M. Juliana McElrath Vaccine and Infectious Disease Division Fred Hutchinson Cancer Research Center Biography Publications Institution JoVE Articles M. Juliana McElrath has not added a biography. If you are M. Juliana McElrath and would like to personalize this page please email our Author Liaison for assistance. Publications MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load PloS One. 2012 | Pubmed ID: 22952672 Quantifying Ongoing HIV-1 Exposure in HIV-1-Serodiscordant Couples to Identify Individuals With Potential Host Resistance to HIV-1 The Journal of Infectious Diseases. Aug, 2012 | Pubmed ID: 22926009 A Novel HIV Vaccine Adjuvanted by IC31 Induces Robust and Persistent Humoral and Cellular Immunity PloS One. 2012 | Pubmed ID: 22848738 Is an HIV Vaccine Possible? Journal of Acquired Immune Deficiency Syndromes (1999). Aug, 2012 | Pubmed ID: 22772390 Two New Monoclonal Antibodies for Biochemical and Flow Cytometric Analyses of Human Interferon Regulatory Factor-3 Activation, Turnover, and Depletion Methods (San Diego, Calif.). Jun, 2012 | Pubmed ID: 22705311 Vpu-Deficient HIV Strains Stimulate Innate Immune Signaling Responses in Target Cells Journal of Virology. Aug, 2012 | Pubmed ID: 22647704 Optimization and Qualification of a Multiplex Bead Array to Assess Cytokine and Chemokine Production by Vaccine-specific Cells Journal of Immunological Methods. Aug, 2012 | Pubmed ID: 22626638 Vpu Mediates Depletion of Interferon Regulatory Factor 3 During HIV Infection by a Lysosome-Dependent Mechanism Journal of Virology. Aug, 2012 | Pubmed ID: 22593165 Decreased Pre-existing Ad5 Capsid and Ad35 Neutralizing Antibodies Increase HIV-1 Infection Risk in the Step Trial Independent of Vaccination PloS One. 2012 | Pubmed ID: 22496775 Immune-correlates Analysis of an HIV-1 Vaccine Efficacy Trial The New England Journal of Medicine. Apr, 2012 | Pubmed ID: 22475592 Human Adenovirus-specific T Cells Modulate HIV-specific T Cell Responses to an Ad5-vectored HIV-1 Vaccine The Journal of Clinical Investigation. Jan, 2012 | Pubmed ID: 22201684 Profiling Immunity to HIV Vaccines with Systems Biology Current Opinion in HIV and AIDS. Jan, 2012 | Pubmed ID: 22134340 Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure PloS One. 2011 | Pubmed ID: 22174851 Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells Journal of Virology. Dec, 2011 | Pubmed ID: 21976645 Timing of Plasmid Cytokine (IL-2/Ig) Administration Affects HIV-1 Vaccine Immunogenicity in HIV-seronegative Subjects The Journal of Infectious Diseases. Nov, 2011 | Pubmed ID: 21940420 Safety and Immunogenicity of an HIV Adenoviral Vector Boost After DNA Plasmid Vaccine Prime by Route of Administration: a Randomized Clinical Trial PloS One. 2011 | Pubmed ID: 21931737 A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade RAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204) PloS One. 2011 | Pubmed ID: 21857901 HIV-DNA Priming Alters T Cell Responses to HIV-adenovirus Vaccine Even when Responses to DNA Are Undetectable Journal of Immunology (Baltimore, Md. : 1950). Sep, 2011 | Pubmed ID: 21844392 Protective HIV-specific CD8+ T Cells Evade Treg Cell Suppression Nature Medicine. Aug, 2011 | Pubmed ID: 21765403 Host Genetic Polymorphisms Associated with Innate Immune Factors and HIV-1 Current Opinion in HIV and AIDS. Sep, 2011 | Pubmed ID: 21734565 Vaccine-induced HIV-specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-specific Regions of HIV-1 Journal of Acquired Immune Deficiency Syndromes (1999). Nov, 2011 | Pubmed ID: 21709567 Mapping HIV-1 Vaccine Induced T-cell Responses: Bias Towards Less-conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study