Lynn W. Enquist Department of Molecular Biology Princeton University Biography Publications Institution JoVE Articles Lynn W. Enquist has not added a biography. If you are Lynn W. Enquist and would like to personalize this page please email our Author Liaison for assistance. Publications Introduction: A New Coronavirus Emerges, This Time Causing a Pandemic Annual Review of Virology. Apr, 2020 | Pubmed ID: 32315256 The Neuropathic Itch Caused by Pseudorabies Virus Pathogens (Basel, Switzerland). Mar, 2020 | Pubmed ID: 32244386 Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A Journal of Virology. Apr, 2020 | Pubmed ID: 32075931 A Kinesin-3 Recruitment Complex Facilitates Axonal Sorting of Enveloped Alpha Herpesvirus Capsids PLoS Pathogens. 01, 2020 | Pubmed ID: 31995633 The Round Trip Model for Severe Herpes Zoster Caused by Live Attenuated Varicella Vaccine Virus Journal of Medical Virology. Jan, 2020 | Pubmed ID: 31943220 Alphaherpesvirus Infection of Mice Primes PNS Neurons to an Inflammatory State Regulated by TLR2 and Type I IFN Signaling PLoS Pathogens. 11, 2019 | Pubmed ID: 31675371 Intranasal Leptin Relieves Sleep-disordered Breathing in Mice with Diet-induced Obesity American Journal of Respiratory and Critical Care Medicine. Mar, 2019 | Pubmed ID: 30309268 Reductio Ad Intellectum Annual Review of Virology. 09, 2018 | Pubmed ID: 30265630 Virulent Pseudorabies Virus Infection Induces a Specific and Lethal Systemic Inflammatory Response in Mice Journal of Virology. 12, 2018 | Pubmed ID: 30258005 Characterization of the Neuroinvasive Profile of a Pseudorabies Virus Recombinant Expressing the MTurquoise2 Reporter in Single and Multiple Injection Experiments Journal of Neuroscience Methods. 10, 2018 | Pubmed ID: 30098326 Retrograde Axonal Transport of Rabies Virus is Unaffected by Interferon Treatment but Blocked by Emetine Locally in Axons PLoS Pathogens. 07, 2018 | Pubmed ID: 30028873 Latent Versus Productive Infection: the Alpha Herpesvirus Switch Future Virology. May, 2018 | Pubmed ID: 29967651 Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26 Journal of Virology. 01, 2018 | Pubmed ID: 29046447 Compartmented Neuronal Cultures Reveal Two Distinct Mechanisms for Alpha Herpesvirus Escape from Genome Silencing PLoS Pathogens. Oct, 2017 | Pubmed ID: 29073268 Gene Expression Profiling with Cre-Conditional Pseudorabies Virus Reveals a Subset of Midbrain Neurons That Participate in Reward Circuitry The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 04, 2017 | Pubmed ID: 28283558 Intrinsic and Innate Defenses of Neurons: Détente with the Herpesviruses Journal of Virology. Jan, 2017 | Pubmed ID: 27795407 Nerve Guidance by a Decellularized Fibroblast Extracellular Matrix Matrix Biology : Journal of the International Society for Matrix Biology. 07, 2017 | Pubmed ID: 27641621 Dual-Color Herpesvirus Capsids Discriminate Inoculum from Progeny and Reveal Axonal Transport Dynamics Journal of Virology. Nov, 2016 | Pubmed ID: 27581973 Exocytosis of Alphaherpesvirus Virions, Light Particles, and Glycoproteins Uses Constitutive Secretory Mechanisms MBio. 06, 2016 | Pubmed ID: 27273828 HSV-1 ICP27 Targets the TBK1-activated STING Signalsome to Inhibit Virus-induced Type I IFN expression The EMBO Journal. 