Marie Stiborova Department of Biochemistry Charles University Biography Publications Institution JoVE Articles Marie Stiborova has not added a biography. If you are Marie Stiborova and would like to personalize this page please email our Author Liaison for assistance. Publications The Impact of Chemotherapeutic Drugs on the CYP1A1-catalysed Metabolism of the Environmental Carcinogen Benzo[a]pyrene: Effects in Human Colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) Cells Toxicology. Feb, 2018 | Pubmed ID: 29471073 Comparative Gene Expression Profiling of Human Metallothionein-3 Up-regulation in Neuroblastoma Cells and Its Impact on Susceptibility to Cisplatin Oncotarget. Jan, 2018 | Pubmed ID: 29435113 Cytochrome Bimpacts on Cytochrome P450-mediated Metabolism of Benzo[a]pyrene and Its DNA Adduct Formation: Studies in Hepatic Cytochrome B/P450 Reductase Null (HBRN) Mice Archives of Toxicology. Jan, 2018 | Pubmed ID: 29368147 Differentiation-associated Urothelial Cytochrome P450 Oxidoreductase Predicates the Xenobiotic-metabolizing Activity of "luminal" Muscle-invasive Bladder Cancers Molecular Carcinogenesis. Jan, 2018 | Pubmed ID: 29323757 The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells International Journal of Molecular Sciences. Jan, 2018 | Pubmed ID: 29304031 Sarcosine Influences Apoptosis and Growth of Prostate Cells Via Cell-type Specific Regulation of Distinct Sets of Genes The Prostate. Feb, 2018 | Pubmed ID: 29105933 Cytochromeplays a Dual Role in the Reaction Cycle of Cytochrome P450 3A4 During Oxidation of the Anticancer Drug Ellipticine Monatshefte Fur Chemie. 2017 | Pubmed ID: 29104319 Comparison of the Oxidation of Carcinogenic Aristolochic Acid I and II by Microsomal Cytochromes P450 in Vitro: Experimental and Theoretical Approaches Monatshefte Fur Chemie. 2017 | Pubmed ID: 29104318 Comparison of Human Cytochrome P450 1A1-catalysed Oxidation of Benzo[]pyrene in Prokaryotic and Eukaryotic Expression Systems Monatshefte Fur Chemie. 2017 | Pubmed ID: 29104317 DNA Adducts Formed by Aristolochic Acid Are Unique Biomarkers of Exposure and Explain the Initiation Phase of Upper Urothelial Cancer International Journal of Molecular Sciences. Oct, 2017 | Pubmed ID: 29036902 An Insight into the Complex Roles of Metallothioneins in Malignant Diseases with Emphasis on (sub)isoforms/isoforms and Epigenetics Phenomena Pharmacology & Therapeutics. Oct, 2017 | Pubmed ID: 28987322 DNA Interaction with Platinum-based Cytostatics Revealed by DNA Sequencing Analytical Biochemistry. Sep, 2017 | Pubmed ID: 28970072 VPA Does Not Enhance Platinum Binding to DNA in Cisplatin-resistant Neuroblastoma Cancer Cells Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Sep, 2017 | Pubmed ID: 28945187 Histone Deacetylase Inhibitors As Anticancer Drugs International Journal of Molecular Sciences. Jul, 2017 | Pubmed ID: 28671573 The Capacity and Effectiveness of Diosmectite and Charcoal in Trapping the Compounds Causing the Most Frequent Intoxications in Acute Medicine: A Comparative Study Environmental Toxicology and Pharmacology. Jun, 2017 | Pubmed ID: 28445845 Apoferritin As an Ubiquitous Nanocarrier with Excellent Shelf Life International Journal of Nanomedicine. 2017 | Pubmed ID: 28392686 Impact of Genetic Modulation of SULT1A Enzymes on DNA Adduct Formation by Aristolochic Acids and 3-nitrobenzanthrone Archives of Toxicology. Apr, 2017 | Pubmed ID: 27557898 Effectiveness of Human Cytochrome P450 3A4 Present in Liposomal and Microsomal Nanoparticles in Formation of Covalent DNA Adducts by Ellipticine Neuro Endocrinology Letters. Dec, 2016 | Pubmed ID: 28263536 Exposure of Rats to Exogenous Endocrine Disruptors 17alpha-ethinylestradiol and Benzo(a)pyrene and an Estrogenic Hormone Estradiol Induces Expression of Cytochromes P450 Involved in Their Metabolism Neuro Endocrinology Letters. Dec, 2016 | Pubmed ID: 28263535 Fully Automated Two-step Assay for Detection of Metallothionein Through Magnetic Isolation Using Functionalized γ-Fe2O3 Particles Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2016 | Pubmed ID: 27825623 Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer PloS One. 