Marileila Varella-Garcia Medicine University of Colorado Denver Anschutz Medical Campus Biography Publications Institution JoVE Articles Marileila Varella-Garcia has not added a biography. If you are Marileila Varella-Garcia and would like to personalize this page please email our Author Liaison for assistance. Publications Responses to Crizotinib Can Occur in High Level MET-amplified Non-small Cell Lung Cancer Independent of MET Exon 14 Alterations: A Brief Report Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Sep, 2016 | Pubmed ID: 27664533 An Anaplastic Lymphoma Kinase (ALK) Immunohistochemistry Negative but Fluorescence in Situ Hybridization (FISH) Positive Lung Adenocarcinoma is Resistant to Crizotinib Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Sep, 2016 | Pubmed ID: 27613526 Do More With Less: Tips and Techniques for Maximizing Small Biopsy and Cytology Specimens for Molecular and Ancillary Testing: The University of Colorado Experience Archives of Pathology & Laboratory Medicine. Sep, 2016 | Pubmed ID: 27610643 A Comprehensively Characterized Cell Line Panel Highly Representative of Clinical Ovarian High-grade Serous Carcinomas Oncotarget. Jun, 2016 | Pubmed ID: 27302921 Identifying the Appropriate FISH Criteria for Defining MET Copy Number-Driven Lung Adenocarcinoma Through Oncogene Overlap Analysis Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Aug, 2016 | Pubmed ID: 27262212 Understanding and Targeting MET Signaling in Solid Tumors - Are We There Yet? Journal of Cancer. 2016 | Pubmed ID: 27076844 An Activating KIT Mutation Induces Crizotinib Resistance in ROS1-Positive Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Aug, 2016 | Pubmed ID: 27068398 Erratum To: Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression After First-Line Platinum-Based Chemotherapy Targeted Oncology. Jun, 2016 | Pubmed ID: 27056749 HER2 Amplification and HER2 Mutation Are Distinct Molecular Targets in Lung Cancers Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Mar, 2016 | Pubmed ID: 26723242 De Novo Generation of Adipocytes from Circulating Progenitor Cells in Mouse and Human Adipose Tissue FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2016 | Pubmed ID: 26581599 A NOTCH1 Gene Copy Number Gain is a Prognostic Indicator of Worse Survival and a Predictive Biomarker to a Notch1 Targeting Antibody in Colorectal Cancer International Journal of Cancer. Jan, 2016 | Pubmed ID: 26152787 Waxing and Waning of MET Amplification in EGFR-Mutated NSCLC in Response to the Presence and Absence of Erlotinib Selection Pressure Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Dec, 2015 | Pubmed ID: 26709484 Molecular Profiling of a Rare Rosette-Forming Glioneuronal Tumor Arising in the Spinal Cord PloS One. 2015 | Pubmed ID: 26371886 RAS-MAPK Dependence Underlies a Rational Polytherapy Strategy in EML4-ALK-positive Lung Cancer Nature Medicine. Sep, 2015 | Pubmed ID: 26301689 An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101 Cancer Discovery. Oct, 2015 | Pubmed ID: 26216294 KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas Journal of Neuropathology and Experimental Neurology. Jul, 2015 | Pubmed ID: 26083571 Fibroblast Growth Factor Receptor 1 and Related Ligands in Small-Cell Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Jul, 2015 | Pubmed ID: 26020126 Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression After First-Line Platinum-Based Chemotherapy Targeted Oncology. Dec, 2015 | Pubmed ID: 26004768 Macrothrombocytopenia As Diagnosis Predictor of 22q11 Deletion Syndrome Among Patients with Congenital Heart Defects American Journal