Myriam Gorospe Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program National Institutes of Health Biography Publications Institution JoVE Articles Myriam Gorospe has not added a biography. If you are Myriam Gorospe and would like to personalize this page please email our Author Liaison for assistance. Publications Alternative Polyadenylation Utilization Results in Ribosome Assembly and MRNA Translation Deficiencies in a Model for Muscle Aging The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Mar, 2022 | Pubmed ID: 35245938 Systematic Identification of NF90 Target RNAs by ICLIP Analysis Scientific Reports. 01, 2022 | Pubmed ID: 35013429 The Versatile Role of HuR in Glioblastoma and Its Potential As a Therapeutic Target for a Multi-pronged Attack Advanced Drug Delivery Reviews. 02, 2022 | Pubmed ID: 34923029 Identification of Atrial-enriched LncRNA Walras Linked to Cardiomyocyte Cytoarchitecture and Atrial Fibrillation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 01, 2022 | Pubmed ID: 34861058 A Brain Proteomic Signature of Incipient Alzheimer's Disease in Young ε4 Carriers Identifies Novel Drug Targets Science Advances. Nov, 2021 | Pubmed ID: 34757788 Systematic Identification of CircRNAs in Alzheimer's Disease Genes. 08, 2021 | Pubmed ID: 34440432 Identification of CircRNA-Interacting Proteins by Affinity Pulldown Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 34417753 SFPQ Rescues F508del-CFTR Expression and Function in Cystic Fibrosis Bronchial Epithelial Cells Scientific Reports. 08, 2021 | Pubmed ID: 34404863 Reduction of Lamin B Receptor Levels by MiR-340-5p Disrupts Chromatin, Promotes Cell Senescence and Enhances Senolysis Nucleic Acids Research. 07, 2021 | Pubmed ID: 34181735 Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function Gastroenterology. 10, 2021 | Pubmed ID: 34116030 Acid Ceramidase Promotes Senescent Cell Survival Aging. 06, 2021 | Pubmed ID: 34102611 GRSF1 Deficiency in Skeletal Muscle Reduces Endurance in Aged Mice Aging. 06, 2021 | Pubmed ID: 34078750 Skeletal Muscle Transcriptome in Healthy Aging Nature Communications. 04, 2021 | Pubmed ID: 33795677 HnRNPK-regulated LINC00263 Promotes Malignant Phenotypes Through MiR-147a/CAPN2 Cell Death & Disease. 03, 2021 | Pubmed ID: 33731671 HuB and HuD Repress Telomerase Activity by Dissociating HuR from TERC Nucleic Acids Research. 03, 2021 | Pubmed ID: 33589924 Ribosome Profiling Analysis of Human Skeletal Muscle Identifies Reduced Translation of Mitochondrial Proteins with Age RNA Biology. 11, 2021 | Pubmed ID: 33472542 AUF1 Ligand CircPCNX Reduces Cell Proliferation by Competing with P21 MRNA to Increase P21 Production Nucleic Acids Research. 02, 2021 | Pubmed ID: 33444453 Characterizing and Circumventing Sequence Restrictions for Synthesis of Circular RNA in Vitro Nucleic Acids Research. 04, 2021 | Pubmed ID: 33406226 Practical Guide for Circular RNA Analysis: Steps, Tips, and Resources Wiley Interdisciplinary Reviews. RNA. 01, 2021 | Pubmed ID: 33112505 Translational Control During Cellular Senescence Molecular and Cellular Biology. 01, 2021 | Pubmed ID: 33077499 Ribonucleoprotein Immunoprecipitation (RIP) Analysis Bio-protocol. Jan, 2020 | Pubmed ID: 33654721 Mitochondrial RNA in Alzheimer's Disease Circulating Extracellular Vesicles Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 33304899 NQO1 Protects Obese Mice Through Improvements in Glucose and Lipid Metabolism NPJ Aging and Mechanisms of Disease. Nov, 2020 | Pubmed ID: 33298924 Interaction of OIP5-AS1 with MEF2C MRNA Promotes Myogenic Gene Expression Nucleic Acids Research. 