Marc. R. Del Bigio The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba Biography Publications Institution JoVE Articles Marc. R. Del Bigio has not added a biography. If you are Marc. R. Del Bigio and would like to personalize this page please email our Author Liaison for assistance. Publications Dr. Dwight Parkinson: a Canadian Neurosurgical Pioneer Journal of Neurosurgery. Sep, 2019 | Pubmed ID: 31561217 Inflammation and Obstruction of Distal Catheter Slits in Ventriculoperitoneal Shunts: Likely Role of Graphite Journal of Neurosurgery. Sep, 2019 | Pubmed ID: 31561214 Establishment of a Biobank for Human Lung Tissues of Congenital Diaphragmatic Hernia and Congenital Pulmonary Airway Malformation Journal of Pediatric Surgery. May, 2019 | Pubmed ID: 31130348 Global DNA Methylation and Histone Posttranslational Modifications in Human and Nonhuman Primate Brain in Association with Prenatal Alcohol Exposure Alcoholism, Clinical and Experimental Research. Jun, 2019 | Pubmed ID: 31074890 DNA Methylation and Histone Post-translational Modification Stability in Post-mortem Brain Tissue Clinical Epigenetics. 01, 2019 | Pubmed ID: 30635019 A Homozygous Canonical Splice Acceptor Site Mutation in PRUNE1 is Responsible for a Rare Childhood Neurodegenerative Disease in Manitoba Cree Families American Journal of Medical Genetics. Part A. 02, 2019 | Pubmed ID: 30556349 Mutation Interrupts Nucleolin-mTOR-P70S6K Signaling in Rett Syndrome Patients Frontiers in Genetics. 2018 | Pubmed ID: 30619462 Characterization of the Ventricular-subventricular Stem Cell Niche During Human Brain Development Development (Cambridge, England). 10, 2018 | Pubmed ID: 30237244 Chronic Near Lifetime Toluene Exposure in Rodents Does Not Replicate Solvent Abuse Leukoencephalopathy in Humans Neurotoxicology. 12, 2018 | Pubmed ID: 30056179 CD271 Cells Are Diagnostic and Prognostic and Exhibit Elevated MAPK Activity in SHH Medulloblastoma Cancer Research. 08, 2018 | Pubmed ID: 29930101 Nimodipine Treatment Does Not Benefit Juvenile Ferrets with Kaolin-induced Hydrocephalus Fluids and Barriers of the CNS. May, 2018 | Pubmed ID: 29720231 Memantine Treatment of Juvenile Rats with Kaolin-induced Hydrocephalus Brain Research. 06, 2018 | Pubmed ID: 29625114 Autopsy Neuropathology Findings in a Child with Chronic Infantile Krabbe Leukoencephalopathy Pediatric Neurology. 05, 2018 | Pubmed ID: 29622486 Characterization of a Novel OTX2-driven Stem Cell Program in Group 3 and Group 4 Medulloblastoma Molecular Oncology. 04, 2018 | Pubmed ID: 29377567 Human Brain Abnormalities Associated With Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder Journal of Neuropathology and Experimental Neurology. Sep, 2017 | Pubmed ID: 28859338 Frequency of MYD88 and CD79B Mutations, and MGMT Methylation in Primary Central Nervous System Diffuse Large B-cell Lymphoma Neuropathology : Official Journal of the Japanese Society of Neuropathology. Dec, 2017 | Pubmed ID: 28856744 Progressive Ataxia and Palatal Tremor: Two Autopsy Cases of a Novel Tauopathy Movement Disorders : Official Journal of the Movement Disorder Society. Oct, 2017 | Pubmed ID: 28736850 Overexpression of Human SOD1 Leads to Discrete Defects in the Cerebellar Architecture in the Mouse Frontiers in Neuroanatomy. 2017 | Pubmed ID: 28424594 Retroocular and Subdural Hemorrhage or Hemosiderin Deposits in Pediatric Autopsies Journal of Neuropathology and Experimental Neurology. 