of Medical Genetics. Part A. Jun, 2015 | Pubmed ID: 25899105 MYC and Human Telomerase Gene (TERC) Copy Number Gain in Early-stage Non-small Cell Lung Cancer American Journal of Clinical Oncology. Apr, 2015 | Pubmed ID: 25806711 Anaplastic Lymphoma Kinase (ALK) Gene Alteration in Signet Ring Cell Carcinoma of the Gastrointestinal Tract Therapeutic Advances in Medical Oncology. Mar, 2015 | Pubmed ID: 25755678 Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. May, 2015 | Pubmed ID: 25738220 Activation of RAS Family Members Confers Resistance to ROS1 Targeting Drugs Oncotarget. Mar, 2015 | Pubmed ID: 25691052 Congenital Heart Disease in Southern Brazil: Potential Impact and Prevention International Journal of Cardiology. Jan, 2015 | Pubmed ID: 25464392 Clinicopathologic Features and Outcomes of Patients with Lung Adenocarcinomas Harboring BRAF Mutations in the Lung Cancer Mutation Consortium Cancer. Feb, 2015 | Pubmed ID: 25273224 Role of Hypocalcemia in Identification of 22q11 Deletion Syndrome Among Patients with Congenital Heart Defects International Journal of Cardiology. Nov, 2014 | Pubmed ID: 25499322 Crizotinib in ROS1-rearranged Non-small-cell Lung Cancer The New England Journal of Medicine. Nov, 2014 | Pubmed ID: 25264305 Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs JAMA. May, 2014 | Pubmed ID: 24846037 Androgen Receptor CAG Repeat Length and TMPRSS2:ETS Prostate Cancer Risk: Results From the Prostate Cancer Prevention Trial Urology. Jul, 2014 | Pubmed ID: 24824408 Increased SOX2 Gene Copy Number is Associated with FGFR1 and PIK3CA Gene Gain in Non-small Cell Lung Cancer and Predicts Improved Survival in Early Stage Disease PloS One. 2014 | Pubmed ID: 24736592 Screening for 22q11 Deletion Syndrome Among Patients with Congenital Heart Defects São Paulo Medical Journal = Revista Paulista De Medicina. 2014 | Pubmed ID: 24714995 Atypical Negative ALK Break-apart FISH Harboring a Crizotinib-responsive ALK Rearrangement in Non-small-cell Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Mar, 2014 | Pubmed ID: 24518095 Phase I Study of Oral Rigosertib (ON 01910.Na), a Dual Inhibitor of the PI3K and Plk1 Pathways, in Adult Patients with Advanced Solid Malignancies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2014 | Pubmed ID: 24493827 Application of SNP Microarrays to the Genome-wide Analysis of Chromosomal Instability in Premalignant Airway Lesions Cancer Prevention Research (Philadelphia, Pa.). Feb, 2014 | Pubmed ID: 24346345 ROS1 and ALK Fusions in Colorectal Cancer, with Evidence of Intratumoral Heterogeneity for Molecular Drivers Molecular Cancer Research : MCR. Jan, 2014 | Pubmed ID: 24296758 Resistance to ROS1 Inhibition Mediated by EGFR Pathway Activation in Non-small Cell Lung Cancer PloS One. 2013 | Pubmed ID: 24349229 Oncogenic and Drug-sensitive NTRK1 Rearrangements in Lung Cancer Nature Medicine. Nov, 2013 | Pubmed ID: 24162815 Native and Rearranged ALK Copy Number and Rearranged Cell Count in Non-small Cell Lung Cancer: Implications for ALK Inhibitor Therapy Cancer. Nov, 2013 | Pubmed ID: 24022839 Genetic Stability of Bone Marrow-derived Human Mesenchymal Stromal Cells in the Quantum System Cytotherapy. Nov, 2013 | Pubmed ID: 23992670 The Dual Pathway Inhibitor Rigosertib is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas Molecular Cancer Therapeutics. Oct, 2013 | Pubmed ID: 23873848 Initial Clinical Sensitivity and Acquired Resistance to MET Inhibition in MET-mutated Papillary Renal Cell Carcinoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2013 | Pubmed ID: 23610116 A Patient Tumor Transplant Model of Squamous Cell Cancer Identifies PI3K Inhibitors As Candidate Therapeutics in Defined Molecular Bins Molecular Oncology. Aug, 2013 | Pubmed ID: 23607916 Association of the Epithelial-to-mesenchymal Transition Phenotype with Responsiveness to the P21-activated Kinase Inhibitor, PF-3758309, in Colon Cancer Models Frontiers in Pharmacology. 