Matthew Burow Department of Medicine Tulane University School of Medicine Biography Publications Institution JoVE Articles Matthew Burow has not added a biography. If you are Matthew Burow and would like to personalize this page please email our Author Liaison for assistance. Publications Dual Inhibition of MEK1/2 and MEK5 Suppresses the EMT/migration Axis in Triple-negative Breast Cancer Through FRA-1 Regulation Journal of Cellular Biochemistry. Apr, 2021 | Pubmed ID: 33876843 EVALUATION OF EXTRACELLULAR MATRIX COMPOSITION TO IMPROVE BREAST CANCER MODELING Tissue Engineering. Part A. Apr, 2021 | Pubmed ID: 33797977 Application of a Small Molecule Inhibitor Screen Approach to Identify CXCR4 Downstream Signaling Pathways That Promote a Mesenchymal and Fulvestrant-resistant Phenotype in Breast Cancer Cells Oncology Letters. May, 2021 | Pubmed ID: 33777204 Diverse and Converging Roles of ERK1/2 and ERK5 Pathways on Mesenchymal to Epithelial Transition in Breast Cancer Translational Oncology. Mar, 2021 | Pubmed ID: 33761370 Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review Current Medicinal Chemistry. Mar, 2021 | Pubmed ID: 33749548 Molecular Mechanisms of Epithelial to Mesenchymal Transition Regulated by ERK5 Signaling Biomolecules. Jan, 2021 | Pubmed ID: 33572742 Patient-Derived Xenografts As an Innovative Surrogate Tumor Model for the Investigation of Health Disparities in Triple Negative Breast Cancer Women's Health Reports (New Rochelle, N.Y.). 2020 | Pubmed ID: 33786503 Evaluation of Deacetylase Inhibition in Metaplastic Breast Carcinoma Using Multiple Derivations of Preclinical Models of a New Patient-derived Tumor PloS One. 2020 | Pubmed ID: 33035223 ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer Frontiers in Oncology. 2020 | Pubmed ID: 32850332 A Novel Screening Approach Comparing Kinase Activity of Small Molecule Inhibitors with Similar Molecular Structures and Distinct Biologic Effects in Triple-negative Breast Cancer to Identify Targetable Signaling Pathways Anti-cancer Drugs. 09, 2020 | Pubmed ID: 32796402 Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer Scientific Reports. 06, 2020 | Pubmed ID: 32483202 Pharmacological Inhibition of the MEK5/ERK5 and PI3K/Akt Signaling Pathways Synergistically Reduces Viability in Triple-negative Breast Cancer Journal of Cellular Biochemistry. 02, 2020 | Pubmed ID: 31464004 Pharmacological, Mechanistic, and Pharmacokinetic Assessment of Novel Melatonin-Tamoxifen Drug Conjugates As Breast Cancer Drugs Molecular Pharmacology. 08, 2019 | Pubmed ID: 31221824 Obesity-Altered Adipose Stem Cells Promote ER⁺ Breast Cancer Metastasis Through Estrogen Independent Pathways International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30897853 Drug Resistance Profiling of a New Triple Negative Breast Cancer Patient-derived Xenograft Model BMC Cancer. Mar, 2019 | Pubmed ID: 30845999 Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy Current Medicinal Chemistry. 2019 | Pubmed ID: 28875842 Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells Via IKKα-Dependent Non-canonical Pathways Frontiers in Oncology. 2018 | Pubmed ID: 30564555 Panobinostat Suppresses the Mesenchymal Phenotype in a Novel Claudin-low Triple Negative Patient-derived Breast Cancer Model Oncoscience. Mar, 2018 | Pubmed ID: 29854878 ZB716, a Steroidal Selective Estrogen Receptor Degrader (SERD), is Orally Efficacious in Blocking Tumor Growth in Mouse Xenograft Models Oncotarget. Jan, 2018 | Pubmed ID: 29467940 A Novel Patient-derived Xenograft Model for Claudin-low Triple-negative Breast Cancer Breast Cancer Research and Treatment. Jun, 2018 | Pubmed ID: 29392581 Obesity Enhances the Conversion of Adipose-Derived Stromal/Stem Cells into Carcinoma-Associated Fibroblast Leading to Cancer Cell Proliferation and Progression to an Invasive Phenotype Stem Cells International. 