Kuniaki Seyama Department of Respiratory Medicine, Juntendo University Graduate School of Medicine Juntendo University Biography Publications Institution JoVE Articles Kuniaki Seyama has not added a biography. If you are Kuniaki Seyama and would like to personalize this page please email our Author Liaison for assistance. Publications Changes in Oxidative Stress Levels During Two Weeks of Smoking Cessation Treatment and Their Association with Nutritional Characteristics in Japanese Smokers Experimental and Therapeutic Medicine. Apr, 2019 | Pubmed ID: 30930973 Familial Multifocal Micronodular Pneumocyte Hyperplasia with a Novel Splicing Mutation in TSC1: Three Cases in One Family PloS One. 2019 | Pubmed ID: 30794603 Safety and Pharmacokinetics of Alpha-1 MP (Prolastin-C) in Japanese Patients with Alpha-antitrypsin (AAT) Deficiency Respiratory Investigation. Jan, 2019 | Pubmed ID: 30416054 Regional Heterogeneity in Response of Airway Epithelial Cells to Cigarette Smoke BMC Pulmonary Medicine. Sep, 2018 | Pubmed ID: 30180847 COPD Assessment Test As a Possible Tool for Evaluating Health-related Quality of Life in Lymphangioleiomyomatosis Respiratory Investigation. Nov, 2018 | Pubmed ID: 30143460 Roles of Human Epidermal Growth Factor Receptor Family in Pulmonary Lymphangioleiomyomatosis Human Pathology. Nov, 2018 | Pubmed ID: 30030119 Correction To: Single Lung Transplantation for Lymphangioleiomyomatosis: a Single-center Experience in Japan Surgery Today. 10, 2018 | Pubmed ID: 29948173 Single Lung Transplantation for Lymphangioleiomyomatosis: a Single-center Experience in Japan Surgery Today. Oct, 2018 | Pubmed ID: 29808303 Mineralization of Alpha-1-antitrypsin Inclusion Bodies in Mmalton Alpha-1-antitrypsin Deficiency Orphanet Journal of Rare Diseases. 05, 2018 | Pubmed ID: 29769092 A Total Pleural Covering of Absorbable Cellulose Mesh Prevents Pneumothorax Recurrence in Patients with Birt-Hogg-Dubé Syndrome Orphanet Journal of Rare Diseases. 05, 2018 | Pubmed ID: 29764481 Skin Lesions of Birt-Hogg-Dubé Syndrome: Clinical and Histopathological Findings in 31 Japanese Patients Who Presented with Pneumothorax And/or Multiple Lung Cysts Journal of Dermatological Science. Jan, 2018 | Pubmed ID: 29157599 Oxidized Regenerated Cellulose Induces Pleural Thickening in Patients with Pneumothorax: Possible Involvement of the Mesothelial-mesenchymal Transition Surgery Today. Apr, 2018 | Pubmed ID: 29027010 Novel Clinical Scoring System to Identify Patients with Pneumothorax with Suspicion for Birt-Hogg-Dubé Syndrome Respirology (Carlton, Vic.). 04, 2018 | Pubmed ID: 28960698 Effect of Telling Patients Their "spirometric-lung-age" on Smoking Cessation in Japanese Smokers Journal of Thoracic Disease. Dec, 2017 | Pubmed ID: 29312710 Difference of the Progression of Pulmonary Cysts Assessed by Computed Tomography Among COPD, Lymphangioleiomyomatosis, and Birt-Hogg-Dubé Syndrome PloS One. 2017 | Pubmed ID: 29220357 Hydrogen-rich Pure Water Prevents Cigarette Smoke-induced Pulmonary Emphysema in SMP30 Knockout Mice Biochemical and Biophysical Research Communications. 10, 2017 | Pubmed ID: 28807355 Risk Factors for Stomatitis in Patients with Lymphangioleiomyomatosis During Treatment with Sirolimus: A Multicenter Investigator-initiated Prospective Study Pharmacoepidemiology and Drug Safety. Oct, 2017 | Pubmed ID: 28752672 Pneumothorax Caused by Cystic and Nodular Lung Metastases from a Malignant Uterine Perivascular Epithelioid Cell Tumor (PEComa) Respiratory Medicine Case Reports. 