2013 | Pubmed ID: 23543898 Diagnostic Assays for Identification of Anaplastic Lymphoma Kinase-positive Non-small Cell Lung Cancer Cancer. Apr, 2013 | Pubmed ID: 23280244 Diphtheria Toxin-epidermal Growth Factor Fusion Protein DAB389EGF for the Treatment of Bladder Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23172881 Predictive Biomarkers of Sensitivity to the Aurora and Angiogenic Kinase Inhibitor ENMD-2076 in Preclinical Breast Cancer Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2013 | Pubmed ID: 23136197 Malformations Detected by Abdominal Ultrasound in Children with Congenital Heart Disease Arquivos Brasileiros De Cardiologia. Dec, 2012 | Pubmed ID: 23197167 Oncogenic Fusions Involving Exon 19 of ALK Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Dec, 2012 | Pubmed ID: 23154568 Activity and Safety of Crizotinib in Patients with ALK-positive Non-small-cell Lung Cancer: Updated Results from a Phase 1 Study The Lancet. Oncology. Oct, 2012 | Pubmed ID: 22954507 Comprehensive Genomic Analysis Identifies SOX2 As a Frequently Amplified Gene in Small-cell Lung Cancer Nature Genetics. Oct, 2012 | Pubmed ID: 22941189 Identifying and Targeting ROS1 Gene Fusions in Non-small Cell Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2012 | Pubmed ID: 22919003 Next-generation Sequencing Identifies and Immunohistochemistry Confirms a Novel Crizotinib-sensitive ALK Rearrangement in a Patient with Metastatic Non-small-cell Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Sep, 2012 | Pubmed ID: 22895149 Common PIK3CA Mutants and a Novel 3' UTR Mutation Are Associated with Increased Sensitivity to Saracatinib Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012 | Pubmed ID: 22553375 Biologic and Genetics Aspects of Chagas Disease at Endemic Areas Journal of Tropical Medicine. 2012 | Pubmed ID: 22529863 ALDH+ Tumor-initiating Cells Exhibiting Gain in NOTCH1 Gene Copy Number Have Enhanced Regrowth Sensitivity to a γ-secretase Inhibitor and Irinotecan in Colorectal Cancer Molecular Oncology. Jun, 2012 | Pubmed ID: 22521243 Randomized Phase II Trial of Erlotinib with and Without Entinostat in Patients with Advanced Non-small-cell Lung Cancer Who Progressed on Prior Chemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2012 | Pubmed ID: 22508830 New Complex Chromosome Abnormalities in Multiple Myeloma Associated with a Poor Prognosis: a Case Report Leukemia Research. Jul, 2012 | Pubmed ID: 22502921 Prognostic Patterns in the Histopathology of Pulmonary Adenocarcinoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2012 | Pubmed ID: 22393082 P95HER2 Truncated Form in Resected Non-small Cell Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Mar, 2012 | Pubmed ID: 22307009 Correlations Between the Percentage of Tumor Cells Showing an Anaplastic Lymphoma Kinase (ALK) Gene Rearrangement, ALK Signal Copy Number, and Response to Crizotinib Therapy in ALK Fluorescence in Situ Hybridization-positive Nonsmall Cell Lung Cancer Cancer. Sep, 2012 | Pubmed ID: 22282074 Oncogene Status Predicts Patterns of Metastatic Spread in Treatment-naive Nonsmall Cell Lung Cancer Cancer. Sep, 2012 | Pubmed ID: 22282022 A Phase I/II Study of Erlotinib in Combination with the Anti-insulin-like Growth Factor-1 Receptor Monoclonal Antibody IMC-A12 (cixutumumab) in Patients