2017 | Pubmed ID: 29527228 Dual Src Kinase/Pretubulin Inhibitor KX-01, Sensitizes ERα-negative Breast Cancers to Tamoxifen Through ERα Reexpression Molecular Cancer Research : MCR. 11, 2017 | Pubmed ID: 28751463 Glycinol Enhances Osteogenic Differentiation and Attenuates the Effects of Age on Mesenchymal Stem Cells Regenerative Medicine. 07, 2017 | Pubmed ID: 28718749 Osteoinductive Effects of Glyceollins on Adult Mesenchymal Stromal/stem Cells from Adipose Tissue and Bone Marrow Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Apr, 2017 | Pubmed ID: 28314478 Oncogenic Signaling of MEK5-ERK5 Cancer Letters. 04, 2017 | Pubmed ID: 28153789 Endocrine Disruptors and the Tumor Microenvironment: A New Paradigm in Breast Cancer Biology Molecular and Cellular Endocrinology. Dec, 2017 | Pubmed ID: 28012841 Argonaute 2 Expression Correlates with a Luminal B Breast Cancer Subtype and Induces Estrogen Receptor Alpha Isoform Variation Non-coding RNA. Sep, 2016 | Pubmed ID: 29657266 The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review Frontiers in Endocrinology. 2016 | Pubmed ID: 28119665 Induction of HOXA9 Expression in Three-dimensional Organotypic Culture of the Claudin-low Breast Cancer Cells Oncotarget. Aug, 2016 | Pubmed ID: 27409175 A Novel Gastrointestinal Microbiome Modulator from Soy Pods Reduces Absorption of Dietary Fat in Mice Obesity (Silver Spring, Md.). Jan, 2016 | Pubmed ID: 26584538 Glyceollin I Reverses Epithelial to Mesenchymal Transition in Letrozole Resistant Breast Cancer Through ZEB1 International Journal of Environmental Research and Public Health. Dec, 2015 | Pubmed ID: 26703648 Leptin Produced by Obese Adipose Stromal/stem Cells Enhances Proliferation and Metastasis of Estrogen Receptor Positive Breast Cancers Breast Cancer Research : BCR. Aug, 2015 | Pubmed ID: 26286584 Glyceollin, a Novel Regulator of MTOR/p70S6 in Estrogen Receptor Positive Breast Cancer The Journal of Steroid Biochemistry and Molecular Biology. Jun, 2015 | Pubmed ID: 25771071 Elevated Expression of Long Intergenic Non-coding RNA HOTAIR in a Basal-like Variant of MCF-7 Breast Cancer Cells Molecular Carcinogenesis. Dec, 2015 | Pubmed ID: 25328122 Concise Review: The Obesity Cancer Paradigm: Exploration of the Interactions and Crosstalk with Adipose Stem Cells Stem Cells (Dayton, Ohio). Feb, 2015 | Pubmed ID: 25267443 Effects of the Endocrine-disrupting Chemical DDT on Self-renewal and Differentiation of Human Mesenchymal Stem Cells Environmental Health Perspectives. Jan, 2015 | Pubmed ID: 25014179 MicroRNA Regulation of Mammalian Target of Rapamycin Expression and Activity Controls Estrogen Receptor Function and RAD001 Sensitivity Molecular Cancer. Oct, 2014 | Pubmed ID: 25283550 Novel Daidzein Analogs Enhance Osteogenic Activity of Bone Marrow-derived Mesenchymal Stem Cells and Adipose-derived Stromal/stem Cells Through Estrogen Receptor Dependent and Independent Mechanisms Stem Cell Research & Therapy. Aug, 2014 | Pubmed ID: 25168698 Bisphenol A Enhances Adipogenic Differentiation of Human Adipose Stromal/stem Cells Journal of Molecular Endocrinology. Dec, 2014 | Pubmed ID: 25143472 Inhibition of Sphingosine Kinase-2 Ablates Androgen Resistant Prostate Cancer Proliferation and Survival