12, 2020 | Pubmed ID: 33270893 Publisher Correction: Regulation of Cellular Sterol Homeostasis by the Oxygen Responsive Noncoding RNA LincNORS Nature Communications. Nov, 2020 | Pubmed ID: 33159065 Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against Frontiers in Immunology. 2020 | Pubmed ID: 33123155 A Small Protein Encoded by a Putative LncRNA Regulates Apoptosis and Tumorigenicity in Human Colorectal Cancer Cells ELife. 10, 2020 | Pubmed ID: 33112233 Regulation of Cellular Sterol Homeostasis by the Oxygen Responsive Noncoding RNA LincNORS Nature Communications. 09, 2020 | Pubmed ID: 32958772 Author Correction: Complex Genetic Signatures in Immune Cells Underlie Autoimmunity and Inform Therapy Nature Genetics. Nov, 2020 | Pubmed ID: 32948852 Complex Genetic Signatures in Immune Cells Underlie Autoimmunity and Inform Therapy Nature Genetics. 10, 2020 | Pubmed ID: 32929287 Circular RNAs in Blood Malignancies Frontiers in Molecular Biosciences. 2020 | Pubmed ID: 32676504 Hepatic HuR Modulates Lipid Homeostasis in Response to High-fat Diet Nature Communications. 06, 2020 | Pubmed ID: 32546794 Regulation of Senescence Traits by MAPKs GeroScience. 04, 2020 | Pubmed ID: 32300964 Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging Trends in Molecular Medicine. 04, 2020 | Pubmed ID: 32277935 RNA-Binding Protein HuR Promotes Th17 Cell Differentiation and Can Be Targeted to Reduce Autoimmune Neuroinflammation Journal of Immunology (Baltimore, Md. : 1950). 04, 2020 | Pubmed ID: 32169842 Survey of Senescent Cell Markers with Age in Human Tissues Aging. 03, 2020 | Pubmed ID: 32160592 A Circular RNA from the Locus Controls Cell Cycle Progression by Suppressing P53 Levels Molecular and Cellular Biology. 04, 2020 | Pubmed ID: 32041821 CircSamd4 Represses Myogenic Transcriptional Activity of PUR Proteins Nucleic Acids Research. 04, 2020 | Pubmed ID: 31980816 Long Noncoding RNA H19 Impairs the Intestinal Barrier by Suppressing Autophagy and Lowering Paneth and Goblet Cell Function Cellular and Molecular Gastroenterology and Hepatology. 2020 | Pubmed ID: 31862317 SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 01, 2020 | Pubmed ID: 31818974 Methods for Analysis of Circular RNAs Wiley Interdisciplinary Reviews. RNA. 01, 2020 | Pubmed ID: 31489773 HuR Regulates Phospholamban Expression in Isoproterenol-induced Cardiac Remodelling Cardiovascular Research. 04, 2020 | Pubmed ID: 31373621 HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A Cancers. Dec, 2019 | Pubmed ID: 31847141 Discovery Proteomics in Aging Human Skeletal Muscle Finds Change in Spliceosome, Immunity, Proteostasis and Mitochondria ELife. 10, 2019 | Pubmed ID: 31642809 Transcriptome Signature of Cellular Senescence Nucleic Acids Research. Dec, 2019 | Pubmed ID: 31612919 'RNA Circles of Influence' in Kaposi Sarcoma Annals of Translational Medicine. Jul, 2019 | Pubmed ID: 31576316 Skewed Macrophage Polarization in Aging Skeletal Muscle Aging Cell. 12, 2019 | Pubmed ID: 31478346 Transcriptome Signature of Cellular Senescence Nucleic Acids Research. 08, 2019 | Pubmed ID: 31251810 Correction: Polysome Fractionation to Analyze MRNA Distribution Profiles Bio-protocol. Feb, 2019 | Pubmed ID: 31187050 MRNA Methylation in Cell Senescence Wiley Interdisciplinary Reviews. RNA. 11, 2019 | Pubmed ID: 31144457 RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 Via Post-transcriptional Control of CNPY3 Gastroenterology. 09, 2019 | Pubmed ID: 31103627 Long Noncoding RNAs in Intestinal Epithelium Homeostasis American Journal of Physiology. Cell Physiology. 07, 2019 | Pubmed ID: 31042423 Loss of MiR-451a Enhances SPARC Production During Myogenesis PloS One. 2019 | Pubmed ID: 30925184 NF90 Regulation of Immune Factor Expression in Response to Malaria Antigens Cell Cycle (Georgetown, Tex.). Mar - Apr, 2019 | Pubmed ID: 30784348 Loss of RNA-binding Protein GRSF1 Activates MTOR to Elicit a Proinflammatory Transcriptional Program Nucleic Acids Research. 03, 2019 | Pubmed ID: 30753671 RPAD (RNase R Treatment, Polyadenylation, and Poly(A)+ RNA Depletion) Method to Isolate Highly Pure Circular RNA Methods (San Diego, Calif.). 02, 2019 | Pubmed ID: 30391514 Intracellular RNA-tracking Methods Open Biology. 10, 2018 | Pubmed ID: 30282659 Cooperative Translational Control of Polymorphic BAFF by NF90 and MiR-15a Nucleic Acids Research. 12, 2018 | Pubmed ID: 30272251 The Coding Potential of CircRNAs Aging. 09, 2018 | Pubmed ID: 30215602 Multi-leveled Suppression of P53 Function by HuR IncRNPs Non-coding RNA Investigation. Jan, 2018 | Pubmed ID: 30148260 Identifying Intronic CircRNAs: Progress and Challenges Non-coding RNA Investigation. Jun, 2018 | Pubmed ID: 30148259 GRSF1 Suppresses Cell Senescence Aging. Aug, 2018 | Pubmed ID: 30086537 AKTions by Cytoplasmic LncRNA CASC9 Promote Hepatocellular Carcinoma Survival Hepatology (Baltimore, Md.). 11, 2018 | Pubmed ID: 30014487 Author Correction: HuR Regulates Telomerase Activity Through TERC Methylation Nature Communications. 07, 2018 | Pubmed ID: 29988036 SCAMP4 Enhances the Senescent Cell Secretome Genes & Development. 07, 2018 | Pubmed ID: 29967290 HuR Regulates Telomerase Activity Through TERC Methylation Nature Communications. 06, 2018 | Pubmed ID: 29880812 Detection and Analysis of Circular RNAs by RT-PCR Bio-protocol. Mar, 2018 | Pubmed ID: 29644261 A RAS-CaMKKβ-AMPKα2 Pathway Promotes Senescence by Licensing Post-translational Activation of C/EBPβ Through a Novel 3'UTR Mechanism Oncogene. 06, 2018 | Pubmed ID: 29563610 Cytoplasmic Functions of Long Noncoding RNAs Wiley Interdisciplinary Reviews. RNA. 05, 2018 | Pubmed ID: 29516680 Noncoding RNAs in Alzheimer's Disease Wiley Interdisciplinary Reviews. RNA. 03, 2018 | Pubmed ID: 29327503 Analysis of Circular RNAs Using the Web Tool CircInteractome Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29322439 STIM1, but Not STIM2, Is the Calcium Sensor Critical for Sweat Secretion The Journal of Investigative Dermatology. 03, 2018 | Pubmed ID: 29054597 Long Noncoding RNA Uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195 Gastroenterology. 02, 2018 | Pubmed ID: 29042220 Regulation of HuR Structure and Function by Dihydrotanshinone-I Nucleic Acids Research. Sep, 2017 | Pubmed ID: 28934484 Identification of Senescent Cell Surface Targetable Protein DPP4 Genes & Development. 08, 2017 | Pubmed ID: 28877934 Senescence-Associated MicroRNAs International Review of Cell and Molecular Biology. 2017 | Pubmed ID: 28838538 The RNA-binding Protein HuR Contributes to Neuroinflammation by Promoting C-C Chemokine Receptor 6 (CCR6) Expression on Th17 Cells The Journal of Biological Chemistry. 09, 2017 | Pubmed ID: 28684423 Polysome Fractionation to Analyze MRNA Distribution Profiles Bio-protocol. Feb, 2017 | Pubmed ID: 28516123 Overexpression of the Cytokine BAFF and Autoimmunity Risk The New England Journal of Medicine. 04, 2017 | Pubmed ID: 28445677 High-purity Circular RNA Isolation Method (RPAD) Reveals Vast Collection of Intronic CircRNAs Nucleic Acids Research. Jul, 2017 | Pubmed ID: 28444238 NSUN2-Mediated M5C Methylation and METTL3/METTL14-Mediated M6A Methylation Cooperatively Enhance P21 Translation Journal of Cellular Biochemistry. 