04, 2017 | Pubmed ID: 28340081 A Truncating Mutation in CEP55 is the Likely Cause of MARCH, a Novel Syndrome Affecting Neuronal Mitosis Journal of Medical Genetics. 07, 2017 | Pubmed ID: 28264986 Chronic Traumatic Encephalopathy-Like Abnormalities in a Routine Neuropathology Service Journal of Neuropathology and Experimental Neurology. 12, 2016 | Pubmed ID: 27815395 Magnesium Sulfate Treatment for Juvenile Ferrets Following Induction of Hydrocephalus with Kaolin Fluids and Barriers of the CNS. Apr, 2016 | Pubmed ID: 27121710 Nonsurgical Therapy for Hydrocephalus: a Comprehensive and Critical Review Fluids and Barriers of the CNS. Feb, 2016 | Pubmed ID: 26846184 Characterization of Novel Biomarkers in Selecting for Subtype Specific Medulloblastoma Phenotypes Oncotarget. Nov, 2015 | Pubmed ID: 26497209 OTX2 Exhibits Cell-context-dependent Effects on Cellular and Molecular Properties of Human Embryonic Neural Precursors and Medulloblastoma Cells Disease Models & Mechanisms. Oct, 2015 | Pubmed ID: 26398939 Growth Arrest in the Ribosomopathy, Bowen-Conradi Syndrome, is Due to Dramatically Reduced Cell Proliferation and a Defect in Mitotic Progression Biochimica Et Biophysica Acta. May, 2015 | Pubmed ID: 25708872 Platinum (IV) Coiled Coil Nanotubes Selectively Kill Human Glioblastoma Cells Nanomedicine : Nanotechnology, Biology, and Medicine. May, 2015 | Pubmed ID: 25680541 Interference with Protease-activated Receptor 1 Does Not Reduce Damage to Subventricular Zone Cells of Immature Rodent Brain Following Exposure to Blood or Blood Plasma Journal of Negative Results in Biomedicine. Feb, 2015 | Pubmed ID: 25649264 Cellular Commitment in the Developing Cerebellum Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25628535 Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein-experimental Autoimmune Encephalomyelitis Mice Magnetic Resonance Insights. 2014 | Pubmed ID: 25520558 DNA Modifications: Function and Applications in Normal and Disease States Biology. Oct, 2014 | Pubmed ID: 25340699 Oncogenic Codon 13 NRAS Mutation in a Primary Mesenchymal Brain Neoplasm and Nevus of a Child with Neurocutaneous Melanosis Acta Neuropathologica Communications. Oct, 2014 | Pubmed ID: 25330907 Oral Antioxidant Therapy for Juvenile Rats with Kaolin-induced Hydrocephalus Fluids and Barriers of the CNS. 2014 | Pubmed ID: 25324960 Traumatic and Other Non-natural Childhood Deaths in Manitoba, Canada: a Retrospective Autopsy Analysis (1989-2010) Canadian Journal of Public Health = Revue Canadienne De Sante Publique. Apr, 2014 | Pubmed ID: 24886844 Purkinje Cell Compartmentation in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant Mouse (nax - Naked-ataxia Mutant Mouse) PloS One. 2014 | Pubmed ID: 24722417 Atypical Features in a Case of Lethal Perinatal Gaucher Disease Neuropathology and Applied Neurobiology. Dec, 2014 | Pubmed ID: 24707850 Neuropathology Training Worldwide-evolution and Comparisons Brain Pathology (Zurich, Switzerland). Apr, 2014 | Pubmed ID: 24251639 C1q-tumour Necrosis Factor-related Protein 8 (CTRP8) is a Novel Interaction Partner of Relaxin Receptor RXFP1 in Human Brain Cancer Cells The Journal of Pathology. Dec, 2013 | Pubmed ID: 24014093 Quantitative MRI and Ultrastructural Examination of the Cuprizone Mouse Model of Demyelination NMR in Biomedicine. Nov, 2013 | Pubmed ID: 23943390 Pre- and Post-shunting