Marie José Goumans Department of Molecular Cell Biology Leiden University Medical Center Biography Publications Institution JoVE Articles Marie José Goumans has not added a biography. If you are Marie José Goumans and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting BMP Signalling in Cardiovascular Disease and Anaemia Nature Reviews. Cardiology. Oct, 2015 | Pubmed ID: 26461965 Environmental Influences on Endothelial to Mesenchymal Transition in Developing Implanted Cardiovascular Tissue-Engineered Grafts Tissue Engineering. Part B, Reviews. Oct, 2015 | Pubmed ID: 26414174 Regional Differences in WT-1 and Tcf21 Expression During Ventricular Development: Implications for Myocardial Compaction PloS One. 2015 | Pubmed ID: 26390289 Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2015 | Pubmed ID: 26373572 Behavior of CMPCs in Unidirectional Constrained and Stress-free 3D Hydrogels Journal of Molecular and Cellular Cardiology. Aug, 2015 | Pubmed ID: 26278995 Histopathology of Aortic Complications in Bicuspid Aortic Valve Versus Marfan Syndrome: Relevance for Therapy? Heart and Vessels. Jul, 2015 | Pubmed ID: 26129868 Mononuclear Cells and Vascular Repair in HHT Frontiers in Genetics. 2015 | Pubmed ID: 25852751 Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections Journal of the American College of Cardiology. Apr, 2015 | Pubmed ID: 25835445 MAb C19 Targets a Novel Surface Marker for the Isolation of Human Cardiac Progenitor Cells from Human Heart Tissue and Differentiated HESCs Journal of Molecular and Cellular Cardiology. May, 2015 | Pubmed ID: 25820071 Functional Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes in Vitro--correlation Between Contraction Force and Electrophysiology Biomaterials. May, 2015 | Pubmed ID: 25771005 Cardiac Endothelial Cells Express Wilms' Tumor-1: Wt1 Expression in the Developing, Adult and Infarcted Heart Journal of Molecular and Cellular Cardiology. Apr, 2015 | Pubmed ID: 25681586 SLUG is Expressed in Endothelial Cells Lacking Primary Cilia to Promote Cellular Calcification Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2015 | Pubmed ID: 25633317 Inhibition of TGFβ Type I Receptor Activity Facilitates Liver Regeneration Upon Acute CCl4 Intoxication in Mice Archives of Toxicology. Jan, 2015 | Pubmed ID: 25566828 Bicuspid Aortic Valve: Phosphorylation of C-Kit and Downstream Targets Are Prognostic for Future Aortopathy European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Nov, 2014 | Pubmed ID: 25161185 The MicroRNA-15 Family Inhibits the TGFβ-pathway in the Heart Cardiovascular Research. Oct, 2014 | Pubmed ID: 25103110 A Straightforward Guide to the Basic Science Behind Cardiovascular Cell-based Therapies Heart (British Cardiac Society). Aug, 2014 | Pubmed ID: 24993501 A Multistep Procedure to Prepare Pre-vascularized Cardiac Tissue Constructs Using Adult Stem Sells, Dynamic Cell Cultures, and Porous Scaffolds Frontiers in Physiology. 2014 | Pubmed ID: 24917827 Nuclear Receptor NR4A1 Promotes Breast Cancer Invasion and Metastasis by Activating TGF-β Signalling Nature Communications. 2014 | Pubmed ID: 24584437 Ascending Aorta Dilation in Association with Bicuspid Aortic Valve: a Maturation Defect of the Aortic Wall The Journal of Thoracic and Cardiovascular Surgery. Oct, 2014 | Pubmed ID: 24560417 ENDOGLIN is Dispensable for Vasculogenesis, but Required for Vascular Endothelial Growth Factor-induced Angiogenesis PloS One. 2014 | Pubmed ID: 24489709 Hippo Pathway Effectors Control Cardiac Progenitor Cell Fate by Acting As Dynamic Sensors of Substrate Mechanics and Nanostructure ACS Nano. Mar, 2014 | Pubmed ID: 24483337 Novel Ex Vivo Culture Method for the Study of Dupuytren's Disease: Effects of TGFβ Type 1 Receptor Modulation by Antisense Oligonucleotides Molecular Therapy. Nucleic Acids. 