2017 | Pubmed ID: 28706850 Protein-losing Enteropathy Caused by Intestinal or Colonic Lymphangiectasia Complicated by Sporadic Lymphangioleiomyomatosis: A Report of Two Cases Internal Medicine (Tokyo, Japan). 2017 | Pubmed ID: 28420844 Antioxidant Nutrients in Plasma of Japanese Patients with Chronic Obstructive Pulmonary Disease, Asthma-COPD Overlap Syndrome and Bronchial Asthma The Clinical Respiratory Journal. Nov, 2017 | Pubmed ID: 26667049 Haploinsufficiency of the Folliculin Gene Leads to Impaired Functions of Lung Fibroblasts in Patients with Birt-Hogg-Dubé Syndrome Physiological Reports. Nov, 2016 | Pubmed ID: 27905298 Benign Clear Cell "sugar" Tumor of the Lung in a Patient with Birt-Hogg-Dubé Syndrome: a Case Report BMC Medical Genetics. Nov, 2016 | Pubmed ID: 27871249 A Total Pleural Covering for Lymphangioleiomyomatosis Prevents Pneumothorax Recurrence PloS One. 2016 | Pubmed ID: 27658250 Efficacy and Safety of Long-Term Sirolimus Therapy for Asian Patients with Lymphangioleiomyomatosis Annals of the American Thoracic Society. 11, 2016 | Pubmed ID: 27513278 A Nationwide Epidemiological Survey of Alpha1-antitrypsin Deficiency in Japan Respiratory Investigation. May, 2016 | Pubmed ID: 27108016 Reductions in Pulmonary Function Detected in Patients with Lymphangioleiomyomatosis: An Analysis of the Japanese National Research Project on Intractable Diseases Database Respiratory Investigation. May, 2016 | Pubmed ID: 27108015 Isolation of Individual Cellular Components from Lung Tissues of Patients with Lymphangioleiomyomatosis American Journal of Physiology. Lung Cellular and Molecular Physiology. 05, 2016 | Pubmed ID: 27016587 Bronchial Involvement in Advanced Stage Lymphangioleiomyomatosis: Histopathologic and Molecular Analyses Human Pathology. Apr, 2016 | Pubmed ID: 26997436 Impact of Airflow Limitation on Comorbidities and Postoperative Complications in Patients Undergoing Thoracic Surgery: A Retrospective Observational Study Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. Jun, 2016 | Pubmed ID: 26935262 Lung Transplantation for Lymphangioleiomyomatosis in Japan PloS One. 2016 | Pubmed ID: 26771878 Detection of Low-prevalence Somatic TSC2 Mutations in Sporadic Pulmonary Lymphangioleiomyomatosis Tissues by Deep Sequencing Human Genetics. Jan, 2016 | Pubmed ID: 26563443 Pleural Covering Application for Recurrent Pneumothorax in a Patient with Birt-Hogg-Dubé Syndrome Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. Jun, 2016 | Pubmed ID: 26370712 MicroRNAs As Therapeutic Targets in Lung Disease: Prospects and Challenges Chronic Obstructive Pulmonary Diseases (Miami, Fla.). Dec, 2015 | Pubmed ID: 28848860 A Model of Lymphangioleiomyomatosis in a Three-Dimensional Culture System Lymphatic Research and Biology. Dec, 2015 | Pubmed ID: 26574997 Lymphangioleiomyomatosis in a Male The Annals of Thoracic Surgery. Sep, 2015 | Pubmed ID: 26354644 Intracrine Steroid Production and Mammalian Target of Rapamycin Pathways in Pulmonary Lymphangioleiomyomatosis Human Pathology. Nov, 2015 | Pubmed ID: 26298231 Accuracy of Chest High-resolution Computed Tomography in Diagnosing Diffuse Cystic Lung Diseases The European Respiratory Journal. Oct, 2015 | Pubmed ID: 26160866 Effects of Transdermal Tulobuterol on Dyspnea and Respiratory Function During Exercise in Patients with Chronic Obstructive Pulmonary Disease Journal of Thoracic Disease. Apr, 2015 | Pubmed ID: 25973235 Computed Tomographic Features of Lymphangioleiomyomatosis: Evaluation in 138 Patients European Journal of Radiology. Mar, 2015 | Pubmed ID: 25544557 What׳s the Role of Sirolimus on the Treatment of Lymphangioleiomyomatosis (LAM)?: Merely Tuning Up of LAM-associated Dysfunctional Lymphatic Vessels Rather Than Cytoreduction? Respiratory Investigation. Jul, 2014 | Pubmed ID: 24998376 Cystic, Nodular and Cavitary Metastases to the Lungs in a Patient with Endometrial Stromal Sarcoma of the Uterus Internal Medicine (Tokyo, Japan). 