PloS One. 2011 | Pubmed ID: 21695251 Demographic Processes Affect HIV-1 Evolution in Primary Infection Before the Onset of Selective Processes Journal of Virology. Aug, 2011 | Pubmed ID: 21593162 Pre-existing Adenovirus Immunity Modifies a Complex Mixed Th1 and Th2 Cytokine Response to an Ad5/HIV-1 Vaccine Candidate in Humans PloS One. 2011 | Pubmed ID: 21533229 Priming CD8+ T Cells with Dendritic Cells Matured Using TLR4 and TLR7/8 Ligands Together Enhances Generation of CD8+ T Cells Retaining CD28 Blood. Jun, 2011 | Pubmed ID: 21493800 A Trimeric, V2-deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers The Journal of Infectious Diseases. Apr, 2011 | Pubmed ID: 21451004 Association Between Peripheral γδ T-cell Profile and Disease Progression in Individuals Infected with HIV-1 or HIV-2 in West Africa Journal of Acquired Immune Deficiency Syndromes (1999). Jun, 2011 | Pubmed ID: 21423026 Trivalent Adenovirus Type 5 HIV Recombinant Vaccine Primes for Modest Cytotoxic Capacity That is Greatest in Humans with Protective HLA Class I Alleles PLoS Pathogens. Feb, 2011 | Pubmed ID: 21383976 Genetic Impact of Vaccination on Breakthrough HIV-1 Sequences from the STEP Trial Nature Medicine. Mar, 2011 | Pubmed ID: 21358627 Standing Guard at the Mucosa Immunity. Feb, 2011 | Pubmed ID: 21349427 Dynamics of Viral Evolution and CTL Responses in HIV-1 Infection PloS One. 2011 | Pubmed ID: 21283794 Host Genetic Determinants of T Cell Responses to the MRKAd5 HIV-1 Gag/pol/nef Vaccine in the Step Trial The Journal of Infectious Diseases. Mar, 2011 | Pubmed ID: 21278214 A Phase I Trial of Preventive HIV Vaccination with Heterologous Poxviral-vectors Containing Matching HIV-1 Inserts in Healthy HIV-uninfected Subjects Vaccine. Feb, 2011 | Pubmed ID: 21216311 Serological Immunity to Adenovirus Serotype 5 is Not Associated with Risk of HIV Infection: a Case-control Study AIDS (London, England). Jan, 2011 | Pubmed ID: 21150554 Equivalence of ELISpot Assays Demonstrated Between Major HIV Network Laboratories PloS One. 2010 | Pubmed ID: 21179404 Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-specific Antibodies PloS One. 2010 | Pubmed ID: 21085486 The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation Science (New York, N.Y.). Dec, 2010 | Pubmed ID: 21051598 Safety and Immunogenicity of a Replication-defective Adenovirus Type 5 HIV Vaccine in Ad5-seronegative Persons: a Randomized Clinical Trial (HVTN 054) PloS One. 2010 | Pubmed ID: 21048953 Induction of Immunity to Human Immunodeficiency Virus Type-1 by Vaccination Immunity. Oct, 2010 | Pubmed ID: 21029964 Immune Responses to HIV Vaccines and Potential Impact on Control of Acute HIV-1 Infection The Journal of Infectious Diseases. Oct, 2010 | Pubmed ID: 20846040 Immunization with Cocktail of HIV-derived Peptides in Montanide ISA-51 is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity PloS One. 2010 | Pubmed ID: 20706632 Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells Through Expression of APOBEC3A Isoforms The Journal of Biological Chemistry. Sep, 2010 | Pubmed ID: 20615867 HIV Vaccines: Mosaic Approach to Virus Diversity Nature Medicine. Mar, 2010 | Pubmed ID: 20208511 In Situ Detection of Gag-specific CD8+ Cells in the GI Tract of SIV Infected Rhesus Macaques Retrovirology. 