Leon J. Schurgers Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM) Maastricht University Biography Publications Institution JoVE Articles Leon J. Schurgers has not added a biography. If you are Leon J. Schurgers and would like to personalize this page please email our Author Liaison for assistance. Publications Prenatal Administration of Multipotent Adult Progenitor Cells Modulates the Systemic and Cerebral Immune Response in an Ovine Model of Chorioamnionitis Brain, Behavior, & Immunity - Health. Aug, 2022 | Pubmed ID: 35647567 Osteomodulin Attenuates Smooth Muscle Cell Osteogenic Transition in Vascular Calcification Clinical and Translational Medicine. 02, 2022 | Pubmed ID: 35184400 Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is the Evidence? Current Vascular Pharmacology. 2022 | Pubmed ID: 35139790 Dietary Magnesium Supplementation Inhibits Abdominal Vascular Calcification in an Experimental Animal Model of Chronic Kidney Disease Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. May, 2022 | Pubmed ID: 35134986 Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells International Journal of Molecular Sciences. Jan, 2022 | Pubmed ID: 35054772 Combining Phosphate Binder Therapy with Vitamin K2 Inhibits Vascular Calcification in an Experimental Animal Model of Kidney Failure Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 03, 2022 | Pubmed ID: 34718756 Deficiency of Myeloid PHD Proteins Aggravates Atherogenesis Via Macrophage Apoptosis and Paracrine Fibrotic Signalling Cardiovascular Research. 03, 2022 | Pubmed ID: 33913468 Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy Frontiers in Physiology. 2021 | Pubmed ID: 35095571 Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity Frontiers in Medicine. 2021 | Pubmed ID: 35004784 Vitamin K-a Neglected Player in Cardiovascular Health: a Narrative Review Open Heart. 11, 2021 | Pubmed ID: 34785587 Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk Nutrients. Oct, 2021 | Pubmed ID: 34684491 Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity Cells. 08, 2021 | Pubmed ID: 34440866 Vitamin K and Cardiovascular Complications in Chronic Kidney Disease Patients Kidney International. 11, 2021 | Pubmed ID: 34310988 Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation During Vascular Remodeling and Intimal Calcification Cells. 05, 2021 | Pubmed ID: 34063989 Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design Nutrients. Mar, 2021 | Pubmed ID: 33808652 Off-target Effects of Oral Anticoagulants - Vascular Effects of Vitamin K Antagonist and Non-vitamin K Antagonist Oral Anticoagulant Dabigatran Etexilate Journal of Thrombosis and Haemostasis : JTH. 05, 2021 | Pubmed ID: 33687782 Functional Vitamin K Insufficiency, Vascular Calcification and Mortality in Advanced Chronic Kidney Disease: A Cohort Study PloS One. 2021 | Pubmed ID: 33626087 Sodium [F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment Cells. 01, 2021 | Pubmed ID: 33573188 γ-Glutamyl Carboxylase Mutations Differentially Affect the Biological Function of Vitamin K-dependent Proteins Blood. 01, 2021 | Pubmed ID: 33507293 Functional Vitamin K Status and Risk of Incident Chronic Kidney Disease and Microalbuminuria: a Prospective General Population-based Cohort Study Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 12, 2021 | Pubmed ID: 33313895 Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification Via Increased Release of Grp78 (Glucose-Regulated Protein, 78 KDa)-Loaded Extracellular Vesicles Arteriosclerosis, Thrombosis, and Vascular Biology. 02, 2021 | Pubmed ID: 33297752 Reduced Vitamin K Status As a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019 Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 12, 2021 | Pubmed ID: 32852539 Combined Low Vitamin D and K Status Amplifies Mortality Risk: a Prospective Study European Journal of Nutrition. Apr, 2021 | Pubmed ID: 32808059 Locking and Loading the Bullet Against Micro-calcification European Journal of Preventive Cardiology. Apr, 2020 | Pubmed ID: 33611501 Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33585456 Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32754594 Intimal and Medial Calcification in Relation to Cardiovascular Risk Factors PloS One. 2020 | Pubmed ID: 32658909 Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug-Bug Interaction? Toxins. 