2014 | Pubmed ID: 24785893 Genistein Attenuates Hypoxic Pulmonary Hypertension Via Enhanced Nitric Oxide Signaling and the Erythropoietin System American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2014 | Pubmed ID: 24705719 Characterization of Pulmonary Cysts in Birt-Hogg-Dubé Syndrome: Histopathological and Morphometric Analysis of 229 Pulmonary Cysts from 50 Unrelated Patients Histopathology. Jul, 2014 | Pubmed ID: 24393238 Vitamin C Prevents Cigarette Smoke-induced Pulmonary Emphysema in Mice and Provides Pulmonary Restoration American Journal of Respiratory Cell and Molecular Biology. Feb, 2014 | Pubmed ID: 24032444 Reversed Halo Sign in Tuberous Sclerosis Complex Case Reports in Radiology. 2013 | Pubmed ID: 24159404 Small-cell Lung Cancer Exhibiting Spontaneous Regression Internal Medicine (Tokyo, Japan). 2013 | Pubmed ID: 24088761 Efficacy and Safety of Low-dose Sirolimus for Treatment of Lymphangioleiomyomatosis Respiratory Investigation. Sep, 2013 | Pubmed ID: 23978644 [Current Understanding and Perspectives of Lymphangioleiomyomatosis] Nihon Rinsho. Japanese Journal of Clinical Medicine. Jun, 2013 | Pubmed ID: 23855221 Pulmonary Manifestations of Birt-Hogg-Dubé Syndrome Familial Cancer. Sep, 2013 | Pubmed ID: 23715758 Prevalence and Clinical Features Of lymphedema in Patients with Lymphangioleiomyomatosis Respiratory Medicine. Aug, 2013 | Pubmed ID: 23688816 Oncostatin M Modulates Fibroblast Function Via Signal Transducers and Activators of Transcription Proteins-3 American Journal of Respiratory Cell and Molecular Biology. Oct, 2013 | Pubmed ID: 23668543 Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice Evidence-based Complementary and Alternative Medicine : ECAM. 2012 | Pubmed ID: 23326296 [109th Scientific Meeting of the Japanese Society of Internal Medicine: Educational Lecture: 17. Lymphangioleiomyomatosis] Nihon Naika Gakkai Zasshi. The Journal of the Japanese Society of Internal Medicine. Sep, 2012 | Pubmed ID: 23205465 Quantitative CT Analysis of Small Pulmonary Vessels in Lymphangioleiomyomatosis European Journal of Radiology. Dec, 2012 | Pubmed ID: 22964373 Hypoxia Induces Gefitinib Resistance in Non-small-cell Lung Cancer with Both Mutant and Wild-type Epidermal Growth Factor Receptors Cancer Science. Nov, 2012 | Pubmed ID: 22863020 Pulmonary Rehabilitation Program Including Respiratory Conditioning for Chronic Obstructive Pulmonary Disease (COPD): Improved Hyperinflation and Expiratory Flow During Tidal Breathing Journal of Thoracic Disease. Jun, 2012 | Pubmed ID: 22754664 Uterine Angiosarcoma Associated with Lymphangioleiomyomatosis in a Patient with Tuberous Sclerosis Complex: an Autopsy Case Report with Immunohistochemical and Genetic Analysis Human Pathology. Oct, 2012 | Pubmed ID: 22748302 Factors Influencing Weaning from Mechanical Ventilation in Elderly Patients with Severe Pneumonia Geriatrics & Gerontology International. Apr, 2012 | Pubmed ID: 22066870 Differentiation Between Birt-Hogg-Dubé Syndrome and Lymphangioleiomyomatosis: Quantitative Analysis of Pulmonary Cysts on Computed Tomography of the Chest in 66 Females European Journal of Radiology. Jun, 2012 | Pubmed ID: 21550193 Prevalence of Uterine and Adnexal Involvement in Pulmonary Lymphangioleiomyomatosis: a Clinicopathologic Study of 10 Patients The American Journal of Surgical Pathology. Dec, 2011 | Pubmed ID: 22020043 Homozygosity Mapping on Homozygosity Haplotype Analysis to Detect Recessive Disease-causing Genes from a Small Number of Unrelated, Outbred Patients PloS One. 2011 | Pubmed ID: 21949849 Breakthrough Lung Scedosporium Prolificans Infection with Multiple Cavity Lesions in a Patient Receiving Voriconazole for Probable Invasive Aspergillosis Associated with Monoclonal Gammopathy of Undetermined Significance (MGUS) Medical Mycology Journal. 