with Advanced Non-small Cell Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Feb, 2012 | Pubmed ID: 22237261 Mechanisms of Resistance to Crizotinib in Patients with ALK Gene Rearranged Non-small Cell Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2012 | Pubmed ID: 22235099 Standardisation of EGFR FISH in Colorectal Cancer: Results of an International Interlaboratory Reproducibility Ring Study Journal of Clinical Pathology. Mar, 2012 | Pubmed ID: 22130903 Effect of Crizotinib on Overall Survival in Patients with Advanced Non-small-cell Lung Cancer Harbouring ALK Gene Rearrangement: a Retrospective Analysis The Lancet Oncology. Oct, 2011 | Pubmed ID: 21933749 Activation of ERBB2 Signaling Causes Resistance to the EGFR-directed Therapeutic Antibody Cetuximab Science Translational Medicine. Sep, 2011 | Pubmed ID: 21900593 Anterior Laryngeal Membrane and 22q11 Deletion Syndrome Brazilian Journal of Otorhinolaryngology. Jul-Aug, 2011 | Pubmed ID: 21860987 HIV-1 Tat Increases Oxidant Burden in the Lungs of Transgenic Mice Free Radical Biology & Medicine. Nov, 2011 | Pubmed ID: 21855628 A Randomized, Phase II, Biomarker-selected Study Comparing Erlotinib to Erlotinib Intercalated with Chemotherapy in First-line Therapy for Advanced Non-small-cell Lung Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2011 | Pubmed ID: 21825259 Detection of Circulating Tumor Cells in Metastatic and Clinically Localized Urothelial Carcinoma Urology. Oct, 2011 | Pubmed ID: 21813167 Increased VEGFR-2 Gene Copy is Associated with Chemoresistance and Shorter Survival in Patients with Non-small-cell Lung Carcinoma Who Receive Adjuvant Chemotherapy Cancer Research. Aug, 2011 | Pubmed ID: 21724587 [22q11.2 Deletion Syndrome and Complex Congenital Heart Defects] Revista Da Associação Médica Brasileira (1992). Jan-Feb, 2011 | Pubmed ID: 21390462 Anaplastic Lymphoma Kinase Gene Rearrangements in Non-small Cell Lung Cancer Are Associated with Prolonged Progression-free Survival on Pemetrexed Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Apr, 2011 | Pubmed ID: 21336183 Finding ALK-positive Lung Cancer: What Are We Really Looking For? Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Mar, 2011 | Pubmed ID: 21317739 Abnormalities of the TITF-1 Lineage-specific Oncogene in NSCLC: Implications in Lung Cancer Pathogenesis and Prognosis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2011 | Pubmed ID: 21257719 Suppression of Leukemia Development Caused by PTEN Loss Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21212363 Genomic Imbalances in Esophageal Squamous Cell Carcinoma Identified by Molecular Cytogenetic Techniques Genetics and Molecular Biology. Apr, 2010 | Pubmed ID: 21637470 Optimizing the Detection of Lung Cancer Patients Harboring Anaplastic Lymphoma Kinase (ALK) Gene Rearrangements Potentially Suitable for ALK Inhibitor Treatment Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2010 | Pubmed ID: 21062932 Anaplastic Lymphoma Kinase Inhibition in Non-small-cell Lung Cancer The New England Journal of Medicine. Oct, 2010 | Pubmed ID: 20979469 [Oculo-auriculo-vertebral Spectrum in Patients with Congenital Heart Defects] Arquivos Brasileiros De Cardiologia. Oct, 2010 | Pubmed ID: 20802965 Gene Array and Fluorescence in Situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2010 | Pubmed ID: 20682712 De Novo Generation of White Adipocytes from the Myeloid Lineage Via Mesenchymal Intermediates is Age, Adipose Depot, and Gender Specific Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20679227 Biomarkers Are Here to Stay for Clinical Research and Standard