05, 2020 | Pubmed ID: 32471179 Matrix Gla Protein is an Independent Predictor of Both Intimal and Medial Vascular Calcification in Chronic Kidney Disease Scientific Reports. 04, 2020 | Pubmed ID: 32313061 Early Vascular Ageing in Chronic Kidney Disease: Impact of Inflammation, Vitamin K, Senescence and Genomic Damage Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 03, 2020 | Pubmed ID: 32162665 Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease Journal of Clinical Medicine. Feb, 2020 | Pubmed ID: 32102408 Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population Frontiers in Nutrition. 2019 | Pubmed ID: 31921878 Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage Frontiers in Neurology. 2019 | Pubmed ID: 31920910 Pharmacological and Nutritional Modulation of Vascular Calcification Nutrients. Dec, 2019 | Pubmed ID: 31905884 A Combination of Seeds and Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity International Journal of Medical Sciences. 2019 | Pubmed ID: 31337958 Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice Scientific Reports. 03, 2019 | Pubmed ID: 30846818 The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K Frontiers in Cardiovascular Medicine. 2019 | Pubmed ID: 30805347 Vitamin K: Double Bonds Beyond Coagulation Insights into Differences Between Vitamin K1 and K2 in Health and Disease International Journal of Molecular Sciences. Feb, 2019 | Pubmed ID: 30791399 Annexin A1 As Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy Journal of Clinical Medicine. Jan, 2019 | Pubmed ID: 30682787 Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults Nutrients. Jan, 2019 | Pubmed ID: 30678199 Vitamin K Deficiency in Critical Ill Patients; a Prospective Observational Study Journal of Critical Care. 02, 2019 | Pubmed ID: 30415179 Target Identification for the Diagnosis and Intervention of Vulnerable Atherosclerotic Plaques Beyond F-fluorodeoxyglucose Positron Emission Tomography Imaging: Promising Tracers on the Horizon European Journal of Nuclear Medicine and Molecular Imaging. 01, 2019 | Pubmed ID: 30302506 Influence of PH and Phosphate Concentration on the Phosphate Binding Capacity of Five Contemporary Binders. An in Vitro Study Nephrology (Carlton, Vic.). Feb, 2019 | Pubmed ID: 29479762 Vitamin K Antagonists, Non-Vitamin K Antagonist Oral Anticoagulants, and Vascular Calcification in Patients with Atrial Fibrillation TH Open : Companion Journal to Thrombosis and Haemostasis. Oct, 2018 | Pubmed ID: 31249966 Missense Mutation of VKORC1 Leads to Medial Arterial Calcification in Rats Scientific Reports. 09, 2018 | Pubmed ID: 30214074 Renal Matrix Gla Protein Expression Increases Progressively with CKD and Predicts Renal Outcome Experimental and Molecular Pathology. 08, 2018 | Pubmed ID: 29981754 A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers Nutrients. Jun, 2018 | Pubmed ID: 29891757 Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study Nutrients. Jun, 2018 | Pubmed ID: 29882816 Ucma/GRP Inhibits Phosphate-induced Vascular Smooth Muscle Cell Calcification Via SMAD-dependent BMP Signalling Scientific Reports. 03, 2018 | Pubmed ID: 29563538 Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design Nutrients. Mar, 2018 | Pubmed ID: 29561783 Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients Nutrients. Jan, 2018 | Pubmed ID: 29303985 Calcific Aortic Valve Stenosis: Hard Disease in the Heart: A Biomolecular Approach Towards Diagnosis and Treatment European Heart Journal. 07, 2018 | Pubmed ID: 29136138 Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging Contrast Media & Molecular Imaging. 