Michele Simonato Department of Neuroscience and Rehabilitation, Section of Pharmacology Universita degli Studi di Ferrara Biography Publications Institution JoVE Articles Michele Simonato has not added a biography. If you are Michele Simonato and would like to personalize this page please email our Author Liaison for assistance. Publications Corrigendum: New Tools for Epilepsy Therapy Frontiers in Cellular Neuroscience. 2018 | Pubmed ID: 30034326 New Tools for Epilepsy Therapy Frontiers in Cellular Neuroscience. 2018 | Pubmed ID: 29896092 Seizure-Suppressant and Neuroprotective Effects of Encapsulated BDNF-Producing Cells in a Rat Model of Temporal Lobe Epilepsy Molecular Therapy. Methods & Clinical Development. Jun, 2018 | Pubmed ID: 29766029 Meta-Analysis of MicroRNAs Dysregulated in the Hippocampal Dentate Gyrus of Animal Models of Epilepsy ENeuro. Nov-Dec, 2017 | Pubmed ID: 29291240 Harmonization in Preclinical Epilepsy Research: A Joint AES/ILAE Translational Initiative Epilepsia. 11, 2017 | Pubmed ID: 29105072 Identification and Characterization of Outcome Measures Reported in Animal Models of Epilepsy: Protocol for a Systematic Review of the Literature-A TASK2 Report of the AES/ILAE Translational Task Force of the ILAE Epilepsia. 11, 2017 | Pubmed ID: 29105071 Standardization Procedure for Plasma Biomarker Analysis in Rat Models of Epileptogenesis: Focus on Circulating MicroRNAs Epilepsia. 12, 2017 | Pubmed ID: 28960286 EIF4B Phosphorylation at Ser504 Links Synaptic Activity with Protein Translation in Physiology and Pathology Scientific Reports. Sep, 2017 | Pubmed ID: 28874824 Deletion of the Virion Host Shut-off Gene Enhances Neuronal-Selective Transgene Expression from an HSV Vector Lacking Functional IE Genes Molecular Therapy. Methods & Clinical Development. Sep, 2017 | Pubmed ID: 28702475 Engineered HSV Vector Achieves Safe Long-term Transgene Expression in the Central Nervous System Scientific Reports. May, 2017 | Pubmed ID: 28473703 Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a Potent NOP Receptor Antagonist, on Molecular, Cellular and Behavioural Alterations Associated with Chronic Mild Stress Journal of Psychopharmacology (Oxford, England). Jun, 2017 | Pubmed ID: 28417659 WONOEP Appraisal: Development of Epilepsy Biomarkers-What We Can Learn from Our Patients? Epilepsia. 06, 2017 | Pubmed ID: 28387933 Common Data Elements and Data Management: Remedy to Cure Underpowered Preclinical Studies Epilepsy Research. Jan, 2017 | Pubmed ID: 28038337 Advances in the Development of Biomarkers for Epilepsy The Lancet. Neurology. Jul, 2016 | Pubmed ID: 27302363 Silencing Status Epilepticus-Induced BDNF Expression with Herpes Simplex Virus Type-1 Based Amplicon Vectors PloS One. 2016 | Pubmed ID: 26954758 Opportunities for Improving Animal Welfare in Rodent Models of Epilepsy and Seizures Journal of Neuroscience Methods. Feb, 2016 | Pubmed ID: 26376175 MicroRNA Profiles in Hippocampal Granule Cells and Plasma of Rats with Pilocarpine-induced Epilepsy--comparison with Human Epileptic Samples Scientific Reports. 2015 | Pubmed ID: 26382856 Increased Extracellular Levels of Glutamate in the Hippocampus of Chronically Epileptic Rats Neuroscience. Aug, 2015 | Pubmed ID: 26073699 Systems Genetics Identifies Sestrin 3 As a Regulator of a Proconvulsant Gene Network in Human Epileptic Hippocampus Nature Communications. Jan, 2015 | Pubmed ID: 25615886 Identification of MiRNAs Differentially Expressed in Human Epilepsy with or Without Granule Cell Pathology PloS One. 2014 | Pubmed ID: 25148080 The Challenge and Promise of Anti-epileptic Therapy Development in Animal Models The Lancet. Neurology. Sep, 2014 | Pubmed ID: 25127174 Impairment of GABA Release in the Hippocampus at the Time of the First Spontaneous Seizure in the Pilocarpine Model of Temporal Lobe Epilepsy Experimental Neurology. Jul, 2014 | Pubmed ID: 24768627 Gene Therapy for Epilepsy Epilepsy & Behavior : E&B. Sep, 2014 | Pubmed ID: 24100249 Implication of Fibroblast Growth Factors in Epileptogenesis-associated Circuit Rearrangements Frontiers in Cellular Neuroscience. Sep, 2013 | Pubmed ID: 24062643 Proposal for a "phase II" Multicenter Trial Model for Preclinical New Antiepilepsy Therapy Development Epilepsia. Aug, 2013 | Pubmed ID: 23909855 Changes in the Sensitivity of GABAA Current Rundown to Drug Treatments in a Model of Temporal Lobe Epilepsy Frontiers in Cellular Neuroscience. 2013 | Pubmed ID: 23874269 Bradykinin B₂ Receptors Increase Hippocampal Excitability and Susceptibility to Seizures in Mice Neuroscience. Sep, 2013 | Pubmed ID: 23811399 Progress in Gene Therapy for Neurological Disorders Nature Reviews. Neurology. May, 2013 | Pubmed ID: 23609618 Increased Excitability in Tat-transgenic Mice: Role of Tat in HIV-related Neurological Disorders Neurobiology of Disease. Jul, 2013 | Pubmed ID: 23454193 Issues for New Antiepilepsy Drug Development Current Opinion in Neurology. Apr, 2013 | Pubmed ID: 23406913 Nociceptin/orphanin FQ Receptor Agonists Attenuate L-DOPA-induced Dyskinesias The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2012 | Pubmed ID: 23152595 Finding a Better Drug for Epilepsy: Antiepileptogenesis Targets Epilepsia. Nov, 2012 | Pubmed ID: 23061663 Finding a Better Drug for Epilepsy: Preclinical Screening Strategies and Experimental Trial Design Epilepsia. Nov, 2012 | Pubmed ID: 22708847 Loss of Cortical GABA Terminals in Unverricht-Lundborg Disease Neurobiology of Disease. Aug, 2012 | Pubmed ID: 22538221 Bystander Effect on Brain Tissue of Mesoangioblasts Producing Neurotrophins Cell Transplantation. 2012 | Pubmed ID: 22525962 Identification of New Epilepsy Treatments: Issues in Preclinical Methodology Epilepsia. Mar, 2012 | Pubmed ID: 22292566 Localized Overexpression of FGF-2 and BDNF in Hippocampus Reduces Mossy Fiber Sprouting and Spontaneous Seizures Up to 4 Weeks After Pilocarpine-induced Status Epilepticus Epilepsia. Mar, 2011 | Pubmed ID: 21269288 Hippocampal FGF-2 and BDNF Overexpression Attenuates Epileptogenesis-associated Neuroinflammation and Reduces Spontaneous Recurrent Seizures Journal of Neuroinflammation. Nov, 2010 | Pubmed ID: 21087489 Are the Neurotrophic Factors a Suitable Therapeutic Target for the Prevention of Epileptogenesis? Epilepsia. Jul, 2010 | Pubmed ID: 20618400 Brain Interstitial Nociceptin/orphanin FQ Levels Are Elevated in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Aug, 2010 | Pubmed ID: 20589874 Enhancement of GABA(A)-current Run-down in the Hippocampus Occurs at the First Spontaneous Seizure in a Model of Temporal Lobe Epilepsy Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133704 The Biocompatibility of Materials Used in Printed Circuit Board Technologies with Respect to Primary Neuronal and K562 Cells Biomaterials. Feb, 2010 | Pubmed ID: 19878988 Localized Delivery of Fibroblast Growth Factor-2 and Brain-derived Neurotrophic Factor Reduces Spontaneous Seizures in an Epilepsy Model Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19366663 Fgf-2 Overexpression Increases Excitability and Seizure Susceptibility but Decreases Seizure-induced Cell Loss The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2008 | Pubmed ID: 19052202 Adenosine Receptor Antagonists Alter the Stability of Human Epileptic GABAA Receptors Proceedings of the National Academy of Sciences of the United States of America. Sep, 2008 | Pubmed ID: 18809912 Functional Antagonism Between Nociceptin/orphanin FQ (N/OFQ) and Corticotropin-releasing Factor (CRF) in the Rat Brain: Evidence for Involvement of the Bed Nucleus of the Stria Terminalis Psychopharmacology. Mar, 2008 | Pubmed ID: 17989958 Angels and Demons: Neurotrophic Factors and Epilepsy Trends in Pharmacological Sciences. Dec, 2006 | Pubmed ID: 17055067 Blockade of Nociceptin/orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2005 | Pubmed ID: 16237164 BODIPY-conjugated Neuropeptide Y Ligands: New Fluorescent Tools to Tag Y1, Y2, Y4 and Y5 Receptor Subtypes British Journal of Pharmacology. Dec, 2005 | Pubmed ID: 16231000 Alterations in Seizure Susceptibility and in Seizure-induced Plasticity After Pharmacologic and Genetic Manipulation of the Fibroblast Growth Factor-2 System Epilepsia. 2005 | Pubmed ID: 15987254 Kainate Seizures Increase Nociceptin/orphanin FQ Release in the Rat Hippocampus and Thalamus: a Microdialysis Study Journal of Neurochemistry. Oct, 2004 | Pubmed ID: 15379884 On the Role of Somatostatin in Seizure Control: Clues from the Hippocampus Reviews in the Neurosciences. 2003 | Pubmed ID: 14513869 Mechanisms of Action of CHF3381 in the Forebrain British Journal of Pharmacology. Aug, 2003 | Pubmed ID: 12890713 Delayed Epileptogenesis in Nociceptin/orphanin FQ-deficient Mice Neuroreport. May, 2003 | Pubmed ID: 12858040 Changes in NPY-mediated Modulation of Hippocampal [3H]D-aspartate Outflow in the Kindling Model of Epilepsy Synapse (New York, N.Y.). Aug, 2003 | Pubmed ID: 12740867 Pro-nociceptin/orphanin FQ and NOP Receptor MRNA Levels in the Forebrain of Food Deprived Rats Brain Research. Dec, 2002 | Pubmed ID: 12445978 Neuroprotective Activity of CHF3381, a Putative N-methyl-D-aspartate Receptor Antagonist Neuroreport. Nov, 2002 | Pubmed ID: 12438928 Involvement of the Neuropeptide Nociceptin/orphanin FQ in Kainate Seizures The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2002 | Pubmed ID: 12427860 Obtaining High-Quality CSF and Blood Samples for Epilepsy Biomarker Discovery (Video) | JoVE Marie Soukupová1, Annunziata Guarino1, Laila Asth1, Pietro Marino1, Mario Barbieri1, Michele Simonato1, Silvia Zucchini1 1Department of Neuroscience and Rehabilitation, Section of Pharmacology, Universita degli Studi di Ferrara JoVE 65636 Neuroscience Microdialysis van Excitatory aminozuren tijdens EEG opnames in vrij bewegende ratten Marie Soukupová1, Chiara Falcicchia1, Francesca Lovisari1, Selene Ingusci1, Mario Barbieri1, Silvia Zucchini1, Michele Simonato1 1Department of Medical Sciences, Section of Pharmacology, Neuroscience Center, University of Ferrara and National Institute of Neuroscience JoVE 58455 Neuroscience Gepersonaliseerde naalden voor Microinjections in de hersenen knaagdier Giovanna Paolone*1, Chiara Falcicchia*1, Gianluca Verlengia*1, Mario Barbieri1, Anna Binaschi1, Federico Paliotto1, Beatrice Paradiso1, Marie Soukupova1, Silvia Zucchini1,2, Michele Simonato1,2 1Department of Medical Sciences, Section of Pharmacology, and National Institute of Neurosciences, University of Ferrara, 2Laboratory for the Technologies for Advanced Therapies (LTTA), University of Ferrara JoVE 55751 Neuroscience
Obtaining High-Quality CSF and Blood Samples for Epilepsy Biomarker Discovery (Video) | JoVE Marie Soukupová1, Annunziata Guarino1, Laila Asth1, Pietro Marino1, Mario Barbieri1, Michele Simonato1, Silvia Zucchini1 1Department of Neuroscience and Rehabilitation, Section of Pharmacology, Universita degli Studi di Ferrara JoVE 65636 Neuroscience
Microdialysis van Excitatory aminozuren tijdens EEG opnames in vrij bewegende ratten Marie Soukupová1, Chiara Falcicchia1, Francesca Lovisari1, Selene Ingusci1, Mario Barbieri1, Silvia Zucchini1, Michele Simonato1 1Department of Medical Sciences, Section of Pharmacology, Neuroscience Center, University of Ferrara and National Institute of Neuroscience JoVE 58455 Neuroscience
Gepersonaliseerde naalden voor Microinjections in de hersenen knaagdier Giovanna Paolone*1, Chiara Falcicchia*1, Gianluca Verlengia*1, Mario Barbieri1, Anna Binaschi1, Federico Paliotto1, Beatrice Paradiso1, Marie Soukupova1, Silvia Zucchini1,2, Michele Simonato1,2 1Department of Medical Sciences, Section of Pharmacology, and National Institute of Neurosciences, University of Ferrara, 2Laboratory for the Technologies for Advanced Therapies (LTTA), University of Ferrara JoVE 55751 Neuroscience