2016 | Pubmed ID: 27824899 Prostate Tumor Attenuation in the Nu/nu Murine Model Due to Anti-sarcosine Antibodies in Folate-targeted Liposomes Scientific Reports. Sep, 2016 | Pubmed ID: 27646588 Zinc and Zinc-containing Biomolecules in Childhood Brain Tumors Journal of Molecular Medicine (Berlin, Germany). Nov, 2016 | Pubmed ID: 27638340 Correction to NADH:Cytochrome B5 Reductase and Cytochrome B5 Can Act As Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene Chemical Research in Toxicology. Sep, 2016 | Pubmed ID: 27575721 Balkan Endemic Nephropathy: an Update on Its Aetiology Archives of Toxicology. Nov, 2016 | Pubmed ID: 27538407 NADH:Cytochrome B5 Reductase and Cytochrome B5 Can Act As Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene Chemical Research in Toxicology. 08, 2016 | Pubmed ID: 27404282 Site-Directed Conjugation of Antibodies to Apoferritin Nanocarrier for Targeted Drug Delivery to Prostate Cancer Cells ACS Applied Materials & Interfaces. Jun, 2016 | Pubmed ID: 27219717 Induced Expression of Microsomal Cytochrome B5 Determined at MRNA and Protein Levels in Rats Exposed to Ellipticine, Benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I) Monatshefte Fur Chemie. 2016 | Pubmed ID: 27110040 Heterologous Expression of Human Cytochrome P450 2S1 Inand Investigation of Its Role in Metabolism of Benzo[]pyrene and Ellipticine Monatshefte Fur Chemie. 2016 | Pubmed ID: 27110039 NADPH- and NADH-dependent Metabolism of and DNA Adduct Formation by Benzo[]pyrene Catalyzed with Rat Hepatic Microsomes and Cytochrome P450 1A1 Monatshefte Fur Chemie. 2016 | Pubmed ID: 27110038 Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide) Sensors (Basel, Switzerland). Feb, 2016 | Pubmed ID: 26927112 The Impact of Individual Cytochrome P450 Enzymes on Oxidative Metabolism of Benzo[a]pyrene in Human Livers Environmental and Molecular Mutagenesis. Apr, 2016 | Pubmed ID: 26919089 Electrochemical Sensing of Etoposide Using Carbon Quantum Dot Modified Glassy Carbon Electrode The Analyst. Apr, 2016 | Pubmed ID: 26882954 Active Site Mutations As a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1 International Journal of Molecular Sciences. Feb, 2016 | Pubmed ID: 26861298 Relation of Exposure to Amino Acids Involved in Sarcosine Metabolic Pathway on Behavior of Non-tumor and Malignant Prostatic Cell Lines The Prostate. May, 2016 | Pubmed ID: 26847870 Induction of Cytochromes P450 1A1 and 1A2 Suppresses Formation of DNA Adducts by Carcinogenic Aristolochic Acid I in Rats in Vivo Toxicology. Feb, 2016 | Pubmed ID: 26845733 The Impact of P53 on DNA Damage and Metabolic Activation of the Environmental Carcinogen Benzo[a]pyrene: Effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) Mice Archives of Toxicology. Apr, 2016 | Pubmed ID: 25995008 The Effects of Heavy Metal Ions, Phthalates and Ochratoxin A on Oxidation of Carcinogenic Aristolochic Acid I Causing Balkan Endemic Nephropathy Neuro Endocrinology Letters. 2015 | Pubmed ID: 26757129 Role of Dihydromyricetin in Cytochrome P450-mediated Metabolism and Carcinogen Activation Neuro Endocrinology Letters. 2015 | Pubmed ID: 26757127 Preparation and Application of Anti-peptide Antibodies for Detection of Orphan Cytochromes P450 Neuro Endocrinology Letters. 2015 | Pubmed ID: 26757124 Ferrous and Ferric State of Cytochromes P450 in Intact Escherichia Coli Cells: a Possible Role of Cytochrome P450-flavodoxin Interactions Neuro Endocrinology Letters. 2015 | Pubmed ID: 26757119 Cytotoxicity of and DNA Adduct Formation by Ellipticine and Its Micellar Form in Human Leukemia Cells in Vitro Neuro Endocrinology Letters. 2015 | Pubmed ID: 26757112 A Study on 17alpha-ethinylestradiol Metabolism in Rat and Pleurotus Ostreatus Neuro Endocrinology Letters. 