Lynn W. Enquist Department of Molecular Biology Princeton University Biography Publications Institution JoVE Articles Lynn W. Enquist has not added a biography. If you are Lynn W. Enquist and would like to personalize this page please email our Author Liaison for assistance. Publications Introduction: A New Coronavirus Emerges, This Time Causing a Pandemic Annual Review of Virology. Apr, 2020 | Pubmed ID: 32315256 The Neuropathic Itch Caused by Pseudorabies Virus Pathogens (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32244386 Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A Journal of Virology. Apr, 2020 | Pubmed ID: 32075931 A Kinesin-3 Recruitment Complex Facilitates Axonal Sorting of Enveloped Alpha Herpesvirus Capsids PLoS Pathogens. 01, 2020 | Pubmed ID: 31995633 The Round Trip Model for Severe Herpes Zoster Caused by Live Attenuated Varicella Vaccine Virus Journal of Medical Virology. Jan, 2020 | Pubmed ID: 31943220 Alphaherpesvirus Infection of Mice Primes PNS Neurons to an Inflammatory State Regulated by TLR2 and Type I IFN Signaling PLoS Pathogens. 11, 2019 | Pubmed ID: 31675371 Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity American Journal of Respiratory and Critical Care Medicine. Mar, 2019 | Pubmed ID: 30309268 Reductio Ad Intellectum Annual Review of Virology. 09, 2018 | Pubmed ID: 30265630 Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice Journal of Virology. 12, 2018 | Pubmed ID: 30258005 Characterization of the Neuroinvasive Profile of a Pseudorabies Virus Recombinant Expressing the MTurquoise2 Reporter in Single and Multiple Injection Experiments Journal of Neuroscience Methods. 10, 2018 | Pubmed ID: 30098326 Retrograde Axonal Transport of Rabies Virus is Unaffected by Interferon Treatment but Blocked by Emetine Locally in Axons PLoS Pathogens. 07, 2018 | Pubmed ID: 30028873 Latent Versus Productive Infection: the Alpha Herpesvirus Switch Future Virology. May, 2018 | Pubmed ID: 29967651 Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26 Journal of Virology. 01, 2018 | Pubmed ID: 29046447 Compartmented Neuronal Cultures Reveal Two Distinct Mechanisms for Alpha Herpesvirus Escape from Genome Silencing PLoS Pathogens. Oct, 2017 | Pubmed ID: 29073268 Gene Expression Profiling with Cre-Conditional Pseudorabies Virus Reveals a Subset of Midbrain Neurons That Participate in Reward Circuitry The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2017 | Pubmed ID: 28283558 Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses Journal of Virology. Jan, 2017 | Pubmed ID: 27795407 Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix Matrix Biology : Journal of the International Society for Matrix Biology. 07, 2017 | Pubmed ID: 27641621 Dual-Color Herpesvirus Capsids Discriminate Inoculum from Progeny and Reveal Axonal Transport Dynamics Journal of Virology. Nov, 2016 | Pubmed ID: 27581973 Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms MBio. 06, 2016 | Pubmed ID: 27273828 HSV-1 ICP27 Targets the TBK1-activated STING Signalsome to Inhibit Virus-induced Type I IFN expression The EMBO Journal. 07, 2016 | Pubmed ID: 27234299 The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions Diabetes. 09, 2016 | Pubmed ID: 27207534 The Diffusive Way Out: Herpesviruses Remodel the Host Nucleus, Enabling Capsids to Access the Inner Nuclear Membrane Nucleus (Austin, Tex.). 2016 | Pubmed ID: 26889771 Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion MBio. Feb, 2016 | Pubmed ID: 26838720 3D Printed Nervous System on a Chip Lab on a Chip. Apr, 2016 | Pubmed ID: 26669842 Defensive Perimeter in the Central Nervous System: Predominance of Astrocytes and Astrogliosis During Recovery from Varicella-Zoster Virus Encephalitis Journal of Virology. 