Mikko Airavaara Neuroscience Center, HiLIFE University of Helsinki Biography Publications Institution JoVE Articles Mikko Airavaara has not added a biography. If you are Mikko Airavaara and would like to personalize this page please email our Author Liaison for assistance. Publications Mitoxantrone, Pixantrone and Mitoxantrone (2-hydroxyethyl)piperazine Are Toll-like Receptor 4 Antagonists, Inhibit NF-κB Activation, and Decrease TNF-alpha Secretion in Primary Microglia European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2020 | Pubmed ID: 32730846 Molecular Profile of the Rat Peri-infarct Region Four Days After Stroke: Study with MANF Experimental Neurology. Jul, 2020 | Pubmed ID: 32229226 Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models Current Protocols in Neuroscience. Mar, 2020 | Pubmed ID: 32049438 MANF Ablation Causes Prolonged Activation of the UPR Without Neurodegeneration in the Mouse Midbrain Dopamine System ENeuro. Jan/Feb, 2020 | Pubmed ID: 32005751 Cerebral Dopamine Neurotrophic Factor-deficiency Leads to Degeneration of Enteric Neurons and Altered Brain Dopamine Neuronal Function in Mice Neurobiology of Disease. 02, 2020 | Pubmed ID: 31783118 Engineered Antibody-functionalized Porous Silicon Nanoparticles for Therapeutic Targeting of Pro-survival Pathway in Endogenous Neuroblasts After Stroke Biomaterials. 01, 2020 | Pubmed ID: 31670035 Neuronal Activation Stimulates Cytomegalovirus Promoter-Driven Transgene Expression Molecular Therapy. Methods & Clinical Development. Sep, 2019 | Pubmed ID: 31380464 Cerebral Dopamine Neurotrophic Factor Diffuses Around the Brainstem and Does Not Undergo Anterograde Transport After Injection to the Substantia Nigra Frontiers in Neuroscience. 2019 | Pubmed ID: 31244598 Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury Frontiers in Physiology. 2019 | Pubmed ID: 31105589 Neuroprotective and Reparative Effects of Endoplasmic Reticulum Luminal Proteins - Mesencephalic Astrocyte-derived Neurotrophic Factor and Cerebral Dopamine Neurotrophic Factor Croatian Medical Journal. Apr, 2019 | Pubmed ID: 31044581 Secondary Pathology of the Thalamus After Focal Cortical Stroke in Rats is Not Associated with Thermal or Mechanical Hypersensitivity and is Not Alleviated by Intra-Thalamic Post-Stroke Delivery of Recombinant CDNF or MANF Cell Transplantation. 04, 2019 | Pubmed ID: 31037983 Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats Neuron. 04, 2019 | Pubmed ID: 30792150 Downregulation of Tyrosine Hydroxylase Phenotype After AAV Injection Above Substantia Nigra: Caution in Experimental Models of Parkinson's Disease Journal of Neuroscience Research. 03, 2019 | Pubmed ID: 30548446 Implementation of Deep Neural Networks to Count Dopamine Neurons in Substantia Nigra The European Journal of Neuroscience. 09, 2018 | Pubmed ID: 30144349 Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease Frontiers in Neurology. 2018 | Pubmed ID: 29973907 Poststroke Delivery of MANF Promotes Functional Recovery in Rats Science Advances. 05, 2018 | Pubmed ID: 29806020 Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury ENeuro. Mar-Apr, 2018 | Pubmed ID: 29766045 Synthesis of 7β-hydroxy-8-ketone Opioid Derivatives with Antagonist Activity at Mu- and Delta-opioid Receptors European Journal of Medicinal Chemistry. May, 2018 | Pubmed ID: 29649744 Towards Developing a Model to Study Alcohol Drinking and Craving in Female Mice Housed in Automated Cages Behavioural Brain Research. 10, 2018 | Pubmed ID: 29572104 The κ-opioid Receptor Antagonist JDTic Decreases Ethanol Intake in Alcohol-preferring AA Rats Psychopharmacology. 05, 2018 | Pubmed ID: 29492614 Differential Spinal and Supraspinal Activation of Glia in a Rat Model of Morphine Tolerance Neuroscience. 04, 2018 | Pubmed ID: 29421434 Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease Neuroscience. 03, 2018 | Pubmed ID: 29408408 MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke Molecular Therapy : the Journal of the American Society of Gene Therapy. 01, 2018 | Pubmed ID: 29050872 Development and Plasticity of Meningeal Lymphatic Vessels The Journal of Experimental Medicine. Dec, 2017 | Pubmed ID: 29141865 MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex ENeuro. Sep-Oct, 2017 | Pubmed ID: 29082311 Multifunctional Nanotube-Mucoadhesive Poly(methyl Vinyl Ether-co-maleic Acid)@Hydroxypropyl Methylcellulose Acetate Succinate Composite for Site-Specific Oral Drug Delivery Advanced Healthcare Materials. Oct, 2017 | Pubmed ID: 28714596 9-cis Retinoic Acid Induces Neurorepair in Stroke Brain Scientific Reports. 