2014 | Pubmed ID: 24448195 Remodeling of the Myocardium in Early Trabeculation and Cardiac Valve Formation; a Role for TGFβ2 The International Journal of Developmental Biology. 2013 | Pubmed ID: 24623077 Quaking, an RNA-binding Protein, is a Critical Regulator of Vascular Smooth Muscle Cell Phenotype Circulation Research. Oct, 2013 | Pubmed ID: 23963726 MicroRNA-1 Enhances the Angiogenic Differentiation of Human Cardiomyocyte Progenitor Cells Journal of Molecular Medicine (Berlin, Germany). Aug, 2013 | Pubmed ID: 23625462 Extraembryonic Endoderm Cells As a Model of Endoderm Development Development, Growth & Differentiation. Apr, 2013 | Pubmed ID: 23414197 Deficiency for Endoglin in Tumor Vasculature Weakens the Endothelial Barrier to Metastatic Dissemination The Journal of Experimental Medicine. Mar, 2013 | Pubmed ID: 23401487 CD26 Inhibition Enhances Perfusion Recovery in ApoE-/-mice Current Vascular Pharmacology. Jan, 2013 | Pubmed ID: 23391419 骨髄の変化と下の血管内皮前駆細胞数肢虚血患者。 PloS One. 2013 | Pubmed ID: 23383236 Reduced CD26 Expression is Associated with Improved Cardiac Function After Acute Myocardial Infarction: Insights from the REPERATOR Study Journal of Molecular and Cellular Cardiology. Dec, 2012 | Pubmed ID: 22982114 Cardiac Regeneration: Stem Cells and Beyond Current Medicinal Chemistry. 2012 | Pubmed ID: 22963568 マトリックスの生産と容量心筋前駆細胞の in Vitro の分化中に改造します。 Journal of Molecular and Cellular Cardiology. Jul, 2012 | Pubmed ID: 22820459 TGFβ and BMP Signaling in Cardiac Cushion Formation: Lessons from Mice and Chicken Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22656450 The Arterial and Cardiac Epicardium in Development, Disease and Repair Differentiation; Research in Biological Diversity. Jul, 2012 | Pubmed ID: 22652098 Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22610569 Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting The Journal of Biological Chemistry. May, 2012 | Pubmed ID: 22493445 Gap Junctional Coupling with Cardiomyocytes is Necessary but Not Sufficient for Cardiomyogenic Differentiation of Cocultured Human Mesenchymal Stem Cells Stem Cells (Dayton, Ohio). Jun, 2012 | Pubmed ID: 22438316 Shear Induced Collateral Artery Growth Modulated by Endoglin but Not by ALK1 Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22436015 Early Statin Treatment Prior to Primary PCI for Acute Myocardial Infarction: REPERATOR, a Randomized Placebo-controlled Pilot Trial Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions. Nov, 2012 | Pubmed ID: 22419603 TGF-β Signaling in Endothelial-to-mesenchymal Transition: the Role of Shear Stress and Primary Cilia Science Signaling. Feb, 2012 | Pubmed ID: 22355187 Human Cardiomyocyte Progenitor Cells: a Short History of Nearly Everything Journal of Cellular and Molecular Medicine. Aug, 2012 | Pubmed ID: 22260290 MicroRNA-214 Inhibits Angiogenesis by Targeting Quaking and Reducing Angiogenic Growth Factor Release Cardiovascular Research. Mar, 2012 | Pubmed ID: 22227154 Cardiomyogenic Differentiation-independent Improvement of Cardiac Function by Human Cardiomyocyte Progenitor Cell Injection in Ischaemic Mouse Hearts Journal of Cellular and Molecular Medicine. Jul, 2012 | Pubmed ID: 22003890 変形性関節症 TGF-β シグナル伝達の年齢依存性の改変。 