Michael K. Lee

Publications

• Small-molecule RA-9 Inhibits Proteasome-associated DUBs and Ovarian Cancer in Vitro and in Vivo Via Exacerbating Unfolded Protein Responses
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2014  |   Pubmed ID: 24727327
• Endoplasmic Reticulum Stress is Important for the Manifestations of α-synucleinopathy in Vivo
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2012  |   Pubmed ID: 22399753
• Accumulation of Toxic α-synuclein Oligomer Within Endoplasmic Reticulum Occurs in α-synucleinopathy in Vivo
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2012  |   Pubmed ID: 22399752
• Neurodegenerative Phenotypes in an A53T α-synuclein Transgenic Mouse Model Are Independent of LRRK2
  Human Molecular Genetics. Jun, 2012  |   Pubmed ID: 22357653
• Magnetization Transfer and Adiabatic R 1ρ MRI in the Brainstem of Parkinson's Disease
  Parkinsonism & Related Disorders. Jun, 2012  |   Pubmed ID: 22265140
• Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2
  PloS One. 2011  |   Pubmed ID: 21494637
• Resistance to MPTP-neurotoxicity in α-synuclein Knockout Mice is Complemented by Human α-synuclein and Associated with Increased β-synuclein and Akt Activation
  PloS One. 2011  |   Pubmed ID: 21304957
• Passive (amyloid-β) Immunotherapy Attenuates Monoaminergic Axonal Degeneration in the AβPPswe/PS1dE9 Mice
  Journal of Alzheimer's Disease : JAD. 2011  |   Pubmed ID: 20966549
• Synphilin-1 Attenuates Neuronal Degeneration in the A53T Alpha-synuclein Transgenic Mouse Model
  Human Molecular Genetics. Jun, 2010  |   Pubmed ID: 20185556
• Increased Expression of Alpha-synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering After Endocytosis
  Neuron. Jan, 2010  |   Pubmed ID: 20152114
• Amyloid Pathology is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008  |   Pubmed ID: 19091971
• Ubiquitin Proteasome System Stress Underlies Synergistic Killing of Ovarian Cancer Cells by Bortezomib and a Novel HDAC6 Inhibitor
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2008  |   Pubmed ID: 19010849
• Lysine 63-linked Ubiquitination Promotes the Formation and Autophagic Clearance of Protein Inclusions Associated with Neurodegenerative Diseases
  Human Molecular Genetics. Feb, 2008  |   Pubmed ID: 17981811
• Differential Regulation of Small Heat Shock Proteins in Transgenic Mouse Models of Neurodegenerative Diseases
  Neurobiology of Aging. Apr, 2008  |   Pubmed ID: 17316906
• Myosin II Co-chaperone General Cell UNC-45 Overexpression is Associated with Ovarian Cancer, Rapid Proliferation, and Motility
  The American Journal of Pathology. Nov, 2007  |   Pubmed ID: 17872978
• Wild-type and Mutant Alpha-synuclein Induce a Multi-component Gene Expression Profile Consistent with Shared Pathophysiology in Different Transgenic Mouse Models of PD
  Experimental Neurology. Mar, 2007  |   Pubmed ID: 17254569
• Inclusion Body Formation and Neurodegeneration Are Parkin Independent in a Mouse Model of Alpha-synucleinopathy
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2006  |   Pubmed ID: 16597723
• Ubiquitin-proteasome System Stress Sensitizes Ovarian Cancer to Proteasome Inhibitor-induced Apoptosis
  Cancer Research. Apr, 2006  |   Pubmed ID: 16585202
• Parkinson's Disease Alpha-synuclein Transgenic Mice Develop Neuronal Mitochondrial Degeneration and Cell Death
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2006  |   Pubmed ID: 16399671
• Ruptured Left Gastric Artery Aneurysm: Unique Presentation with Hemothorax and Hemomediastinum
  Cardiovascular and Interventional Radiology. May-Jun, 2006  |   Pubmed ID: 16283575
• Locomotor Hyperactivity and Alterations in Dopamine Neurotransmission Are Associated with Overexpression of A53T Mutant Human Alpha-synuclein in Mice
  Neurobiology of Disease. Feb, 2006  |   Pubmed ID: 16230020
• Alpha-synuclein Phosphorylation Enhances Eosinophilic Cytoplasmic Inclusion Formation in SH-SY5Y Cells
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2005  |   Pubmed ID: 15944382
• Antiapoptotic Property of Human Alpha-synuclein in Neuronal Cell Lines is Associated with the Inhibition of Caspase-3 but Not Caspase-9 Activity
  Journal of Neurochemistry. Jun, 2005  |   Pubmed ID: 15935070
• Abeta Deposition is Associated with Enhanced Cortical Alpha-synuclein Lesions in Lewy Body Diseases
  Neurobiology of Aging. Aug-Sep, 2005  |   Pubmed ID: 15917102
• Aggregation Promoting C-terminal Truncation of Alpha-synuclein is a Normal Cellular Process and is Enhanced by the Familial Parkinson's Disease-linked Mutations
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15684072
• Association of DJ-1 and Parkin Mediated by Pathogenic DJ-1 Mutations and Oxidative Stress
  Human Molecular Genetics. Jan, 2005  |   Pubmed ID: 15525661
• Stabilization of Alpha-synuclein Protein with Aging and Familial Parkinson's Disease-linked A53T Mutation
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2004  |   Pubmed ID: 15317865
• Axonal Transport of Human Alpha-synuclein Slows with Aging but is Not Affected by Familial Parkinson's Disease-linked Mutations
  Journal of Neurochemistry. Jan, 2004  |   Pubmed ID: 14690528
• Mutant Presenilins Specifically Elevate the Levels of the 42 Residue Beta-amyloid Peptide in Vivo: Evidence for Augmentation of a 42-specific Gamma Secretase
  Human Molecular Genetics. Jan, 2004  |   Pubmed ID: 14645205
• No-reflow is an Independent Predictor of Death and Myocardial Infarction After Percutaneous Coronary Intervention
  American Heart Journal. Jan, 2003  |   Pubmed ID: 12514653
• Human Alpha-synuclein-harboring Familial Parkinson's Disease-linked Ala-53 --> Thr Mutation Causes Neurodegenerative Disease with Alpha-synuclein Aggregation in Transgenic Mice
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002  |   Pubmed ID: 12084935
• Accumulation of Proteolytic Fragments of Mutant Presenilin 1 and Accelerated Amyloid Deposition Are Co-regulated in Transgenic Mice
  Neurobiology of Aging. Mar-Apr, 2002  |   Pubmed ID: 11804700