Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 Mehrere Mittel Zum Gleichen Zweck: Die Genetische Basis Der Erworbenen Stressresistenz in Der Hefe PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 Zusammengesetzte Priorisierung Methoden Erhöhen Preise Der Chemischen Sonde Entdeckung in Modellorganismen Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 Dosierung Unterdrückung Genetische Interaktion Netze Verbessern Funktionale Schaltpläne Der Zelle Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 Eine Umfassende Plattform Für Multiplex Hoch Säugetier-funktionale Genetische Schirme BMC Genomics. 2011 | Pubmed ID: 21548937 Barcode Hoch-Multiplex-Sequenzierung: Eine Effiziente Methode Zur Parallelen Analyse Von Mischproben Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 Genotyp, Phänotyp: Ein Komplexes Problem Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 Eine Vergleichende Analyse Der DNA Microarray Barcode Größe BMC Genomics. 2009 | Pubmed ID: 19825181 Quantitative Pathologies über Tiefe Barcode Sequenzierung Genome Research. Oct, 2009 | Pubmed ID: 19622793 Chemische-genetische Profilierung Von Imidazo [1, 2-a] Pyridines Und -Pyrimidine Enthüllt Deiner Wege Zwischen Hefe Und Menschlichen Zellen Konserviert PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 Weg-Ziel-Wirkungen Von Psychopharmaka Offenbart Mit Genomweiten Tests in Der Hefe PLoS Genetics. 2008 | Pubmed ID: 18688276 Hefe-Barcoders: Eine Chemogenomic Anwendung Einer Universal-Geber-Dehnungs-Sammlung Mit Barcode-Bezeichner Nature Methods. Aug, 2008 | Pubmed ID: 18622398 Genomische DNA-Funktionen Als Universelle Externe Standard in Quantitative Echtzeit-PCR Nucleic Acids Research. 2006 | Pubmed ID: 16840529 CpG-Insel Microarray-Sonden-Sequenzen Von Einer Physischen Bibliothek Abgeleitet Sind Repräsentativ Für Die CpG-Inseln Annotiert über Das Menschliche Genom Nucleic Acids Research. 2005 | Pubmed ID: 15911630 Competitive Genomic Screens von Barcoded Hefe Bibliotheken Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
Competitive Genomic Screens von Barcoded Hefe Bibliotheken Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology