Michel C. Nussenzweig Laboratory of Molecular Immunology The Rockefeller University Biography Publications Institution JoVE Articles Michel C. Nussenzweig has not added a biography. If you are Michel C. Nussenzweig and would like to personalize this page please email our Author Liaison for assistance. Publications Epistasis Lowers the Genetic Barrier to SARS-CoV-2 Neutralizing Antibody Escape Nature Communications. Jan, 2023 | Pubmed ID: 36653360 Continuous Germinal Center Invasion Contributes to the Diversity of the Immune Response Cell. Jan, 2023 | Pubmed ID: 36565698 Antibody Feedback Regulates Immune Memory After SARS-CoV-2 MRNA Vaccination Nature. Jan, 2023 | Pubmed ID: 36473496 HIV-1 Vpu Restricts Fc-mediated Effector Functions In vivo Cell Reports. Nov, 2022 | Pubmed ID: 36351384 Administration of Broadly Neutralizing Anti-HIV-1 Antibodies at ART Initiation Maintains Long-term CD8 T Cell Immunity Nature Communications. Oct, 2022 | Pubmed ID: 36309514 Early Intervention with 3BNC117 and Romidepsin at Antiretroviral Treatment Initiation in People with HIV-1: a Phase 1b/2a, Randomized Trial Nature Medicine. Nov, 2022 | Pubmed ID: 36253609 HIV-1 CD4-binding Site Germline Antibody-Env Structures Inform Vaccine Design Nature Communications. Oct, 2022 | Pubmed ID: 36253376 Memory B Cell Responses to Omicron Subvariants After SARS-CoV-2 MRNA Breakthrough Infection in Humans The Journal of Experimental Medicine. Dec, 2022 | Pubmed ID: 36149398 Distinct Gene Expression by Expanded Clones of Quiescent Memory CD4 T cells Harboring Intact Latent HIV-1 Proviruses Cell Reports. Sep, 2022 | Pubmed ID: 36070690 Antigen Presentation Dynamics Shape the Response to Emergent Variants Like SARS-CoV-2 Omicron Strain After Multiple Vaccinations with Wild Type Strain BioRxiv : the Preprint Server for Biology. Aug, 2022 | Pubmed ID: 36052368 Epistasis Lowers the Genetic Barrier to SARS-CoV-2 Neutralizing Antibody Escape BioRxiv : the Preprint Server for Biology. Aug, 2022 | Pubmed ID: 36032981 Two Complementary Features of Humoral Immune Memory Confer Protection Against the Same or Variant Antigens Proceedings of the National Academy of Sciences of the United States of America. Sep, 2022 | Pubmed ID: 36006981 Humoral Immunity to SARS-CoV-2 Elicited by Combination COVID-19 Vaccination Regimens The Journal of Experimental Medicine. Oct, 2022 | Pubmed ID: 36006380 Antibody Feedback Regulation of Memory B Cell Development in SARS-CoV-2 MRNA Vaccination MedRxiv : the Preprint Server for Health Sciences. Aug, 2022 | Pubmed ID: 35982682 A Naturally Arising Broad and Potent CD4-binding Site Antibody with Low Somatic Mutation Science Advances. Aug, 2022 | Pubmed ID: 35960796 Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection Open Forum Infectious Diseases. Jul, 2022 | Pubmed ID: 35818364 Plasma and Memory Antibody Responses to Gamma SARS-CoV-2 Provide Limited Cross-protection to Other Variants The Journal of Experimental Medicine. Sep, 2022 | Pubmed ID: 35796685 Antibody Evolution to SARS-CoV-2 After Single-dose Ad26.COV2.S Vaccine in Humans The Journal of Experimental Medicine. Aug, 2022 | Pubmed ID: 35776090 Combination Anti-HIV Antibodies Provide Sustained Virological Suppression Nature. Jun, 2022 | Pubmed ID: 35650437 Effect of 3BNC117 and Romidepsin on the HIV-1 Reservoir in People Taking Suppressive Antiretroviral Therapy (ROADMAP): a Randomised, Open-label, Phase 2A Trial The Lancet. Microbe. Mar, 2022 | Pubmed ID: 35544074 Analysis of Memory B Cells Identifies Conserved Neutralizing Epitopes on the N-terminal Domain of Variant SARS-Cov-2 Spike Proteins Immunity. Jun, 2022 | Pubmed ID: 35447092 Increased Memory B Cell Potency and Breadth After a SARS-CoV-2 MRNA Boost Nature. Jul, 2022 | Pubmed ID: 35447027 Prolonged Viral Suppression with Anti-HIV-1 Antibody Therapy Nature. Jun, 2022 | Pubmed ID: 35418681 The RIO Trial: Rationale, Design, and the Role of Community Involvement in a Randomised Placebo-controlled Trial of Antiretroviral Therapy Plus Dual Long-acting HIV-specific Broadly Neutralising Antibodies (bNAbs) in Participants Diagnosed with Recent HIV Infection-study Protocol for a Two-stage Randomised Phase II Trial Trials. Apr, 2022 | Pubmed ID: 35382844 Neutralizing Antibodies Induced in Immunized Macaques Recognize the CD4-binding Site on an Occluded-open