07, 2016 | Pubmed ID: 27234299 The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions Diabetes. 09, 2016 | Pubmed ID: 27207534 The Diffusive Way Out: Herpesviruses Remodel the Host Nucleus, Enabling Capsids to Access the Inner Nuclear Membrane Nucleus (Austin, Tex.). 2016 | Pubmed ID: 26889771 Two Modes of the Axonal Interferon Response Limit Alphaherpesvirus Neuroinvasion MBio. Feb, 2016 | Pubmed ID: 26838720 3D Printed Nervous System on a Chip Lab on a Chip. Apr, 2016 | Pubmed ID: 26669842 Defensive Perimeter in the Central Nervous System: Predominance of Astrocytes and Astrogliosis During Recovery from Varicella-Zoster Virus Encephalitis Journal of Virology. 01, 2016 | Pubmed ID: 26491149 3D Printed Anatomical Nerve Regeneration Pathways Advanced Functional Materials. Oct, 2015 | Pubmed ID: 26924958 Structural Basis of Vesicle Formation at the Inner Nuclear Membrane Cell. Dec, 2015 | Pubmed ID: 26687357 Fluorescent Protein Approaches in Alpha Herpesvirus Research Viruses. Nov, 2015 | Pubmed ID: 26610544 Open LED Illuminator: A Simple and Inexpensive LED Illuminator for Fast Multicolor Particle Tracking in Neurons PloS One. 2015 | Pubmed ID: 26600461 The Big ASM Tent: How to Represent the Microbial Sciences? MBio. Oct, 2015 | Pubmed ID: 26463168 Remodeling Nuclear Architecture Allows Efficient Transport of Herpesvirus Capsids by Diffusion Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26438852 The Number of Alphaherpesvirus Particles Infecting Axons and the Axonal Protein Repertoire Determines the Outcome of Neuronal Infection MBio. Mar, 2015 | Pubmed ID: 25805728 Investigating the Biology of Alpha Herpesviruses with MS-based Proteomics Proteomics. Jun, 2015 | Pubmed ID: 25764121 Axonal Spread of Neuroinvasive Viral Infections Trends in Microbiology. May, 2015 | Pubmed ID: 25639651 The Neuroinvasive Profiles of H129 (herpes Simplex Virus Type 1) Recombinants with Putative Anterograde-only Transneuronal Spread Properties Brain Structure & Function. 2015 | Pubmed ID: 24585022 Cellular Mechanisms of Alpha Herpesvirus Egress: Live Cell Fluorescence Microscopy of Pseudorabies Virus Exocytosis PLoS Pathogens. Dec, 2014 | Pubmed ID: 25474634 Characterization of a Replication-incompetent Pseudorabies Virus Mutant Lacking the Sole Immediate Early Gene IE180 MBio. Nov, 2014 | Pubmed ID: 25389174 Nuclear Herpesvirus Capsid Motility is Not Dependent on F-actin MBio. Oct, 2014 | Pubmed ID: 25293761 Long-term Cre-mediated Retrograde Tagging of Neurons Using a Novel Recombinant Pseudorabies Virus Frontiers in Neuroanatomy. 2014 | Pubmed ID: 25232307 Transneuronal Circuit Analysis with Pseudorabies Viruses Current Protocols in Neuroscience. Jul, 2014 | Pubmed ID: 24984685 Evolution and Diversity in Human Herpes Simplex Virus Genomes Journal of Virology. Jan, 2014 | Pubmed ID: 24227835 In Vivo Imaging of Alphaherpesvirus Infection Reveals Synchronized Activity Dependent on Axonal Sorting of Viral Proteins Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23980169 Fast GCaMPs for Improved Tracking of Neuronal Activity Nature Communications. Jul, 2013 | Pubmed ID: 23863808 Glycoproteins GE and GI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons