Lawrence E. Heisler Donnelly Centre for Cellular and Biomolecular Research University of Toronto Biography Publications Institution JoVE Articles Lawrence E. Heisler has not added a biography. If you are Lawrence E. Heisler and would like to personalize this page please email our Author Liaison for assistance. Publications The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression Cell. May, 2018 | Pubmed ID: 29681457 Mitochondrial Mutations Drive Prostate Cancer Aggression Nature Communications. 09, 2017 | Pubmed ID: 28939825 Genomic Hallmarks of Localized, Non-indolent Prostate Cancer Nature. 01, 2017 | Pubmed ID: 28068672 Germline BRCA2 Mutations Drive Prostate Cancers with Distinct Evolutionary Trajectories Nature Communications. Jan, 2017 | Pubmed ID: 28067867 A Comprehensive Assessment of Somatic Mutation Detection in Cancer Using Whole-genome Sequencing Nature Communications. Dec, 2015 | Pubmed ID: 26647970 A Genome Scale Overexpression Screen to Reveal Drug Activity in Human Cells Genome Medicine. 2014 | Pubmed ID: 24944581 Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures Science (New York, N.Y.). Apr, 2014 | Pubmed ID: 24723613 CHIP-MYTH: a Novel Interactive Proteomics Method for the Assessment of Agonist-dependent Interactions of the Human β₂-adrenergic Receptor Biochemical and Biophysical Research Communications. Mar, 2014 | Pubmed ID: 24561123 Miniature Short Hairpin RNA Screens to Characterize Antiproliferative Drugs G3 (Bethesda, Md.). Aug, 2013 | Pubmed ID: 23797109 Effects of the Paf1 Complex and Histone Modifications on SnoRNA 3'-end Formation Reveal Broad and Locus-specific Regulation Molecular and Cellular Biology. Jan, 2013 | Pubmed ID: 23109428 Functional Analysis with a Barcoder Yeast Gene Overexpression System G3 (Bethesda, Md.). Oct, 2012 | Pubmed ID: 23050238 Comparative Chemogenomics to Examine the Mechanism of Action of Dna-targeted Platinum-acridine Anticancer Agents ACS Chemical Biology. Nov, 2012 | Pubmed ID: 22928710 Identification of Yeast Genes That Confer Resistance to Chitosan Oligosaccharide (COS) Using Chemogenomics BMC Genomics. Jun, 2012 | Pubmed ID: 22727066 同じエンドに複数の手段:酵母のストレス耐性獲得の遺伝的基礎 PLoS Genetics. Nov, 2011 | Pubmed ID: 22102822 化合物の優先順位付けの方法は、モデル生物のケミカルプローブ探索の率を高める Chemistry & Biology. Oct, 2011 | Pubmed ID: 22035796 用量の抑制遺伝的相互作用のネットワークは、細胞の機能配線図を強化 Nature Biotechnology. Jun, 2011 | Pubmed ID: 21572441 高多重哺乳類の機能遺伝子スクリーニングのための包括的なプラットフォーム BMC Genomics. 2011 | Pubmed ID: 21548937 高度に多重化されたバーコード·シーケンシング:プールされたサンプルの並列解析のための効率的な方法 Nucleic Acids Research. Jul, 2010 | Pubmed ID: 20460461 表現型に遺伝子型:複雑な問題 Science (New York, N.Y.). Apr, 2010 | Pubmed ID: 20413493 DNAバーコードのマイクロアレイのフィーチャーサイズの比較分析 BMC Genomics. 2009 | Pubmed ID: 19825181 ディープバーコードシーケンス経由で定量的な表現型 Genome Research. Oct, 2009 | Pubmed ID: 19622793 イミダゾ[1,2-a]ピリジン - ピリミジンとの化学遺伝的プロファイリングは、ターゲットを明らかに酵母とヒト細胞の間で保存パスウェイ PLoS Genetics. Nov, 2008 | Pubmed ID: 19043571 向精神薬のオフターゲット効果は、酵母のゲノムワイドアッセイで明らかに PLoS Genetics. 2008 | Pubmed ID: 18688276 酵母Barcoders:バーコード識別子を運ぶユニバーサルドナー株コレクションのChemogenomicアプリケーション Nature Methods. Aug, 2008 | Pubmed ID: 18622398 ゲノム DNA は定量的リアルタイム PCR で普遍的な外部標準として機能します。 Nucleic Acids Research. 2006 | Pubmed ID: 16840529 物理ライブラリから派生したCpGアイランドマイクロアレイプローブ配列は、ヒトゲノム上の注釈のCpGアイランドの代表的なものである Nucleic Acids Research. 2005 | Pubmed ID: 15911630 バーコード酵母ライブラリーの競争力のあるゲノム画面 Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology
バーコード酵母ライブラリーの競争力のあるゲノム画面 Andrew M. Smith*1,2, Tanja Durbic*2,3, Julia Oh*4, Malene Urbanus1,2, Michael Proctor5, Lawrence E. Heisler2,3, Guri Giaever2,6, Corey Nislow1,2,3 1Banting and Best Department of Medical Research and Department of Molecular Genetics, University of Toronto, 2Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 3Donnelly Sequencing Centre, University of Toronto, 4Genetics and Molecular Biology Branch, National Human Genome Research Institute, NIH, 5Stanford Genome Technology Center, Stanford School of Medicine, Stanford University, 6Department of Pharmaceutical Sciences, University of Toronto JoVE 2864 Biology