Michael Sendtner Institute for Clinical Neurobiology University of Wuerzburg Biography Publications Institution JoVE Articles Michael Sendtner has not added a biography. If you are Michael Sendtner and would like to personalize this page please email our Author Liaison for assistance. Publications Microtubule Associated Tumor Suppressor 1 Deficient Mice Develop Spontaneous Heart Hypertrophy and SLE-like Lymphoproliferative Disease International Journal of Oncology. Apr, 2012 | Pubmed ID: 22200760 Na(+)-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-dependent Incretin Secretion Diabetes. Jan, 2012 | Pubmed ID: 22124465 Ribosomal Deficiencies in Diamond-Blackfan Anemia Impair Translation of Transcripts Essential for Differentiation of Murine and Human Erythroblasts Blood. Jan, 2012 | Pubmed ID: 22058113 Molecular Pathways of Motor Neuron Injury in Amyotrophic Lateral Sclerosis Nature Reviews. Neurology. Nov, 2011 | Pubmed ID: 22051914 Therapeutic Effects of PEGylated Insulin-like Growth Factor I in the Pmn Mouse Model of Motoneuron Disease Experimental Neurology. Dec, 2011 | Pubmed ID: 21963648 A Hexanucleotide Repeat Expansion in C9ORF72 is the Cause of Chromosome 9p21-linked ALS-FTD Neuron. Oct, 2011 | Pubmed ID: 21944779 Regenerative Medicine: Bespoke Cells for the Human Brain Nature. Aug, 2011 | Pubmed ID: 21833079 A New Postal Code for Dendritic MRNA Transport in Neurons EMBO Reports. Jul, 2011 | Pubmed ID: 21681203 TDP-43: Multiple Targets, Multiple Disease Mechanisms? Nature Neuroscience. Apr, 2011 | Pubmed ID: 21445063 Loss of Striatal Type 1 Cannabinoid Receptors is a Key Pathogenic Factor in Huntington's Disease Brain : a Journal of Neurology. Jan, 2011 | Pubmed ID: 20929960 C-terminal FUS/TLS Mutations in Familial and Sporadic ALS in Germany Neurobiology of Aging. Mar, 2011 | Pubmed ID: 20018407 Functional Role of Brain-derived Neurotrophic Factor in Neuroprotective Autoimmunity: Therapeutic Implications in a Model of Multiple Sclerosis Brain : a Journal of Neurology. Aug, 2010 | Pubmed ID: 20826430 Therapy Development in Spinal Muscular Atrophy Nature Neuroscience. Jul, 2010 | Pubmed ID: 20581815 PTEN Depletion Rescues Axonal Growth Defect and Improves Survival in SMN-deficient Motor Neurons Human Molecular Genetics. Aug, 2010 | Pubmed ID: 20525971 Downregulation of Genes with a Function in Axon Outgrowth and Synapse Formation in Motor Neurones of the VEGFdelta/delta Mouse Model of Amyotrophic Lateral Sclerosis BMC Genomics. 2010 | Pubmed ID: 20346106 The Heterogeneous Nuclear Ribonucleoprotein-R is Necessary for Axonal Beta-actin MRNA Translocation in Spinal Motor Neurons Human Molecular Genetics. May, 2010 | Pubmed ID: 20167579 Global Deprivation of Brain-derived Neurotrophic Factor in the CNS Reveals an Area-specific Requirement for Dendritic Growth The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2010 | Pubmed ID: 20130183 Neuromuscular Defects and Breathing Disorders in a New Mouse Model of Spinal Muscular Atrophy Neurobiology of Disease. Apr, 2010 | Pubmed ID: 20085811 Isolation and Enrichment of Embryonic Mouse Motoneurons from the Lumbar Spinal Cord of Individual Mouse Embryos Nature Protocols. 2010 | Pubmed ID: 20057379 Ciliary Neurotrophic Factor-induced Sprouting Preserves Motor Function in a Mouse Model of Mild Spinal Muscular Atrophy Human Molecular Genetics. Mar, 2010 | Pubmed ID: 20022887 Progressive Postnatal Motoneuron Loss in Mice Lacking GDF-15 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19864576 Synaptic PRG-1 Modulates Excitatory Transmission Via Lipid Phosphate-mediated Signaling Cell. Sep, 2009 | Pubmed ID: 19766573 Valproic Acid Blocks Excitability in SMA Type I Mouse Motor Neurons Neurobiology of Disease. Dec, 2009 | Pubmed ID: 19733665 P90 Ribosomal S6 Kinase 2 Negatively Regulates Axon Growth in Motoneurons Molecular and Cellular Neurosciences. Oct, 2009 | Pubmed ID: 19555761 A Two-stage Genome-wide Association Study of Sporadic Amyotrophic Lateral Sclerosis Human Molecular Genetics. Apr, 2009 | Pubmed ID: 19193627 Drosophila RSK Negatively Regulates Bouton Number at the Neuromuscular Junction Developmental Neurobiology. Mar, 2009 | Pubmed ID: 19160443 Stem Cells: Tailor-made Diseased Neurons Nature. Jan, 2009 | Pubmed ID: 19148087 Novel Role for Vascular Endothelial Growth Factor (VEGF) Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2008 | Pubmed ID: 18923022 Spiral Ganglion Outgrowth and Hearing Development in P75-deficient Mice Audiology & Neuro-otology. 