Journal of Virology. Sep, 2013 | Pubmed ID: 23804637 Imaging the Transport Dynamics of Single Alphaherpesvirus Particles in Intact Peripheral Nervous System Explants from Infected Mice MBio. 2013 | Pubmed ID: 23736287 Virus Infections in the Nervous System Cell Host & Microbe. Apr, 2013 | Pubmed ID: 23601101 Role of Us9 Phosphorylation in Axonal Sorting and Anterograde Transport of Pseudorabies Virus PloS One. 2013 | Pubmed ID: 23527020 Directional Spread of Alphaherpesviruses in the Nervous System Viruses. Feb, 2013 | Pubmed ID: 23435239 Efficient Retrograde Transport of Pseudorabies Virus Within Neurons Requires Local Protein Synthesis in Axons Cell Host & Microbe. Jan, 2013 | Pubmed ID: 23332155 Kinesin-3 Mediates Axonal Sorting and Directional Transport of Alphaherpesvirus Particles in Neurons Cell Host & Microbe. Dec, 2012 | Pubmed ID: 23245325 Alphaherpesvirus Axon-to-cell Spread Involves Limited Virion Transmission Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23027939 Alphaherpesvirus Infection Disrupts Mitochondrial Transport in Neurons Cell Host & Microbe. May, 2012 | Pubmed ID: 22607803 이중 감염 Pseudorabies 바이러스 조건부 기자에 대 한 접근 복잡 한 신경 회로에서 담보 하는 신경에 투영 식별 PloS One. 2011 | Pubmed ID: 21698154 헤 르 페 스의 단순 바이러스 1 PUL34 바이러스 바이러스 복제에 있는 그것의 역할의 셀 확산에 중요 한 역할을 한다 Journal of Virology. Jul, 2011 | Pubmed ID: 21561917 바이러스 감염 시 말라 Cytoskeleton의 전복입니다 Nature Reviews. Microbiology. Jun, 2011 | Pubmed ID: 21522191 Brainbow Herpesvirus에서 조건부 기자 식으로 신경망의 인 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2011 | Pubmed ID: 21292985 Brainbow 카세트를 들고 Herpesviruses 공개 복제 및 들어오는 게놈의 제한 된 숫자의 표현 Nature Communications. 2010 | Pubmed ID: 21266996 Alphaherpesvirus 감염에 일반적인 신경 응답입니다 Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Sep, 2010 | Pubmed ID: 20401540 칼슘의 신경 회로 회로 추적 Pseudorabies 바이러스를 사용 하 여 in Vivo 영상 Cold Spring Harbor Protocols. Apr, 2010 | Pubmed ID: 20360364 Pseudorabies 바이러스 감염 신경 활동과 연결 체 외를 변경합니다 PLoS Pathogens. Oct, 2009 | Pubmed ID: 19876391 형광 기반 회로 추적 Pseudorabies 바이러스를 사용 하 여 생체 조건 신경 활동의 모니터링 PloS One. 2009 | Pubmed ID: 19742327 Virion 통합 당단백질 B Transneuronal Pseudorabies 바이러스의 확산을 중재 합니다 Journal of Virology. Aug, 2009 | Pubmed ID: 19494011 21 세기의 바이러스학입니다 Journal of Virology. Jun, 2009 | Pubmed ID: 19297504 조건부 바이러스 성 Transneuronal 추적 하 여 밝혀 Serotonergic 뉴런에 대 한 입력 합니다 The Journal of Comparative Neurology. May, 2009 | Pubmed ID: 19274668 Herpesvirus 호스트 Cytoskeleton와 상호 작용 합니다 Journal of Virology. Mar, 2009 | Pubmed ID: 18842724 축 삭을 Pseudorabies 바이러스 구조 단백질의 대상으로 지질 뗏목 바이러스 Us9 단백질 연관이 필요 합니다 PLoS Pathogens. May, 2008 | Pubmed ID: 18483549 알파 Herpesvirus 감염 핵 말라 필 라 멘 트의 형성을 유도 한다 PLoS Pathogens. Aug, 2006 | Pubmed ID: 16933992 악성 및 감쇠 Pseudorabies 바이러스에 감염 된 설치류 두뇌의 Transcriptome 서명 Journal of Virology. Feb, 2006 | Pubmed ID: 16439534 UL54 Null Pseudorabies 바이러스 생쥐에서 감쇠 하지만 생산적으로 문화에 있는 세포를 감염 Journal of Virology. Jan, 2006 | Pubmed ID: 16378979 헤 르 페 스의 단순 바이러스 타입 1 당단백질 E Capsid, Tegument, 그리고 막 Glycoproteins의 Axonal 지역화 요구 됩니다 Journal of Virology. Nov, 2005 | Pubmed ID: 16227258 Pseudorabies 바이러스 게놈의 완전 한, 주석이 추가 된 시퀀스입니다 Journal of Virology. Jan, 2004 | Pubmed ID: 14671123 회로 분석에 대 한 Neurotropic 바이러스의 사용의 최근 발전 Current Opinion in Neurobiology. Oct, 