HIV-1 Envelope Trimer Nature Communications. Feb, 2022 | Pubmed ID: 35136084 Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins BioRxiv : the Preprint Server for Biology. Feb, 2022 | Pubmed ID: 35132412 Germinal Centers Annual Review of Immunology. Apr, 2022 | Pubmed ID: 35113731 Longitudinal Clonal Dynamics of HIV-1 Latent Reservoirs Measured by Combination Quadruplex Polymerase Chain Reaction and Sequencing Proceedings of the National Academy of Sciences of the United States of America. Jan, 2022 | Pubmed ID: 35042816 Plasma Neutralization Properties of the SARS-CoV-2 Omicron Variant MedRxiv : the Preprint Server for Health Sciences. Dec, 2021 | Pubmed ID: 34931199 Sequential Immunization of Macaques Elicits Heterologous Neutralizing Antibodies Targeting the V3-glycan Patch of HIV-1 Env Science Translational Medicine. Nov, 2021 | Pubmed ID: 34818054 Antibody Elicited by HIV-1 Immunogen Vaccination in Macaques Displaces Env Fusion Peptide and Destroys a Neutralizing Epitope NPJ Vaccines. Oct, 2021 | Pubmed ID: 34697307 Integration Features of Intact Latent HIV-1 in CD4+ T Cell Clones Contribute to Viral Persistence The Journal of Experimental Medicine. Dec, 2021 | Pubmed ID: 34636876 Anti-SARS-CoV-2 Receptor-binding Domain Antibody Evolution After MRNA Vaccination Nature. Dec, 2021 | Pubmed ID: 34619745 High Genetic Barrier to SARS-CoV-2 Polyclonal Neutralizing Antibody Escape Nature. Dec, 2021 | Pubmed ID: 34544114 Broad Cross-reactivity Across Sarbecoviruses Exhibited by a Subset of COVID-19 Donor-derived Neutralizing Antibodies Cell Reports. Sep, 2021 | Pubmed ID: 34534459 Autoantibodies Neutralizing Type I IFNs Are Present in 4% of Uninfected Individuals over 70 Years Old and Account for 20% of COVID-19 Deaths Science Immunology. Aug, 2021 | Pubmed ID: 34413139 Detection and Characterization of the SARS-CoV-2 Lineage B.1.526 in New York Nature Communications. Aug, 2021 | Pubmed ID: 34373458 Publisher Correction: Bispecific IgG Neutralizes SARS-CoV-2 Variants and Prevents Escape in Mice Nature. Sep, 2021 | Pubmed ID: 34345019 Affinity Maturation of SARS-CoV-2 Neutralizing Antibodies Confers Potency, Breadth, and Resilience to Viral Escape Mutations Immunity. Aug, 2021 | Pubmed ID: 34331873 Prevention and Therapy of SARS-CoV-2 and the B.1.351 Variant in Mice Cell Reports. Jul, 2021 | Pubmed ID: 34289384 Mapping Mutations to the SARS-CoV-2 RBD That Escape Binding by Different Classes of Antibodies Nature Communications. Jul, 2021 | Pubmed ID: 34234131 Early Treatment with a Combination of Two Potent Neutralizing Antibodies Improves Clinical Outcomes and Reduces Virus Replication and Lung Inflammation in SARS-CoV-2 Infected Macaques PLoS Pathogens. Jul, 2021 | Pubmed ID: 34228761 Naturally Enhanced Neutralizing Breadth Against SARS-CoV-2 One Year After Infection Nature. Jul, 2021 | Pubmed ID: 34126625 Germinal Center-dependent and -independent Memory B Cells Produced Throughout the Immune Response The Journal of Experimental Medicine. Aug, 2021 | Pubmed ID: 34106207 Nanobodies from Camelid Mice and Llamas Neutralize SARS-CoV-2 Variants Nature. Jul, 2021 | Pubmed ID: 34098567 Broadly Neutralizing Antibody-mediated Protection of Macaques Against Repeated Intravenous Exposures to Simian-human Immunodeficiency Virus AIDS (London, England). Aug, 2021 | Pubmed ID: 33966028 Broad Cross-reactivity Across Sarbecoviruses Exhibited by a Subset of COVID-19 Donor-derived Neutralizing Antibodies BioRxiv : the Preprint Server for Biology. Apr, 2021 | Pubmed ID: 33948592 Detection and Characterization of the SARS-CoV-2 Lineage B.1.526 in New York BioRxiv : the Preprint Server for Biology. Apr, 2021 | Pubmed ID: 33907745 Broad and Potent Neutralizing Human Antibodies to Tick-borne Flaviviruses Protect Mice from Disease The Journal of Experimental Medicine. May, 2021 | Pubmed ID: 33831141 Sequencing, Cloning, and Antigen Binding Analysis of Monoclonal Antibodies Isolated from Single Mouse B Cells STAR Protocols. Jun, 2021 | Pubmed ID: 33778783 Bispecific IgG Neutralizes SARS-CoV-2 Variants and Prevents Escape in Mice Nature. May, 2021 | Pubmed ID: 33767445 Development of Potency, Breadth and Resilience to Viral Escape Mutations in SARS-CoV-2 Neutralizing Antibodies BioRxiv : the Preprint Server for Biology. Mar, 2021 | Pubmed ID: 33758864 Mutational Escape from the