2008 | Pubmed ID: 18663291 Single-dose Application of CNTF and BDNF Improves Remyelination of Regenerating Nerve Fibers After C7 Ventral Root Avulsion and Replantation Journal of Neurotrauma. Apr, 2008 | Pubmed ID: 18373486 Leukemia Inhibitory Factor Deficiency Modulates the Immune Response and Limits Autoimmune Demyelination: a New Role for Neurotrophic Cytokines in Neuroinflammation Journal of Immunology (Baltimore, Md. : 1950). Feb, 2008 | Pubmed ID: 18250427 Adenosine Receptor A2A-R Contributes to Motoneuron Survival by Transactivating the Tyrosine Kinase Receptor TrkB Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17940030 Haploinsufficiency of C-Met in Cd44-/- Mice Identifies a Collaboration of CD44 and C-Met in Vivo Molecular and Cellular Biology. Dec, 2007 | Pubmed ID: 17923692 Defective Ca2+ Channel Clustering in Axon Terminals Disturbs Excitability in Motoneurons in Spinal Muscular Atrophy The Journal of Cell Biology. Oct, 2007 | Pubmed ID: 17923533 Hypomorphic Sox10 Alleles Reveal Novel Protein Functions and Unravel Developmental Differences in Glial Lineages Development (Cambridge, England). Sep, 2007 | Pubmed ID: 17699610 Differential Modulation of Neurite Growth by the S- and the L-forms of Bag1, a Co-chaperone of Hsp70 Neuro-degenerative Diseases. 2007 | Pubmed ID: 17596720 The CB1 Cannabinoid Receptor Mediates Excitotoxicity-induced Neural Progenitor Proliferation and Neurogenesis The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17556369 Large-scale Pathways-based Association Study in Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Sep, 2007 | Pubmed ID: 17439985 Novel SOD1 N86K Mutation is Associated with a Severe Phenotype in Familial ALS Muscle & Nerve. Jul, 2007 | Pubmed ID: 17299743 Fgfr2 and Fgfr3 Are Not Required for Patterning and Maintenance of the Midbrain and Anterior Hindbrain Developmental Biology. Mar, 2007 | Pubmed ID: 17150206 High-efficiency Gene Transfer into Cultured Embryonic Motoneurons Using Recombinant Lentiviruses Histochemistry and Cell Biology. Apr, 2007 | Pubmed ID: 17102992 Sox10 Regulates Ciliary Neurotrophic Factor Gene Expression in Schwann Cells Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16684879 Loss of Leukemia Inhibitory Factor Receptor Beta or Cardiotrophin-1 Causes Similar Deficits in Preganglionic Sympathetic Neurons and Adrenal Medulla The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2006 | Pubmed ID: 16467531 Distinct and Overlapping Alterations in Motor and Sensory Neurons in a Mouse Model of Spinal Muscular Atrophy Human Molecular Genetics. Feb, 2006 | Pubmed ID: 16396995 Damaging Secretions: Chromogranins Team Up with Mutant SOD1 Nature Neuroscience. Jan, 2006 | Pubmed ID: 16378088 The Role of Neurotrophins in Muscle Under Physiological and Pathological Conditions Muscle & Nerve. Apr, 2006 | Pubmed ID: 16228973 Evidence That Embryonic Neurons Regulate the Onset of Cortical Gliogenesis Via Cardiotrophin-1 Neuron. Oct, 2005 | Pubmed ID: 16242406 Bag1 is Essential for Differentiation and Survival of Hematopoietic and Neuronal Cells Nature Neuroscience. Sep, 2005 | Pubmed ID: 16116448 Mechanisms of Axonal Degeneration in EAE--lessons from CNTF and MHC I Knockout Mice Journal of the Neurological Sciences. Jun, 2005 | Pubmed ID: 15949503 Motoneuron Survival After C7 Nerve Root Avulsion and Replantation in the Adult Rabbit: Effects of Local Ciliary Neurotrophic Factor and Brain-derived Neurotrophic Factor Application Plastic and Reconstructive Surgery. Jun, 2005 | Pubmed ID: 15923853 Triple Knock-out of CNTF, LIF, and CT-1 Defines Cooperative and Distinct Roles of These Neurotrophic Factors for Motoneuron Maintenance and Function The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2005 | Pubmed ID: 15716414 Glycinergic and GABAergic Synaptic Activity Differentially Regulate Motoneuron Survival and Skeletal Muscle Innervation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2005 | Pubmed ID: 15689563 Optical Assessment of Motoneuron Function in a "twenty-four-hour" Acute Spinal Cord Slice Model from Fetal Rats Journal of Neuroscience Methods. Feb, 2005 | Pubmed ID: 15661313 Truncated TrkB Receptor-induced Outgrowth of Dendritic Filopodia Involves the