2010 | Pubmed ID: 20158906 Virus-specific CD8+ T-cell Responses Better Define HIV Disease Progression Than HLA Genotype Journal of Virology. May, 2010 | Pubmed ID: 20147397 Ex Vivo Comparison of Microbicide Efficacies for Preventing HIV-1 Genomic Integration in Intraepithelial Vaginal Cells Antimicrobial Agents and Chemotherapy. Feb, 2010 | Pubmed ID: 19949052 Differential Specificity and Immunogenicity of Adenovirus Type 5 Neutralizing Antibodies Elicited by Natural Infection or Immunization Journal of Virology. Jan, 2010 | Pubmed ID: 19846512 Conserved HIV-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-lymphocyte Responses The Journal of Infectious Diseases. Dec, 2009 | Pubmed ID: 19909083 Polymorphisms in Toll-like Receptor 4 and Toll-like Receptor 9 Influence Viral Load in a Seroincident Cohort of HIV-1-infected Individuals AIDS (London, England). Nov, 2009 | Pubmed ID: 19855253 Preinfection Human Immunodeficiency Virus (HIV)-specific Cytotoxic T Lymphocytes Failed to Prevent HIV Type 1 Infection from Strains Genetically Unrelated to Viruses in Long-term Exposed Partners Journal of Virology. Oct, 2009 | Pubmed ID: 19706711 Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses Within Infected Cells Journal of Virology. Oct, 2009 | Pubmed ID: 19706707 Variable Fitness Impact of HIV-1 Escape Mutations to Cytotoxic T Lymphocyte (CTL) Response PLoS Pathogens. Apr, 2009 | Pubmed ID: 19343217 Post-step Modifications for Research on HIV Vaccines AIDS (London, England). Jan, 2009 | Pubmed ID: 19050380 Safety and Immunogenicity of a CTL Multiepitope Peptide Vaccine for HIV with or Without GM-CSF in a Phase I Trial Vaccine. Jan, 2009 | Pubmed ID: 18996425 T Cell Responses Generated by HIV Vaccines in Clinical Trials Current Opinion in HIV and AIDS. May, 2008 | Pubmed ID: 19372993 HIV-1 Vaccine-induced Immunity in the Test-of-concept Step Study: a Case-cohort Analysis Lancet. Nov, 2008 | Pubmed ID: 19012957 Efficacy Assessment of a Cell-mediated Immunity HIV-1 Vaccine (the Step Study): a Double-blind, Randomised, Placebo-controlled, Test-of-concept Trial Lancet. Nov, 2008 | Pubmed ID: 19012954 Impaired Viral Entry Cannot Explain Reduced CD4+ T Cell Susceptibility to HIV Type 1 in Certain Highly Exposed Individuals AIDS Research and Human Retroviruses. Nov, 2008 | Pubmed ID: 19000021 Development of an Automated Analysis System for Data from Flow Cytometric Intracellular Cytokine Staining Assays from Clinical Vaccine Trials Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Sep, 2008 | Pubmed ID: 18615598 Setting the Stage: Host Invasion by HIV Nature Reviews. Immunology. Jun, 2008 | Pubmed ID: 18469831 Novel Cytotoxic T-lymphocyte Escape Mutation by a Three-amino-acid Insertion in the Human Immunodeficiency Virus Type 1 P6Pol and P6Gag Late Domain Associated with Drug Resistance Journal of Virology. Jan, 2008 | Pubmed ID: 17942528 A Framework for Assessing Immunological Correlates of Protection in Vaccine Trials The Journal of Infectious Diseases. Nov, 2007 | Pubmed ID: 17922394 Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-lymphocyte Epitopes: Fitness-balanced Escape Journal of Virology. Nov, 2007 | Pubmed ID: 17728222 Role of Human Immunodeficiency Virus (HIV)-specific T-cell Immunity in Control of Dual HIV-1 and HIV-2 Infection Journal of Virology. Sep, 2007 | Pubmed ID: 17582003 Optimization and Validation of an 8-color Intracellular Cytokine Staining (ICS) Assay to Quantify Antigen-specific T Cells Induced by Vaccination Journal of Immunological Methods. May, 2007 | Pubmed ID: 17451739 Macaques Infected with a CCR5-tropic Simian/human Immunodeficiency Virus (SHIV) Develop Broadly Reactive Anti-HIV Neutralizing Antibodies Journal of Virology. Jun, 2007 | Pubmed ID: 17392364 Defining Blood Processing Parameters for Optimal Detection of Cryopreserved Antigen-specific Responses for HIV Vaccine Trials Journal of Immunological Methods. Apr, 2007 | Pubmed ID: 17382342 Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection Journal of Virology. May, 