2015 | Pubmed ID: 26757108 A Mechanism of O-Demethylation of Aristolochic Acid I by Cytochromes P450 and Their Contributions to This Reaction in Human and Rat Livers: Experimental and Theoretical Approaches International Journal of Molecular Sciences. Nov, 2015 | Pubmed ID: 26593908 Photo-initiated Crosslinking Extends Mapping of the Protein-protein Interface to Membrane-embedded Portions of Cytochromes P450 2B4 and B₅ Methods (San Diego, Calif.). Nov, 2015 | Pubmed ID: 26235815 Vacuolar-ATPase-mediated Intracellular Sequestration of Ellipticine Contributes to Drug Resistance in Neuroblastoma Cells International Journal of Oncology. Sep, 2015 | Pubmed ID: 26134421 The Synergistic Effects of DNA-damaging Drugs Cisplatin and Etoposide with a Histone Deacetylase Inhibitor Valproate in High-risk Neuroblastoma Cells International Journal of Oncology. Jul, 2015 | Pubmed ID: 25963435 Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene Toxicological Sciences : an Official Journal of the Society of Toxicology. Aug, 2015 | Pubmed ID: 25911668 Doxorubicin Interactions with Bovine Serum Albumin Revealed by Microdialysis with On-line Laser-induced Fluorescence Detection at Subpicogram Level Electrophoresis. Jun, 2015 | Pubmed ID: 25808901 Fluorescent Cellular Assay for Screening Agents Inhibiting Pseudomonas Aeruginosa Adherence Sensors (Basel, Switzerland). Jan, 2015 | Pubmed ID: 25602268 The Influence of Ochratoxin A on DNA Adduct Formation by the Carcinogen Aristolochic Acid in Rats Archives of Toxicology. Nov, 2015 | Pubmed ID: 25209566 Enzymes Oxidizing the Azo Dye 1-phenylazo-2-naphthol (Sudan I) and Their Contribution to Its Genotoxicity and Carcinogenicity Current Drug Metabolism. 2014 | Pubmed ID: 25658126 The Anticancer Drug Ellipticine Activated with Cytochrome P450 Mediates DNA Damage Determining Its Pharmacological Efficiencies: Studies with Rats, Hepatic Cytochrome P450 Reductase Null (HRN™) Mice and Pure Enzymes International Journal of Molecular Sciences. Dec, 2014 | Pubmed ID: 25547492 Modulation of Induced Cytotoxicity of Doxorubicin by Using Apoferritin and Liposomal Cages International Journal of Molecular Sciences. Dec, 2014 | Pubmed ID: 25514405 Formation of DNA Adducts by Ellipticine and Its Micellar Form in Rats - a Comparative Study Sensors (Basel, Switzerland). Dec, 2014 | Pubmed ID: 25479328 Role of Rat Cytochromes P450 in the Oxidation of 17α-ethinylestradiol Environmental Toxicology and Pharmacology. Nov, 2014 | Pubmed ID: 25461545 Flexible Docking-based Molecular Dynamics/steered Molecular Dynamics Calculations of Protein-protein Contacts in a Complex of Cytochrome P450 1A2 with Cytochrome B5 Biochemistry. Oct, 2014 | Pubmed ID: 25313797 Introduction of Water into the Heme Distal Side by Leu65 Mutations of an Oxygen Sensor, YddV, Generates Verdoheme and Carbon Monoxide, Exerting the Heme Oxygenase Reaction Journal of Inorganic Biochemistry. Nov, 2014 | Pubmed ID: 25046385 Mechanisms of Enzyme-catalyzed Reduction of Two Carcinogenic Nitro-aromatics, 3-nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches International Journal of Molecular Sciences. Jun, 2014 | Pubmed ID: 24918288 The Application of an Emerging Technique for Protein-protein Interaction Interface Mapping: the Combination of Photo-initiated Cross-linking Protein Nanoprobes with Mass Spectrometry International Journal of Molecular Sciences. May, 2014 | Pubmed ID: 24865487 The Effect of Aristolochic Acid I on Expression of NAD(P)H:quinone Oxidoreductase in Mice and Rats--a Comparative Study Mutation Research. Genetic Toxicology and Environmental Mutagenesis. Jul, 2014 | Pubmed ID: 24769487 The Influence of Dicoumarol on the Bioactivation of the Carcinogen Aristolochic Acid I in Rats Mutagenesis. May, 2014 | Pubmed ID: 24598128 Cytochrome B5 and Epoxide Hydrolase Contribute to Benzo[a]pyrene-DNA Adduct Formation Catalyzed by Cytochrome P450 1A1 Under Low NADPH:P450 Oxidoreductase Conditions Toxicology. Apr, 2014 | Pubmed ID: 24530354 Hypoxia-mediated Histone Acetylation and Expression of N-myc Transcription Factor Dictate Aggressiveness of Neuroblastoma Cells Oncology Reports. Apr, 2014 | Pubmed ID: 24481548 Cisplatin-resistant Prostate Cancer Model: Differences in Antioxidant System, Apoptosis and Cell Cycle International Journal of Oncology. Mar, 2014 | Pubmed ID: 24366574 Histone Deacetylase Inhibitors in Cancer Therapy. A Review Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2014 | Pubmed ID: 24263215 Knockout and Humanized Mice As Suitable Tools to Identify Enzymes Metabolizing the Human Carcinogen Aristolochic Acid Xenobiotica; the Fate of Foreign Compounds in Biological Systems. Jan, 2014 | Pubmed ID: 24152141 Ellipticines As DNA-targeted Chemotherapeutics Current Medicinal Chemistry. 