Michael A. Hill Division of Cardiovascular Medicine University of Missouri Biography Publications Institution JoVE Articles Michael A. Hill has not added a biography. If you are Michael A. Hill and would like to personalize this page please email our Author Liaison for assistance. Publications Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice Endocrinology. 12, 2019 | Pubmed ID: 31617909 Epithelial Sodium Channels in Endothelial Cells Mediate Diet-induced Endothelium Stiffness and Impaired Vascular Relaxation in Obese Female Mice Metabolism: Clinical and Experimental. 10, 2019 | Pubmed ID: 31302199 Mineralocorticoid Antagonists and ENaC Inhibitors in Hyperaldosteronism Journal of Clinical Hypertension (Greenwich, Conn.). Jul, 2019 | Pubmed ID: 31169977 TRPV4 Increases Cardiomyocyte Calcium Cycling and Contractility Yet Contributes to Damage in the Aged Heart Following Hypoosmotic Stress Cardiovascular Research. 01, 2019 | Pubmed ID: 29931225 A Calcium Mediated Mechanism Coordinating Vascular Smooth Muscle Cell Adhesion During KCl Activation Frontiers in Physiology. 2018 | Pubmed ID: 30618822 PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity Frontiers in Pharmacology. 2018 | Pubmed ID: 30319420 Role of Renin-Angiotensin-Aldosterone System Activation in Promoting Cardiovascular Fibrosis and Stiffness Hypertension (Dallas, Tex. : 1979). 09, 2018 | Pubmed ID: 29987104 Epithelial Sodium Channel in Aldosterone-Induced Endothelium Stiffness and Aortic Dysfunction Hypertension (Dallas, Tex. : 1979). 09, 2018 | Pubmed ID: 29987101 Alpha -adrenergic Stimulation Selectively Enhances Endothelium-mediated Vasodilation in Rat Cremaster Arteries Physiological Reports. 05, 2018 | Pubmed ID: 29756401 Arteriolar Vasodilation Involves Actin Depolymerization American Journal of Physiology. Heart and Circulatory Physiology. 08, 2018 | Pubmed ID: 29727217 Chronic Interval Exercise Training Prevents BK Channel-mediated Coronary Vascular Dysfunction in Aortic-banded Miniswine Journal of Applied Physiology (Bethesda, Md. : 1985). 07, 2018 | Pubmed ID: 29596016 Depletion of Dendritic Cells in Perivascular Adipose Tissue Improves Arterial Relaxation Responses in Type 2 Diabetic Mice Metabolism: Clinical and Experimental. 08, 2018 | Pubmed ID: 29530798 Diabetic Cardiomyopathy: An Update of Mechanisms Contributing to This Clinical Entity Circulation Research. 02, 2018 | Pubmed ID: 29449364 Enhanced Endothelium Epithelial Sodium Channel Signaling Prompts Left Ventricular Diastolic Dysfunction in Obese Female Mice Metabolism: Clinical and Experimental. 01, 2018 | Pubmed ID: 28920862 Interaction of IL-6 and TNF-α Contributes to Endothelial Dysfunction in Type 2 Diabetic Mouse Hearts PloS One. 2017 | Pubmed ID: 29095915 Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension Hypertension (Dallas, Tex. : 1979). 12, 2017 | Pubmed ID: 29061726 N-Cadherin, a Novel and Rapidly Remodelling Site Involved in Vasoregulation of Small Cerebral Arteries The Journal of Physiology. 03, 2017 | Pubmed ID: 28008617 Nonenzymatic Glycation Interferes with Fibronectin-integrin Interactions in Vascular Smooth Muscle Cells Microcirculation (New York, N.Y. : 1994). 04, 2017 | Pubmed ID: 28005306 Oxidant Signaling Underlies PKGIα Modulation of Ca2+ Sparks and BKCa in Myogenically Active Arterioles Science Signaling. 10, 2016 | Pubmed ID: 27729549 Vascular Mineralocorticoid Receptor Regulates MicroRNA-155 to Promote Vasoconstriction and Rising Blood Pressure with Aging JCI Insight. Sep, 2016 | Pubmed ID: 27683672 Small Artery Mechanobiology: Roles of Cellular and Non-cellular Elements Microcirculation (New York, N.Y. : 1994). 11, 2016 | Pubmed ID: 27681605 Mechanical Activation of Angiotensin II Type 1 Receptors Causes Actin Remodelling and Myogenic Responsiveness in Skeletal Muscle Arterioles The Journal of Physiology. 