Observations in Adult Sheep with Kaolin-induced Hydrocephalus Fluids and Barriers of the CNS. 2013 | Pubmed ID: 23845003 Reduced Subventricular Zone Proliferation and White Matter Damage in Juvenile Ferrets with Kaolin-induced Hydrocephalus Experimental Neurology. Oct, 2013 | Pubmed ID: 23769908 Outcomes of Persons with Blastomycosis Involving the Central Nervous System Diagnostic Microbiology and Infectious Disease. Apr, 2013 | Pubmed ID: 23566338 Deconstruction of Medulloblastoma Cellular Heterogeneity Reveals Differences Between the Most Highly Invasive and Self-renewing Phenotypes Neoplasia (New York, N.Y.). Apr, 2013 | Pubmed ID: 23555184 INSL5 is a Novel Marker for Human Enteroendocrine Cells of the Large Intestine and Neuroendocrine Tumours Oncology Reports. Jan, 2013 | Pubmed ID: 23128569 Antenatal and Postnatal Diagnosis of Coxsackie B4 Infection: Case Series AJP Reports. Nov, 2012 | Pubmed ID: 23946895 Novel Autosomal Recessive C10orf2 Mutations Causing Infantile-Onset Spinocerebellar Ataxia Case Reports in Pediatrics. 2012 | Pubmed ID: 22928142 Blood-brain Barrier Disruption in CCL2 Transgenic Mice During Pertussis Toxin-induced Brain Inflammation Fluids and Barriers of the CNS. Apr, 2012 | Pubmed ID: 22546091 Cerebral White Matter Oxidation and Nitrosylation in Young Rodents with Kaolin-induced Hydrocephalus Journal of Neuropathology and Experimental Neurology. Apr, 2012 | Pubmed ID: 22437339 Magnetic Resonance Imaging Indicators of Blood-brain Barrier and Brain Water Changes in Young Rats with Kaolin-induced Hydrocephalus Fluids and Barriers of the CNS. Aug, 2011 | Pubmed ID: 21834998 Fetal Intracranial Hemorrhage at 24 Weeks' Gestation Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstetrique Et Gynecologie Du Canada : JOGC. Jul, 2011 | Pubmed ID: 21749744 Extramedullary Hematopoiesis Involving the Central Nervous System and Surrounding Structures Human Pathology. Oct, 2011 | Pubmed ID: 21496873 Cell Proliferation in Human Ganglionic Eminence and Suppression After Prematurity-associated Haemorrhage Brain : a Journal of Neurology. May, 2011 | Pubmed ID: 21478186 Fatty Acid Transport Protein Expression in Human Brain and Potential Role in Fatty Acid Transport Across Human Brain Microvessel Endothelial Cells Journal of Neurochemistry. May, 2011 | Pubmed ID: 21395585 Infantile Muscular Dystrophy in Canadian Aboriginals is an αB-crystallinopathy Annals of Neurology. May, 2011 | Pubmed ID: 21337604 An Unusual Inflammatory Response to Implanted Deep Brain Electrodes The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Jan, 2011 | Pubmed ID: 21156454 Neuropathology in Canada: the First One Hundred Years The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Nov, 2010 | Pubmed ID: 21059534 Association Among Amyloid Plaque, Lipid, and Creatine in Hippocampus of TgCRND8 Mouse Model for Alzheimer Disease The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20682779 Neuropathology in Canada: Overview of Development and Current Status The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Mar, 2010 | Pubmed ID: 20437930 Neuropathology and Structural Changes in Hydrocephalus Developmental Disabilities Research Reviews. 