01, 2016 | Pubmed ID: 26491149 3D Printed Anatomical Nerve Regeneration Pathways Advanced Functional Materials. Oct, 2015 | Pubmed ID: 26924958 Structural Basis of Vesicle Formation at the Inner Nuclear Membrane Cell. Dec, 2015 | Pubmed ID: 26687357 Fluorescent Protein Approaches in Alpha Herpesvirus Research Viruses. Nov, 2015 | Pubmed ID: 26610544 Open LED Illuminator: A Simple and Inexpensive LED Illuminator for Fast Multicolor Particle Tracking in Neurons PloS One. 2015 | Pubmed ID: 26600461 The Big ASM Tent: How to Represent the Microbial Sciences? MBio. Oct, 2015 | Pubmed ID: 26463168 Remodeling Nuclear Architecture Allows Efficient Transport of Herpesvirus Capsids by Diffusion Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26438852 The Number of Alphaherpesvirus Particles Infecting Axons and the Axonal Protein Repertoire Determines the Outcome of Neuronal Infection MBio. Mar, 2015 | Pubmed ID: 25805728 Investigating the Biology of Alpha Herpesviruses with MS-based Proteomics Proteomics. Jun, 2015 | Pubmed ID: 25764121 Axonal Spread of Neuroinvasive Viral Infections Trends in Microbiology. May, 2015 | Pubmed ID: 25639651 The Neuroinvasive Profiles of H129 (herpes Simplex Virus Type 1) Recombinants with Putative Anterograde-only Transneuronal Spread Properties Brain Structure & Function. 2015 | Pubmed ID: 24585022 Cellular Mechanisms of Alpha Herpesvirus Egress: Live Cell Fluorescence Microscopy of Pseudorabies Virus Exocytosis PLoS Pathogens. Dec, 2014 | Pubmed ID: 25474634 Characterization of a Replication-incompetent Pseudorabies Virus Mutant Lacking the Sole Immediate Early Gene IE180 MBio. Nov, 2014 | Pubmed ID: 25389174 Nuclear Herpesvirus Capsid Motility is Not Dependent on F-actin MBio. Oct, 2014 | Pubmed ID: 25293761 Long-term Cre-mediated Retrograde Tagging of Neurons Using a Novel Recombinant Pseudorabies Virus Frontiers in Neuroanatomy. 2014 | Pubmed ID: 25232307 Transneuronal Circuit Analysis with Pseudorabies Viruses Current Protocols in Neuroscience. Jul, 2014 | Pubmed ID: 24984685 Evolution and Diversity in Human Herpes Simplex Virus Genomes Journal of Virology. Jan, 2014 | Pubmed ID: 24227835 In Vivo Imaging of Alphaherpesvirus Infection Reveals Synchronized Activity Dependent on Axonal Sorting of Viral Proteins Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23980169 Fast GCaMPs for Improved Tracking of Neuronal Activity Nature Communications. Jul, 2013 | Pubmed ID: 23863808 Glycoproteins GE and GI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons Journal of Virology. Sep, 2013 | Pubmed ID: 23804637 Imaging the Transport Dynamics of Single Alphaherpesvirus Particles in Intact Peripheral Nervous System Explants from Infected Mice MBio. 2013 | Pubmed ID: 23736287 Virus Infections in the Nervous System Cell Host & Microbe. Apr, 2013 | Pubmed ID: 23601101 Role of Us9 Phosphorylation in Axonal Sorting and Anterograde Transport of Pseudorabies Virus PloS One. 2013 | Pubmed ID: 23527020 Directional Spread of Alphaherpesviruses in the Nervous System Viruses. Feb, 2013 | Pubmed ID: 23435239 Efficient Retrograde Transport of Pseudorabies Virus Within Neurons Requires Local Protein Synthesis in Axons Cell Host & Microbe. Jan, 2013 | Pubmed ID: 23332155 Kinesin-3 Mediates Axonal Sorting and Directional Transport of Alphaherpesvirus Particles in Neurons Cell Host & Microbe. Dec, 2012 | Pubmed ID: 23245325 Alphaherpesvirus Axon-to-cell Spread Involves Limited Virion Transmission Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23027939 Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons Cell Host & Microbe. May, 2012 | Pubmed ID: 22607803 複雑な神経回路における担保ニューロンへの見通しを識別するために重感染オーエスキーウイルス付きレポーターのアプローチ PloS One. 2011 | Pubmed ID: 21698154 単純ヘルペスウイルス1 PUL34は、ウイルス複製における役割に加えてウイルスの細胞間拡散において重要な役割を果たしている単純 Journal of Virology. Jul, 2011 | Pubmed ID: 21561917 ウイルス感染時のアクチン細胞骨格の転覆 Nature Reviews. Microbiology. Jun, 2011 | Pubmed ID: 21522191 Brainbowヘルペスウイルスから条件レポーター発現によるニューラルネットワークの顕微解剖 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21292985 Brainbowカセットを運ぶヘルペスウイルスは着信ゲノムの限られた数の複製と発現を明らかに Nature Communications. 2010 | Pubmed ID: 21266996 Alphaherpesvirus感染に共通する神経応答 Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Sep, 2010 | Pubmed ID: 20401540 回線トレース仮性狂犬病ウイルスを用いたin Vivoにおける神経回路のカルシウムイメージング Cold Spring Harbor Protocols. Apr, 2010 | Pubmed ID: 20360364 仮性狂犬病ウイルス感染は、in Vitroでの神経活動との接続を変更します。 PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876391 回線トレース仮性狂犬病ウイルスを用いたin Vivo神経活動での蛍光ベースの監視 PloS One. 2009 | Pubmed ID: 19742327 仮性狂犬病ウイルスのビリオンに取り込まれた糖タンパク質Bの仲介transneuronalなスプレッド Journal of Virology. Aug, 2009 | Pubmed ID: 19494011 21世紀のウイルス学 Journal of Virology. Jun, 2009 | Pubmed ID: 19297504 条件付きウイルスtransneuronalなトレースによって明らかにされたセロトニン作動性ニューロンへの入力 The Journal of Comparative Neurology. May, 2009 | Pubmed ID: 19274668 ホスト細胞骨格とヘルペスウイルスの相互作用 Journal of Virology. Mar, 2009 | Pubmed ID: 18842724 軸索に仮性狂犬病ウイルス構造タンパク質の標的は、脂質ラフトとウイルスUS9タンパク質の協会が必要です PLoS Pathogens. May, 2008 | Pubmed ID: 18483549 α-ヘルペスウイルス感染症は、核アクチンフィラメントの形成を誘導する PLoS Pathogens. Aug, 2006 | Pubmed ID: 16933992 強毒と弱毒オーエスキーウイルスに感染した齧歯類の脳のトランスクリプトームの署名 Journal of Virology. Feb, 2006 | Pubmed ID: 16439534 UL54-ヌルオーエスウイルスは、マウスにおける弱毒であるが、生産性の培養細胞に感染する Journal of Virology. Jan, 2006 | Pubmed ID: 16378979 単純ヘルペスウイルス1型糖蛋白Eは軸索キャプシドのローカリゼーション、テグメント、及び膜糖タンパク質が必要です単純 Journal of Virology. Nov, 2005 | Pubmed ID: 16227258 オーエスキーウイルスゲノムの完全な注釈付きシーケンス Journal of Virology. Jan, 2004 | Pubmed ID: 14671123 回路解析のための神経向性ウイルスの使用における最近の進歩 Current Opinion in Neurobiology. Oct, 2003 | Pubmed ID: 14630225 交感神経モータ回路の脳幹基板は、仮性狂犬病ウイルス組換え体とトランスシナプスのトレースを使用して識別 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2003 | Pubmed ID: 12805305 軸索からAlphaherpesvirusのin Vivo出口で Journal of Virology. Aug, 2002 | Pubmed ID: 12134036 エンベロープ糖タンパク質仮性狂犬病ウイルスのEとMとの主なテグメント·タンパク質UL49間の物理的相互作用 Journal of Virology. Aug, 2002 | Pubmed ID: 12134026 仮性狂犬病ウイルスの糖蛋白Bの細胞質尾部のチロシンベースのMotifは、ウイルス糖タンパク質の抗体誘導性の内部化と効率的な細胞間拡散の両方に重要です Journal of Virology. Jul, 2002 | Pubmed ID: 12050399 のみ逆行性経シナプス輸送による自律回路を介してハムスター視交叉上核の感染で弱毒オーエスキーウイルスPRVバーサ結果の硝子体内注射 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2002 | Pubmed ID: 11923435 二倍体TRL/IRL13遺伝子のヒトサイトメガロウイルスゲノムと変異を含む自己切除可能細菌人工染色体の構築 Journal of Virology. Mar, 2002 | Pubmed ID: 11836410 ヘルペスウイルスは、感覚ニューロンに広がるように双方向の高速軸索輸送を使用します。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2001 | Pubmed ID: 11248101 Pseudorabies Virus Expressing Enhanced Green Fluorescent Protein: A Tool for in Vitro Electrophysiological Analysis of Transsynaptically Labeled Neurons in Identified Central Nervous System Circuits Proceedings of the National Academy of Sciences of the United States of America. Aug, 2000 | Pubmed ID: 10922076 A Self-recombining Bacterial Artificial Chromosome and Its Application for Analysis of Herpesvirus Pathogenesis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2000 | Pubmed ID: 10781094 Directional Transneuronal Infection by Pseudorabies Virus is Dependent on an Acidic Internalization Motif in the Us9 Cytoplasmic Tail Journal of Virology. May, 2000 | Pubmed ID: 10775591 ビリオン形成におけるオーエスキーウイルス糖蛋白質Eの細胞質尾部の役割 Journal of Virology. May, 2000 | Pubmed ID: 10756012 Circuit-specific Coinfection of Neurons in the Rat Central Nervous System with Two Pseudorabies Virus Recombinants Journal of Virology. Nov, 1999 | Pubmed ID: 10516061 Construction and Transposon Mutagenesis in Escherichia Coli of a Full-length Infectious Clone of Pseudorabies Virus, an Alphaherpesvirus Journal of Virology. Aug, 1999 | Pubmed ID: 10400733 Pseudorabies Virus-induced Leukocyte Trafficking into the Rat Central Nervous System Journal of Virology. Nov, 1998 | Pubmed ID: 9765465 Different Patterns of Neuronal Infection After Intracerebral Injection of Two Strains of Pseudorabies Virus Journal of Virology. May, 1998 | Pubmed ID: 9557737 Interconnected Parallel Circuits Between Rat Nucleus Accumbens and Thalamus Revealed by Retrograde Transynaptic Transport of Pseudorabies Virus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 1997 | Pubmed ID: 9045740 Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in the CNS Molecular Therapy. Methods & Clinical Development. | Pubmed ID: 32368565 ウイルス誘導神経炎症反応を研究するマウスフットパッド接種モデル Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunology and Infection
ウイルス誘導神経炎症反応を研究するマウスフットパッド接種モデル Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunology and Infection