Biological Chemistry. Feb, 2009 | Pubmed ID: 19098003 ErbB4 and Its Isoforms: Patentable Drug Targets? Recent Patents on DNA & Gene Sequences. 2008 | Pubmed ID: 19075942 Role of ErbB4 in Breast Cancer Journal of Mammary Gland Biology and Neoplasia. Jun, 2008 | Pubmed ID: 18454307 Isoform-specific Monoubiquitination, Endocytosis, and Degradation of Alternatively Spliced ErbB4 Isoforms Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18334649 O 硫酸细菌多糖具有低抗凝血活性抑制转移。 Seminars in Thrombosis and Hemostasis. Jul, 2007 | Pubmed ID: 17629853 Proteome Analysis of Cultivated Vascular Smooth Muscle Cells from a CADASIL Patient Molecular Medicine (Cambridge, Mass.). May-Jun, 2007 | Pubmed ID: 17622327 Intra- and Extracellular Signaling by Endothelial Neuregulin-1 Experimental Cell Research. Aug, 2007 | Pubmed ID: 17499242 The Intracellular Domain of ErbB4 Induces Differentiation of Mammary Epithelial Cells Molecular Biology of the Cell. Sep, 2006 | Pubmed ID: 16837552 蛋白水解的分裂和肿瘤相关的 ErbB4 鼻息肉的磷酸化促进配体独立生存和癌症细胞的生长。 Molecular Biology of the Cell. Jan, 2006 | Pubmed ID: 16251361 DNA Topoisomerase I is a Cofactor for C-Jun in the Regulation of Epidermal Growth Factor Receptor Expression and Cancer Cell Proliferation Molecular and Cellular Biology. Jun, 2005 | Pubmed ID: 15923621 Cleavable ErbB4 Isoform in Estrogen Receptor-regulated Growth of Breast Cancer Cells Cancer Research. Feb, 2005 | Pubmed ID: 15735025 Identification of Patients with Transitional Cell Carcinoma of the Bladder Overexpressing ErbB2, ErbB3, or Specific ErbB4 Isoforms: Real-time Reverse Transcription-PCR Analysis in Estimation of ErbB Receptor Status from Cancer Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2003 | Pubmed ID: 14614020 Angiopoietin-regulated Recruitment of Vascular Smooth Muscle Cells by Endothelial-derived Heparin Binding EGF-like Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2003 | Pubmed ID: 12958167 Endothelial Cell-matrix Interactions Microscopy Research and Technique. Jan, 2003 | Pubmed ID: 12500256 N-arginine Dibasic Convertase is a Specific Receptor for Heparin-binding EGF-like Growth Factor That Mediates Cell Migration The EMBO Journal. Jul, 2001 | Pubmed ID: 11432822 通过分子动力学模拟破译激活EGFR体电突变的结构效应 Mahlet Z. Tamirat1, Kari J. Kurppa2, Klaus Elenius2,3,4, Mark S. Johnson1 1Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 2Medicity Research Laboratories and Institute of Biomedicine, University of Turku, 3Turku Bioscience Centre, University of Turku and Åbo Akademi University, 4Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital JoVE 61125 Biochemistry
通过分子动力学模拟破译激活EGFR体电突变的结构效应 Mahlet Z. Tamirat1, Kari J. Kurppa2, Klaus Elenius2,3,4, Mark S. Johnson1 1Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, 2Medicity Research Laboratories and Institute of Biomedicine, University of Turku, 3Turku Bioscience Centre, University of Turku and Åbo Akademi University, 4Department of Oncology and Radiotherapy, University of Turku and Turku University Hospital JoVE 61125 Biochemistry