2014 | Pubmed ID: 24059226 Alcoholic Liver Cirrhosis Increases the Risk of Left Ventricular Diastolic Dysfunction Neuro Endocrinology Letters. 2013 | Pubmed ID: 24362094 Oxidation of Carcinogenic Benzo[a]pyrene by Human and Rat Cytochrome P450 1A1 and Its Influencing by Cytochrome B5 - a Comparative Study Neuro Endocrinology Letters. 2013 | Pubmed ID: 24362093 The Effect of Benzo[a]pyrene on Metabolic Activation of Anticancer Drug Ellipticine in Mice Neuro Endocrinology Letters. 2013 | Pubmed ID: 24362092 A Novel Insight into the Cardiotoxicity of Antineoplastic Drug Doxorubicin International Journal of Molecular Sciences. Oct, 2013 | Pubmed ID: 24185911 The Relationship Between DNA Adduct Formation by Benzo[a]pyrene and Expression of Its Activation Enzyme Cytochrome P450 1A1 in Rat Environmental Toxicology and Pharmacology. Nov, 2013 | Pubmed ID: 24095716 Sarcosine As a Potential Prostate Cancer Biomarker--a Review International Journal of Molecular Sciences. Jul, 2013 | Pubmed ID: 23880848 Apoferritin Modified Magnetic Particles As Doxorubicin Carriers for Anticancer Drug Delivery International Journal of Molecular Sciences. Jun, 2013 | Pubmed ID: 23807501 Enzymes Metabolizing Aristolochic Acid and Their Contribution to the Development of Aristolochic Acid Nephropathy and Urothelial Cancer Current Drug Metabolism. Jul, 2013 | Pubmed ID: 23701164 The Role of Metallothionein in Oxidative Stress International Journal of Molecular Sciences. Mar, 2013 | Pubmed ID: 23502468 Induced Expression of Cytochrome P450 1A and NAD(P)H:quinone Oxidoreductase Determined at MRNA, Protein, and Enzyme Activity Levels in Rats Exposed to the Carcinogenic Azo Dye 1-phenylazo-2-naphthol (Sudan I) Chemical Research in Toxicology. Feb, 2013 | Pubmed ID: 23289503 Effects of Cytochrome P450 Inhibitors on Peroxidase Activity Neuro Endocrinology Letters. 2012 | Pubmed ID: 23353841 Theoretical Investigation of Differences in Nitroreduction of Aristolochic Acid I by Cytochromes P450 1A1, 1A2 and 1B1 Neuro Endocrinology Letters. 2012 | Pubmed ID: 23353840 Impact of Histone Deacetylase Inhibitor Valproic Acid on the Anticancer Effect of Etoposide on Neuroblastoma Cells Neuro Endocrinology Letters. 2012 | Pubmed ID: 23353839 Activation and Detoxification Metabolism of Urban Air Pollutants 2-nitrobenzanthrone and Carcinogenic 3-nitrobenzanthrone by Rat and Mouse Hepatic Microsomes Neuro Endocrinology Letters. 2012 | Pubmed ID: 23353838 Modern Micro and Nanoparticle-based Imaging Techniques Sensors (Basel, Switzerland). Nov, 2012 | Pubmed ID: 23202187 NAD(P)H:quinone Oxidoreductase Expression in Cyp1a-knockout and CYP1A-humanized Mouse Lines and Its Effect on Bioactivation of the Carcinogen Aristolochic Acid I Toxicology and Applied Pharmacology. Dec, 2012 | Pubmed ID: 22982977 Ellipticine Oxidation and DNA Adduct Formation in Human Hepatocytes is Catalyzed by Human Cytochromes P450 and Enhanced by Cytochrome B5 Toxicology. Dec, 2012 | Pubmed ID: 22917556 Analysis of Covalent Ellipticine- and Doxorubicin-derived Adducts in DNA of Neuroblastoma Cells by the ³²P-postlabeling Technique Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2012 | Pubmed ID: 22837132 Formation, Persistence, and Identification of DNA Adducts Formed by the Carcinogenic Environmental Pollutant O-anisidine in Rats Toxicological Sciences : an Official Journal of the Society of Toxicology. Jun, 2012 | Pubmed ID: 22403159 Cytochrome B5 Increases Cytochrome P450 3A4-mediated Activation of Anticancer Drug Ellipticine to 13-hydroxyellipticine Whose Covalent Binding to DNA is Elevated by Sulfotransferases and N,O-acetyltransferases Chemical Research in Toxicology. May, 2012 | Pubmed ID: 22390216 Bioactivation Versus Detoxication of the Urothelial Carcinogen Aristolochic Acid I by Human Cytochrome P450 1A1 and 1A2 Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2012 | Pubmed ID: 22086975 Mechanisms of Ellipticine-mediated Resistance in UKF-NB-4 Neuroblastoma Cells Cancer Science. Feb, 2012 | Pubmed ID: 22040216 Role of Cytochromes P450 in Metabolism of Carcinogenic Aristolochic Acid I: Evidence of Their Contribution to Aristolochic Acid I Detoxication and Activation in Rat Liver Neuro Endocrinology Letters. 