Polyclonal Antibody Response to SARS-CoV-2 Infection is Largely Shaped by a Single Class of Antibodies BioRxiv : the Preprint Server for Biology. Mar, 2021 | Pubmed ID: 33758856 A Clinical Trial of Non-invasive Imaging with an Anti-HIV Antibody Labelled with Copper-64 in People Living with HIV and Uninfected Controls EBioMedicine. Mar, 2021 | Pubmed ID: 33640794 MRNA Vaccine-elicited Antibodies to SARS-CoV-2 and Circulating Variants Nature. Apr, 2021 | Pubmed ID: 33567448 Dynamic Regulation of T Selection During the Germinal Centre Reaction Nature. Mar, 2021 | Pubmed ID: 33536617 Persistent Cellular Immunity to SARS-CoV-2 Infection The Journal of Experimental Medicine. Apr, 2021 | Pubmed ID: 33533915 Prevention and Therapy of SARS-CoV-2 and the B.1.351 Variant in Mice BioRxiv : the Preprint Server for Biology. Apr, 2021 | Pubmed ID: 33532765 Evolution of Antibody Immunity to SARS-CoV-2 Nature. Mar, 2021 | Pubmed ID: 33461210 Heightened Resistance to Host Type 1 Interferons Characterizes HIV-1 at Transmission and After Antiretroviral Therapy Interruption Science Translational Medicine. Jan, 2021 | Pubmed ID: 33441429 Mosaic Nanoparticles Elicit Cross-reactive Immune Responses to Zoonotic Coronaviruses in Mice Science (New York, N.Y.). Feb, 2021 | Pubmed ID: 33436524 Sequence Evaluation and Comparative Analysis of Novel Assays for Intact Proviral HIV-1 DNA Journal of Virology. Feb, 2021 | Pubmed ID: 33361426 Enhanced SARS-CoV-2 Neutralization by Dimeric IgA Science Translational Medicine. Jan, 2021 | Pubmed ID: 33288661 Mosaic Nanoparticles Elicit Cross-reactive Immune Responses to Zoonotic Coronaviruses in Mice BioRxiv : the Preprint Server for Biology. Jan, 2021 | Pubmed ID: 33236016 Antibody Potency, Effector Function, and Combinations in Protection and Therapy for SARS-CoV-2 Infection in Vivo The Journal of Experimental Medicine. Mar, 2021 | Pubmed ID: 33211088 Single-Cell Sorting of HBsAg-Binding Memory B Cells from Human Peripheral Blood Mononuclear Cells and Antibody Cloning STAR Protocols. Dec, 2020 | Pubmed ID: 33377023 Persistent Cellular Immunity to SARS-CoV-2 Infection BioRxiv : the Preprint Server for Biology. Dec, 2020 | Pubmed ID: 33330867 Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies Against Primary African Isolates Journal of Virology. Dec, 2020 | Pubmed ID: 33298542 Antibody Affinity Shapes the Choice Between Memory and Germinal Center B Cell Fates Cell. Nov, 2020 | Pubmed ID: 33125897 Escape from Neutralizing Antibodies by SARS-CoV-2 Spike Protein Variants ELife. Oct, 2020 | Pubmed ID: 33112236 A Broadly Neutralizing Macaque Monoclonal Antibody Against the HIV-1 V3-Glycan Patch ELife. Oct, 2020 | Pubmed ID: 33084569 SARS-CoV-2 Neutralizing Antibody Structures Inform Therapeutic Strategies Nature. Dec, 2020 | Pubmed ID: 33045718 Antibody Potency, Effector Function and Combinations in Protection from SARS-CoV-2 Infection BioRxiv : the Preprint Server for Biology. Sep, 2020 | Pubmed ID: 32995782 ReScan, a Multiplex Diagnostic Pipeline, Pans Human Sera for SARS-CoV-2 Antigens Cell Reports. Medicine. Oct, 2020 | Pubmed ID: 32995758 Autoantibodies Against Type I IFNs in Patients with Life-threatening COVID-19 Science (New York, N.Y.). Oct, 2020 | Pubmed ID: 32972996 An Apoptosis-dependent Checkpoint for Autoimmunity in Memory B and Plasma Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2020 | Pubmed ID: 32963096 Enhanced SARS-CoV-2 Neutralization by Secretory IgA in Vitro BioRxiv : the Preprint Server for Biology. Sep, 2020 | Pubmed ID: 32935095 Recommendations for Measuring HIV Reservoir Size in Cure-directed Clinical Trials Nature Medicine. Sep, 2020 | Pubmed ID: 32895573 Structural Classification of Neutralizing Antibodies Against the SARS-CoV-2 Spike Receptor-binding Domain Suggests Vaccine and Therapeutic Strategies BioRxiv : the Preprint Server for Biology. Aug, 2020 | Pubmed ID: 32869026 Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration Antibodies (Basel, Switzerland). Jul, 2020 | Pubmed ID: 32751063 Measuring SARS-CoV-2 Neutralizing Antibody Activity Using Pseudotyped and Chimeric Viruses The Journal of Experimental Medicine. Nov, 2020 | Pubmed ID: 32692348 Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies Cell. Aug, 2020 | Pubmed ID: 32645326 Durable Protection Against Repeated Penile Exposures to