Lorne Zinman Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Biography Publications Institution JoVE Articles Lorne Zinman has not added a biography. If you are Lorne Zinman and would like to personalize this page please email our Author Liaison for assistance. Publications Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 Clinical Reasoning: A 42-year-old Man with Unilateral Leg Weakness Neurology. Mar, 2018 | Pubmed ID: 29555890 Downregulation of Exosomal MiR-204-5p and MiR-632 As a Biomarker for FTD: a GENFI Study Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2018 | Pubmed ID: 29434051 Motor Unit Number Index and Neurophysiological Index As Candidate Biomarkers of Presymptomatic Motor Neuron Loss in Amyotrophic Lateral Sclerosis Muscle & Nerve. Jan, 2018 | Pubmed ID: 29381812 Unaffected Mosaiccase: RNA Foci, Dipeptide Proteins, but Upregulated C9orf72 Expression Neurology. Jan, 2018 | Pubmed ID: 29282338 Loss of CHCHD10-CHCHD2 Complexes Required for Respiration Underlies the Pathogenicity of a CHCHD10 Mutation in ALS Human Molecular Genetics. Jan, 2018 | Pubmed ID: 29121267 Clinical and Neuropathological Features of ALS/FTD with TIA1 Mutations Acta Neuropathologica Communications. Dec, 2017 | Pubmed ID: 29216908 Neuroleptics As Therapeutic Compounds Stabilizing Neuromuscular Transmission in Amyotrophic Lateral Sclerosis JCI Insight. Nov, 2017 | Pubmed ID: 29202456 Dysregulation of Chromatin Remodelling Complexes in Amyotrophic Lateral Sclerosis Human Molecular Genetics. Nov, 2017 | Pubmed ID: 28973294 TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics Neuron. Aug, 2017 | Pubmed ID: 28817800 Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI) Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28671116 DNA Methylation Age-acceleration is Associated with Disease Duration and Age at Onset in C9orf72 Patients Acta Neuropathologica. Aug, 2017 | Pubmed ID: 28439722 Speech Movement Measures As Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis Journal of Speech, Language, and Hearing Research : JSLHR. Oct, 2016 | Pubmed ID: 27679842 Physician-assisted Death: A Canada-wide Survey of ALS Health Care Providers Neurology. Sep, 2016 | Pubmed ID: 27178703 Genetic and Epigenetic Study of ALS-discordant Identical Twins with Double Mutations in SOD1 and ARHGEF28 Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2016 | Pubmed ID: 27154192 Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems PloS One. 2016 | Pubmed ID: 27148967 C9orf72 Isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration Brain Research. 09, 2016 | Pubmed ID: 27134035 Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) PloS One. 2016 | Pubmed ID: 26789001 MTHFSD and DDX58 Are Novel RNA-binding Proteins Abnormally Regulated in Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Jan, 2016 | Pubmed ID: 26525917 Isoform-specific Antibodies Reveal Distinct Subcellular Localizations of C9orf72 in Amyotrophic Lateral Sclerosis Annals of Neurology. Oct, 2015 | Pubmed ID: 26174152 Jump from Pre-mutation to Pathologic Expansion in C9orf72 American Journal of Human Genetics. Jun, 2015 | Pubmed ID: 26004200 Mutation Analysis of CHCHD10 in Different Neurodegenerative Diseases Brain : a Journal of Neurology. Sep, 2015 | Pubmed ID: 25833818 Low Molecular Weight Species of TDP-43 Generated by Abnormal Splicing Form Inclusions in Amyotrophic Lateral Sclerosis and Result in Motor Neuron Death Acta Neuropathologica. Jul, 2015 | Pubmed ID: 25788357 The C9orf72 Repeat Expansion