2011 | Pubmed ID: 22167220 Isolation and Partial Characterization of Extracellular NADPH-dependent Phenol Hydroxylase Oxidizing Phenol to Catechol in Comamonas Testosteroni Neuro Endocrinology Letters. 2011 | Pubmed ID: 22167219 Impact of Beta-naphthoflavone on Genotoxicity of Food-derived Carcinogens Neuro Endocrinology Letters. 2011 | Pubmed ID: 22167217 Comparison of Activation of Aristolochic Acid I and II with NADPH:quinone Oxidoreductase, Sulphotransferases and N-acetyltranferases Neuro Endocrinology Letters. 2011 | Pubmed ID: 22167209 Anticancer Agent Ellipticine Combined with Histone Deacetylase Inhibitors, Valproic Acid and Trichostatin A, is an Effective DNA Damage Strategy in Human Neuroblastoma Neuro Endocrinology Letters. 2011 | Pubmed ID: 22167207 Human Cytochrome-P450 Enzymes Metabolize N-(2-methoxyphenyl)hydroxylamine, a Metabolite of the Carcinogens O-anisidine and O-nitroanisole, Thereby Dictating Its Genotoxicity Mutation Research. Dec, 2011 | Pubmed ID: 21946300 Ellipticine Cytotoxicity to Cancer Cell Lines - a Comparative Study Interdisciplinary Toxicology. Jun, 2011 | Pubmed ID: 21753906 Cytochrome B(5) Shifts Oxidation of the Anticancer Drug Ellipticine by Cytochromes P450 1A1 and 1A2 from Its Detoxication to Activation, Thereby Modulating Its Pharmacological Efficacy Biochemical Pharmacology. Sep, 2011 | Pubmed ID: 21683692 The Human Carcinogen Aristolochic Acid I is Activated to Form DNA Adducts by Human NAD(P)H:quinone Oxidoreductase Without the Contribution of Acetyltransferases or Sulfotransferases Environmental and Molecular Mutagenesis. Jul, 2011 | Pubmed ID: 21370283 Role of Cytochromes P450 1A1/2 in Detoxication and Activation of Carcinogenic Aristolochic Acid I: Studies with the Hepatic NADPH:cytochrome P450 Reductase Null (HRN) Mouse Model Toxicological Sciences : an Official Journal of the Society of Toxicology. May, 2011 | Pubmed ID: 21362632 Induction of Biotransformation Enzymes by the Carcinogenic Air-pollutant 3-nitrobenzanthrone in Liver, Kidney and Lung, After Intra-tracheal Instillation in Rats Mutation Research. Feb, 2011 | Pubmed ID: 21167309 DNA and Histone Deacetylases As Targets for Neuroblastoma Treatment Interdisciplinary Toxicology. Jun, 2010 | Pubmed ID: 21217872 Identification of Rat Cytochromes P450 Metabolizing N-(2-methoxyphenyl)hydroxylamine, a Human Metabolite of the Environmental Pollutants and Carcinogens O-anisidine and O-nitroanisole Neuro Endocrinology Letters. 2010 | Pubmed ID: 21187827 Role of Cytochromes P450 and Peroxidases in Metabolism of the Anticancer Drug Ellipticine: Additional Evidence of Their Contribution to Ellipticine Activation in Rat Liver, Lung and Kidney Neuro Endocrinology Letters. 2010 | Pubmed ID: 21187821 Glycosylation Protects Proteins Against Free Radicals Generated from Toxic Xenobiotics Toxicological Sciences : an Official Journal of the Society of Toxicology. Oct, 2010 | Pubmed ID: 20616208 The Binding Affinity of Carcinogenic N-nitrosodimethylamine and N-nitrosomethylaniline to Cytochromes P450 2B4, 2E1 and 3A6 Does Not Dictate the Rate of Their Enzymatic N-demethylation General Physiology and Biophysics. Jun, 2010 | Pubmed ID: 20577029 Mechanisms of the Different DNA Adduct Forming Potentials of the Urban Air Pollutants 2-nitrobenzanthrone and Carcinogenic 3-nitrobenzanthrone Chemical Research in Toxicology. Jul, 2010 | Pubmed ID: 20545351 Analysis of Benzo[a]pyrene Metabolites Formed by Rat Hepatic Microsomes Using High Pressure Liquid Chromatography: Optimization of the Method Interdisciplinary Toxicology. Dec, 2009 | Pubmed ID: 21217860 Histone Deacetylase Inhibitors Valproate and Trichostatin A Are Toxic to Neuroblastoma Cells and Modulate Cytochrome P450 1A1, 1B1 and 3A4 Expression in These Cells Interdisciplinary Toxicology. Sep, 2009 | Pubmed ID: 21217856 The Effects of Selected Flavonoids on Cytochromes P450 in Rat Liver and Small Intestine