2007 | Pubmed ID: 17329342 Initial Events in Establishing Vaginal Entry and Infection by Human Immunodeficiency Virus Type-1 Immunity. Feb, 2007 | Pubmed ID: 17306567 Comprehensive Epitope Analysis of Cross-clade Gag-specific T-cell Responses in Individuals with Early HIV-1 Infection in the US Epidemic Vaccine. Jan, 2007 | Pubmed ID: 17112643 Phase 2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and in Combination with Rgp120: Negative Results Fail to Trigger a Phase 3 Correlates Trial Journal of Acquired Immune Deficiency Syndromes (1999). Feb, 2007 | Pubmed ID: 17106277 Durable HIV-1 Antibody and T-cell Responses Elicited by an Adjuvanted Multi-protein Recombinant Vaccine in Uninfected Human Volunteers Vaccine. Jan, 2007 | Pubmed ID: 17049679 Preservation of T Cell Proliferation Restricted by Protective HLA Alleles is Critical for Immune Control of HIV-1 Infection Journal of Immunology (Baltimore, Md. : 1950). Nov, 2006 | Pubmed ID: 17082660 Induction of Human Immunodeficiency Virus Type 1 (HIV-1)-specific T-cell Responses in HIV Vaccine Trial Participants Who Subsequently Acquire HIV-1 Infection Journal of Virology. Oct, 2006 | Pubmed ID: 16973582 Selection on the Human Immunodeficiency Virus Type 1 Proteome Following Primary Infection Journal of Virology. Oct, 2006 | Pubmed ID: 16973556 Abacavir Hypersensitivity Reaction in Primary HIV Infection AIDS (London, England). Jun, 2006 | Pubmed ID: 16816555 Genetic Association of the Antiviral Restriction Factor TRIM5alpha with Human Immunodeficiency Virus Type 1 Infection Journal of Virology. Mar, 2006 | Pubmed ID: 16474153 Repeat-region Polymorphisms in the Gene for the Dendritic Cell-specific Intercellular Adhesion Molecule-3-grabbing Nonintegrin-related Molecule: Effects on HIV-1 Susceptibility The Journal of Infectious Diseases. Mar, 2006 | Pubmed ID: 16453266 CD4+ T Cell Receptor Repertoire Perturbations in HIV-1 Infection: Association with Plasma Viremia and Disease Progression Clinical Immunology (Orlando, Fla.). Apr, 2006 | Pubmed ID: 16403675 Combined Effect of CCR5-Delta32 Heterozygosity and the CCR5 Promoter Polymorphism -2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 Transmission Journal of Virology. Sep, 2005 | Pubmed ID: 16140745 High-dose Recombinant Canarypox Vaccine Expressing HIV-1 Protein, in Seronegative Human Subjects The Journal of Infectious Diseases. Oct, 2005 | Pubmed ID: 16136469 Most DC-SIGNR Transcripts at Mucosal HIV Transmission Sites Are Alternatively Spliced Isoforms European Journal of Human Genetics : EJHG. Jun, 2005 | Pubmed ID: 15812562 Demographic Factors That Influence the Neutralizing Antibody Response in Recipients of Recombinant HIV-1 Gp120 Vaccines The Journal of Infectious Diseases. Dec, 2004 | Pubmed ID: 15529261 Correlation Between Interferon- Gamma Secretion and Cytotoxicity, in Virus-specific Memory T Cells The Journal of Infectious Diseases. Nov, 2004 | Pubmed ID: 15478077 Effect of Adjunct Hydroxyurea on Helper T Cell Immunity in HIV Type 1-infected Patients with Virological Suppression AIDS Research and Human Retroviruses. Aug, 2004 | Pubmed ID: 15320983 Analysis of Genetic Polymorphisms in CCR5, CCR2, Stromal Cell-derived Factor-1, RANTES, and Dendritic Cell-specific Intercellular Adhesion Molecule-3-grabbing Nonintegrin in Seronegative Individuals Repeatedly Exposed to HIV-1 The Journal of Infectious Diseases. Sep, 2004 | Pubmed ID: 15319853 Breakthrough Infections During Phase 1 and 2 Prime-boost HIV-1 Vaccine Trials with Canarypox Vectors (ALVAC) and Booster Dose of Recombinant Gp120 or Gp160 The Journal of Infectious Diseases. Sep, 2004 | Pubmed ID: 15295694 Absence of Immunodominant