Care Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Aug, 2010 | Pubmed ID: 20661083 Somatic Chromosome Abnormalities in the Lungs of Patients with Pulmonary Arterial Hypertension American Journal of Respiratory and Critical Care Medicine. Nov, 2010 | Pubmed ID: 20581168 Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2010 | Pubmed ID: 20530704 Insulin-like Growth Factor Receptor 1 (IGF1R) Gene Copy Number is Associated with Survival in Operable Non-small-cell Lung Cancer: a Comparison Between IGF1R Fluorescent in Situ Hybridization, Protein Expression, and MRNA Expression Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2010 | Pubmed ID: 20351332 The Detection of Chromosomal Aneusomy by Fluorescence in Situ Hybridization in Sputum Predicts Lung Cancer Incidence Cancer Prevention Research (Philadelphia, Pa.). Apr, 2010 | Pubmed ID: 20332298 Chromosomal Imbalances Are Uncommon in Chagasic Megaesophagus BMC Gastroenterology. 2010 | Pubmed ID: 20163722 Chromosomal and Genomic Changes in Lung Cancer Cell Adhesion & Migration. Jan-Mar, 2010 | Pubmed ID: 20139701 Cytoskeleton Alterations in Melanoma: Aberrant Expression of Cortactin, an Actin-binding Adapter Protein, Correlates with Melanocytic Tumor Progression Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2010 | Pubmed ID: 19898426 Identification of Biomarkers in Human Head and Neck Tumor Cell Lines That Predict for in Vitro Sensitivity to Gefitinib Clinical and Translational Science. Jun, 2009 | Pubmed ID: 20443891 ALK Gene Rearrangements: a New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Dec, 2009 | Pubmed ID: 20009909 Oncogene Mutations, Copy Number Gains and Mutant Allele Specific Imbalance (MASI) Frequently Occur Together in Tumor Cells PloS One. 2009 | Pubmed ID: 19826477 Genetic Abnormalities of the EGFR Pathway in African American Patients with Non-small-cell Lung Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2009 | Pubmed ID: 19786660 [22q11.2 Deletion Syndrome: Importance of Clinical Evaluation and FISH Analysis] Revista Da Associação Médica Brasileira (1992). Jul-Aug, 2009 | Pubmed ID: 19750312 HER Family Receptor Abnormalities in Lung Cancer Brain Metastases and Corresponding Primary Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2009 | Pubmed ID: 19622585 Recurrent Genomic Gains in Preinvasive Lesions As a Biomarker of Risk for Lung Cancer PloS One. 2009 | Pubmed ID: 19547694 Phase III Study of Gefitinib Compared with Intravenous Methotrexate for Recurrent Squamous Cell Carcinoma of the Head and Neck [corrected] Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2009 | Pubmed ID: 19289630 Randomized Phase II Study of Gefitinib Compared with Placebo in Chemotherapy-naive Patients with Advanced Non-small-cell Lung Cancer and Poor Performance Status Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2009 | Pubmed ID: 19289623 Increased MET Gene Copy Number Negatively Affects Survival of Surgically Resected Non-small-cell Lung Cancer Patients Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Apr, 2009 | Pubmed ID: 19255323 EGFR and HER2 Genomic Gain in Recurrent Non-small Cell Lung Cancer After Surgery: Impact on Outcome to Treatment with Gefitinib and Association with EGFR and KRAS Mutations in a Japanese Cohort Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Mar, 2009 | Pubmed ID: 19247083 Alterations in Genes of the EGFR Signaling Pathway and Their Relationship to EGFR Tyrosine Kinase Inhibitor Sensitivity in Lung Cancer Cell Lines PloS One. 2009 | Pubmed ID: 19238210 Dual Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Inhibition with Vandetanib Sensitizes Bladder Cancer Cells