Interdisciplinary Toxicology. Sep, 2009 | Pubmed ID: 21217855 Oxidation of the Carcinogenic Non-aminoazo Dye 1-phenylazo-2-hydroxy-naphthalene (Sudan I) by Cytochromes P450 and Peroxidases: a Comparative Study Interdisciplinary Toxicology. Sep, 2009 | Pubmed ID: 21217854 Genotoxic Mechanisms for the Carcinogenicity of the Environmental Pollutants and Carcinogens O-anisidine and 2-nitroanisole Follow from Adducts Generated by Their Metabolite N-(2-methoxyphenyl)-hydroxylamine with Deoxyguanosine in DNA Interdisciplinary Toxicology. Mar, 2009 | Pubmed ID: 21217841 Isolation and Partial Characterization of Catechol 1,2-dioxygenase of Phenol Degrading Yeast Candida Tropicalis Neuro Endocrinology Letters. 2009 | Pubmed ID: 20027149 Preparation of Apo-cytochrome B5 Utilizing Heme Transfer to Apo-myoglobin Neuro Endocrinology Letters. 2009 | Pubmed ID: 20027148 Modulation of Cytochrome P450 Enzyme System by Selected Flavonoids Neuro Endocrinology Letters. 2009 | Pubmed ID: 20027147 Cytotoxicity of and DNA Adduct Formation by Ellipticine in Human U87MG Glioblastoma Cancer Cells Neuro Endocrinology Letters. 2009 | Pubmed ID: 20027146 Oxidation of 3-aminobenzanthrone, a Human Metabolite of Carcinogenic Environmental Pollutant 3-nitrobenzanthrone, by Cytochromes P450 - Similarity Between Human and Rat Enzymes Neuro Endocrinology Letters. 2009 | Pubmed ID: 20027145 Rat Cytochromes P450 Oxidize 2-nitrophenol, a Human Metabolite of Carcinogenic 2-nitroanisole Neuro Endocrinology Letters. 2009 | Pubmed ID: 20027144 The Mechanism of Cytotoxicity and DNA Adduct Formation by the Anticancer Drug Ellipticine in Human Neuroblastoma Cells Biochemical Pharmacology. May, 2009 | Pubmed ID: 19426684 3-aminobenzanthrone, a Human Metabolite of the Carcinogenic Environmental Pollutant 3-nitrobenzanthrone, Induces Biotransformation Enzymes in Rat Kidney and Lung Mutation Research. May, 2009 | Pubmed ID: 19398038 The Role of Biotransformation Enzymes in the Development of Renal Injury and Urothelial Cancer Caused by Aristolochic Acid: Urgent Questions and Difficult Answers Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Mar, 2009 | Pubmed ID: 19365519 Preparation of a Biologically Active Apo-cytochrome B5 Via Heterologous Expression in Escherichia Coli Protein Expression and Purification. Aug, 2009 | Pubmed ID: 19358889 Isolation of Cytoplasmic NADPH-dependent Phenol Hydroxylase and Catechol-1,2-dioxygenase from Candida Tropicalis Yeast Interdisciplinary Toxicology. Dec, 2008 | Pubmed ID: 21218120 Cytochrome P450-mediated Metabolism of N-(2-methoxyphenyl)-hydroxylamine, a Human Metabolite of the Environmental Pollutants and Carcinogens O-anisidine and O-nitroanisole Interdisciplinary Toxicology. Dec, 2008 | Pubmed ID: 21218119 Optimalization of Preparation of Apo-cytochrome B(5) Utilizing Apo-myoglobin Interdisciplinary Toxicology. Sep, 2008 | Pubmed ID: 21218111 The Comparison of Cytotoxicity of the Anticancer Drugs Doxorubicin and Ellipticine to Human Neuroblastoma Cells Interdisciplinary Toxicology. Sep, 2008 | Pubmed ID: 21218110 Oxidation of Carcinogenic 2-nitroanisole by Rat Cytochromes P450 - Similarity Between Human and Rat Enzymes Interdisciplinary Toxicology. Sep, 2008 | Pubmed ID: 21218109 Ellipticine and Benzo(a)pyrene Increase Their Own Metabolic Activation Via Modulation of Expression and Enzymatic Activity of Cytochromes P450 1A1 and 1A2 Interdisciplinary Toxicology. Sep, 2008 | Pubmed ID: 21218107 Experimental Approaches to Evaluate Activities of Cytochromes P450 3A Interdisciplinary Toxicology. Sep, 2008 | Pubmed ID: 21218106 Rat Cytochromes P450 Oxidize 3-aminobenzanthrone, a Human Metabolite of the Carcinogenic Environmental Pollutant 3-nitrobenzanthrone Interdisciplinary Toxicology. Sep, 2008 | Pubmed ID: 21218105 Contribution of Biotransformation Enzymes to the Development of Renal Injury and Urothelial Cancer Caused by Aristolochic Acid: Urgent Questions, Difficult Answers Interdisciplinary Toxicology. Jun, 2008 | Pubmed ID: 21218097 A One-electron Oxidation of Carcinogenic Nonaminoazo Dye Sudan I by Horseradish Peroxidase Neuro Endocrinology Letters. Oct, 2008 | Pubmed ID: 18987613 Human Cytochromes