09, 2017 | Pubmed ID: 28247949 TIA-1 RRM23 Binding and Recognition of Target Oligonucleotides Nucleic Acids Research. 05, 2017 | Pubmed ID: 28184449 RNA in Extracellular Vesicles Wiley Interdisciplinary Reviews. RNA. 07, 2017 | Pubmed ID: 28130830 Mitochondrial Noncoding RNA Transport BMB Reports. Apr, 2017 | Pubmed ID: 28115039 Identification of HuR Target Circular RNAs Uncovers Suppression of PABPN1 Translation by CircPABPN1 RNA Biology. 03, 2017 | Pubmed ID: 28080204 HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation Molecular and Cellular Biology. 04, 2017 | Pubmed ID: 28031329 Bioinformatic Tools for Analysis of CLIP Ribonucleoprotein Data Wiley Interdisciplinary Reviews. RNA. 07, 2017 | Pubmed ID: 28008714 Identification of Senescence-associated Circular RNAs (SAC-RNAs) Reveals Senescence Suppressor CircPVT1 Nucleic Acids Research. 04, 2017 | Pubmed ID: 27928058 RT-qPCR Detection of Senescence-Associated Circular RNAs Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27812869 Emerging Roles and Context of Circular RNAs Wiley Interdisciplinary Reviews. RNA. 03, 2017 | Pubmed ID: 27612318 Posttranslational Control of HuR Function Wiley Interdisciplinary Reviews. RNA. 01, 2017 | Pubmed ID: 27307117 Affinity Pulldown of Biotinylated RNA for Detection of Protein-RNA Complexes Bio-protocol. Dec, 2016 | Pubmed ID: 28516119 UNRelenting Translation UNRestrains Melanoma Migration Cancer Cell. 11, 2016 | Pubmed ID: 27846383 Cockayne Syndrome Group A and B Proteins Converge on Transcription-linked Resolution of Non-B DNA Proceedings of the National Academy of Sciences of the United States of America. Nov, 2016 | Pubmed ID: 27791127 HuR Silencing Elicits Oxidative Stress and DNA Damage and Sensitizes Human Triple-negative Breast Cancer Cells to Radiotherapy Oncotarget. 10, 2016 | Pubmed ID: 27588488 The Long and the Short of TRF2 in Neurogenesis Cell Cycle (Georgetown, Tex.). Nov, 2016 | Pubmed ID: 27565210 Novel RNA-binding Activity of NQO1 Promotes SERPINA1 MRNA Translation Free Radical Biology & Medicine. 10, 2016 | Pubmed ID: 27515817 Identification of Neural Stem Cell Differentiation Repressor Complex Pnky-PTBP1 Stem Cell Investigation. 2016 | Pubmed ID: 27358902 RPTOR, a Novel Target of MiR-155, Elicits a Fibrotic Phenotype of Cystic Fibrosis Lung Epithelium by Upregulating CTGF RNA Biology. 09, 2016 | Pubmed ID: 27284727 RNA Topoisomerase is Prevalent in All Domains of Life and Associates with Polyribosomes in Animals Nucleic Acids Research. 07, 2016 | Pubmed ID: 27257063 Mammalian Ataxin-2 Modulates Translation Control at the Pre-initiation Complex Via PI3K/mTOR and is Induced by Starvation Biochimica Et Biophysica Acta. Sep, 2016 | Pubmed ID: 27240544 HuR and GRSF1 Modulate the Nuclear Export and Mitochondrial Localization of the LncRNA RMRP Genes & Development. 05, 2016 | Pubmed ID: 27198227 RNA Methyltransferase NSUN2 Promotes Stress-induced HUVEC Senescence Oncotarget. Apr, 2016 | Pubmed ID: 26992231 Metformin-mediated Increase in DICER1 Regulates MicroRNA Expression and Cellular Senescence Aging Cell. Jun, 2016 | Pubmed ID: 26990999 Identification of MRNA-Interacting Factors by MS2-TRAP (MS2-Tagged RNA Affinity Purification) Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26965253 LncRNA OIP5-AS1/cyrano Sponges RNA-binding Protein HuR Nucleic Acids Research. Mar, 2016 | Pubmed ID: 26819413 Cross-Linking Immunoprecipitation and QPCR (CLIP-qPCR) Analysis to Map Interactions Between Long Noncoding RNAs and RNA-Binding Proteins Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26721479 Long Noncoding RNA SPRY4-IT1 Regulates Intestinal Epithelial Barrier Function by Modulating the Expression Levels of Tight Junction Proteins Molecular Biology of the Cell. Feb, 2016 | Pubmed ID: 26680741 CircInteractome: A Web Tool for Exploring Circular RNAs and Their Interacting Proteins and MicroRNAs RNA Biology. 2016 | Pubmed ID: 26669964 Long Noncoding RNAs in Diseases of Aging Biochimica Et Biophysica Acta. Jan, 2016 | Pubmed ID: 26141605 NSun2 Delays Replicative Senescence by Repressing P27 (KIP1) Translation and Elevating CDK1 Translation Aging. Dec, 2015 | Pubmed ID: 26687548 Novel RNA- and FMRP-binding Protein TRF2-S Regulates Axonal MRNA Transport and Presynaptic Plasticity Nature Communications. Nov, 2015 | Pubmed ID: 26586091 Circular RNAs in Monkey Muscle: Age-dependent Changes Aging. Nov, 2015 | Pubmed ID: 26546448 Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637 Molecular and Cellular Biology. Dec, 2015 | Pubmed ID: 26438598 NSun2 Promotes Cell Growth Via Elevating Cyclin-Dependent Kinase 1 Translation Molecular and Cellular Biology. Dec, 2015 | Pubmed ID: 26391950 Noncoding RNA Control of Cellular Senescence Wiley Interdisciplinary Reviews. RNA. Nov-Dec, 2015 | Pubmed ID: 26331977 B Cell-Intrinsic Expression of the HuR RNA-Binding Protein Is Required for the T Cell-Dependent Immune Response In Vivo Journal of Immunology (Baltimore, Md. : 1950). Oct, 2015 | Pubmed ID: 26320247 AUF1 Promotes Let-7b Loading on Argonaute 2 Genes & Development. Aug, 2015 | Pubmed ID: 26253535 Transgenic Expression of MiR-222 Disrupts Intestinal Epithelial Regeneration by Targeting Multiple Genes Including Frizzled-7 Molecular Medicine (Cambridge, Mass.). Nov, 2015 | Pubmed ID: 26252186 MiR-431 Promotes Differentiation and Regeneration of Old Skeletal Muscle by Targeting Smad4 Genes & Development. Aug, 2015 | Pubmed ID: 26215566 RNA-Binding Protein Musashi1 Is a Central Regulator of Adhesion Pathways in Glioblastoma Molecular and Cellular Biology. Sep, 2015 | Pubmed ID: 26100017 Competition Between RNA-binding Proteins CELF1 and HuR Modulates MYC Translation and Intestinal Epithelium Renewal Molecular Biology of the Cell. May, 2015 | Pubmed ID: 25808495 JunD Enhances MiR-29b Levels Transcriptionally and Posttranscriptionally to Inhibit Proliferation of Intestinal Epithelial Cells American Journal of Physiology. Cell Physiology. May, 2015 | Pubmed ID: 25788572 Long Noncoding RNA Turnover Biochimie. Oct, 2015 | Pubmed ID: 25769416 Modulation by MiR-29b of Intestinal Epithelium Homoeostasis Through the Repression of Menin Translation The Biochemical Journal. Jan, 2015 | Pubmed ID: 25317587 Novel RNA-binding Protein P311 Binds Eukaryotic Translation Initiation Factor 3 Subunit B (eIF3b) to Promote Translation of Transforming Growth Factor β1-3 (TGF-β1-3) The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25336651 RNA-binding Protein HuR Promotes Growth of Small Intestinal Mucosa by Activating the Wnt Signaling Pathway Molecular Biology of the Cell. Nov, 2014 | Pubmed ID: 25165135 Activation of TRPML1 Clears Intraneuronal Aβ in Preclinical Models of HIV Infection The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2014 | Pubmed ID: 25143627 7SL RNA Represses P53 Translation by Competing with HuR Nucleic Acids Research. Sep, 2014 | Pubmed ID: 25123665 Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b Molecular and Cellular Biology. Oct, 2014 | Pubmed ID: 25047833 Destabilization of Nucleophosmin MRNA by the HuR/KSRP Complex is Required for Muscle Fibre Formation Nature Communications. Jun, 2014 | Pubmed ID: 24969639 Functional Interactions Among MicroRNAs and Long Noncoding RNAs Seminars in Cell & Developmental Biology. Oct, 2014 | Pubmed ID: 24965208 RNA-binding Protein AUF1 Promotes Myogenesis by Regulating MEF2C Expression Levels Molecular and Cellular Biology. Aug, 2014 | Pubmed ID: 24891619 RNA Binding Protein HuR Regulates the Expression of ABCA1 Journal of Lipid Research. 