2010 | Pubmed ID: 20419767 Brain Damage in a Large Cohort of Solvent Abusers Acta Neuropathologica. Apr, 2010 | Pubmed ID: 20300918 Ependymal Cells: Biology and Pathology Acta Neuropathologica. Jan, 2010 | Pubmed ID: 20024659 Fetal Hydrocephalus Caused by Cryptic Intraventricular Hemorrhage Brain Pathology (Zurich, Switzerland). Mar, 2010 | Pubmed ID: 19476462 Pathological Evidence of Vacuolar Myelinopathy in a Child Following Vigabatrin Administration Journal of Child Neurology. Dec, 2009 | Pubmed ID: 19773459 Ataxia-telangiectasia: Atypical Presentation and Toxicity of Cancer Treatment The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. Jul, 2009 | Pubmed ID: 19650357 Toxic Effect of Blood Components on Perinatal Rat Subventricular Zone Cells and Oligodendrocyte Precursor Cell Proliferation, Differentiation and Migration in Culture Journal of Neurochemistry. Jun, 2009 | Pubmed ID: 19476544 Early-onset Neurodegenerative Disease of the Cerebellum and Motor Axons Pediatric Neurology. May, 2009 | Pubmed ID: 19380073 Simultaneous Determination of Mechanical Properties and Physiologic Parameters in Living Rat Brain Biomechanics and Modeling in Mechanobiology. Oct, 2009 | Pubmed ID: 19112584 Eosinophilic Intracytoplasmic Inclusions in Purkinje Neurons of Children Neuropathology : Official Journal of the Japanese Society of Neuropathology. Feb, 2009 | Pubmed ID: 18498283 Surface Dialysis After Experimental Brain Injury: Modification of Edema Fluid Flow in the Rat Model Journal of Neurosurgery. Oct, 2008 | Pubmed ID: 18826354 Effect of Hydrocephalus on Rat Brain Extracellular Compartment Cerebrospinal Fluid Research. Jul, 2008 | Pubmed ID: 18616813 Proinflammatory Cytokine Production by Cultured Neonatal Rat Microglia After Exposure to Blood Products Brain Research. May, 2008 | Pubmed ID: 18410909 Treatment of Recurrent Ventriculoperitoneal Shunt Failure Associated with Persistent Cerebrospinal Fluid Eosinophilia and Latex Allergy by Use of an "extracted" Shunt Journal of Neurosurgery. Pediatrics. Mar, 2008 | Pubmed ID: 18352769 Calcium Antagonism in Neonatal Rats with Kaolin-induced Hydrocephalus Journal of Child Neurology. Oct, 2007 | Pubmed ID: 17940241 Protein and Synthetic Polymer Injection for Induction of Obstructive Hydrocephalus in Rats Cerebrospinal Fluid Research. Sep, 2007 | Pubmed ID: 17894867 Dense-core and Diffuse Abeta Plaques in TgCRND8 Mice Studied with Synchrotron FTIR Microspectroscopy Biopolymers. Nov, 2007 | Pubmed ID: 17680701 Magnetic Resonance Imaging of Blood-spinal Cord Barrier Disruption in Mice with Experimental Autoimmune Encephalomyelitis Magnetic Resonance in Medicine. Aug, 2007 | Pubmed ID: 17654586 Multifocal Atrophy of Cerebellar Internal Granular Neurons in Lesch-nyhan Disease: Case Reports and Review Journal of Neuropathology and Experimental Neurology. May, 2007 | Pubmed ID: 17483691 Please Slow Down the CanMEDS Express CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Mar, 2007 | Pubmed ID: 17353540 Cerebral Trypanosomiasis in an Incarcerated Man CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Feb, 2007 | Pubmed ID: 17296955 Animal Models of Germinal Matrix Hemorrhage Journal of Child Neurology. May, 2006 | Pubmed ID: 16901440 Aquaporin 4 Changes in Rat Brain with Severe Hydrocephalus The European Journal of Neuroscience. Jun, 2006 | Pubmed ID: 16819982 Brain Damage in Neonatal Rats Following Kaolin Induction of Hydrocephalus Experimental Neurology. Aug, 2006 | Pubmed ID: 16624304 Persistent Motor Deficit Following Infusion of Autologous Blood into the Periventricular Region of Neonatal Rats Experimental