Motoi Ohba Advanced Cancer Translational Research Institute Showa University Biography Publications Institution JoVE Articles Motoi Ohba has not added a biography. If you are Motoi Ohba and would like to personalize this page please email our Author Liaison for assistance. Publications and Amplifications Mediate Resistance to Rociletinib and Osimertinib in Acquired Afatinib-Resistant NSCLC Harboring Exon 19 Deletion/T790M in Molecular Cancer Therapeutics. 01, 2019 | Pubmed ID: 30322949 Receptor Tyrosine Kinase-Targeted Cancer Therapy International Journal of Molecular Sciences. Nov, 2018 | Pubmed ID: 30404198 Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms International Journal of Molecular Sciences. Nov, 2017 | Pubmed ID: 29140271 Distinct Afatinib Resistance Mechanisms Identified in Lung Adenocarcinoma Harboring an EGFR Mutation Molecular Cancer Research : MCR. Jul, 2017 | Pubmed ID: 28289161 Up-regulation of Syndecan-4 Contributes to TGF-β1-induced Epithelial to Mesenchymal Transition in Lung Adenocarcinoma A549 Cells Biochemistry and Biophysics Reports. Mar, 2016 | Pubmed ID: 28955801 Acquired Resistance Mechanisms to Combination Met-TKI/EGFR-TKI Exposure in Met-Amplified EGFR-TKI-Resistant Lung Adenocarcinoma Harboring an Activating EGFR Mutation Molecular Cancer Therapeutics. Dec, 2016 | Pubmed ID: 27612490 Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients Scientific Reports. May, 2015 | Pubmed ID: 25994878 Vascular Endothelial Tight Junctions and Barrier Function Are Disrupted by 15(S)-hydroxyeicosatetraenoic Acid Partly Via Protein Kinase C ε-mediated Zona Occludens-1 Phosphorylation at Threonine 770/772 The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24338688 B Lymphocyte-induced Maturation Protein 1 is a Novel Target Gene of Aryl Hydrocarbon Receptor Journal of Dermatological Science. Jun, 2010 | Pubmed ID: 20478695 Protein Kinase C Delta and Eta Differently Regulate the Expression of Loricrin and Jun Family Proteins in Human Keratinocytes Biochemical and Biophysical Research Communications. Mar, 2010 | Pubmed ID: 20184865 激活蛋白酶激活受体 2 的刺激可溶性血管内皮生长因子受体 1 释放经由表皮生长因子受体转录激活内皮细胞。 Hypertension. Mar, 2010 | Pubmed ID: 20124108 Lysophosphatidylcholine Activates Adipocyte Glucose Uptake and Lowers Blood Glucose Levels in Murine Models of Diabetes The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19815546 Functional Characterization of IL-17F As a Selective Neutrophil Attractant in Psoriasis The Journal of Investigative Dermatology. Mar, 2009 | Pubmed ID: 18830271 蛋白激酶 C α 和 Zeta 差异调节香烟烟雾提取物诱导细胞凋亡诱导死亡信号复杂地层。 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18354190 A Protein Kinase Cepsilon-anti-apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells Against Apoptosis Through Induction of Bcl-2 The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17785460 Activation of Protein Kinase Czeta Mediates Luteinizing Hormone- or Forskolin-induced NGFI-B Expression in Preovulatory Granulosa Cells of Rat Ovary Molecular and Cellular Endocrinology. May, 2007 | Pubmed ID: 17416458 Pituitary Adenylate Cyclase-activating Polypeptide-induced Differentiation of Embryonic Neural Stem Cells into Astrocytes is Mediated Via the Beta Isoform of Protein Kinase C Journal of Neuroscience Research. Dec, 2006 | Pubmed ID: 17022039 A Role for Proteinase-activated Receptor 2 and PKC-epsilon in