P450 1A1 and 1A2 Participate in Detoxication of Carcinogenic Aristolochic Acid Neuro Endocrinology Letters. Oct, 2008 | Pubmed ID: 18987598 Induction of Cytochromes P450 in Small Intestine by Chemopreventive Compounds Neuro Endocrinology Letters. Oct, 2008 | Pubmed ID: 18987596 Isolation and Partial Characterization of the Adduct Formed by 13-hydroxyellipticine with Deoxyguanosine in DNA Neuro Endocrinology Letters. Oct, 2008 | Pubmed ID: 18987592 Structural Analysis of Binding of a Diamantoid Substrate to Cytochrome P450 2B4: Possible Role of Arg 133 in Modulation of Function and Activity of This Enzyme Neuro Endocrinology Letters. Oct, 2008 | Pubmed ID: 18987581 Macleaya Cordata Extract and Sangrovit Genotoxicity. Assessment in Vivo Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jun, 2008 | Pubmed ID: 18795072 Redox Cycling in the Metabolism of the Environmental Pollutant and Suspected Human Carcinogen O-anisidine by Rat and Rabbit Hepatic Microsomes Chemical Research in Toxicology. Aug, 2008 | Pubmed ID: 18624415 The Environmental Pollutant and Carcinogen 3-nitrobenzanthrone Induces Cytochrome P450 1A1 and NAD(P)H:quinone Oxidoreductase in Rat Lung and Kidney, Thereby Enhancing Its Own Genotoxicity Toxicology. May, 2008 | Pubmed ID: 18329153 Role of Hepatic Cytochromes P450 in Bioactivation of the Anticancer Drug Ellipticine: Studies with the Hepatic NADPH:cytochrome P450 Reductase Null Mouse Toxicology and Applied Pharmacology. Feb, 2008 | Pubmed ID: 17976674 Metabolic Activation of Carcinogenic Aristolochic Acid, a Risk Factor for Balkan Endemic Nephropathy Mutation Research. Jan-Feb, 2008 | Pubmed ID: 17851120 Utilizing of Square Wave Voltammetry to Detect Flavonoids in the Presence of Human Urine Sensors (Basel, Switzerland). Oct, 2007 | Pubmed ID: 28903234 Mapping of Cytochrome P450 2B4 Substrate Binding Sites by Photolabile Probe 3-azidiamantane: Identification of Putative Substrate Access Regions Archives of Biochemistry and Biophysics. Dec, 2007 | Pubmed ID: 17961497 The Anticancer Drug Ellipticine is a Potent Inducer of Rat Cytochromes P450 1A1 and 1A2, Thereby Modulating Its Own Metabolism Drug Metabolism and Disposition: the Biological Fate of Chemicals. Oct, 2007 | Pubmed ID: 17656468 Formation and Persistence of DNA Adducts of Anticancer Drug Ellipticine in Rats Toxicology. Jul, 2007 | Pubmed ID: 17482743 DNA Adduct Formation by the Anticancer Drug Ellipticine in Human Leukemia HL-60 and CCRF-CEM Cells Cancer Letters. Jul, 2007 | Pubmed ID: 17306925 Mammalian Peroxidases Activate Anticancer Drug Ellipticine to Intermediates Forming Deoxyguanosine Adducts in DNA Identical to Those Found in Vivo and Generated from 12-hydroxyellipticine and 13-hydroxyellipticine International Journal of Cancer. Jan, 2007 | Pubmed ID: 17066455 Modulation of CYP1A1-mediated Oxidation of Carcinogenic Azo Dye Sudan I and Its Binding to DNA by Cytochrome B5 Neuro Endocrinology Letters. Dec, 2006 | Pubmed ID: 17159775 Cytochromes P450 Reconstituted with NADPH: P450 Reductase Mimic the Activating and Detoxicating Metabolism of the Anticancer Drug Ellipticine in Microsomes Neuro Endocrinology Letters. Dec, 2006 | Pubmed ID: 17159771 Toxicological Aspects of Flavonoid Interaction with Biomacromolecules Neuro Endocrinology Letters. Dec, 2006 | Pubmed ID: 17159770 Oxidative Detoxication of Carcinogenic 2-nitroanisole by Human, Rat and Rabbit Cytochrome P450 Neuro Endocrinology Letters. Dec, 2006 | Pubmed ID: 17159769 Molecular Mechanisms of Antineoplastic Action of an Anticancer Drug Ellipticine Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Jul, 2006 | Pubmed ID: 16936898 The Environmental Pollutant and Carcinogen 3-nitrobenzanthrone and Its Human Metabolite 3-aminobenzanthrone Are Potent Inducers of Rat Hepatic Cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone Oxidoreductase Drug Metabolism and Disposition: the Biological Fate of Chemicals. Aug, 2006 | Pubmed ID: 16714372 Oxidation of an Antitumor Drug Ellipticine by Peroxidases Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005 | Pubmed ID: 16601808 Carcinogenic Pollutants O-nitroanisole and O-anisidine Are Substrates and