06, 2014 | Pubmed ID: 24729624 DCK Expression Correlates with 5-fluorouracil Efficacy and HuR Cytoplasmic Expression in Pancreatic Cancer: a Dual-institutional Follow-up with the RTOG 9704 Trial Cancer Biology & Therapy. Jun, 2014 | Pubmed ID: 24618665 Inhibition of Smurf2 Translation by MiR-322/503 Modulates TGF-β/Smad2 Signaling and Intestinal Epithelial Homeostasis Molecular Biology of the Cell. Apr, 2014 | Pubmed ID: 24554769 Conditional Knockout of the RNA-binding Protein HuR in CD4⁺ T Cells Reveals a Gene Dosage Effect on Cytokine Production Molecular Medicine (Cambridge, Mass.). Mar, 2014 | Pubmed ID: 24477678 The RNA-binding Protein HuD Regulates Autophagosome Formation in Pancreatic β Cells by Promoting Autophagy-related Gene 5 Expression The Journal of Biological Chemistry. Jan, 2014 | Pubmed ID: 24275661 Age-associated MiRNA Alterations in Skeletal Muscle from Rhesus Monkeys Reversed by Caloric Restriction Aging. Sep, 2013 | Pubmed ID: 24036467 Top3β is an RNA Topoisomerase That Works with Fragile X Syndrome Protein to Promote Synapse Formation Nature Neuroscience. Sep, 2013 | Pubmed ID: 23912945 MiR-29b Represses Intestinal Mucosal Growth by Inhibiting Translation of Cyclin-dependent Kinase 2 Molecular Biology of the Cell. Oct, 2013 | Pubmed ID: 23904268 Loss of CARM1 is Linked to Reduced HuR Function in Replicative Senescence BMC Molecular Biology. Jul, 2013 | Pubmed ID: 23837869 Senescence-associated LncRNAs: Senescence-associated Long Noncoding RNAs Aging Cell. Oct, 2013 | Pubmed ID: 23758631 MicroRNA 33 Regulates Glucose Metabolism Molecular and Cellular Biology. Aug, 2013 | Pubmed ID: 23716591 Distinct Binding Properties of TIAR RRMs and Linker Region RNA Biology. Apr, 2013 | Pubmed ID: 23603827 Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB PLoS Genetics. Mar, 2013 | Pubmed ID: 23555285 Modulation of Cancer Traits by Tumor Suppressor MicroRNAs International Journal of Molecular Sciences. Jan, 2013 | Pubmed ID: 23325049 Posttranscriptional Gene Regulation by Long Noncoding RNA Journal of Molecular Biology. Oct, 2013 | Pubmed ID: 23178169 Competitive Binding of CUGBP1 and HuR to Occludin MRNA Controls Its Translation and Modulates Epithelial Barrier Function Molecular Biology of the Cell. Jan, 2013 | Pubmed ID: 23155001 NF90 Coordinately Represses the Senescence-associated Secretory Phenotype Aging. Oct, 2012 | Pubmed ID: 23117626 LincRNA-p21 Suppresses Target MRNA Translation Molecular Cell. Aug, 2012 | Pubmed ID: 22841487 RNA-binding Protein Nucleolin in Disease RNA Biology. Jun, 2012 | Pubmed ID: 22617883 The RNA-binding Protein Human Antigen R Controls Global Changes in Gene Expression During Schwann Cell Development The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2012 | Pubmed ID: 22492050 Interaction Between MicroRNAs and Actin-associated Protein Arpc5 Regulates Translational Suppression During Male Germ Cell Differentiation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2012 | Pubmed ID: 22447776 Cannabinoids Induce Pancreatic β-cell Death by Directly Inhibiting Insulin Receptor