to Cisplatin in a Dose- and Sequence-dependent Manner BJU International. Jun, 2009 | Pubmed ID: 19220256 MYC and EIF3H Coamplification Significantly Improve Response and Survival of Non-small Cell Lung Cancer Patients (NSCLC) Treated with Gefitinib Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Apr, 2009 | Pubmed ID: 19204574 MET Gene Amplification or EGFR Mutation Activate MET in Lung Cancers Untreated with EGFR Tyrosine Kinase Inhibitors International Journal of Cancer. Journal International Du Cancer. Apr, 2009 | Pubmed ID: 19117057 Epidermal Growth Factor Receptor Abnormalities in the Pathogenesis and Progression of Lung Adenocarcinomas Cancer Prevention Research (Philadelphia, Pa.). Aug, 2008 | Pubmed ID: 19138956 Fluorescence in Situ Hybridization Subgroup Analysis of TRIBUTE, a Phase III Trial of Erlotinib Plus Carboplatin and Paclitaxel in Non-small Cell Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2008 | Pubmed ID: 18829515 Gefitinib Versus Vinorelbine in Chemotherapy-naive Elderly Patients with Advanced Non-small-cell Lung Cancer (INVITE): a Randomized, Phase II Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2008 | Pubmed ID: 18779612 Increased EGFR Gene Copy Number Detected by Fluorescent in Situ Hybridization Predicts Outcome in Non-small-cell Lung Cancer Patients Treated with Cetuximab and Chemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2008 | Pubmed ID: 18612151 First-generation Epidermal Growth Factor Receptor Inhibitors in Non-small Cell Lung Cancer: Clinical Impact of the Epidermal Growth Factor Receptor Fluorescence in Situ Hybridization Assay Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Jun, 2008 | Pubmed ID: 18520298 22q11.2 Deletion Syndrome in Patients Admitted to a Cardiac Pediatric Intensive Care Unit in Brazil American Journal of Medical Genetics. Part A. Jul, 2008 | Pubmed ID: 18512234 Multi-genetic Events Collaboratively Contribute to Pten-null Leukaemia Stem-cell Formation Nature. May, 2008 | Pubmed ID: 18463637 Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer Cancer Research. Apr, 2008 | Pubmed ID: 18413752 Six1 Overexpression in Mammary Cells Induces Genomic Instability and is Sufficient for Malignant Transformation Cancer Research. Apr, 2008 | Pubmed ID: 18381426 Chromosomal Aneusomy in Bronchial High-grade Lesions is Associated with Invasive Lung Cancer American Journal of Respiratory and Critical Care Medicine. Feb, 2008 | Pubmed ID: 17989344 Spectral Karyotyping Detects Chromosome Damage in Bronchial Cells of Smokers and Patients with Cancer American Journal of Respiratory and Critical Care Medicine. Sep, 2007 | Pubmed ID: 17600274 EGFR-mutant Lung Adenocarcinoma in a Patient with Li-Fraumeni Syndrome The Lancet. Oncology. Jun, 2007 | Pubmed ID: 17540308 Prospective Study of Gefitinib in Epidermal Growth Factor Receptor Fluorescence in Situ Hybridization-positive/phospho-Akt-positive or Never Smoker Patients with Advanced Non-small-cell Lung Cancer: the ONCOBELL Trial Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2007 | Pubmed ID: 17538169 KRAS Mutation is an Important Predictor of Resistance to Therapy with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small-cell Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2007 | Pubmed ID: 17504988 EGFR and HER2 Gene Copy Number and Response to First-line Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer (NSCLC) Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. May, 2007 | Pubmed ID: 17473658 Unusual Chemosensitivity of Advanced Bronchioalveolar Carcinoma After Gefitinib Response and Progression: a Case