P75 Neurotrophin Receptor Journal of Cell Science. Nov, 2004 | Pubmed ID: 15507485 Characterization of Ighmbp2 in Motor Neurons and Implications for the Pathomechanism in a Mouse Model of Human Spinal Muscular Atrophy with Respiratory Distress Type 1 (SMARD1) Human Molecular Genetics. Sep, 2004 | Pubmed ID: 15269181 The Notch Target Genes Hey1 and Hey2 Are Required for Embryonic Vascular Development Genes & Development. Apr, 2004 | Pubmed ID: 15107403 The P75NTR-interacting Protein SC1 Inhibits Cell Cycle Progression by Transcriptional Repression of Cyclin E The Journal of Cell Biology. Mar, 2004 | Pubmed ID: 15051733 Axonal Defects in Mouse Models of Motoneuron Disease Journal of Neurobiology. Feb, 2004 | Pubmed ID: 14704958 Dynamic Changes in C-Raf Phosphorylation and 14-3-3 Protein Binding in Response to Growth Factor Stimulation: Differential Roles of 14-3-3 Protein Binding Sites The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14688280 Smn, the Spinal Muscular Atrophy-determining Gene Product, Modulates Axon Growth and Localization of Beta-actin MRNA in Growth Cones of Motoneurons The Journal of Cell Biology. Nov, 2003 | Pubmed ID: 14623865 Endogenous Ciliary Neurotrophic Factor Protects GABAergic, but Not Cholinergic, Septohippocampal Neurons Following Fimbria-fornix Transection Brain Pathology (Zurich, Switzerland). Jul, 2003 | Pubmed ID: 12946020 Early Onset of Degenerative Changes at Nodes of Ranvier in Alpha-motor Axons of Cntf Null (-/-) Mutant Mice Glia. Jun, 2003 | Pubmed ID: 12730954 Gene Disruption Discloses Role of Selenoprotein P in Selenium Delivery to Target Tissues The Biochemical Journal. Mar, 2003 | Pubmed ID: 12521380 A Transgene Carrying an A2G Missense Mutation in the SMN Gene Modulates Phenotypic Severity in Mice with Severe (type I) Spinal Muscular Atrophy The Journal of Cell Biology. Jan, 2003 | Pubmed ID: 12515823 Missense Mutation in the Tubulin-specific Chaperone E (Tbce) Gene in the Mouse Mutant Progressive Motor Neuronopathy, a Model of Human Motoneuron Disease The Journal of Cell Biology. Nov, 2002 | Pubmed ID: 12446740 Neurotrophins: from Enthusiastic Expectations Through Sobering Experiences to Rational Therapeutic Approaches Nature Neuroscience. Nov, 2002 | Pubmed ID: 12403983 Gene Targeting of Gemin2 in Mice Reveals a Correlation Between Defects in the Biogenesis of U SnRNPs and Motoneuron Cell Death Proceedings of the National Academy of Sciences of the United States of America. Jul, 2002 | Pubmed ID: 12091709 CNTF is a Major Protective Factor in Demyelinating CNS Disease: a Neurotrophic Cytokine As Modulator in Neuroinflammation Nature Medicine. Jun, 2002 | Pubmed ID: 12042814 Early Onset of Severe Familial Amyotrophic Lateral Sclerosis with a SOD-1 Mutation: Potential Impact of CNTF As a Candidate Modifier Gene American Journal of Human Genetics. May, 2002 | Pubmed ID: 11951178 Association of a Null Mutation in the CNTF Gene with Early Onset of Multiple Sclerosis Archives of Neurology. Mar, 2002 | Pubmed ID: 11890844 Conditional Gene Ablation of Stat3 Reveals Differential Signaling Requirements for Survival of Motoneurons During Development and After Nerve Injury in the Adult The Journal of Cell Biology. Jan, 2002 | Pubmed ID: 11807093 Specific Interaction of Smn, the Spinal Muscular Atrophy Determining Gene Product, with HnRNP-R and Gry-rbp/hnRNP-Q: a Role for Smn in RNA Processing in Motor Axons? Human Molecular Genetics. Jan, 2002 | Pubmed ID: 11773003 The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and Its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse The European Journal of Neuroscience. Oct, 1991 | Pubmed ID: 12106247 Lectin القائم على عزل وثقافة حركية مماثلة الجنينية الماوس Rebecca Conrad1, Sibylle Jablonka2, Teresa Sczepan1, Michael Sendtner2, Stefan Wiese1, Alice Klausmeyer1 1Institute for Cellmorphology and molecular Neurobiology, Group for Cellbiology, Ruhr-University Bochum, 2Institute for Clinical Neurobiology, University of Wuerzburg JoVE 3200 Neuroscience
Lectin القائم على عزل وثقافة حركية مماثلة الجنينية الماوس Rebecca Conrad1, Sibylle Jablonka2, Teresa Sczepan1, Michael Sendtner2, Stefan Wiese1, Alice Klausmeyer1 1Institute for Cellmorphology and molecular Neurobiology, Group for Cellbiology, Ruhr-University Bochum, 2Institute for Clinical Neurobiology, University of Wuerzburg JoVE 3200 Neuroscience