2011 | Pubmed ID: 21441711 Identification of Intragenic Deletions and Duplication in the FLCN Gene in Birt-Hogg-Dubé Syndrome Genes, Chromosomes & Cancer. Jun, 2011 | Pubmed ID: 21412933 Characteristics of Pulmonary Cysts in Birt-Hogg-Dubé Syndrome: Thin-section CT Findings of the Chest in 12 Patients European Journal of Radiology. Mar, 2011 | Pubmed ID: 19782489 A Quantitatively-modeled Homozygosity Mapping Algorithm, QHomozygosityMapping, Utilizing Whole Genome Single Nucleotide Polymorphism Genotyping Data BMC Bioinformatics. Oct, 2010 | Pubmed ID: 21106127 Loss of Heterozygosity on Tuberous Sclerosis Complex Genes in Multifocal Micronodular Pneumocyte Hyperplasia Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Sep, 2010 | Pubmed ID: 20526286 Clinical and Genetic Spectrum of Birt-Hogg-Dube Syndrome Patients in Whom Pneumothorax And/or Multiple Lung Cysts Are the Presenting Feature Journal of Medical Genetics. Apr, 2010 | Pubmed ID: 20413710 Lymphangioleiomyomatosis: a Disease Involving the Lymphatic System Lymphatic Research and Biology. Mar, 2010 | Pubmed ID: 20235884 A Pleuro-peritoneal Communication Through the Diaphragm Affected with Lymphangioleiomyomatosis Internal Medicine (Tokyo, Japan). 2010 | Pubmed ID: 20190480 [Two Cases of Familial Summer-type Hypersensitivity Pneumonitis Requiring Differentiation from Bird Breeder's Lung] Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society. Oct, 2009 | Pubmed ID: 19882921 [A Case of Pulmonary Metastases from Bladder Cancer, Suspected of Recurrent Wegener's Granulomatosis] Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society. Oct, 2009 | Pubmed ID: 19882920 Osteopontin Expression in Pulmonary Tumor Thrombotic Microangiopathy Caused by Gastric Carcinoma Pathology International. Oct, 2009 | Pubmed ID: 19788622 Cytologic, Immunocytochemical and Ultrastructural Characterization of Lymphangioleiomyomatosis Cell Clusters in Chylous Effusions of Patients with Lymphangioleiomyomatosis Acta Cytologica. Jul-Aug, 2009 | Pubmed ID: 19697724 Refractory Recurrent Thymoma Successfully Treated with Long-acting Somatostatin Analogue and Prednisolone Internal Medicine (Tokyo, Japan). 2009 | Pubmed ID: 19525599 Malignant Pleurisy Associated with Primary Lung Cancer Well Controlled by Pleurodesis Using Distilled Water Internal Medicine (Tokyo, Japan). 2009 | Pubmed ID: 19525597 [Efficacy of Gefitinib According to Smoking Status in Non-small Cell Lung Cancer Patients] Gan to Kagaku Ryoho. Cancer & Chemotherapy. Dec, 2008 | Pubmed ID: 19098404 Peritoneovenous Shunting for Intractable Chylous Ascites Complicated with Lymphangioleiomyomatosis Internal Medicine (Tokyo, Japan). 2008 | Pubmed ID: 18277030 Phosphodiesterase 4 Inhibitor GPD-1116 Markedly Attenuates the Development of Cigarette Smoke-induced Emphysema in Senescence-accelerated Mice P1 Strain American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2008 | Pubmed ID: 17993591 [A Case of Pulmonary Arteriovenous Fistula Associated with Multiple Hepatic Arterioportal Shunts] Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society. Sep, 2007 | Pubmed ID: 17929475 Lymphangioleiomyomatosis Diagnosed by Immunocytochemical and Genetic Analysis of Lymphangioleiomyomatosis Cell Clusters Found in Chylous Pleural Effusion Internal Medicine (Tokyo, Japan). 