Report Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Jan, 2007 | Pubmed ID: 17410018 Genetic and Epigenetic Regulation of the Human Prostacyclin Synthase Promoter in Lung Cancer Cell Lines Molecular Cancer Research : MCR. Mar, 2007 | Pubmed ID: 17374734 Overexpression of Cyclin D1 and Cortactin is Primarily Independent of Gene Amplification in Salivary Gland Adenoid Cystic Carcinoma Oral Oncology. Sep, 2007 | Pubmed ID: 17113340 Antitumor Activity of the Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Gefitinib (ZD1839, Iressa) in Non-small Cell Lung Cancer Cell Lines Correlates with Gene Copy Number and EGFR Mutations but Not EGFR Protein Levels Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2006 | Pubmed ID: 17145836 Molecular Predictors of Outcome with Gefitinib in a Phase III Placebo-controlled Study in Advanced Non-small-cell Lung Cancer Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2006 | Pubmed ID: 17075123 Karyotypic Characteristics of Human Uterine Leiomyoma and Myometrial Cell Lines Following Telomerase Induction Cancer Genetics and Cytogenetics. Oct, 2006 | Pubmed ID: 16965960 Increased Epidermal Growth Factor Receptor Gene Copy Number is Associated with Poor Prognosis in Head and Neck Squamous Cell Carcinomas Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2006 | Pubmed ID: 16943533 Spontaneous Fusion With, and Transformation of Mouse Stroma By, Malignant Human Breast Cancer Epithelium Cancer Research. Aug, 2006 | Pubmed ID: 16912208 Cortactin Overexpression Regulates Actin-related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification Cancer Research. Aug, 2006 | Pubmed ID: 16912177 Stratification of Non-small Cell Lung Cancer Patients for Therapy with Epidermal Growth Factor Receptor Inhibitors: the EGFR Fluorescence in Situ Hybridization Assay Diagnostic Pathology. 2006 | Pubmed ID: 16911776 Selecting Lung Cancer Patients for Treatment with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by Immunohistochemistry and Fluorescence in Situ Hybridization--why, When, and How? Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2006 | Pubmed ID: 16857819 Biological Markers for Non-small Cell Lung Cancer Patient Selection for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2006 | Pubmed ID: 16778092 HER2 Mutation and Response to Trastuzumab Therapy in Non-small-cell Lung Cancer The New England Journal of Medicine. Jun, 2006 | Pubmed ID: 16775247 Epidermal Growth Factor Receptor Messenger RNA Expression, Gene Dosage, and Gefitinib Sensitivity in Non-small Cell Lung Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006 | Pubmed ID: 16707605 Isolation of Immunoresistant Human Glioma Cell Clones After Selection with Alloreactive Cytotoxic T Lymphocytes: Cytogenetic and Molecular Cytogenetic Characterization Cancer Genetics and Cytogenetics. Mar, 2006 | Pubmed ID: 16527606 Infertility and Marker Chromosomes: Application of Molecular Cytogenetic Techniques in a Case of Inv Dup(15) Journal of Applied Genetics. 2006 | Pubmed ID: 16424615 Increased HER2 Gene Copy Number is Associated with Response to Gefitinib Therapy in Epidermal Growth Factor Receptor-positive Non-small-cell Lung Cancer Patients Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2005 | Pubmed ID: 16051952 Increased Epidermal Growth Factor Receptor Gene Copy Number Detected by Fluorescence in Situ Hybridization Associates with Increased Sensitivity to Gefitinib in Patients with Bronchioloalveolar Carcinoma Subtypes: a Southwest Oncology Group Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2005 | Pubmed ID: 15998906 Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non-small-cell