Simian-human Immunodeficiency Virus by Broadly Neutralizing Antibodies Nature Communications. Jun, 2020 | Pubmed ID: 32581216 Measuring SARS-CoV-2 Neutralizing Antibody Activity Using Pseudotyped and Chimeric Viruses BioRxiv : the Preprint Server for Biology. Jun, 2020 | Pubmed ID: 32577658 Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies BioRxiv : the Preprint Server for Biology. May, 2020 | Pubmed ID: 32577645 Convergent Antibody Responses to SARS-CoV-2 in Convalescent Individuals Nature. Aug, 2020 | Pubmed ID: 32555388 Convergent Antibody Responses to SARS-CoV-2 Infection in Convalescent Individuals BioRxiv : the Preprint Server for Biology. May, 2020 | Pubmed ID: 32511384 A Combination of Human Broadly Neutralizing Antibodies Against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations Cell Host & Microbe. Aug, 2020 | Pubmed ID: 32504577 Structural Basis for Zika Envelope Domain III Recognition by a Germline Version of a Recurrent Neutralizing Antibody Proceedings of the National Academy of Sciences of the United States of America. May, 2020 | Pubmed ID: 32321830 Antigen-responsive CD4+ T Cell Clones Contribute to the HIV-1 Latent Reservoir The Journal of Experimental Medicine. Jul, 2020 | Pubmed ID: 32311008 A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques Proceedings of the National Academy of Sciences of the United States of America. Apr, 2020 | Pubmed ID: 32209664 Combination Anti-HIV-1 Antibody Therapy is Associated with Increased Virus-specific T Cell Immunity Nature Medicine. Feb, 2020 | Pubmed ID: 32015556 Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin Journal of Virology. Feb, 2020 | Pubmed ID: 31852794 Risk of Zika Microcephaly Correlates with Features of Maternal Antibodies The Journal of Experimental Medicine. Oct, 2019 | Pubmed ID: 31413072 Safety, Pharmacokinetics, and Immunogenicity of the Combination of the Broadly Neutralizing Anti-HIV-1 Antibodies 3BNC117 and 10-1074 in Healthy Adults: A Randomized, Phase 1 Study PloS One. 2019 | Pubmed ID: 31393868 Combination of Quadruplex QPCR and Next-generation Sequencing for Qualitative and Quantitative Analysis of the HIV-1 Latent Reservoir The Journal of Experimental Medicine. Oct, 2019 | Pubmed ID: 31350309 Protein Amounts of the MYC Transcription Factor Determine Germinal Center B Cell Division Capacity Immunity. Aug, 2019 | Pubmed ID: 31350178 Anti-idiotypic Antibodies Elicit Anti-HIV-1-specific B Cell Responses The Journal of Experimental Medicine. Oct, 2019 | Pubmed ID: 31345931 Immunization Expands B Cells Specific to HIV-1 V3 Glycan in Mice and Macaques Nature. Jun, 2019 | Pubmed ID: 31142836 Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope Immunity. Jun, 2019 | Pubmed ID: 31126879 HIV-specific Humoral Immune Responses by CRISPR/Cas9-edited B Cells The Journal of Experimental Medicine. Jun, 2019 | Pubmed ID: 30975893 Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies in the Clinic Nature Medicine. Apr, 2019 | Pubmed ID: 30936546 Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption Journal of Virology. 04, 2019 | Pubmed ID: 30700598 Relationship Between Intact HIV-1 Proviruses in Circulating CD4 T Cells and Rebound Viruses Emerging During Treatment Interruption Proceedings of the National Academy of Sciences of the United States of America. Nov, 2018 | Pubmed ID: 30420517 A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates Cell Reports. Nov, 2018 | Pubmed ID: 30403995 Partially Open HIV-1 Envelope Structures Exhibit Conformational Changes Relevant for Coreceptor Binding and Fusion Cell Host & Microbe. Oct, 2018 | Pubmed ID: 30308160 The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination Molecular Cell. Nov, 2018 | Pubmed ID: 30293785 Safety and Antiviral Activity of Combination HIV-1 Broadly Neutralizing Antibodies in Viremic Individuals Nature Medicine. Nov, 2018 | Pubmed ID: 30258217 Combination Therapy with Anti-HIV-1 Antibodies Maintains Viral Suppression Nature. Sep, 2018 | Pubmed ID: 30258136 Disruption of an Antimycobacterial Circuit Between Dendritic and Helper T Cells in Human SPPL2a Deficiency Nature Immunology. Sep, 2018 | Pubmed ID: 30127434 Relationship Between Latent and Rebound Viruses in a Clinical Trial of Anti-HIV-1 Antibody 3BNC117 The Journal of Experimental Medicine. Sep, 2018 | Pubmed ID: 30072495 Clonal CD4 T Cells in the HIV-1 Latent Reservoir Display a Distinct Gene Profile Upon Reactivation Nature Medicine. May, 2018 | Pubmed ID: 29686423 Anti-HIV-1 B Cell Responses Are Dependent on B Cell Precursor Frequency and Antigen-binding Affinity Proceedings of the National Academy of Sciences of the United States of America. May, 2018 | Pubmed ID: 29666227 Redemption for Self-reactive Antibodies Science (New York, N.Y.). Apr, 2018 | Pubmed ID: 29650658 Structural Characterization of a Highly-potent V3-glycan Broadly Neutralizing Antibody Bound to Natively-glycosylated HIV-1 Envelope Nature Communications. Mar, 2018 | Pubmed ID: 29593217 Potential of Conventional & Bispecific Broadly Neutralizing Antibodies for Prevention of HIV-1 Subtype A, C & D Infections PLoS Pathogens. Mar, 2018 | Pubmed ID: 29505593 Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies Against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells Journal of Virology. Mar, 2018 | Pubmed ID: 29237833 The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center Science (New York, N.Y.). Oct, 2017 | Pubmed ID: 28935768 Design and Crystal Structure of a Native-like HIV-1 Envelope Trimer That Engages Multiple Broadly Neutralizing Antibody Precursors in Vivo The Journal of Experimental Medicine. Sep, 2017 | Pubmed ID: 28847869 Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo Cell. Aug, 2017 | Pubmed ID: 28757252 Asymmetric Recognition of HIV-1 Envelope Trimer by V1V2 Loop-targeting Antibodies ELife. May, 2017 | Pubmed ID: 28548638 Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico Cell. May, 2017 | Pubmed ID: 28475892 HIV: Persistence Through Division The Journal of Experimental Medicine. Apr, 2017 | Pubmed ID: 28348204 Early Antibody Therapy Can Induce Long-lasting Immunity to SHIV Nature. Mar, 2017 | Pubmed ID: 28289286 RAG1/2 Induces Genomic Insertions by Mobilizing DNA into RAG1/2-independent Breaks The Journal of Experimental Medicine. Mar, 2017 | Pubmed ID: 28179379 Antibody 10-1074 Suppresses Viremia in HIV-1-infected Individuals Nature Medicine. Feb, 2017 | Pubmed ID: 28092665 Progress Toward Active or Passive HIV-1 Vaccination The Journal of Experimental Medicine. Jan, 2017 | Pubmed ID: 28003309 The Cell Cycle Restricts Activation-induced Cytidine Deaminase Activity to Early G1 The Journal of Experimental Medicine. Jan, 2017 | Pubmed ID: 27998928 The Heterogeneity of Ly6C(hi) Monocytes Controls Their Differentiation into INOS(+) Macrophages or Monocyte-Derived Dendritic Cells Immunity. Dec, 2016 | Pubmed ID: 28002729 Paired Quantitative and Qualitative Assessment of the Replication-competent HIV-1 Reservoir and Comparison with Integrated Proviral DNA Proceedings of the National Academy of Sciences of the United States of America. Dec, 2016 | Pubmed ID: 27872306 Human Dendritic Cells (DCs) Are Derived from Distinct Circulating Precursors That Are Precommitted to Become CD1c+ or CD141+ DCs The Journal of Experimental Medicine. Dec, 2016 | Pubmed ID: 27864467 Sequencing and Cloning of Antigen-specific Antibodies from Mouse Memory B Cells Nature Protocols. Oct, 2016 | Pubmed ID: 27658009 HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies Immunity. Sep, 2016 | Pubmed ID: 27617678 Natively Glycosylated HIV-1 Env Structure Reveals New Mode for Antibody Recognition of the CD4-binding Site Nature Structural & Molecular Biology. Oct, 2016 | Pubmed ID: 27617431 Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice Cell. Sep, 2016 | Pubmed ID: 27610569 HIV-1 Antibody 3BNC117 Suppresses Viral Rebound in Humans During Treatment Interruption Nature. Jul, 2016 | Pubmed ID: 27338952 Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency Cell. Jun, 2016 | Pubmed ID: 27315478 Enhanced Clearance of HIV-1-infected Cells by Broadly Neutralizing Antibodies Against HIV-1 in Vivo Science (New York, N.Y.). May, 2016 | Pubmed ID: 27199430 HIV-1 Therapy with Monoclonal Antibody 3BNC117 Elicits Host Immune Responses Against HIV-1 Science (New York, N.Y.). May, 2016 | Pubmed ID: 27199429 A Single Injection of Anti-HIV-1 Antibodies Protects Against Repeated SHIV Challenges Nature. May, 2016 | Pubmed ID: 27120156 Inducible Targeting of CDCs and Their Subsets in Vivo Journal of Immunological Methods. Jul, 2016 | Pubmed ID: 27073171 Optimal Combinations of Broadly Neutralizing Antibodies for Prevention and Treatment of HIV-1 Clade C Infection PLoS Pathogens. Mar, 2016 | Pubmed ID: 27028935 Absence of MHC Class II on CDCs Results in Microbial-dependent Intestinal Inflammation The Journal of Experimental Medicine. Apr, 2016 | Pubmed ID: 27001748 Structural Basis for Germline Antibody Recognition of HIV-1 Immunogens ELife. Mar, 2016 | Pubmed ID: 26997349 Independent Roles of Switching and Hypermutation in the Development and Persistence of B Lymphocyte Memory Immunity. Apr, 2016 | Pubmed ID: 26944202 Specifically Modified Env Immunogens Activate B-cell Precursors of Broadly Neutralizing HIV-1 Antibodies in Transgenic Mice Nature Communications. Feb, 2016 | Pubmed ID: 26907590 A New Way to Diversify Antibodies by DNA Transposition Cell. Feb, 2016 | Pubmed ID: 26871626 Towards HIV-1 Remission: Potential Roles for Broadly Neutralizing Antibodies The Journal of Clinical Investigation. Feb, 2016 | Pubmed ID: 26752643 V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1 Journal of Acquired Immune Deficiency Syndromes (1999). Mar, 2016 | Pubmed ID: 26413851 A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo PLoS Pathogens. Oct, 2015 | Pubmed ID: 26516768 Antibodies to a Conformational Epitope on Gp41 Neutralize HIV-1 by Destabilizing the Env Spike Nature Communications. Sep, 2015 | Pubmed ID: 26404402 Orientation-specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching Nature. Sep, 2015 | Pubmed ID: 26308889 Defining Human Dendritic Cell Progenitors by Multiparametric Flow Cytometry Nature Protocols. Sep, 2015 | Pubmed ID: 26292072 Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma Cell. Aug, 2015 | Pubmed ID: 26276629 HUMORAL IMMUNITY. T Cell Help Controls the Speed of the Cell Cycle in Germinal Center B Cells Science (New York, N.Y.). Aug, 2015 | Pubmed ID: 26184917 Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice Cell. Jun, 2015 | Pubmed ID: 26091035 Clonal Analysis of Human Dendritic Cell Progenitor Using a Stromal Cell Culture Journal of Immunological Methods. Oct, 2015 | Pubmed ID: 26056939 Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors Cell. Jun, 2015 | Pubmed ID: 26004070 Neutralization Properties of Simian Immunodeficiency Viruses Infecting Chimpanzees and Gorillas MBio. Apr, 2015 | Pubmed ID: 25900654 Viraemia Suppressed in HIV-1-infected Humans by Broadly Neutralizing Antibody 3BNC117 Nature. Jun, 2015 | Pubmed ID: 25855300 AAV-expressed ECD4-Ig Provides Durable Protection from Multiple SHIV Challenges Nature. Mar, 2015 | Pubmed ID: 25707797 Restricted Dendritic Cell and Monocyte Progenitors in Human Cord Blood and Bone Marrow The Journal of Experimental Medicine. Mar, 2015 | Pubmed ID: 25687283 Circulating Precursors of Human CD1c+ and CD141+ Dendritic Cells The Journal of Experimental Medicine. Mar, 2015 | Pubmed ID: 25687281 Amplification of Highly Mutated Human Ig Lambda Light Chains from an HIV-1 Infected Patient Journal of Immunological Methods. Mar, 2015 | Pubmed ID: 25667013 Intra-spike Crosslinking Overcomes Antibody Evasion by HIV-1 Cell. Jan, 2015 | Pubmed ID: 25635457 HIV-1 Integration Landscape During Latent and Active Infection Cell. Jan, 2015 | Pubmed ID: 25635456 Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes Journal of Virology. Mar, 2015 | Pubmed ID: 25520506 An Inherited Immunoglobulin Class-switch Recombination Deficiency Associated with a Defect in the INO80 Chromatin Remodeling Complex The Journal of Allergy and Clinical Immunology. Apr, 2015 | Pubmed ID: 25312759 Epigenetic Targeting of Activation-induced Cytidine Deaminase Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014 | Pubmed ID: 25512519 B Cell Super-enhancers and Regulatory Clusters Recruit AID Tumorigenic Activity Cell. Dec, 2014 | Pubmed ID: 25483777 Convergent Transcription at Intragenic Super-enhancers Targets AID-initiated Genomic Instability Cell. Dec, 2014 | Pubmed ID: 25483776 Enhanced HIV-1 Immunotherapy by Commonly Arising Antibodies That Target Virus Escape Variants The Journal of Experimental Medicine. Nov, 2014 | Pubmed ID: 25385756 A Robust Pipeline for Rapid Production of Versatile Nanobody Repertoires Nature Methods. Dec, 2014 | Pubmed ID: 25362362 Broadly Neutralizing Anti-HIV-1 Antibodies Require Fc Effector Functions for in Vivo Activity Cell. Sep, 2014 | Pubmed ID: 25215485 Dynamic Signaling by T Follicular Helper Cells During Germinal Center B Cell Selection Science (New York, N.Y.). Aug, 2014 | Pubmed ID: 25170154 Passive Transfer of Modest Titers of Potent and Broadly Neutralizing Anti-HIV Monoclonal Antibodies Block SHIV Infection in Macaques The Journal of Experimental Medicine. Sep, 2014 | Pubmed ID: 25155019 Classical Flt3L-dependent Dendritic Cells Control Immunity to Protein Vaccine The Journal of Experimental Medicine. Aug, 2014 | Pubmed ID: 25135299 Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice Cell. Aug, 2014 | Pubmed ID: 25131989 Identification of Chromosomal Translocation Hotspots Via Scan Statistics Bioinformatics (Oxford, England). Sep, 2014 | Pubmed ID: 24860160 Antigen Delivery to CD11c+CD8- Dendritic Cells Induces Protective Immune Responses Against Experimental Melanoma in Mice in Vivo Journal of Immunology (Baltimore, Md. : 1950). Jun, 2014 | Pubmed ID: 24829411 Clonal Selection in the Germinal Centre by Regulated Proliferation and Hypermutation Nature. May, 2014 | Pubmed ID: 24805232 Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike Cell Reports. May, 2014 | Pubmed ID: 24767986 Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy Cell. Feb, 2014 | Pubmed ID: 24529371 L-Myc Expression by Dendritic Cells is Required for Optimal T-cell Priming Nature. Mar, 2014 | Pubmed ID: 24509714 Broadly Neutralizing Antibodies That Inhibit HIV-1 Cell to Cell Transmission The Journal of Experimental Medicine. Dec, 2013 | Pubmed ID: 24277152 Therapeutic Efficacy of Potent Neutralizing HIV-1-specific Monoclonal Antibodies in SHIV-infected Rhesus Monkeys Nature. Nov, 2013 | Pubmed ID: 24172905 Antibody-mediated Immunotherapy of Macaques Chronically Infected with SHIV Suppresses Viraemia Nature. Nov, 2013 | Pubmed ID: 24172896 HIV-1 Suppression and Durable Control by Combining Single Broadly Neutralizing Antibodies and Antiretroviral Drugs in Humanized Mice Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24043801 Intestinal Monocytes and Macrophages Are Required for T Cell Polarization in Response to Citrobacter Rodentium The Journal of Experimental Medicine. Sep, 2013 | Pubmed ID: 24043764 Isolation of HIV-1-reactive Antibodies Using Cell Surface-expressed Gp160Δc(BaL.) Journal of Immunological Methods. Nov, 2013 | Pubmed ID: 24041474 Antibodies in HIV-1 Vaccine Development and Therapy Science (New York, N.Y.). Sep, 2013 | Pubmed ID: 24031012 The Origin of B Cell Recurrent Chromosomal Translocations: Proximity Versus DNA Damage Molecular Cell. Aug, 2013 | Pubmed ID: 23932709 Notch2-dependent Classical Dendritic Cells Orchestrate Intestinal Immunity to Attaching-and-effacing Bacterial Pathogens Nature Immunology. Sep, 2013 | Pubmed ID: 23913046 Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-class Antibodies Immunity. Aug, 2013 | Pubmed ID: 23911655 T Follicular Helper Cell Dynamics in Germinal Centers Science (New York, N.Y.). Aug, 2013 | Pubmed ID: 23887872 Fate Mapping for Activation-induced Cytidine Deaminase (AID) Marks Non-lymphoid Cells During Mouse Development PloS One. 2013 | Pubmed ID: 23861962 Residue-level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains Journal of Virology. Sep, 2013 | Pubmed ID: 23843642 Computational Analysis of Anti-HIV-1 Antibody Neutralization Panel Data to Identify Potential Functional Epitope Residues Proceedings of the National Academy of Sciences of the United States of America. Jun, 2013 | Pubmed ID: 23754383 Antibody and Antiretroviral Preexposure Prophylaxis Prevent Cervicovaginal HIV-1 Infection in a Transgenic Mouse Model Journal of Virology. Aug, 2013 | Pubmed ID: 23720722 High-throughput Sequencing Reveals Principles of Adeno-associated Virus Serotype 2 Integration Journal of Virology. Aug, 2013 | Pubmed ID: 23720718 Restricting HIV-1 Pathways for Escape Using Rationally Designed Anti-HIV-1 Antibodies The Journal of Experimental Medicine. Jun, 2013 | Pubmed ID: 23712429 Inflammatory Flt3l is Essential to Mobilize Dendritic Cells and for T Cell Responses During Plasmodium Infection Nature Medicine. Jun, 2013 | Pubmed ID: 23685841 Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization Cell. Mar, 2013 | Pubmed ID: 23540694 Structural Basis for HIV-1 Gp120 Recognition by a Germ-line Version of a Broadly Neutralizing