Itself is Methylated in ALS and FTLD Patients Acta Neuropathologica. May, 2015 | Pubmed ID: 25716178 Electrical Impedance Myography in the Evaluation of the Tongue Musculature in Amyotrophic Lateral Sclerosis Muscle & Nerve. Oct, 2015 | Pubmed ID: 25580728 Mutation Analysis of Patients with Neurodegenerative Disorders Using NeuroX Array Neurobiology of Aging. Jan, 2015 | Pubmed ID: 25174650 Identical Twins with the C9orf72 Repeat Expansion Are Discordant for ALS Neurology. Oct, 2014 | Pubmed ID: 25209579 Economic Burden of Amyotrophic Lateral Sclerosis: a Canadian Study of Out-of-pocket Expenses Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Sep, 2014 | Pubmed ID: 25025935 Hypermethylation of the CpG-island Near the C9orf72 G₄C₂-repeat Expansion in FTLD Patients Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24908669 Venous Thromboembolism in Amyotrophic Lateral Sclerosis: a Prospective Study Neurology. May, 2014 | Pubmed ID: 24727309 Mutations in the Matrin 3 Gene Cause Familial Amyotrophic Lateral Sclerosis Nature Neuroscience. May, 2014 | Pubmed ID: 24686783 Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics Journal of Medical Speech-language Pathology. Mar, 2013 | Pubmed ID: 27453680 Bulbar and Speech Motor Assessment in ALS: Challenges and Future Directions Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Jul, 2013 | Pubmed ID: 23898888 Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion American Journal of Human Genetics. Jun, 2013 | Pubmed ID: 23731538 Mortality Associated with Periodic Limb Movements During Sleep in Amyotrophic Lateral Sclerosis Patients Einstein (Sao Paulo, Brazil). Oct-Dec, 2012 | Pubmed ID: 23386081 Enhancing Clinical Trials in Neurodegenerative Disorders: Lessons from Amyotrophic Lateral Sclerosis Current Opinion in Neurology. Dec, 2012 | Pubmed ID: 23160423 Enquête De C9orf72 Dans Les Troubles Neurodégénératifs 4 Archives of Neurology. Sep, 2012 | Pubmed ID: 22964832 Tongue Movements and Their Acoustic Consequences in Amyotrophic Lateral Sclerosis Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP). 2012 | Pubmed ID: 22555651 Une Expansion De Répétitions De Hexanucléotide Dans C9ORF72 Est La Cause Du Chromosome 9p21 Lié SLA-DFT Neuron. Oct, 2011 | Pubmed ID: 21944779 Myopathie Paraspinal Avec Novel éclat Semblable à Agrégats Compacts De Minces Filaments Muscle & Nerve. Jul, 2011 | Pubmed ID: 21660984 Hétérogénéité Pathologique Dans La Sclérose Latérale Amyotrophique à Des Mutations Du FUS: Deux Modèles Distincts Corrélation Avec La Sévérité De La Maladie Et De Mutation Acta Neuropathologica. Jul, 2011 | Pubmed ID: 21604077 Cibles Des Traitements Avancés Et Dans La Sclérose Latérale Amyotrophique Lancet Neurology. May, 2011 | Pubmed ID: 21511200 Cibles D'ARN De TDP-43 Identifié Par UV-CLIP Sont Déréglementés Dans La SLA Molecular and Cellular Neurosciences. Jul, 2011 | Pubmed ID: 21421050 Distinct Signatures Biochimiques Caractériser Peripherin Isoform Expression Dans Les Deux Lésions Neuronales Traumatique Et Maladie Du Motoneurone Journal of Neurochemistry. Aug, 2010 | Pubmed ID: 20533992 Sécurité Et Efficacité Du Lithium En Association Avec Le Riluzole Pour Le Traitement De La Sclérose Latérale Amyotrophique: Un Randomisée, En Double Aveugle, Contrôlée Contre Placebo Lancet Neurology. May, 2010 | Pubmed ID: 20363190 La Ventilation Non Invasive Pour Les Patients Canadiens Atteints De La SLA: Ne Nous Avons Un Consensus? The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Jan, 2010 | Pubmed ID: 20169767 