2017 | Pubmed ID: 29204107 Platelet Extracellular Vesicles Induce a Pro-inflammatory Smooth Muscle Cell Phenotype Journal of Extracellular Vesicles. 2017 | Pubmed ID: 28717419 Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study Circulation. 05, 2017 | Pubmed ID: 28533322 Does Statins Promote Vascular Calcification in Chronic Kidney Disease? European Journal of Clinical Investigation. Feb, 2017 | Pubmed ID: 28036114 Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice PloS One. 2016 | Pubmed ID: 27636705 What's in a Name? The Pharmacy of Vitamin K British Journal of Haematology. 09, 2016 | Pubmed ID: 26492096 New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs) Nutrients. Nov, 2015 | Pubmed ID: 26593943 Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis PloS One. 2015 | Pubmed ID: 26555788 Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial) Nutrients. Oct, 2015 | Pubmed ID: 26516910 High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification Nutrients. Aug, 2015 | Pubmed ID: 26295257 Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet PloS One. 2015 | Pubmed ID: 26090792 Prevention of Vasculopathy by Vitamin K Supplementation: Can We Turn Fiction into Fact? Atherosclerosis. May, 2015 | Pubmed ID: 25744701 Vascular Smooth Muscle Cell Calcification is Mediated by Regulated Exosome Secretion Circulation Research. Apr, 2015 | Pubmed ID: 25711438 Differential Cellular Effects of Old and New Oral Anticoagulants: Consequences to the Genesis and Progression of Atherosclerosis Thrombosis and Haemostasis. Nov, 2014 | Pubmed ID: 25298033 AnxA5 Reduces Plaque Inflammation of Advanced Atherosclerotic Lesions in ApoE(-/-) Mice Journal of Cellular and Molecular Medicine. Oct, 2014 | Pubmed ID: 25214012 The Realm of Vitamin K Dependent Proteins: Shifting from Coagulation Toward Calcification Molecular Nutrition & Food Research. Aug, 2014 | Pubmed ID: 24668744 Vitamin K: Key Vitamin in Controlling Vascular Calcification in Chronic Kidney Disease Kidney International. May, 2013 | Pubmed ID: 23633049 Vitamin K-dependent Carboxylation of Matrix Gla-protein: a Crucial Switch to Control Ectopic Mineralization Trends in Molecular Medicine. Apr, 2013 | Pubmed ID: 23375872 Mechanisms of Arterial Remodeling: Lessons from Genetic Diseases Frontiers in Genetics. 2012 | Pubmed ID: 23248645 Vitamin K Intake and Plasma Desphospho-uncarboxylated Matrix Gla-protein Levels in Kidney Transplant Recipients PloS One. 2012 | Pubmed ID: 23118917 Incorporation of Disulfide Containing Protein Modules into Multivalent Antigenic Conjugates: Generation of Antibodies Against the Thrombin-sensitive Region of Murine Protein S Journal of the American Chemical Society. Nov, 2012 | Pubmed ID: 23066897 Molecular Imaging to Identify the Vulnerable Plaque--from Basic Research to Clinical Practice Molecular Imaging and Biology. Oct, 2012 | Pubmed ID: 22983911 Vitamin K-antagonists Accelerate Atherosclerotic Calcification and Induce a Vulnerable Plaque Phenotype PloS One. 2012 | Pubmed ID: 22952653 Vitamin K Intake and Status Are Low in Hemodialysis Patients Kidney International. Sep, 2012 | Pubmed ID: 22648294 Low-dose Menaquinone-7 Supplementation Improved Extra-hepatic Vitamin K Status, but Had No Effect on Thrombin Generation in Healthy Subjects The British Journal of Nutrition. Nov, 2012 | Pubmed ID: 22289649 Association of Vitamin K Status with Adiponectin and Body Composition in Healthy Subjects: Uncarboxylated Osteocalcin is Not Associated with Fat Mass and Body Weight The British Journal of Nutrition. Sep, 2012 | Pubmed ID: 22136751 Patients Using Vitamin K Antagonists Show Increased Levels of Coronary Calcification: an Observational Study in Low-risk Atrial Fibrillation Patients European Heart Journal. Oct, 2011 | Pubmed ID: 21775389 Vitamin K Supplementation Increases Vitamin K Tissue Levels but Fails to Counteract Ectopic Calcification in a Mouse Model for Pseudoxanthoma Elasticum Journal of Molecular Medicine (Berlin, Germany). Nov, 