In JoVE (1)

Other Publications (2)

Articles by Madeline Fryer in JoVE

 JoVE Immunology and Infection

Murine Full-thickness Skin Transplantation

1Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 2Department of Liver and Transplantation Surgery, Chang-Gung Transplantation Institute, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, 3Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine


JoVE 55105

Other articles by Madeline Fryer on PubMed

Abstract 11: the Role of Donor Antigen Persistance in Maintaining Immune Tolerance to a Vascularized Composite Allograft

Plastic and Reconstructive Surgery. Mar, 2014  |  Pubmed ID: 25942122

Exploring Cell-based Tolerance Strategies for Hand and Face Transplantation

Expert Review of Clinical Immunology. Nov, 2015  |  Pubmed ID: 26289376

Broader clinical application of reconstructive hand and face transplantation is hindered by the need for lifelong immunosuppression for allograft maintenance. In this review, we summarize various cell-based approaches to tolerance induction currently under investigation in both clinical and pre-clinical models to alleviate the need for chronic immunosuppression. These include strategies to induce mixed hematopoietic chimerism, therapy with T and B regulatory cells, regulatory macrophages, tolerogenic dendritic cells, and mesenchymal stem cells. The vascularized, intragraft bone components inherent to reconstructive transplants serve as a continuous source of donor-derived hematopoietic cells, and make hand and face transplants uniquely well suited for cell-based approaches to tolerance that may ultimately tilt the risk-benefit balance for these life-changing, but not life-saving, procedures.

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