Cell and Tissue Research. Jan, 2012 | Pubmed ID: 21638205 Letter by Sluijter Et Al Regarding Article, "Human Cardiac Stem Cell Differentiation is Regulated by a Mircrine Mechanism" Circulation. Oct, 2011 | Pubmed ID: 22025645 Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate Toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts PloS One. 2011 | Pubmed ID: 21931658 MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production Circulation Research. Sep, 2011 | Pubmed ID: 21778427 2 つのユニークな TGF-β による制御血管新生タイプ I 受容体のシグナル伝達経路。 Histology and Histopathology. Sep, 2011 | Pubmed ID: 21751154 Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2011 | Pubmed ID: 21720378 Forkhead Box Protein P1 As a Downstream Target of Transforming Growth Factor-β Induces Collagen Synthesis and Correlates with a More Stable Plaque Phenotype Atherosclerosis. Sep, 2011 | Pubmed ID: 21683954 シグナル伝達経路血管新生における TGF-β 受容体;抗血管新生療法のための新興ターゲット。 Current Pharmaceutical Biotechnology. May, 2011 | Pubmed ID: 21619534 Tgfβ/Alk5 シグナリング胚大動脈内皮細胞におけるせん断応力誘起 Klf2 式が必要です。 Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jul, 2011 | Pubmed ID: 21604321 In Vitro Epithelial-to-mesenchymal Transformation in Human Adult Epicardial Cells is Regulated by TGFβ-signaling and WT1 Basic Research in Cardiology. Sep, 2011 | Pubmed ID: 21516490 Human Mesenchymal Stem Cell-conditioned Medium Improves Cardiac Function Following Myocardial Infarction Stem Cell Research. May, 2011 | Pubmed ID: 21419744 一次繊毛の素数の欠如は、せん断誘発内皮から間葉移行 Circulation Research. Apr, 2011 | Pubmed ID: 21393577 Low Oxygen Tension Positively Influences Cardiomyocyte Progenitor Cell Function Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21306557 Epithelial-to-mesenchymal Transformation Alters Electrical Conductivity of Human Epicardial Cells Journal of Cellular and Molecular Medicine. Dec, 2011 | Pubmed ID: 21251220 Molecular MRI of Murine Atherosclerotic Plaque Targeting NGAL: a Protein Associated with Unstable Human Plaque Characteristics Cardiovascular Research. Feb, 2011 | Pubmed ID: 21030534 MicroRNA-155 Prevents Necrotic Cell Death in Human Cardiomyocyte Progenitor Cells Via Targeting RIP1 Journal of Cellular and Molecular Medicine. Jul, 2011 | Pubmed ID: 20550618 Modulation of TGF-β/BMP-6 Expression and Increased Levels of Circulating Smooth Muscle Progenitor Cells in a Type I Diabetes Mouse Model Cardiovascular Diabetology. 2010 | Pubmed ID: 20858224 Cardiac Malformations in Pdgfralpha Mutant Embryos Are Associated with Increased Expression of WT1 and Nkx2.5 in the Second Heart Field Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2010 | Pubmed ID: 20658695 血管の形態形成と疾患における TGF ベータ家族のメンバーによってシグナル。 Trends in Cell Biology. Sep, 2010 | Pubmed ID: 20656490 Hyaluronic Acid Metabolism is Increased in Unstable Plaques European Journal of Clinical Investigation. Sep, 2010 | Pubmed ID: 20597964 Peripheral Blood Derived Cell Trafficking for Cardiac Regeneration Current Stem Cell Research & Therapy. Dec, 2010 | Pubmed ID: 20528755 IFN Gamma-dependent SOCS3 Expression Inhibits IL-6-induced STAT3 Phosphorylation and Differentially Affects IL-6 Mediated Transcriptional Responses in Endothelial Cells American Journal of Physiology. Cell Physiology. Aug, 2010 | Pubmed ID: 20484656 Active Wnt Signaling in Response to Cardiac Injury Basic Research in Cardiology. Sep, 2010 | Pubmed ID: 20373104 Hyperpolarization Induces Differentiation in Human Cardiomyocyte Progenitor Cells Stem Cell Reviews. Jun, 2010 | Pubmed ID: 20354915 Foetal and Adult Cardiomyocyte Progenitor Cells Have Different Developmental Potential Journal of Cellular and Molecular Medicine. Apr, 2010 | Pubmed ID: 20219011 MicroRNA-1 and -499 Regulate Differentiation and Proliferation in Human-derived Cardiomyocyte Progenitor Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2010 | Pubmed ID: 20081117 遺伝的および薬理学的にアクチビン受容体様キナーゼ 1 のターゲットと腫瘍の増殖および血管新生を損ないます。 