2007 | Pubmed ID: 17878649 Mutations of the Birt Hogg Dube Gene in Patients with Multiple Lung Cysts and Recurrent Pneumothorax Journal of Medical Genetics. Sep, 2007 | Pubmed ID: 17496196 [Spirometry and Other Pulmonary Function Tests for the Screening and Evaluation of Patients with Chronic Obstructive Pulmonary Disease (COPD)] Nihon Rinsho. Japanese Journal of Clinical Medicine. Apr, 2007 | Pubmed ID: 17419385 Vascular Endothelial Growth Factor-D is Increased in Serum of Patients with Lymphangioleiomyomatosis Lymphatic Research and Biology. 2006 | Pubmed ID: 17034294 Senescence Marker Protein-30 Protects Mice Lungs from Oxidative Stress, Aging, and Smoking American Journal of Respiratory and Critical Care Medicine. Sep, 2006 | Pubmed ID: 16728709 Induction of Human Neutrophil Chemotaxis by Candida Albicans-derived Beta-1,6-long Glycoside Side-chain-branched Beta-glucan Journal of Leukocyte Biology. Jul, 2006 | Pubmed ID: 16670126 An Early Case of Pulmonary Lymphangioleiomyomatosis Diagnosed by Video-assisted Thoracoscopic Surgery Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. Dec, 2005 | Pubmed ID: 16401991 Clinical Efficacy and Safety of Transdermal Tulobuterol in the Treatment of Stable COPD: an Open-label Comparison with Inhaled Salmeterol Treatments in Respiratory Medicine. 2005 | Pubmed ID: 16336029 Lymphangiogenesis-mediated Shedding of LAM Cell Clusters As a Mechanism for Dissemination in Lymphangioleiomyomatosis The American Journal of Surgical Pathology. Oct, 2005 | Pubmed ID: 16160479 Lymphangiogenesis in Lymphangioleiomyomatosis: Its Implication in the Progression of Lymphangioleiomyomatosis The American Journal of Surgical Pathology. Aug, 2004 | Pubmed ID: 15252306 Senescence Marker Protein-30 Knockout Mouse As a Novel Murine Model of Senile Lung Pathology International. Mar, 2004 | Pubmed ID: 14989739 [A Case of Primary Squamous Cell Carcinoma of the Lung with a Metastatic Thyroid Tumor Improved Following Chemotherapy] Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society. Jan, 2004 | Pubmed ID: 14768372 [Proteases Involved in Airway Inflammation of COPD] Nihon Rinsho. Japanese Journal of Clinical Medicine. Dec, 2003 | Pubmed ID: 14674319 Quantification of Elastin Cross-linking Amino Acids, Desmosine and Isodesmosine, in Hydrolysates of Rat Lung by Ion-pair Liquid Chromatography-mass Spectrometry Analytical Biochemistry. Jul, 2003 | Pubmed ID: 12782027 Mutation Analysis of the TSC1 and TSC2 Genes in Japanese Patients with Pulmonary Lymphangioleiomyomatosis Journal of Human Genetics. 2002 | Pubmed ID: 11829138 चूहे में वातस्फीति के मूल्यांकन के लिए लगातार दबाव के तहत फेफड़ों का निर्धारण Keiko Karasutani1,2, Hario Baskoro1, Tadashi Sato1, Naoko Arano1, Yohei Suzuki1, Aki Mitsui1, Naoko Shimada1, Yuzo Kodama1, Kuniaki Seyama1, Yoshinosuke Fukuchi1, Kazuhisa Takahashi1 1Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Juntendo University, 2Pharmaceutical Planning Group, Otsuka Pharmaceutical Co., Ltd. JoVE 58197 Medicine
चूहे में वातस्फीति के मूल्यांकन के लिए लगातार दबाव के तहत फेफड़ों का निर्धारण Keiko Karasutani1,2, Hario Baskoro1, Tadashi Sato1, Naoko Arano1, Yohei Suzuki1, Aki Mitsui1, Naoko Shimada1, Yuzo Kodama1, Kuniaki Seyama1, Yoshinosuke Fukuchi1, Kazuhisa Takahashi1 1Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Juntendo University, 2Pharmaceutical Planning Group, Otsuka Pharmaceutical Co., Ltd. JoVE 58197 Medicine