Neurology. Jan, 2006 | Pubmed ID: 16271716 Focally Elevated Creatine Detected in Amyloid Precursor Protein (APP) Transgenic Mice and Alzheimer Disease Brain Tissue The Journal of Biological Chemistry. Jan, 2006 | Pubmed ID: 16267054 Injections of Blood, Thrombin, and Plasminogen More Severely Damage Neonatal Mouse Brain Than Mature Mouse Brain Brain Pathology (Zurich, Switzerland). Oct, 2005 | Pubmed ID: 16389939 Does Thrombin Play a Role in the Pathogenesis of Brain Damage After Periventricular Hemorrhage? Brain Pathology (Zurich, Switzerland). Jul, 2005 | Pubmed ID: 16196391 Immune Pre-activation Exacerbates Hemorrhagic Brain Injury in Immature Mouse Brain Journal of Neuroimmunology. Aug, 2005 | Pubmed ID: 15964638 Hutterite Brothers Both Affected with Two Forms of Limb Girdle Muscular Dystrophy: LGMD2H and LGMD2I European Journal of Human Genetics : EJHG. Aug, 2005 | Pubmed ID: 15886712 Neuropathological, Biochemical and Molecular Findings in a Glutaric Acidemia Type 1 Cohort Brain : a Journal of Neurology. Apr, 2005 | Pubmed ID: 15689364 Cellular Damage and Prevention in Childhood Hydrocephalus Brain Pathology (Zurich, Switzerland). Jul, 2004 | Pubmed ID: 15446588 Comparison of Brain Cell Death and Inflammatory Reaction in Three Models of Intracerebral Hemorrhage in Adult Rats Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. May-Jun, 2003 | Pubmed ID: 17903920 Tacrolimus and Cyclosporine A Are of No Benefit to Young Rats with Kaolin-induced Hydrocephalus Pediatric Neurosurgery. Dec, 2003 | Pubmed ID: 14734865 Age-related Differences in 1p and 19q Deletions in Oligodendrogliomas BMC Clinical Pathology. Dec, 2003 | Pubmed ID: 14670088 Periventricular/intraventricular Hemorrhage in Neonatal Mouse Cerebrum Journal of Neuropathology and Experimental Neurology. Nov, 2003 | Pubmed ID: 14656073 Chronic Hydrocephalus in Rats and Humans: White Matter Loss and Behavior Changes Annals of Neurology. Mar, 2003 | Pubmed ID: 12601701 Mixed Gangliocytoma--adenoma of the Sella: Case Report Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes. Dec, 2002 | Pubmed ID: 12500383 Sodium Channel-blocking Agents Are Not of Benefit to Rats with Kaolin-induced Hydrocephalus Neurosurgery. Aug, 2002 | Pubmed ID: 12182785 Analysis of Age-dependant Alteration in the Brain Gene Expression Profile Following Induction of Hydrocephalus in Rats Experimental Neurology. Jan, 2002 | Pubmed ID: 11771943 胚性マウス小脳から単離されたニューロンの一次培養 Shahin Shabanipour1,2, Azadeh Dalvand1,2, Xiaodan Jiao1,2, Maryam Rahimi Balaei1,2, Seung H. Chung3, Jiming Kong1, Marc. R. Del Bigio2,4, Hassan Marzban1,2 1Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 2The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 3Department of Oral Biology, University of Illinois at Chicago, 4Department of Pathology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba JoVE 60168 Neuroscience
胚性マウス小脳から単離されたニューロンの一次培養 Shahin Shabanipour1,2, Azadeh Dalvand1,2, Xiaodan Jiao1,2, Maryam Rahimi Balaei1,2, Seung H. Chung3, Jiming Kong1, Marc. R. Del Bigio2,4, Hassan Marzban1,2 1Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 2The Children's Hospital Research Institute of Manitoba (CHRIM), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 3Department of Oral Biology, University of Illinois at Chicago, 4Department of Pathology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba JoVE 60168 Neuroscience