Lung Cancer Journal of the National Cancer Institute. May, 2005 | Pubmed ID: 15870435 Gene Amplification is a Mechanism of Six1 Overexpression in Breast Cancer Cancer Research. Apr, 2005 | Pubmed ID: 15805264 Epidermal Growth Factor Receptor and Cyclin D1 Are Independently Amplified and Overexpressed in Esophageal Squamous Cell Carcinoma Journal of Cancer Research and Clinical Oncology. Feb, 2005 | Pubmed ID: 15672286 Multi-target Interphase Fluorescence in Situ Hybridization Assay Increases Sensitivity of Sputum Cytology As a Predictor of Lung Cancer Cancer Detection and Prevention. 2004 | Pubmed ID: 15350627 The Use of Trastuzumab in the Treatment of Hormone Refractory Prostate Cancer; Phase II Trial The Prostate. Sep, 2004 | Pubmed ID: 15264245 The UroVysion Fluorescence in Situ Hybridization Assay is an Effective Tool for Monitoring Recurrence of Bladder Cancer Urologic Oncology. Jan-Feb, 2004 | Pubmed ID: 14969798 The Development of Diabetes in E2f1/E2f2 Mutant Mice Reveals Important Roles for Bone Marrow-derived Cells in Preventing Islet Cell Loss Proceedings of the National Academy of Sciences of the United States of America. Oct, 2003 | Pubmed ID: 14566047 Spectral Karyotype (SKY) Analysis of Human Prostate Carcinoma Cell Lines The Prostate. Nov, 2003 | Pubmed ID: 14518030 Molecular Characterization of Human Prostate Carcinoma Cell Lines The Prostate. Nov, 2003 | Pubmed ID: 14518029 Epidermal Growth Factor Receptor in Non-small-cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2003 | Pubmed ID: 12953099 Epidermal Growth Factor Family of Receptors in Preneoplasia and Lung Cancer: Perspectives for Targeted Therapies Lung Cancer (Amsterdam, Netherlands). Aug, 2003 | Pubmed ID: 12867060 Human Pulmonary Chimerism After Hematopoietic Stem Cell Transplantation American Journal of Respiratory and Critical Care Medicine. Aug, 2003 | Pubmed ID: 12724127 Chromosomal Abnormalities in Non-small Cell Lung Carcinomas and in Bronchial Epithelia of High-risk Smokers Detected by Multi-target Interphase Fluorescence in Situ Hybridization The Journal of Molecular Diagnostics : JMD. May, 2003 | Pubmed ID: 12707375 Molecular Cytogenetics in Solid Tumors: Laboratorial Tool for Diagnosis, Prognosis, and Therapy The Oncologist. 2003 | Pubmed ID: 12604731 Translocation (11;19)(q23;p13.3) Associated with a Novel T(5;16) (q13;q22) in a Patient with Acute Myelocytic Leukemia Cancer Genetics and Cytogenetics. Feb, 2003 | Pubmed ID: 12581901 Tetrasomy 15q11-q13 Identified by Fluorescence in Situ Hybridization in a Patient with Autistic Disorder Arquivos De Neuro-psiquiatria. Jun, 2002 | Pubmed ID: 12068363 Preclinical Studies of Gemcitabine and Trastuzumab in Breast and Lung Cancer Cell Lines Clinical Breast Cancer. May, 2002 | Pubmed ID: 12057039 Molecular and Cytogenetic Analyses on Brazilian Youths with Pervasive Developmental Disorders Journal of Autism and Developmental Disorders. Feb, 2002 | Pubmed ID: 11916331 HER2/neu Expression in Malignant Lung Tumors Seminars in Oncology. Feb, 2002 | Pubmed ID: 11894014 विकास और एक Preclinical रोगी व्युत्पन्न ट्यूमर उपन्यास विरोधी कैंसर उपचार की जांच के लिए Xenograft मॉडल का रखरखाव Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Cancer Research
विकास और एक Preclinical रोगी व्युत्पन्न ट्यूमर उपन्यास विरोधी कैंसर उपचार की जांच के लिए Xenograft मॉडल का रखरखाव Stacey Bagby1, Wells A. Messersmith1, Todd M. Pitts1, Anna Capasso1, Marileila Varella-Garcia1, Peter J. Klauck1, Jihye Kim1, Aik-Choon Tan1, S. Gail Eckhardt1, John J. Tentler1, John Arcaroli1 1Medicine, University of Colorado Denver Anschutz Medical Campus JoVE 54393 Cancer Research