Activation Science Signaling. Mar, 2012 | Pubmed ID: 22434934 The TRNA Methyltransferase NSun2 Stabilizes P16INK⁴ MRNA by Methylating the 3'-untranslated Region of P16 Nature Communications. Mar, 2012 | Pubmed ID: 22395603 RNA-binding Protein HuD Controls Insulin Translation Molecular Cell. Mar, 2012 | Pubmed ID: 22387028 The Oncogenic RNA-binding Protein Musashi1 is Regulated by HuR Via MRNA Translation and Stability in Glioblastoma Cells Molecular Cancer Research : MCR. Jan, 2012 | Pubmed ID: 22258704 Array-based Nuclear Run-on Analysis Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22113297 MiR-503 Represses CUG-binding Protein 1 Translation by Recruiting CUGBP1 MRNA to Processing Bodies Molecular Biology of the Cell. Jan, 2012 | Pubmed ID: 22072795 SRT1720 Improves Survival and Healthspan of Obese Mice Scientific Reports. 2011 | Pubmed ID: 22355589 Impact of Pyrrolidine Dithiocarbamate and Interleukin-6 on Mammalian Target of Rapamycin Complex 1 Regulation and Global Protein Translation The Journal of Pharmacology and Experimental Therapeutics. Dec, 2011 | Pubmed ID: 21917559 UneCLIPsing HuR Nuclear Function Molecular Cell. Aug, 2011 | Pubmed ID: 21816340 Altered Glycobiology of Stem Cells Linked to Age-related Osteoarthritis Aging. Jul, 2011 | Pubmed ID: 21808096 Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs Frontiers in Molecular Neuroscience. 2011 | Pubmed ID: 21747757 Regulation of Cyclin-dependent Kinase 4 Translation Through CUG-binding Protein 1 and MicroRNA-222 by Polyamines Molecular Biology of the Cell. Sep, 2011 | Pubmed ID: 21737690 Role of RNA Binding Protein HuR in Ductal Carcinoma in Situ of the Breast The Journal of Pathology. Aug, 2011 | Pubmed ID: 21480233 Paradoxical MicroRNAs: Individual Gene Repressors, Global Translation Enhancers Cell Cycle (Georgetown, Tex.). Mar, 2011 | Pubmed ID: 21311220 Different Modes of Interaction by TIAR and HuR with Target RNA and DNA Nucleic Acids Research. Feb, 2011 | Pubmed ID: 21233170 Chemokine Transcripts As Targets of the RNA-binding Protein HuR in Human Airway Epithelium Journal of Immunology (Baltimore, Md. : 1950). Feb, 2011 | Pubmed ID: 21220697 ATM Regulates a DNA Damage Response Posttranscriptional RNA Operon in Lymphocytes Blood. Feb, 2011 | Pubmed ID: 21209379 The Human Glucocorticoid Receptor As an RNA-binding Protein: Global Analysis of Glucocorticoid Receptor-associated Transcripts and Identification of a Target RNA Motif Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21148795 Pp32 (ANP32A) Expression Inhibits Pancreatic Cancer Cell Growth and Induces Gemcitabine Resistance by Disrupting HuR Binding to MRNAs PloS One. Nov, 2010 | Pubmed ID: 21152064 MicroRNA Expression Patterns Reveal Differential Expression of Target Genes with Age PloS One. May, 2010 | Pubmed ID: 20505758 HuR Uses AUF1 As a Cofactor to Promote P16INK4 MRNA Decay Molecular and Cellular Biology. Aug, 2010 | Pubmed ID: 20498276 HnRNP C Promotes APP Translation by Competing with FMRP for APP MRNA Recruitment to P Bodies Nature Structural & Molecular Biology. Jun, 2010 | Pubmed ID: 20473314 MiR-519 Suppresses Tumor Growth by Reducing HuR Levels Cell Cycle (Georgetown, Tex.). Apr, 2010 | Pubmed ID: 20305372 Post-transcriptional Regulation of Androgen Receptor MRNA by an ErbB3 Binding Protein 1 in Prostate Cancer Nucleic Acids Research. Jun, 2010 | Pubmed ID: 20159994 HuR/methyl-HuR and AUF1 Regulate the MAT Expressed During Liver Proliferation, Differentiation, and Carcinogenesis Gastroenterology. May, 2010 | Pubmed ID: 20102719 Minireview: Posttranscriptional