2003 | Pubmed ID: 14630225 Pseudorabies 바이러스 Recombinants와 트랜스 시 냅 스 추적을 사용 하 여 식별 하는 Sympatho 모터 회로의 Brainstem 기판 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2003 | Pubmed ID: 12805305 축 삭에서 Alphaherpesvirus의 생체 조건 탈출구입니다 Journal of Virology. Aug, 2002 | Pubmed ID: 12134036 봉투 Glycoproteins E와 M Pseudorabies 바이러스의 주요 Tegument 단백질 UL49 사이의 실제 상호 작용 Journal of Virology. Aug, 2002 | Pubmed ID: 12134026 Pseudorabies 바이러스 당단백질 B의 세포질 꼬리에 있는 티로신 기반 주제 바이러스 성 Glycoproteins 및 효율적인 셀 확산의 두 항 체 유도 국제화에 대 한 중요 하다 Journal of Virology. Jul, 2002 | Pubmed ID: 12050399 PRV Bartha 감쇠 Pseudorabies 바이러스의 주입 Intravitreal 햄스터 Suprachiasmatic 핵의 감염 자율 회로 통해 퇴행 성 Transsynaptic 전송에 의해서만 발생합니다 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2002 | Pubmed ID: 11923435 포함 하는 인간의 세포 게놈 및 Mutagenesis Diploid TRL/IRL13 유전자의 Self-excisable 세균 인공 염색체의 건설 Journal of Virology. Mar, 2002 | Pubmed ID: 11836410 Herpesviruses 양방향 패스트 Axonal 전송 사용 하 여 감각 신경 세포에 확산 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2001 | Pubmed ID: 11248101 Pseudorabies Virus Expressing Enhanced Green Fluorescent Protein: A Tool for in Vitro Electrophysiological Analysis of Transsynaptically Labeled Neurons in Identified Central Nervous System Circuits Proceedings of the National Academy of Sciences of the United States of America. Aug, 2000 | Pubmed ID: 10922076 A Self-recombining Bacterial Artificial Chromosome and Its Application for Analysis of Herpesvirus Pathogenesis Proceedings of the National Academy of Sciences of the United States of America. Apr, 2000 | Pubmed ID: 10781094 Directional Transneuronal Infection by Pseudorabies Virus is Dependent on an Acidic Internalization Motif in the Us9 Cytoplasmic Tail Journal of Virology. May, 2000 | Pubmed ID: 10775591 Pseudorabies 바이러스 당단백질 E Virion 형성에서의 세포질 꼬리의 역할 Journal of Virology. May, 2000 | Pubmed ID: 10756012 Circuit-specific Coinfection of Neurons in the Rat Central Nervous System with Two Pseudorabies Virus Recombinants Journal of Virology. Nov, 1999 | Pubmed ID: 10516061 Construction and Transposon Mutagenesis in Escherichia Coli of a Full-length Infectious Clone of Pseudorabies Virus, an Alphaherpesvirus Journal of Virology. Aug, 1999 | Pubmed ID: 10400733 Pseudorabies Virus-induced Leukocyte Trafficking into the Rat Central Nervous System Journal of Virology. Nov, 1998 | Pubmed ID: 9765465 Different Patterns of Neuronal Infection After Intracerebral Injection of Two Strains of Pseudorabies Virus Journal of Virology. May, 1998 | Pubmed ID: 9557737 Interconnected Parallel Circuits Between Rat Nucleus Accumbens and Thalamus Revealed by Retrograde Transynaptic Transport of Pseudorabies Virus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 1997 | Pubmed ID: 9045740 Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in the CNS Molecular Therapy. Methods & Clinical Development. | Pubmed ID: 32368565 바이러스 유발 신경 염증 반응을 연구하는 마우스 풋패드 접종 모델 Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunology and Infection
바이러스 유발 신경 염증 반응을 연구하는 마우스 풋패드 접종 모델 Kathlyn Laval1, Carola J. Maturana2, Lynn W. Enquist1 1Department of Molecular Biology, Princeton University, 2Princeton Neuroscience Institute, Princeton University JoVE 61121 Immunology and Infection