Pharmacological Reports : PR. Feb, 2014 | Pubmed ID: 24905325 Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells ACS Medicinal Chemistry Letters. Feb, 2014 | Pubmed ID: 24900787 Obesity Associated Alterations in the Biology of Adipose Stem Cells Mediate Enhanced Tumorigenesis by Estrogen Dependent Pathways Breast Cancer Research : BCR. 2013 | Pubmed ID: 24176089 MEK5/ERK5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-independent Tumorigenesis PloS One. 2013 | Pubmed ID: 23950888 Discovery of a Series of Thiazole Derivatives As Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion ACS Medicinal Chemistry Letters. Feb, 2013 | Pubmed ID: 23526571 Inhibition of P38 Mitogen-activated Protein Kinase Alters MicroRNA Expression and Reverses Epithelial-to-mesenchymal Transition International Journal of Oncology. Apr, 2013 | Pubmed ID: 23403951 In Vitro and in Vivo Evaluation of Novel Anticancer Agents in Triple Negative Breast Cancer Models Journal of Health Care for the Poor and Underserved. Feb, 2013 | Pubmed ID: 23395947 Sphingosine Kinase Isoforms As a Therapeutic Target in Endocrine Therapy Resistant Luminal and Basal-A Breast Cancer Experimental Biology and Medicine (Maywood, N.J.). Jul, 2012 | Pubmed ID: 22859737 Altered Death Receptor Signaling Promotes Epithelial-to-mesenchymal Transition and Acquired Chemoresistance Scientific Reports. 2012 | Pubmed ID: 22844580 Inhibition of P38-MAPK Alters SRC Coactivation and Estrogen Receptor Phosphorylation Cancer Biology & Therapy. Sep, 2012 | Pubmed ID: 22825349 The Organochlorine O,p'-DDT Plays a Role in Coactivator-mediated MAPK Crosstalk in MCF-7 Breast Cancer Cells Environmental Health Perspectives. Sep, 2012 | Pubmed ID: 22609851 The MicroRNA Expression Associated with Morphogenesis of Breast Cancer Cells in Three-dimensional Organotypic Culture Oncology Reports. Jul, 2012 | Pubmed ID: 22576799 Dual Inhibition of Sphingosine Kinase Isoforms Ablates TNF-induced Drug Resistance Oncology Reports. Jun, 2012 | Pubmed ID: 22469881 Proteomic Analysis of Acquired Tamoxifen Resistance in MCF-7 Cells Reveals Expression Signatures Associated with Enhanced Migration Breast Cancer Research : BCR. Mar, 2012 | Pubmed ID: 22417809 Environmental Signaling and Reproduction: a Comparative Biological and Chemical Perspective Molecular and Cellular Endocrinology. May, 2012 | Pubmed ID: 22178089 Glyceollin-elicited Soy Protein Consumption Induces Distinct Transcriptional Effects As Compared to Standard Soy Protein Journal of Agricultural and Food Chemistry. Jan, 2012 | Pubmed ID: 22126086 MEK5/ERK5 Pathway: the First Fifteen Years Biochimica Et Biophysica Acta. Jan, 2012 | Pubmed ID: 22020294 Sorafenib Enhances Pemetrexed Cytotoxicity Through an Autophagy-dependent Mechanism in Cancer Cells Cancer Research. Jul, 2011 | Pubmed ID: 21622715 Pharmacological Inhibition of Sphingosine Kinase Isoforms Alters Estrogen Receptor Signaling in Human Breast Cancer Journal of Molecular Endocrinology. Jun, 2011 | Pubmed ID: 21321095 Targeting NFĸB Mediated Breast Cancer Chemoresistance Through Selective Inhibition of Sphingosine Kinase-2 Cancer Biology & Therapy. Apr, 2011 | Pubmed ID: 21307639 Inhibition of Breast Cancer Cell Invasion by Melatonin is Mediated Through Regulation of the P38 Mitogen-activated Protein Kinase Signaling Pathway Breast Cancer Research : BCR. 2010 | Pubmed ID: 21167057 Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640 Endocrinology. Nov, 2010 | Pubmed ID: 20861237 Effects of 7-O Substitutions on Estrogenic and Anti-estrogenic Activities