Thrombin-mediated Induction of Decay-accelerating Factor on Human Endothelial Cells American Journal of Physiology. Cell Physiology. Dec, 2005 | Pubmed ID: 16079188 Novel Functions of the Phospholipase D2-Phox Homology Domain in Protein Kinase Czeta Activation Molecular and Cellular Biology. Apr, 2005 | Pubmed ID: 15798205 Protein Kinase Calpha is Implicated in Cholecystokinin-induced Activation of 70-kd S6 Kinase in AR42J Cells Pancreas. Jan, 2005 | Pubmed ID: 15632699 Angiotensin II-induced Protein Kinase D Activation is Regulated by Protein Kinase Cdelta and Mediated Via the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2004 | Pubmed ID: 15499041 Decay-accelerating Factor Induction on Vascular Endothelium by Vascular Endothelial Growth Factor (VEGF) is Mediated Via a VEGF Receptor-2 (VEGF-R2)- and Protein Kinase C-alpha/epsilon (PKCalpha/epsilon)-dependent Cytoprotective Signaling Pathway and is Inhibited by Cyclosporin A The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15284224 Protein Kinase Cdelta Mediates Lysophosphatidic Acid-induced NF-kappaB Activation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15280372 Role of CPI-17 in the Regulation of Endothelial Cytoskeleton American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2004 | Pubmed ID: 15234908 Transcriptional and Post-transcriptional Regulation of the PKC Delta Gene by Etoposide in L1210 Murine Leukemia Cells: Implication of PKC Delta Autoregulation Journal of Molecular Biology. Jul, 2004 | Pubmed ID: 15223313 PKCalpha Mediates TGFbeta-induced Growth Inhibition of Human Keratinocytes Via Phosphorylation of S100C/A11 The Journal of Cell Biology. Mar, 2004 | Pubmed ID: 15051732 Differential Regulation of Alpha6beta4 Integrin by PKC Isoforms in Murine Skin Keratinocytes Biochemical and Biophysical Research Communications. Jan, 2004 | Pubmed ID: 14715240 PKCdelta Inhibits PKCalpha-mediated Activation of Phospholipase D1 in a Manner Independent of Its Protein Kinase Activity FEBS Letters. Nov, 2003 | Pubmed ID: 14596936 The Eta Isoform of Protein Kinase C Inhibits UV-induced Activation of Caspase-3 in Normal Human Keratinocytes Biochemical and Biophysical Research Communications. Mar, 2003 | Pubmed ID: 12646210 Insulin-induced Akt Activation is Inhibited by Angiotensin II in the Vasculature Through Protein Kinase C-alpha Hypertension (Dallas, Tex. : 1979). Mar, 2003 | Pubmed ID: 12623995 Distinct Mechanisms of Receptor and Nonreceptor Tyrosine Kinase Activation by Reactive Oxygen Species in Vascular Smooth Muscle Cells: Role of Metalloprotease and Protein Kinase C-delta Molecular and Cellular Biology. Mar, 2003 | Pubmed ID: 12588978 Thrombin Rapidly Induces Protein Kinase D Phosphorylation, and Protein Kinase C Delta Mediates the Activation The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12431976 Protein Kinase C Eta (PKC Eta): Its Involvement in Keratinocyte Differentiation Journal of Biochemistry. Dec, 2002 | Pubmed ID: 12473186 Localization of Phospholipase D1 to Caveolin-enriched Membrane Via Palmitoylation: Implications for Epidermal Growth Factor Signaling Molecular Biology of the Cell. Nov, 2002 | Pubmed ID: 12429840 Ligand-independent Trans-activation of the Platelet-derived Growth Factor Receptor by Reactive Oxygen Species Requires Protein Kinase C-delta and C-Src The Journal of Biological Chemistry. Nov, 2002 | Pubmed