Michael Reth

Publications

• What Goes Up Must Come Down: A Tripartite Dok-3/Grb2/SHIP1 Inhibitory Module Limits BCR Signaling
  European Journal of Immunology. Nov, 2016  |   Pubmed ID: 27813071
• Molecular Requirements of the B-cell Antigen Receptor for Sensing Monovalent Antigens
  The EMBO Journal. Nov, 2016  |   Pubmed ID: 27634959
• Corrigendum: Signalling Thresholds and Negative B-cell Selection in Acute Lymphoblastic Leukaemia
  Nature. 06, 2016  |   Pubmed ID: 26958840
• Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function
  Journal of Immunology (Baltimore, Md. : 1950). Mar, 2016  |   Pubmed ID: 26843325
• Receptor Dissociation and B-Cell Activation
  Current Topics in Microbiology and Immunology. 2016  |   Pubmed ID: 26428245
• B Cell Antigen Receptors of the IgM and IgD Classes Are Clustered in Different Protein Islands That Are Altered During B Cell Activation
  Science Signaling. Sep, 2015  |   Pubmed ID: 26373673
• Kidins220/ARMS Binds to the B Cell Antigen Receptor and Regulates B Cell Development and Activation
  The Journal of Experimental Medicine. Sep, 2015  |   Pubmed ID: 26324445
• Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2015  |   Pubmed ID: 26157172
• Erratum: Responsiveness of B Cells is Regulated by the Hinge Region of IgD
  Nature Immunology. Jul, 2015  |   Pubmed ID: 26086144
• Responsiveness of B Cells is Regulated by the Hinge Region of IgD
  Nature Immunology. May, 2015  |   Pubmed ID: 25848865
• Signalling Thresholds and Negative B-cell Selection in Acute Lymphoblastic Leukaemia
  Nature. May, 2015  |   Pubmed ID: 25799995
• TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-mesenchymal Transition
  Developmental Cell. Mar, 2015  |   Pubmed ID: 25727005
• Fundamental Properties of Unperturbed Haematopoiesis from Stem Cells in Vivo
  Nature. Feb, 2015  |   Pubmed ID: 25686605
• Preface to Special Issue on Nanoscale Membrane Organisations
  Biochimica Et Biophysica Acta. Apr, 2015  |   Pubmed ID: 25677899
• CD19 and BAFF-R Can Signal to Promote B-cell Survival in the Absence of Syk
  The EMBO Journal. Apr, 2015  |   Pubmed ID: 25630702
• The Nanoscale Organization of the B Lymphocyte Membrane
  Biochimica Et Biophysica Acta. Apr, 2015  |   Pubmed ID: 25450974
• Suboptimal B-cell Antigen Receptor Signaling Activity in Vivo Elicits Germinal Center Counterselection Mechanisms
  European Journal of Immunology. Feb, 2015  |   Pubmed ID: 25382621
• The AP-1 Transcription Factor Fra1 Inhibits Follicular B Cell Differentiation into Plasma Cells
  The Journal of Experimental Medicine. Oct, 2014  |   Pubmed ID: 25288397
• Production of IgG Autoantibody Requires Expression of Activation-induced Deaminase in Early-developing B Cells in a Mouse Model of SLE
  European Journal of Immunology. Oct, 2014  |   Pubmed ID: 25044405
• PDK1 Regulates B Cell Differentiation and Homeostasis
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 24979759
• B Cell Activation Involves Nanoscale Receptor Reorganizations and Inside-out Signaling by Syk
  ELife. Jun, 2014  |   Pubmed ID: 24963139
• The Role of the Syk/Shp-1 Kinase-phosphatase Equilibrium in B Cell Development and Signaling
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2014  |   Pubmed ID: 24899508
• The Ligand-binding Domain of Siglec-G is Crucial for Its Selective Inhibitory Function on B1 Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014  |   Pubmed ID: 24790146
• MIF Promotes B Cell Chemotaxis Through the Receptors CXCR4 and CD74 and ZAP-70 Signaling
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014  |   Pubmed ID: 24760155
• Pillars Article: Antigen Receptor Tail Clue. Nature. 1989. 338: 383-384
  Journal of Immunology (Baltimore, Md. : 1950). May, 2014  |   Pubmed ID: 24748635
• The Protein Tyrosine Phosphatase PTP1B is a Negative Regulator of CD40 and BAFF-R Signaling and Controls B Cell Autoimmunity