Inducers of Cytochromes P450 Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005 | Pubmed ID: 16601807 Antitumor Drug Ellipticine Inhibits the Activities of Rat Hepatic Cytochromes P450 Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005 | Pubmed ID: 16601806 Molecular Mechanism of Genotoxicity of the Environmental Pollutant 3-nitrobenzanthrone Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. Dec, 2005 | Pubmed ID: 16601755 The Binding of Aristolochic Acid I to the Active Site of Human Cytochromes P450 1A1 and 1A2 Explains Their Potential to Reductively Activate This Human Carcinogen Cancer Letters. Nov, 2005 | Pubmed ID: 16125300 Structural Requirements for Inhibitors of Cytochromes P450 2B: Assessment of the Enzyme Interaction with Diamondoids Journal of Enzyme Inhibition and Medicinal Chemistry. Feb, 2005 | Pubmed ID: 15895681 Identification of a Genotoxic Mechanism for the Carcinogenicity of the Environmental Pollutant and Suspected Human Carcinogen O-anisidine International Journal of Cancer. Sep, 2005 | Pubmed ID: 15828049 Expression of Cytochrome P450 1A1 and Its Contribution to Oxidation of a Potential Human Carcinogen 1-phenylazo-2-naphthol (Sudan I) in Human Livers Cancer Letters. Apr, 2005 | Pubmed ID: 15766589 Human Hepatic and Renal Microsomes, Cytochromes P450 1A1/2, NADPH:cytochrome P450 Reductase and Prostaglandin H Synthase Mediate the Formation of Aristolochic Acid-DNA Adducts Found in Patients with Urothelial Cancer International Journal of Cancer. Jan, 2005 | Pubmed ID: 15386410 The Anticancer Drug Ellipticine Forms Covalent DNA Adducts, Mediated by Human Cytochromes P450, Through Metabolism to 13-hydroxyellipticine and Ellipticine N2-oxide Cancer Research. Nov, 2004 | Pubmed ID: 15548707 Enzymes Involved in the Metabolism of the Carcinogen 2-nitroanisole: Evidence for Its Oxidative Detoxication by Human Cytochromes P450 Chemical Research in Toxicology. May, 2004 | Pubmed ID: 15144223 Identification of a Genotoxic Mechanism for 2-nitroanisole Carcinogenicity and of Its Carcinogenic Potential for Humans Carcinogenesis. May, 2004 | Pubmed ID: 14729594 DNA Adduct Formation by the Anticancer Drug Ellipticine in Rats Determined by 32P Postlabeling International Journal of Cancer. Dec, 2003 | Pubmed ID: 14601046 Human Cytosolic Enzymes Involved in the Metabolic Activation of Carcinogenic Aristolochic Acid: Evidence for Reductive Activation by Human NAD(P)H:quinone Oxidoreductase Carcinogenesis. Oct, 2003 | Pubmed ID: 12869422 Rat Microsomes Activating the Anticancer Drug Ellipticine to Species Covalently Binding to Deoxyguanosine in DNA Are a Suitable Model Mimicking Ellipticine Bioactivation in Humans Chemical Research in Toxicology. Jan, 2003 | Pubmed ID: 12693029 Sudan I is a Potential Carcinogen for Humans: Evidence for Its Metabolic Activation and Detoxication by Human Recombinant Cytochrome P450 1A1 and Liver Microsomes Cancer Research. Oct, 2002 | Pubmed ID: 12384524 DNA Adduct Formation from Quaternary Benzo[c]phenanthridine Alkaloids Sanguinarine and Chelerythrine As Revealed by the 32P-postlabeling Technique Chemico-biological Interactions. Aug, 2002 | Pubmed ID: 12204579 New Selective Inhibitors of Cytochromes P450 2B and Their Application to Antimutagenesis of Tamoxifen Archives of Biochemistry and Biophysics. Jul, 2002 | Pubmed ID: 12061800 Carcinogenic Aristolochic Acids Upon Activation by DT-diaphorase Form Adducts Found in DNA of Patients with Chinese Herbs Nephropathy Carcinogenesis. Apr, 2002 | Pubmed ID: 11960915 Mechanism of Peroxidase-mediated Oxidation of Carcinogenic O-anisidine and Its Binding to DNA Mutation Research. Mar, 2002 | Pubmed ID: 11890934 Flavonoids-potent and Versatile Biologically Active Compounds Interacting with Cytochromes P450 Chemico-biological Interactions. Jan, 2002 | Pubmed ID: 11803026 형성 화학식 DNA Adducts 효소 활성화 된 발암 물질 및 생체 외에서 마약 및 32P postlabeling에 의해 그들의 결정에 의해 Marie Stiborova1 1Department of Biochemistry, Charles University JoVE 57177 Biochemistry
형성 화학식 DNA Adducts 효소 활성화 된 발암 물질 및 생체 외에서 마약 및 32P postlabeling에 의해 그들의 결정에 의해 Marie Stiborova1 1Department of Biochemistry, Charles University JoVE 57177 Biochemistry