Antibody Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23524883 Role of 53BP1 Oligomerization in Regulating Double-strand Break Repair Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23345425 Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching Science (New York, N.Y.). Feb, 2013 | Pubmed ID: 23306439 RPA Accumulation During Class Switch Recombination Represents 5'-3' DNA-end Resection During the S-G2/M Phase of the Cell Cycle Cell Reports. Jan, 2013 | Pubmed ID: 23291097 Mechanism of DNA Resection During Intrachromosomal Recombination and Immunoglobulin Class Switching The Journal of Experimental Medicine. Jan, 2013 | Pubmed ID: 23254285 Chromosome Translocation, B Cell Lymphoma, and Activation-induced Cytidine Deaminase Annual Review of Pathology. Jan, 2013 | Pubmed ID: 22974238 Complex-type N-glycan Recognition by Potent Broadly Neutralizing HIV Antibodies Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23115339 HIV Therapy by a Combination of Broadly Neutralizing Antibodies in Humanized Mice Nature. Dec, 2012 | Pubmed ID: 23103874 A Blueprint for HIV Vaccine Discovery Cell Host & Microbe. Oct, 2012 | Pubmed ID: 23084910 A Mouse Model for HIV-1 Entry Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 23019371 The Proto-oncogene MYC is Required for Selection in the Germinal Center and Cyclic Reentry Nature Immunology. Nov, 2012 | Pubmed ID: 23001145 DEC-205 is a Cell Surface Receptor for CpG Oligonucleotides Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 22988114 The HSSB1 Orthologue Obfc2b is Essential for Skeletogenesis but Dispensable for the DNA Damage Response in Vivo The EMBO Journal. Oct, 2012 | Pubmed ID: 22940690 Zinc Finger Transcription Factor ZDC is a Negative Regulator Required to Prevent Activation of Classical Dendritic Cells in the Steady State The Journal of Experimental Medicine. Aug, 2012 | Pubmed ID: 22851594 Broad Neutralization by a Combination of Antibodies Recognizing the CD4 Binding Site and a New Conformational Epitope on the HIV-1 Envelope Protein The Journal of Experimental Medicine. Jul, 2012 | Pubmed ID: 22826297 Expression of the Zinc Finger Transcription Factor ZDC (Zbtb46, Btbd4) Defines the Classical Dendritic Cell Lineage The Journal of Experimental Medicine. Jun, 2012 | Pubmed ID: 22615130 Activation-induced Cytidine Deaminase in Antibody Diversification and Chromosome Translocation Advances in Cancer Research. 2012 | Pubmed ID: 22429855 Enhanced HIV-1 Neutralization by Antibody Heteroligation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2012 | Pubmed ID: 22219363 Polyreactive Antibodies in Adaptive Immune Responses to Viruses Cellular and Molecular Life Sciences : CMLS. May, 2012 | Pubmed ID: 22045557 Translocation Capture Sequencing: a Method for High Throughput Mapping of Chromosomal Rearrangements Journal of Immunological Methods. Jan, 2012 | Pubmed ID: 22033343 Differential Regulation of Self-reactivity Discriminates Between IgG+ Human Circulating Memory B Cells and Bone Marrow Plasma Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2011 | Pubmed ID: 22025722 Genbewerking van primaire resusapen B-cellen Harald Hartweger1, Rajeev Gautam2, Yoshiaki Nishimura2, Fabian Schmidt3,5, Kai-Hui Yao1, Amelia Escolano1,6, Mila Jankovic1, Malcolm A. Martin2, Michel C. Nussenzweig1,4 1Laboratory of Molecular Immunology, The Rockefeller University, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 3Laboratory of Retrovirology, The Rockefeller University, 4Howard Hughes Medical Institute, The Rockefeller University, 5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST), 6Vaccine and Immunotherapy Center, Wistar Institute JoVE 64858 Immunology and Infection
Genbewerking van primaire resusapen B-cellen Harald Hartweger1, Rajeev Gautam2, Yoshiaki Nishimura2, Fabian Schmidt3,5, Kai-Hui Yao1, Amelia Escolano1,6, Mila Jankovic1, Malcolm A. Martin2, Michel C. Nussenzweig1,4 1Laboratory of Molecular Immunology, The Rockefeller University, 2Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 3Laboratory of Retrovirology, The Rockefeller University, 4Howard Hughes Medical Institute, The Rockefeller University, 5Laboratory of Applied Virology and Precision Medicine, King Abdullah University of Science and Technology (KAUST), 6Vaccine and Immunotherapy Center, Wistar Institute JoVE 64858 Immunology and Infection