ID: 12226102 Enhancement of Anchorage-independent Growth of Human Pancreatic Carcinoma MIA PaCa-2 Cells by Signaling from Protein Kinase C to Mitogen-activated Protein Kinase Molecular Carcinogenesis. Aug, 2002 | Pubmed ID: 12203369 Novel Protein Kinase C Isoforms Regulate Human Keratinocyte Differentiation by Activating a P38 Delta Mitogen-activated Protein Kinase Cascade That Targets CCAAT/enhancer-binding Protein Alpha The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12080077 Dual Regulation of Phospholipase D1 by Protein Kinase C Alpha in Vivo Biochemical and Biophysical Research Communications. Jun, 2002 | Pubmed ID: 12074591 Protein Kinase Cdelta Amplifies Ceramide Formation Via Mitochondrial Signaling in Prostate Cancer Cells The Journal of Clinical Investigation. Mar, 2002 | Pubmed ID: 11901191 Lysophosphatidylcholine Inhibits Insulin-induced Akt Activation Through Protein Kinase C-alpha in Vascular Smooth Muscle Cells Hypertension (Dallas, Tex. : 1979). Feb, 2002 | Pubmed ID: 11882599 Requirement of Ca(2+) and PKCdelta for Janus Kinase 2 Activation by Angiotensin II: Involvement of PYK2 Molecular Endocrinology (Baltimore, Md.). Feb, 2002 | Pubmed ID: 11818507 Phosphorylation-dependent Regulation of Phospholipase D2 by Protein Kinase C Delta in Rat Pheochromocytoma PC12 Cells The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11744693 Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCalpha The Journal of Biological Chemistry. Jan, 2002 | Pubmed ID: 11584014 Activation of Protein Kinase C Zeta Induces Serine Phosphorylation of VAMP2 in the GLUT4 Compartment and Increases Glucose Transport in Skeletal Muscle Molecular and Cellular Biology. Nov, 2001 | Pubmed ID: 11604519 Phorbol Ester-induced G1 Arrest in BALB/MK-2 Mouse Keratinocytes is Mediated by Delta and Eta Isoforms of Protein Kinase C Japanese Journal of Cancer Research : Gann. Nov, 1998 | Pubmed ID: 9914781 Induction of Differentiation in Normal Human Keratinocytes by Adenovirus-mediated Introduction of the Eta and Delta Isoforms of Protein Kinase C Molecular and Cellular Biology. Sep, 1998 | Pubmed ID: 9710604 建立和表征三个抗阿法替尼的肺腺癌PC-9细胞系与增加剂量的阿法替尼开发 Toshimitsu Yamaoka1, Motoi Ohba1, Yuki Matsunaga2, Junji Tsurutani1, Tohru Ohmori3 1Advanced Cancer Translational Research Institute, Showa University, 2Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine, 3Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine JoVE 59473 Cancer Research 建立双抗 EGFR-使用 tki 药物治疗和满足使用 tki 药物治疗在肺腺癌细胞体外与 2 步剂量升级程序 Toshimitsu Yamaoka1, Motoi Ohba1, Satoru Arata1,2, Tohru Ohmori1 1Institute of Molecular Oncology, Showa University, 2Center for Biotechnology, Showa University JoVE 55967 Cancer Research
建立和表征三个抗阿法替尼的肺腺癌PC-9细胞系与增加剂量的阿法替尼开发 Toshimitsu Yamaoka1, Motoi Ohba1, Yuki Matsunaga2, Junji Tsurutani1, Tohru Ohmori3 1Advanced Cancer Translational Research Institute, Showa University, 2Division of Breast Surgical Oncology, Department of Surgery, Showa University School of Medicine, 3Division of Allergology and Respiratory Medicine, Department of Medicine, Showa University School of Medicine JoVE 59473 Cancer Research
建立双抗 EGFR-使用 tki 药物治疗和满足使用 tki 药物治疗在肺腺癌细胞体外与 2 步剂量升级程序 Toshimitsu Yamaoka1, Motoi Ohba1, Satoru Arata1,2, Tohru Ohmori1 1Institute of Molecular Oncology, Showa University, 2Center for Biotechnology, Showa University JoVE 55967 Cancer Research