  The Journal of Experimental Medicine. Mar, 2014  |   Pubmed ID: 24590766
• Signaling Circuits in Early B-cell Development
  Advances in Immunology. 2014  |   Pubmed ID: 24507157
• Michael Neuberger (1953-2013)
  Immunity. Dec, 2013  |   Pubmed ID: 24479157
• Pre-clustering of the B Cell Antigen Receptor Demonstrated by Mathematically Extended Electron Microscopy
  Frontiers in Immunology. 2013  |   Pubmed ID: 24367367
• Proximity Ligation Assay for High-content Profiling of Cell Signaling Pathways on a Microfluidic Chip
  Molecular & Cellular Proteomics : MCP. Dec, 2013  |   Pubmed ID: 24072685
• Inhibition of MTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells
  Cell. Aug, 2013  |   Pubmed ID: 23953116
• The Serine/threonine Phosphatase PP4 is Required for Pro-B Cell Development Through Its Promotion of Immunoglobulin VDJ Recombination
  PloS One. 2013  |   Pubmed ID: 23874770
• Matching Cellular Dimensions with Molecular Sizes
  Nature Immunology. Aug, 2013  |   Pubmed ID: 23867923
• CD22 Ligand-binding and Signaling Domains Reciprocally Regulate B-cell Ca2+ Signaling
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013  |   Pubmed ID: 23836650
• Semi-supervised Prediction of SH2-peptide Interactions from Imbalanced High-throughput Data
  PloS One. 2013  |   Pubmed ID: 23690949
• Immunoglobulins Drive Terminal Maturation of Splenic Dendritic Cells
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013  |   Pubmed ID: 23345431
• Non-cell-autonomous Hedgehog Signaling Promotes Murine B Lymphopoiesis from Hematopoietic Progenitors
  Blood. Jun, 2012  |   Pubmed ID: 22517907
• Synthetic Immune Signaling
  Current Opinion in Biotechnology. Oct, 2012  |   Pubmed ID: 22326912
• The E3 Ubiquitin Ligase Mule Acts Through the ATM-p53 Axis to Maintain B Lymphocyte Homeostasis
  The Journal of Experimental Medicine. Jan, 2012  |   Pubmed ID: 22213803
• The SH2-domain of SHIP1 Interacts with the SHIP1 C-terminus: Impact on SHIP1/Ig-α Interaction
  Biochimica Et Biophysica Acta. Feb, 2012  |   Pubmed ID: 22182704
• Drosophila S2 Schneider Cells: a Useful Tool for Rebuilding and Redesigning Approaches in Synthetic Biology
  Methods in Molecular Biology (Clifton, N.J.). 2012  |   Pubmed ID: 22083752
• B Cells That Produce Immunoglobulin E Mediate Colitis in BALB/c Mice
  Gastroenterology. Jan, 2012  |   Pubmed ID: 21983080
• Bacillus Subtilis MreB Orthologs Self-organize into Filamentous Structures Underneath the Cell Membrane in a Heterologous Cell System
  PloS One. 2011  |   Pubmed ID: 22069484
• B Cell Homeostasis and Plasma Cell Homing Controlled by Krüppel-like Factor 2
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011  |   Pubmed ID: 21187409
• Syk is a Dual-specificity Kinase That Self-regulates the Signal Output from the B-cell Antigen Receptor
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2010  |   Pubmed ID: 20940318
• The Dissociation Activation Model of B Cell Antigen Receptor Triggering
  FEBS Letters. Dec, 2010  |   Pubmed ID: 20920502
• Oligomeric Organization of the B-cell Antigen Receptor on Resting Cells
  Nature. Sep, 2010  |   Pubmed ID: 20818374
• N-linked Glycosylation Selectively Regulates Autonomous Precursor BCR Function
  Nature Immunology. Aug, 2010  |   Pubmed ID: 20622883
• Arginine Methylation of the B Cell Antigen Receptor Promotes Differentiation
  The Journal of Experimental Medicine. Apr, 2010  |   Pubmed ID: 20231378
• Voltage Control for B Cell Activation
  Nature Immunology. Mar, 2010  |   Pubmed ID: 20157299
• Analysis of Novel Phospho-ITAM Specific Antibodies in a S2 Reconstitution System for TCR-CD3 Signalling
  Immunology Letters. May, 2010  |   Pubmed ID: 20005895
• Autoinhibition and Adapter Function of Syk
  Immunological Reviews. Nov, 2009  |   Pubmed ID: 19909371
• Induction of B-cell Development in Adult Mice Reveals the Ability of Bone Marrow to Produce B-1a Cells
  Blood. Dec, 2009  |   Pubmed ID: 19812384