The Journal of Experimental Medicine. Jan, 2010 | Pubmed ID: 20065063 Endothelial Cells Are Activated During Hypoxia Via Endoglin/ALK-1/SMAD1/5 Signaling in Vivo and in Vitro Biochemical and Biophysical Research Communications. Feb, 2010 | Pubmed ID: 20060813 雑種骨化性進行性にリンクされた ALK2 R206H 突然変異を与える構成アクティビティ BMP にタイプ I 受容体および BMP 誘導骨芽細胞分化および骨形成する間葉系細胞の感受性を高めます。 Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2010 | Pubmed ID: 19929436 Impaired Recruitment of HHT-1 Mononuclear Cells to the Ischaemic Heart is Due to an Altered CXCR4/CD26 Balance Cardiovascular Research. Feb, 2010 | Pubmed ID: 19762327 Human Cardiomyocyte Progenitor Cell-derived Cardiomyocytes Display a Maturated Electrical Phenotype Journal of Molecular and Cellular Cardiology. Jan, 2010 | Pubmed ID: 19460390 Improvement of Cardiac Efficacy and Safety Models in Drug Discovery by the Use of Stem Cell-derived Cardiomyocytes Expert Opinion on Drug Discovery. Apr, 2009 | Pubmed ID: 23485039 A New Direction for Cardiac Regeneration Therapy: Application of Synergistically Acting Epicardium-derived Cells and Cardiomyocyte Progenitor Cells Circulation. Heart Failure. Nov, 2009 | Pubmed ID: 19919990 VEGFとTGFbeta I型受容体キナーゼの阻害剤は、相乗的にALPHA5インテグリンの発現を誘導することによって血管形成を促進 Journal of Cell Science. Sep, 2009 | Pubmed ID: 19706683 Increase in ALK1/ALK5 Ratio As a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2009 | Pubmed ID: 19494318 Human Cardiomyocyte Progenitor Cell Transplantation Preserves Long-term Function of the Infarcted Mouse Myocardium Cardiovascular Research. Aug, 2009 | Pubmed ID: 19429921 貧しい血管形成 ALK5 L45 ループ変異 Smad の活性化に欠陥を表現するノックイン マウスから胚では。 Laboratory Investigation; a Journal of Technical Methods and Pathology. Jul, 2009 | Pubmed ID: 19398960 A New in Vitro Model for Stem Cell Differentiation and Interaction Stem Cell Research. Mar, 2009 | Pubmed ID: 19383416 Cell Therapy for Myocardial Regeneration Current Molecular Medicine. Apr, 2009 | Pubmed ID: 19355911 Human Cardiomyocyte Progenitor Cells Differentiate into Functional Mature Cardiomyocytes: an in Vitro Model for Studying Human Cardiac Physiology and Pathophysiology Nature Protocols. 2009 | Pubmed ID: 19197267 Stem Cells from In- or Outside of the Heart: Isolation, Characterization, and Potential for Myocardial Tissue Regeneration Pediatric Cardiology. Jul, 2009 | Pubmed ID: 19184178 TGF-β シグナリング血管生物学および機能不全。 Cell Research. Jan, 2009 | Pubmed ID: 19114994 Increased Expression of the Transforming Growth Factor-beta Signaling Pathway, Endoglin, and Early Growth Response-1 in Stable Plaques Stroke; a Journal of Cerebral Circulation. Feb, 2009 | Pubmed ID: 19074480 増殖因子ベータ誘導内皮間葉転換の変換: 心筋線維化への切り替えですか? Trends in Cardiovascular Medicine. Nov, 2008 | Pubmed ID: 19345316 Endoglin の血管新生と血管疾患では。 Angiogenesis. 2008 | Pubmed ID: 18283546 Balance Between Angiopoietin-1 and Angiopoietin-2 is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density Journal of Vascular Research. 2008 | Pubmed ID: 18182823 Toll-like Receptor 4 Mediates Maladaptive Left Ventricular Remodeling and Impairs Cardiac Function After Myocardial Infarction Circulation Research. Feb, 2008 | Pubmed ID: 18007026 TGF-beta1 Induces Efficient Differentiation of Human Cardiomyocyte Progenitor Cells into Functional Cardiomyocytes in Vitro Stem Cell Research. Nov, 2007 | Pubmed ID: 19383394 代償的なシグナリング卵黄嚢の血管系で削除マウスによる Tgf β 受容体の誘導。 Journal of Cell Science. Dec, 2007 | Pubmed ID: 18029401 Isolation and Expansion of Resident Cardiac Progenitor Cells Expert Review of Cardiovascular Therapy. Jan, 2007 | Pubmed ID: 17187455 Endoglin に重要な役割血細胞による血管の修理でがあります。 