Anti-Gag P17 (SL9) Responses Among Gag CTL-positive, HIV-uninfected Vaccine Recipients Expressing the HLA-A*0201 Allele Journal of Immunology (Baltimore, Md. : 1950). Aug, 2004 | Pubmed ID: 15265949 Statistical Considerations for the Design and Analysis of the ELISpot Assay in HIV-1 Vaccine Trials Journal of Immunological Methods. May, 2004 | Pubmed ID: 15183082 Comparison of Systemic and Mucosal Delivery of 2 Canarypox Virus Vaccines Expressing Either HIV-1 Genes or the Gene for Rabies Virus G Protein The Journal of Infectious Diseases. Apr, 2004 | Pubmed ID: 15031791 Association of T Cell Proliferative Responses and Phenotype with Virus Control in Chronic Progressive HIV-1 Disease The Journal of Infectious Diseases. Feb, 2004 | Pubmed ID: 14745710 Incomplete Immune Reconstitution After Initiation of Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus-infected Patients with Severe CD4+ Cell Depletion The Journal of Infectious Diseases. Dec, 2003 | Pubmed ID: 14673757 Broadly Increased Sensitivity to Cytotoxic T Lymphocytes Resulting from Nef Epitope Escape Mutations Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14530319 Evolution of CD8+ T Cell Immunity and Viral Escape Following Acute HIV-1 Infection Journal of Immunology (Baltimore, Md. : 1950). Oct, 2003 | Pubmed ID: 14500685 Hepatitis C Virus-specific Cytolytic T Cell Responses After Antiviral Therapy Clinical Immunology (Orlando, Fla.). Sep, 2003 | Pubmed ID: 14499244 Most Highly Exposed Seronegative Men Lack HIV-1-specific, IFN-gamma-secreting T Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12928421 HIV-1 Vaccination Administered Intramuscularly Can Induce Both Systemic and Mucosal T Cell Immunity in HIV-1-uninfected Individuals Journal of Immunology (Baltimore, Md. : 1950). Jul, 2003 | Pubmed ID: 12847284 Comprehensive Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-specific Gamma Interferon-secreting CD8+ T Cells in Primary HIV-1 Infection Journal of Virology. Jun, 2003 | Pubmed ID: 12768006 Persistence of Extraordinarily Low Levels of Genetically Homogeneous Human Immunodeficiency Virus Type 1 in Exposed Seronegative Individuals Journal of Virology. Jun, 2003 | Pubmed ID: 12743268 Moving to Human Immunodeficiency Virus Type 1 Vaccine Efficacy Trials: Defining T Cell Responses As Potential Correlates of Immunity The Journal of Infectious Diseases. Jan, 2003 | Pubmed ID: 12552447 Early Induction and Maintenance of Env-specific T-helper Cells Following Human Immunodeficiency Virus Type 1 Infection Journal of Virology. Feb, 2003 | Pubmed ID: 12552005 Progress in the Development of a Preventive HIV-1 Vaccine Clinics in Laboratory Medicine. Dec, 2002 | Pubmed ID: 12489290 Safety and Immunogenicity of a High-titered Canarypox Vaccine in Combination with Rgp120 in a Diverse Population of HIV-1-uninfected Adults: AIDS Vaccine Evaluation Group Protocol 022A Journal of Acquired Immune Deficiency Syndromes (1999). Mar, 2002 | Pubmed ID: 11873074 Telling av Store perifert blod leukocytter populasjoner multisenter kliniske studier med en Fullblod fenotyping Assay Tiffany R. Hensley1, Austin B. Easter1, Sarah E. Gerdts1, Stephen C. De Rosa1, Antje Heit1, M. Juliana McElrath1, Erica Andersen-Nissen1 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center JoVE 4302 Immunology and Infection
Telling av Store perifert blod leukocytter populasjoner multisenter kliniske studier med en Fullblod fenotyping Assay Tiffany R. Hensley1, Austin B. Easter1, Sarah E. Gerdts1, Stephen C. De Rosa1, Antje Heit1, M. Juliana McElrath1, Erica Andersen-Nissen1 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center JoVE 4302 Immunology and Infection