of Daidzein Analogues in MCF-7 Breast Cancer Cells Journal of Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20669983 Regulation of ERalpha-mediated Transcription of Bcl-2 by PI3K-AKT Crosstalk: Implications for Breast Cancer Cell Survival International Journal of Oncology. Sep, 2010 | Pubmed ID: 20664923 Systems Genetics Analyses Predict a Transcription Role for P2P-R: Molecular Confirmation That P2P-R is a Transcriptional Co-repressor BMC Systems Biology. Feb, 2010 | Pubmed ID: 20184719 Design, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogues in Chemoresistant Breast Cancer Cells Journal of Medicinal Chemistry. Sep, 2009 | Pubmed ID: 19694470 Sphingolipids As Determinants of Apoptosis and Chemoresistance in the MCF-7 Cell Model System Experimental Biology and Medicine (Maywood, N.J.). Nov, 2009 | Pubmed ID: 19546354 Molecular Effects of Soy Phytoalexin Glyceollins in Human Prostate Cancer Cells LNCaP Molecular Carcinogenesis. Sep, 2009 | Pubmed ID: 19263441 Combination of Methylselenocysteine with Tamoxifen Inhibits MCF-7 Breast Cancer Xenografts in Nude Mice Through Elevated Apoptosis and Reduced Angiogenesis Breast Cancer Research and Treatment. Nov, 2009 | Pubmed ID: 18855134 Proteomic Analysis of Tumor Necrosis Factor-alpha Resistant Human Breast Cancer Cells Reveals a MEK5/Erk5-mediated Epithelial-mesenchymal Transition Phenotype Breast Cancer Research : BCR. 2008 | Pubmed ID: 19087274 Drugs Designed to Inhibit Human P38 Mitogen-activated Protein Kinase Activation Treat Toxoplasma Gondii and Encephalitozoon Cuniculi Infection Antimicrobial Agents and Chemotherapy. Dec, 2007 | Pubmed ID: 17923491 P38 Mitogen-activated Protein Kinase Stimulates Estrogen-mediated Transcription and Proliferation Through the Phosphorylation and Potentiation of the P160 Coactivator Glucocorticoid Receptor-interacting Protein 1 Molecular Endocrinology (Baltimore, Md.). May, 2006 | Pubmed ID: 16410316 PKC-mediated Survival Signaling in Breast Carcinoma Cells: a Role for MEK1-AP1 Signaling International Journal of Oncology. Mar, 2005 | Pubmed ID: 15703835 Sensitization of Apoptotically-resistant Breast Carcinoma Cells to TNF and TRAIL by Inhibition of P38 Mitogen-activated Protein Kinase Signaling International Journal of Oncology. Jun, 2004 | Pubmed ID: 15138590 Identification of Mitogen-activated Protein Kinase Kinase As a Chemoresistant Pathway in MCF-7 Cells by Using Gene Expression Microarray Surgery. Aug, 2002 | Pubmed ID: 12219026 نمذجة سرطان الثدي في أنسجة الثدي البشرية باستخدام نظام الفيزيولوجيا الدقيقة Loren M. Brown1, Katherine L. Hebert2, Rakesh R. Gurrala3, C. Ethan Byrne4, Matthew Burow5, Elizabeth C. Martin4, Frank H. Lau1 1Department of Surgery, Louisiana State University Health Sciences Center, 2Department of Bioinnovation, Tulane University, 3Tulane University School of Medicine, 4Department of Biological and Agricultural Engineering, Louisiana State University, 5Department of Medicine, Tulane University School of Medicine JoVE 62009 Cancer Research
نمذجة سرطان الثدي في أنسجة الثدي البشرية باستخدام نظام الفيزيولوجيا الدقيقة Loren M. Brown1, Katherine L. Hebert2, Rakesh R. Gurrala3, C. Ethan Byrne4, Matthew Burow5, Elizabeth C. Martin4, Frank H. Lau1 1Department of Surgery, Louisiana State University Health Sciences Center, 2Department of Bioinnovation, Tulane University, 3Tulane University School of Medicine, 4Department of Biological and Agricultural Engineering, Louisiana State University, 5Department of Medicine, Tulane University School of Medicine JoVE 62009 Cancer Research