12, 2016 | Pubmed ID: 27531064 Arterial Stiffening in Western Diet-Fed Mice Is Associated with Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma Neuraminidase Frontiers in Physiology. 2016 | Pubmed ID: 27458385 Small Artery Elastin Distribution and Architecture-Focus on Three Dimensional Organization Microcirculation (New York, N.Y. : 1994). 11, 2016 | Pubmed ID: 27362628 Inherent Rhythm of Smooth Muscle Cells in Rat Mesenteric Arterioles: An Eigensystem Formulation Physical Review. E. 04, 2016 | Pubmed ID: 27176337 Adiponectin Receptor Agonist, AdipoRon, Causes Vasorelaxation Predominantly Via a Direct Smooth Muscle Action Microcirculation (New York, N.Y. : 1994). Apr, 2016 | Pubmed ID: 26728950 Brief Serotonin Exposure Initiates Arteriolar Inward Remodeling Processes in Vivo That Involve Transglutaminase Activation and Actin Cytoskeleton Reorganization American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2016 | Pubmed ID: 26566730 Regulation of Coronary Endothelial Function by Interactions Between TNF-α, LOX-1 and Adiponectin in Apolipoprotein E Knockout Mice Journal of Vascular Research. 2015 | Pubmed ID: 27050429 Disconnect Between Adipose Tissue Inflammation and Cardiometabolic Dysfunction in Ossabaw Pigs Obesity (Silver Spring, Md.). Dec, 2015 | Pubmed ID: 26524201 Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure Hypertension (Dallas, Tex. : 1979). Nov, 2015 | Pubmed ID: 26351033 Lymphatic Vascular Integrity is Disrupted in Type 2 Diabetes Due to Impaired Nitric Oxide Signalling Cardiovascular Research. Jul, 2015 | Pubmed ID: 25852084 Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels Journal of Cardiovascular Pharmacology. Jul, 2015 | Pubmed ID: 25815673 Heterogeneity in Kv7 Channel Function in the Cerebral and Coronary Circulation Microcirculation (New York, N.Y. : 1994). Feb, 2015 | Pubmed ID: 25476662 Augmented Vascular Smooth Muscle Cell Stiffness and Adhesion when Hypertension is Superimposed on Aging Hypertension (Dallas, Tex. : 1979). Feb, 2015 | Pubmed ID: 25452471 Large Conductance Ca2+-activated K+ Channel (BKCa) α-subunit Splice Variants in Resistance Arteries from Rat Cerebral and Skeletal Muscle Vasculature PloS One. 2014 | Pubmed ID: 24921651 Autoimmune Basis for Postural Tachycardia Syndrome Journal of the American Heart Association. Feb, 2014 | Pubmed ID: 24572257 N-cadherin, a Vascular Smooth Muscle Cell-cell Adhesion Molecule: Function and Signaling for Vasomotor Control Microcirculation (New York, N.Y. : 1994). Apr, 2014 | Pubmed ID: 24521477 Vasoactive Agonists Exert Dynamic and Coordinated Effects on Vascular Smooth Muscle Cell Elasticity, Cytoskeletal Remodelling and Adhesion The Journal of Physiology. Mar, 2014 | Pubmed ID: 24445320 Aldosterone and Vascular Mineralocorticoid Receptors: Regulators of Ion Channels Beyond the Kidney Hypertension (Dallas, Tex. : 1979). Apr, 2014 | Pubmed ID: 24379184 Should We Be Sympathetic to Angiotensin II Infusion? The Journal of Physiology. Nov, 2013 | Pubmed ID: 24187078 Vascular Transcriptional Alterations Produced by Juvenile Obesity in Ossabaw Swine Physiological Genomics. Jun, 2013 | Pubmed ID: 23592636 Mechanisms Underlying Regional Differences in the Ca2+ Sensitivity of BK(Ca) Current in Arteriolar Smooth Muscle The Journal of Physiology. Mar, 2013 | Pubmed ID: 23297302 Does C-reactive Protein Contribute to Atherothrombosis Via Oxidant-mediated Release of Pro-thrombotic Factors and Activation of Platelets? Frontiers in Physiology. 