2011 | Pubmed ID: 21725681 Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries The American Journal of Pathology. Jun, 2011 | Pubmed ID: 21531376 Circulating Nonphosphorylated Carboxylated Matrix Gla Protein Predicts Survival in ESRD Journal of the American Society of Nephrology : JASN. Feb, 2011 | Pubmed ID: 21289218 Arterial Calcifications Journal of Cellular and Molecular Medicine. Sep, 2010 | Pubmed ID: 20716128 Characterisation and Potential Diagnostic Value of Circulating Matrix Gla Protein (MGP) Species Thrombosis and Haemostasis. Oct, 2010 | Pubmed ID: 20694284 Calcium Scores and Matrix Gla Protein Levels: Association with Vitamin K Status European Journal of Clinical Investigation. Apr, 2010 | Pubmed ID: 20486996 The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein with Mortality in Coronary Artery Disease: the Heart and Soul Study Annals of Internal Medicine. May, 2010 | Pubmed ID: 20479029 Chronic Coumarin Treatment is Associated with Increased Extracoronary Arterial Calcification in Humans Blood. Jun, 2010 | Pubmed ID: 20354170 The Association of Uncarboxylated Matrix Gla Protein with Mitral Annular Calcification Differs by Diabetes Status: The Heart and Soul Study Atherosclerosis. May, 2010 | Pubmed ID: 20015492 Association of Kidney Function and Uncarboxylated Matrix Gla Protein: Data from the Heart and Soul Study Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. Jul, 2009 | Pubmed ID: 19204017 Uncarboxylated Matrix Gla Protein (ucMGP) is Associated with Coronary Artery Calcification in Haemodialysis Patients Thrombosis and Haemostasis. Feb, 2009 | Pubmed ID: 19190822 Matrix Gla-protein: the Calcification Inhibitor in Need of Vitamin K Thrombosis and Haemostasis. Oct, 2008 | Pubmed ID: 18841280 Anticoagulant Effect of Dietary Fish Oil in Hyperlipidemia: a Study of Hepatic Gene Expression in APOE2 Knock-in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2008 | Pubmed ID: 18757293 The Circulating Inactive Form of Matrix Gla Protein (ucMGP) As a Biomarker for Cardiovascular Calcification Journal of Vascular Research. 2008 | Pubmed ID: 18401181 Regression of Warfarin-induced Medial Elastocalcinosis by High Intake of Vitamin K in Rats Blood. Apr, 2007 | Pubmed ID: 17138823 Novel Conformation-specific Antibodies Against Matrix Gamma-carboxyglutamic Acid (Gla) Protein: Undercarboxylated Matrix Gla Protein As Marker for Vascular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2005 | Pubmed ID: 15961706 Characteristics and Performance of an Immunosorbent Assay for Human Matrix Gla-protein Clinica Chimica Acta; International Journal of Clinical Chemistry. Jan, 2005 | Pubmed ID: 15563881 Novel Effects of Diets Enriched with Corn Oil or with an Olive Oil/sunflower Oil Mixture on Vitamin K Metabolism and Vitamin K-dependent Proteins in Young Men Journal of Lipid Research. Jun, 2002 | Pubmed ID: 12032162 Differential Lipoprotein Transport Pathways of K-vitamins in Healthy Subjects Biochimica Et Biophysica Acta. Feb, 2002 | Pubmed ID: 11960685 विट्रो में कैल्शियम जमाव की मात्रा निर्धारित करने के लिए एक अर्ध-स्वचालित और प्रतिलिपि प्रस्तुत करने योग्य जैविक-आधारित विधि Armand M. G. Jaminon*1, Nikolas Rapp*1, Asim C. Akbulut1, Robert Dzhanaev2, Chris P. Reutelingsperger1, Willi Jahnen-Dechent2, Leon J. Schurgers1,3 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 2Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 3Institute of Experimental Medicine and Systems Biology, RWTH Aachen University JoVE 64029 Biochemistry
विट्रो में कैल्शियम जमाव की मात्रा निर्धारित करने के लिए एक अर्ध-स्वचालित और प्रतिलिपि प्रस्तुत करने योग्य जैविक-आधारित विधि Armand M. G. Jaminon*1, Nikolas Rapp*1, Asim C. Akbulut1, Robert Dzhanaev2, Chris P. Reutelingsperger1, Willi Jahnen-Dechent2, Leon J. Schurgers1,3 1Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 2Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, 3Institute of Experimental Medicine and Systems Biology, RWTH Aachen University JoVE 64029 Biochemistry