• Molecular Components of the B-cell Antigen Receptor Complex of the IgM Class. 1990
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2009  |   Pubmed ID: 19620316
• Regulation of B-cell Proliferation and Differentiation by Pre-B-cell Receptor Signalling
  Nature Reviews. Immunology. Mar, 2009  |   Pubmed ID: 19240758
• Genomic Instability Resulting from Blm Deficiency Compromises Development, Maintenance, and Function of the B Cell Lineage
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2009  |   Pubmed ID: 19109166
• Clustering Models
  Advances in Experimental Medicine and Biology. 2008  |   Pubmed ID: 19065784
• Enhanced B-cell Activation Mediated by TLR4 and BCR Crosstalk
  European Journal of Immunology. Sep, 2008  |   Pubmed ID: 18819072
• Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008  |   Pubmed ID: 18566414
• SLP-65 Regulates Immunoglobulin Light Chain Gene Recombination Through the PI(3)K-PKB-Foxo Pathway
  Nature Immunology. Jun, 2008  |   Pubmed ID: 18488031
• The Kinase Syk As an Adaptor Controlling Sustained Calcium Signalling and B-cell Development
  The EMBO Journal. May, 2008  |   Pubmed ID: 18369315
• The TCR Binding Site Does Move
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007  |   Pubmed ID: 17925433
• Mutations of the Igbeta Gene Cause Agammaglobulinemia in Man
  The Journal of Experimental Medicine. Sep, 2007  |   Pubmed ID: 17709424
• Immunoreceptors and Integrins
  Immunological Reviews. Aug, 2007  |   Pubmed ID: 17624940
• Yin Yang 1 is a Critical Regulator of B-cell Development
  Genes & Development. May, 2007  |   Pubmed ID: 17504937
• Survival of Liver Failure Pigs by Transplantation of Reversibly Immortalized Human Hepatocytes with Tamoxifen-mediated Self-recombination
  Journal of Hepatology. Jul, 2007  |   Pubmed ID: 17434229
• Association of Protein Kinase C-delta with the B Cell Antigen Receptor Complex
  Cellular Signalling. Apr, 2007  |   Pubmed ID: 17098397
• Identification of Disulfide Bonds in the Ig-alpha/Ig-beta Component of the B Cell Antigen Receptor Using the Drosophila S2 Cell Reconstitution System
  International Immunology. Sep, 2006  |   Pubmed ID: 16877534
• Canonical NF-kappaB Activity, Dispensable for B Cell Development, Replaces BAFF-receptor Signals and Promotes B Cell Proliferation Upon Activation
  Immunity. Jun, 2006  |   Pubmed ID: 16782029
• Human T-cell Leukemia Virus Type-I Oncoprotein Tax Inhibits Fas-mediated Apoptosis by Inducing Cellular FLIP Through Activation of NF-kappaB
  Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Feb, 2006  |   Pubmed ID: 16436054
• Two Dimensional Blue Native-/SDS-PAGE Analysis of SLP Family Adaptor Protein Complexes
  Immunology Letters. Apr, 2006  |   Pubmed ID: 16356554
• B Cell Signaling and Tumorigenesis
  Annual Review of Immunology. 2005  |   Pubmed ID: 15771577
• Postnatal Isl1+ Cardioblasts Enter Fully Differentiated Cardiomyocyte Lineages
  Nature. Feb, 2005  |   Pubmed ID: 15703750
• A Leucine Zipper in the N Terminus Confers Membrane Association to SLP-65
  Nature Immunology. Feb, 2005  |   Pubmed ID: 15654340
• Reversible Switching of Immunoglobulin Hypermutation Machinery in a Chicken B Cell Line
  Biochemical and Biophysical Research Communications. Feb, 2005  |   Pubmed ID: 15629431
• Adenosine and CAMP Are Potent Inhibitors of the NF-kappa B Pathway Downstream of Immunoreceptors
  European Journal of Immunology. Jan, 2005  |   Pubmed ID: 15580656
• Perspectives on the Nature of BCR-mediated Survival Signals
  Molecular Cell. Jun, 2004  |   Pubmed ID: 15200948
• B-cell Signal Transduction: Tyrosine Phosphorylation, Kinase Activity, and Calcium Mobilization
  Methods in Molecular Biology (Clifton, N.J.). 2004  |   Pubmed ID: 15146122
• Functional Folding of a Cytoplasmic Single-chain Variable Fragment and Its Use As Elutable Protein Purification Tag
  Immunology Letters. Mar, 2004  |   Pubmed ID: 15081544