2012 | Pubmed ID: 23162475 Passive Pressure-Diameter Relationship and Structural Composition of Rat Mesenteric Lymphangions Lymphatic Research and Biology. Nov, 2012 | Pubmed ID: 23145980 Direct Regulation of Blood Pressure by Smooth Muscle Cell Mineralocorticoid Receptors Nature Medicine. Sep, 2012 | Pubmed ID: 22922412 Arteriolar Vascular Smooth Muscle Cells: Mechanotransducers in a Complex Environment The International Journal of Biochemistry & Cell Biology. Sep, 2012 | Pubmed ID: 22677491 Temporal Analysis of Vascular Smooth Muscle Cell Elasticity and Adhesion Reveals Oscillation Waveforms That Differ with Aging Aging Cell. Oct, 2012 | Pubmed ID: 22639979 Adiponectin Abates Diabetes-induced Endothelial Dysfunction by Suppressing Oxidative Stress, Adhesion Molecules, and Inflammation in Type 2 Diabetic Mice American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2012 | Pubmed ID: 22561304 Agonistic Autoantibodies As Vasodilators in Orthostatic Hypotension: a New Mechanism Hypertension. Feb, 2012 | Pubmed ID: 22215709 Autoantibody Activation of Beta-adrenergic and Muscarinic Receptors Contributes to an "autoimmune" Orthostatic Hypotension Journal of the American Society of Hypertension : JASH. Jan-Feb, 2012 | Pubmed ID: 22130180 Hydrogen Sulfide Preconditioning or Neutrophil Depletion Attenuates Ischemia-reperfusion-induced Mitochondrial Dysfunction in Rat Small Intestine American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2012 | Pubmed ID: 21921289 Spatial Distribution and Mechanical Function of Elastin in Resistance Arteries: a Role in Bearing Longitudinal Stress Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2011 | Pubmed ID: 21979438 N-cadherin and Integrin Blockade Inhibit Arteriolar Myogenic Reactivity but Not Pressure-induced Increases in Intracellular Ca Frontiers in Physiology. 2010 | Pubmed ID: 21423400 Development of an Image-based System for Measurement of Membrane Potential, Intracellular Ca(2+) and Contraction in Arteriolar Smooth Muscle Cells Microcirculation (New York, N.Y. : 1994). Nov, 2010 | Pubmed ID: 21044217 Antecedent Hydrogen Sulfide Elicits an Anti-inflammatory Phenotype in Postischemic Murine Small Intestine: Role of BK Channels American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2010 | Pubmed ID: 20833953 Large Conductance, Ca2+-activated K+ Channels (BKCa) and Arteriolar Myogenic Signaling FEBS Letters. May, 2010 | Pubmed ID: 20178789 Therapeutic Potential of Pharmacologically Targeting Arteriolar Myogenic Tone Trends in Pharmacological Sciences. Jul, 2009 | Pubmed ID: 19541373 Heterogeneity in Function of Small Artery Smooth Muscle BKCa: Involvement of the Beta1-subunit The Journal of Physiology. Jun, 2009 | Pubmed ID: 19359368 The Plastic Nature of the Vascular Wall: a Continuum of Remodeling Events Contributing to Control of Arteriolar Diameter and Structure Physiology (Bethesda, Md.). Feb, 2009 | Pubmed ID: 19196651 Extracellular Matrix-specific Focal Adhesions in Vascular Smooth Muscle Produce Mechanically Active Adhesion Sites American Journal of Physiology. Cell Physiology. Jul, 2008 | Pubmed ID: 18495809 Decreased Activity of the Smooth Muscle Na+/Ca2+ Exchanger Impairs Arteriolar Myogenic Reactivity The Journal of Physiology. Mar, 2008 | Pubmed ID: 18218677 New Technologies for Dissecting the Arteriolar Myogenic Response Trends in Pharmacological Sciences. Jul, 2007 | Pubmed ID: 17573129 Coupling a Change in Intraluminal Pressure to Vascular Smooth Muscle Depolarization: Still Stretching for an Explanation American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2007 | Pubmed ID: 17384129 Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model Neekun Sharma*1,3, Zhe Sun*2,3, Michael A. Hill1,2,3, Chetan P. Hans1,2,3 1Division of Cardiovascular Medicine, University of Missouri, 2Medical Pharmacology and Physiology, University of Missouri, 3Dalton Cardiovascular Research Center, University of Missouri JoVE 60515 Immunology and Infection
Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model Neekun Sharma*1,3, Zhe Sun*2,3, Michael A. Hill1,2,3, Chetan P. Hans1,2,3 1Division of Cardiovascular Medicine, University of Missouri, 2Medical Pharmacology and Physiology, University of Missouri, 3Dalton Cardiovascular Research Center, University of Missouri JoVE 60515 Immunology and Infection