07, 2017 | Pubmed ID: 28674431 Nigral Injection of a Proteasomal Inhibitor, Lactacystin, Induces Widespread Glial Cell Activation and Shows Various Phenotypes of Parkinson's Disease in Young and Adult Mouse Experimental Brain Research. 07, 2017 | Pubmed ID: 28439627 Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra ENeuro. Jan-Feb, 2017 | Pubmed ID: 28275710 AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models Genes. Feb, 2017 | Pubmed ID: 28208742 Role of Microglia in Ischemic Focal Stroke and Recovery: Focus on Toll-like Receptors Progress in Neuro-psychopharmacology & Biological Psychiatry. 10, 2017 | Pubmed ID: 27389423 Update of Neurotrophic Factors in Neurobiology of Addiction and Future Directions Neurobiology of Disease. 01, 2017 | Pubmed ID: 27189755 Accumbal μ-Opioid Receptors Modulate Ethanol Intake in Alcohol-Preferring Alko Alcohol Rats Alcoholism, Clinical and Experimental Research. 10, 2016 | Pubmed ID: 27508965 Developing Therapeutically More Efficient Neurturin Variants for Treatment of Parkinson's Disease Neurobiology of Disease. Dec, 2016 | Pubmed ID: 27425888 Oral Hypoglycaemic Effect of GLP-1 and DPP4 Inhibitor Based Nanocomposites in a Diabetic Animal Model Journal of Controlled Release : Official Journal of the Controlled Release Society. 06, 2016 | Pubmed ID: 27091697 Characterization of a New Low-dose 6-hydroxydopamine Model of Parkinson's Disease in Rat Journal of Neuroscience Research. Apr, 2016 | Pubmed ID: 26762168 Therapeutic Potential of the Endoplasmic Reticulum Located and Secreted CDNF/MANF Family of Neurotrophic Factors in Parkinson's Disease FEBS Letters. Dec, 2015 | Pubmed ID: 26450777 Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy Human Gene Therapy. Aug, 2015 | Pubmed ID: 26176331 AAV-mediated Targeting of Gene Expression to the Peri-infarct Region in Rat Cortical Stroke Model Journal of Neuroscience Methods. Oct, 2014 | Pubmed ID: 25152446 Short-term Preoperative Dietary Restriction is Neuroprotective in a Rat Focal Stroke Model PloS One. 2014 | Pubmed ID: 24705386 Local Administration of AAV-BDNF to Subventricular Zone Induces Functional Recovery in Stroke Rats PloS One. 2013 | Pubmed ID: 24312581 Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Secretion and Cell Surface Binding Are Modulated by KDEL Receptors The Journal of Biological Chemistry. Feb, 2013 | Pubmed ID: 23255601 Neurorestoration Parkinsonism & Related Disorders. Jan, 2012 | Pubmed ID: 22166416 CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice Cell Transplantation. 2012 | Pubmed ID: 21943517 WITHDRAWN: Neurorestoration Parkinsonism & Related Disorders. Sep, 2011 | Pubmed ID: 21924941 Chronic Nicotine Modifies the Effects of Morphine on Extracellular Striatal Dopamine and Ventral Tegmental GABA Journal of Neurochemistry. Nov, 2008 | Pubmed ID: 18786163 Characterization of the Striatal Dopaminergic Neurotransmission in MEN2B Mice with Elevated Cerebral Tissue Dopamine Journal of Neurochemistry. Jun, 2008 | Pubmed ID: 18248620 Constitutive Ret Activity in Knock-in Multiple Endocrine Neoplasia Type B Mice Induces Profound Elevation of Brain Dopamine Concentration Via Enhanced Synthesis and Increases the Number of TH-positive Cells in the Substantia Nigra The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2007 | Pubmed ID: 17475787 Effects of Repeated Morphine on Locomotion, Place Preference and Dopamine in Heterozygous Glial Cell Line-derived Neurotrophic Factor Knockout Mice Genes, Brain, and Behavior. Apr, 2007 | Pubmed ID: 16879618 In Heterozygous GDNF Knockout Mice the Response of Striatal Dopaminergic System to Acute Morphine is Altered Synapse (New York, N.Y.). May, 2006 | Pubmed ID: 16437537 Increased Extracellular Dopamine Concentrations and FosB/DeltaFosB Expression in Striatal Brain Areas of Heterozygous GDNF Knockout Mice The European Journal of Neuroscience. Nov, 2004 | Pubmed ID: 15525275 原発性胚マウス中脳ドーパミンニューロンにおける前形成線維誘導α-シヌクレイン蓄積の研究 Safak Er1, Irena Hlushchuk1, Mikko Airavaara2, Piotr Chmielarz1,3, Andrii Domanskyi1 1Institute of Biotechnology, HiLIFE, University of Helsinki, 2Neuroscience Center, HiLIFE, University of Helsinki, 3Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences JoVE 61118 Neuroscience
原発性胚マウス中脳ドーパミンニューロンにおける前形成線維誘導α-シヌクレイン蓄積の研究 Safak Er1, Irena Hlushchuk1, Mikko Airavaara2, Piotr Chmielarz1,3, Andrii Domanskyi1 1Institute of Biotechnology, HiLIFE, University of Helsinki, 2Neuroscience Center, HiLIFE, University of Helsinki, 3Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences JoVE 61118 Neuroscience