• B Cell Antigen Receptor Assembly and Syk Activation in the S2 Cell Reconstitution System
  Immunology Letters. Mar, 2004  |   Pubmed ID: 15081529
• Feedback Regulation of Lymphocyte Signalling
  Nature Reviews. Immunology. Apr, 2004  |   Pubmed ID: 15057785
• A Revised and Complete Map of the Chicken C-mil/raf-1 Locus
  Oncogene. Apr, 2004  |   Pubmed ID: 14968114
• Activation of the CKI-CDK-Rb-E2F Pathway in Full Genome Hepatitis C Virus-expressing Cells
  The Journal of Biological Chemistry. Apr, 2004  |   Pubmed ID: 14747471
• Importance of TRF1 for Functional Telomere Structure
  The Journal of Biological Chemistry. Jan, 2004  |   Pubmed ID: 14559908
• Identification of Novel ERK-mediated Feedback Phosphorylation Sites at the C-terminus of B-Raf
  Oncogene. Dec, 2003  |   Pubmed ID: 14654779
• Identification of a Pre-BCR Lacking Surrogate Light Chain
  The Journal of Experimental Medicine. Dec, 2003  |   Pubmed ID: 14638847
• B Cell Defects in SLP65/BLNK-deficient Mice Can Be Partially Corrected by the Absence of CD22, an Inhibitory Coreceptor for BCR Signaling
  European Journal of Immunology. Dec, 2003  |   Pubmed ID: 14635051
• A High-molecular-weight Complex of Membrane Proteins BAP29/BAP31 is Involved in the Retention of Membrane-bound IgD in the Endoplasmic Reticulum
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003  |   Pubmed ID: 12886015
• Bruton's Tyrosine Kinase Cooperates with the B Cell Linker Protein SLP-65 As a Tumor Suppressor in Pre-B Cells
  The Journal of Experimental Medicine. Jul, 2003  |   Pubmed ID: 12835482
• Establishment of Immortalized Human Hepatic Stellate Scavenger Cells to Develop Bioartificial Livers
  Transplantation. Jun, 2003  |   Pubmed ID: 12811248
• Deficiency of the Adaptor SLP-65 in Pre-B-cell Acute Lymphoblastic Leukaemia
  Nature. May, 2003  |   Pubmed ID: 12761551
• Genetic Changes Occurring in Established Tumors Rapidly Stimulate New Antibody Responses
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003  |   Pubmed ID: 12702750
• NF-kappaB is Required for Cell Death Induction by Latent Membrane Protein 1 of Epstein-Barr Virus
  Cellular Signalling. Apr, 2003  |   Pubmed ID: 12618217
• Essential Role of Src-family Protein Tyrosine Kinases in NF-kappaB Activation During B Cell Development
  Nature Immunology. Mar, 2003  |   Pubmed ID: 12563261
• Activation of T Cells Via Tumor Antigen Specific Chimeric Receptors: the Role of the Intracellular Signaling Domain
  International Journal of Cancer. Jan, 2003  |   Pubmed ID: 12471624
• The Adaptor Protein SLP-65 Acts As a Tumor Suppressor That Limits Pre-B Cell Expansion
  Nature Immunology. Jan, 2003  |   Pubmed ID: 12436112
• Amplification of B Cell Antigen Receptor Signaling by a Syk/ITAM Positive Feedback Loop
  Molecular Cell. Nov, 2002  |   Pubmed ID: 12453414
• Hydrogen Peroxide As Second Messenger in Lymphocyte Activation
  Nature Immunology. Dec, 2002  |   Pubmed ID: 12447370
• Inducible Gene Deletion Reveals Different Roles for B-Raf and Raf-1 in B-cell Antigen Receptor Signalling
  The EMBO Journal. Nov, 2002  |   Pubmed ID: 12411479
• BCR Mutants Deficient in Ligand-independent and More Sensitive for Ligand-dependent Signaling
  European Journal of Immunology. Jun, 2002  |   Pubmed ID: 12115644
• B Cell Progenitors Are Arrested in Maturation but Have Intact VDJ Recombination in the Absence of Ig-alpha and Ig-beta
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2002  |   Pubmed ID: 12097390
• The Role of SHIP in Mast Cell Degranulation and IgE-induced Mast Cell Survival
  Immunology Letters. Jun, 2002  |   Pubmed ID: 12008029
• The Procaspase-8 Isoform, Procaspase-8L, Recruited to the BAP31 Complex at the Endoplasmic Reticulum
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002  |   Pubmed ID: 11917123
• Cre Recombinase-controlled Expression of the Mb-1 Allele
  Genesis (New York, N.Y. : 2000). Feb, 2002  |   Pubmed ID: 11857807