Circulation. Nov, 2006 | Pubmed ID: 17088457 Controlling Cardiomyocyte Survival Novartis Foundation Symposium. 2006 | Pubmed ID: 17019805 Smad7 とタンパク質ホスファターゼ 1 α は重要な決定要因 TGF-β が ALK1 内皮細胞内シグナリングの期間です。 BMC Cell Biology. 2006 | Pubmed ID: 16571110 TGF-beta Type II Receptor-deficient Thymocytes Develop Normally but Demonstrate Increased CD8+ Proliferation in Vivo Blood. Dec, 2005 | Pubmed ID: 16131565 Involvement of Furin-like Proprotein Convertases in the Arterial Response to Injury Cardiovascular Research. Oct, 2005 | Pubmed ID: 15963479 The Role of Stem Cells in Cardiac Regeneration Journal of Cellular and Molecular Medicine. Jan-Mar, 2005 | Pubmed ID: 15784162 Gene Expression Profiling Demonstrates That TGF-beta1 Signals Exclusively Through Receptor Complexes Involving Alk5 and Identifies Targets of TGF-beta Signaling Physiological Genomics. May, 2005 | Pubmed ID: 15769904 Endoglin 変異マウスの卵黄嚢の血管系でによる Tgf β に対するシグナル伝達不良のパラクリン: 遺伝性出血性毛細血管拡張症のためのパラダイム。 Development (Cambridge, England). Dec, 2004 | Pubmed ID: 15548578 Endoglin は、内皮細胞の増殖および TGF-β が ALK1 シグナル伝達を促進します。 The EMBO Journal. Oct, 2004 | Pubmed ID: 15385967 Human Stem Cells Shape the Future of Cardiac Regeneration Research International Journal of Cardiology. Jun, 2004 | Pubmed ID: 15336839 A Gain of Function Mutation in the Activation Loop of Platelet-derived Growth Factor Beta-receptor Deregulates Its Kinase Activity The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15284236 Synergy and Antagonism Between Notch and BMP Receptor Signaling Pathways in Endothelial Cells The EMBO Journal. Feb, 2004 | Pubmed ID: 14739937 による骨形成タンパク質受容体細胞の運命を制御します。 Molecular and Cellular Endocrinology. Dec, 2003 | Pubmed ID: 14656483 アクチビン受容体様キナーゼ (アルク) 1 横 Tgf β に対する/ALK5 シグナリングは拮抗メディエーターです。 Molecular Cell. Oct, 2003 | Pubmed ID: 14580334 Controlling the Angiogenic Switch: a Balance Between Two Distinct TGF-b Receptor Signaling Pathways Trends in Cardiovascular Medicine. Oct, 2003 | Pubmed ID: 14522471 TGF β シグナリング欠乏の造血幹細胞は通常の自己複製と生体内で生体外での増加の増殖能力にもかかわらず再生能力があります。 Blood. Nov, 2003 | Pubmed ID: 12842983 リン酸化 Smad2 の分布 TGF ベータ配位子マウス開発の標的組織を識別します。 Gene Expression Patterns : GEP. Jun, 2003 | Pubmed ID: 12799085 Expression and Activation of the BMP-signaling Components in Human Fracture Nonunions The Journal of Bone and Joint Surgery. American Volume. Nov, 2002 | Pubmed ID: 12429748 刺激による骨形成タンパク質 Id1 発現の十分なと骨形成タンパク質誘起活性内皮細胞のために必要です。 Circulation. Oct, 2002 | Pubmed ID: 12390958 Smad7 の過剰発現は、複数の上皮組織における重度病理学的変化の結果します。 The EMBO Journal. Jun, 2002 | Pubmed ID: 12032071 成長因子 β のシグナル伝達を変換します。 Journal of Leukocyte Biology. May, 2002 | Pubmed ID: 11994497 内皮細胞を介して 2 つの個別のアクティベーションの状態を分散 TGF-β 型受容体。 The EMBO Journal. Apr, 2002 | Pubmed ID: 11927558 Smad タンパク質による細胞増殖の制御。 Journal of Cellular Physiology. Apr, 2002 | Pubmed ID: 11920677 ミニチュア組織培養系でマウス心臓弁の培養 Boudewijn P.T. Kruithof1, Samuel C. Lieber2, Marianna Kruithof-de Julio3, Vincian Gaussin4, Marie José Goumans1 1Department of Molecular Cell Biology, Leiden University Medical Center, 2Department of Engineering Technology, New Jersey Institute of Technology, 3Department of Urology, Leiden University Medical Center, 4Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School Bioengineering
ミニチュア組織培養系でマウス心臓弁の培養 Boudewijn P.T. Kruithof1, Samuel C. Lieber2, Marianna Kruithof-de Julio3, Vincian Gaussin4, Marie José Goumans1 1Department of Molecular Cell Biology, Leiden University Medical Center, 2Department of Engineering Technology, New Jersey Institute of Technology, 3Department of Urology, Leiden University Medical Center, 4Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School Bioengineering