La Sclérose Latérale Amyotrophique Est Une Maladie Non-amyloïde, Dans Laquelle Misfolding étendue De La SOD1 Est Unique à La Forme Familiale Acta Neuropathologica. Mar, 2010 | Pubmed ID: 20111867 Cinématique De Progression De La Maladie Bulbaire Journal of Communication Disorders. Jan-Feb, 2010 | Pubmed ID: 19683250 Sécurité Sur La Vaccination Antigrippale Chez Les Patients Atteints De Myasthénie Grave: Une étude Basée Sur La Population Muscle & Nerve. Dec, 2009 | Pubmed ID: 19902540 Manque De Preuves D'un Monomère / Mal Repliées Superoxyde Dismutase-1 Dans La Sclérose Latérale Amyotrophique Annals of Neurology. Jul, 2009 | Pubmed ID: 19670443 Sont Des Médicaments à Base De Statine Sécurité Chez Les Patients Atteints De La SLA? Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. Aug, 2008 | Pubmed ID: 18608105 Traitement Par IgIV Pour La Myasthénie Grave: L'efficacité, La Prescription Et De Nouvelles Stratégies Thérapeutiques Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567877 Surrogate Mesures Des Résultats Thérapeutiques Chez Les Patients Atteints De Myasthénie Muscle & Nerve. Feb, 2008 | Pubmed ID: 17918748 Les études Génétiques De GRN Et IFT74 Dans La Sclérose Latérale Amyotrophique Neurobiology of Aging. Aug, 2008 | Pubmed ID: 17383054 Evidence That TDP-43 N'est Pas La Cible Majeure Ubiquitinée Dans Les Inclusions Pathologiques De La Sclérose Latérale Amyotrophique Journal of Neuropathology and Experimental Neurology. Dec, 2007 | Pubmed ID: 18090923 Immunoglobulines IV Chez Les Patients Atteints De Myasthénie Grave: Un Essai Contrôlé Randomisé Neurology. Mar, 2007 | Pubmed ID: 17353471 Sensibilité Des Répétitive Facial-stimulation Nerveuse Chez Les Patients Atteints De Myasthénie Muscle & Nerve. May, 2006 | Pubmed ID: 16421884 Refroidissement Seuils De Détection Dans L'évaluation De La Polyneuropathie Diabétique Sensorielle: Comparaison Des CAS IV Et Du Médoc Instruments Diabetes Care. Jul, 2004 | Pubmed ID: 15220245 Traitement Au Laser à Faible Intensité Pour Les Symptômes Douloureux De Diabétique De Polyneuropathie Sensitivo: Un Essai Contrôlé Diabetes Care. Apr, 2004 | Pubmed ID: 15047649 Ciblé le séquençage Next-generation et bioinformatique Pipeline afin d’évaluer les déterminants génétiques de la maladie constitutionnelle Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetics Un protocole pour l'évaluation globale de la dysfonction bulbaire de la sclérose latérale amyotrophique (SLA) Yana Yunusova1,2, Jordan R. Green3, Jun Wang3, Gary Pattee4, Lorne Zinman2,5 1Department of Speech-Language Pathology, University of Toronto, 2ALS/ MN Clinic, Sunnybrook Health Science Centre, 3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center, 5Department of Neurology, University of Toronto JoVE 2422 Medicine
Ciblé le séquençage Next-generation et bioinformatique Pipeline afin d’évaluer les déterminants génétiques de la maladie constitutionnelle Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetics
Un protocole pour l'évaluation globale de la dysfonction bulbaire de la sclérose latérale amyotrophique (SLA) Yana Yunusova1,2, Jordan R. Green3, Jun Wang3, Gary Pattee4, Lorne Zinman2,5 1Department of Speech-Language Pathology, University of Toronto, 2ALS/ MN Clinic, Sunnybrook Health Science Centre, 3Department of Special Education and Communication Disorders, University of Nebraska-Lincoln, 4Department of Neurology, Munroe-Meyer Institute, University of Nebraska Medical Center, 5Department of Neurology, University of Toronto JoVE 2422 Medicine