Regulation of the Insulin and Insulin-like Growth Factor Systems Endocrinology. Apr, 2010 | Pubmed ID: 20032049 Reduced Nuclear Export of HuR MRNA by HuR is Linked to the Loss of HuR in Replicative Senescence Nucleic Acids Research. Mar, 2010 | Pubmed ID: 20007147 NF90 Selectively Represses the Translation of Target MRNAs Bearing an AU-rich Signature Motif Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19850717 The 'RNA-binding Ome': Future Implications for Chemotherapeutic Efficacy Future Oncology (London, England). Nov, 2009 | Pubmed ID: 19903059 Increased MKK4 Abundance with Replicative Senescence is Linked to the Joint Reduction of Multiple MicroRNAs Science Signaling. 2009 | Pubmed ID: 19861690 Polyamines Regulate C-Myc Translation Through Chk2-dependent HuR Phosphorylation Molecular Biology of the Cell. Dec, 2009 | Pubmed ID: 19812253 HuR Regulates Gap Junctional Intercellular Communication by Controlling Beta-catenin Levels and Adherens Junction Integrity Hepatology (Baltimore, Md.). Nov, 2009 | Pubmed ID: 19676129 Factors Interacting with HIF-1alpha MRNA: Novel Therapeutic Targets Current Pharmaceutical Design. 2009 | Pubmed ID: 19671045 Ribonucleoprotein Dynamics Connects MRNA Networks with Drug Mechanisms Molecular Systems Biology. 2009 | Pubmed ID: 19638970 RNA-binding Proteins Implicated in the Hypoxic Response Journal of Cellular and Molecular Medicine. Sep, 2009 | Pubmed ID: 19583805 HuR Recruits Let-7/RISC to Repress C-Myc Expression Genes & Development. Aug, 2009 | Pubmed ID: 19574298 Novel Roles of Hakai in Cell Proliferation and Oncogenesis Molecular Biology of the Cell. Aug, 2009 | Pubmed ID: 19535458 Ribosomal Protein MRNAs Are Primary Targets of Regulation in RNase-L-induced Senescence RNA Biology. Jul-Aug, 2009 | Pubmed ID: 19411840 Analysis of Nitric Oxide-stabilized MRNAs in Human Fibroblasts Reveals HuR-dependent Heme Oxygenase 1 Upregulation Molecular and Cellular Biology. May, 2009 | Pubmed ID: 19289500 The RNA-binding Protein HuR Regulates DNA Methylation Through Stabilization of DNMT3b MRNA Nucleic Acids Research. May, 2009 | Pubmed ID: 19270063 Identification of a Signature Motif in Target MRNAs of RNA-binding Protein AUF1 Nucleic Acids Research. Jan, 2009 | Pubmed ID: 19033365 MiR-519 Reduces Cell Proliferation by Lowering RNA-binding Protein HuR Levels Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19088191 Modification at HuR(S242) Alters HuR Localization and Proliferative Influence Cell Cycle (Georgetown, Tex.). Nov, 2008 | Pubmed ID: 18948743 Phosphorylated HuR Shuttles in Cycles Cell Cycle (Georgetown, Tex.). Oct, 2008 | Pubmed ID: 18927508 Protecting the Stress Response, Guarding the MKP-1 MRNA Cell Cycle (Georgetown, Tex.). Sep, 2008 | Pubmed ID: 18728392 Post-transcriptional Gene Regulation by HuR Promotes a More Tumorigenic Phenotype Oncogene. Oct, 2008 | Pubmed ID: 18641687 Nuclear HuR Accumulation Through Phosphorylation by Cdk1 Genes & Development. Jul, 2008 | Pubmed ID: 18593881 JunD Represses Transcription and Translation of the Tight Junction Protein Zona Occludens-1 Modulating Intestinal Epithelial Barrier Function Molecular Biology of the Cell. Sep, 2008 | Pubmed ID: 18562690 MKP-1 MRNA Stabilization and Translational Control by RNA-binding Proteins HuR and NF90 Molecular and Cellular Biology. Jul, 2008 | Pubmed ID: 18490444 P16(INK4a) Translation Suppressed by MiR-24 PloS One. 2008 | Pubmed ID: 18365017 Posttranscriptional Regulation of IL-13 in T Cells: Role of the RNA-binding Protein HuR The Journal of Allergy and Clinical Immunology. Apr, 2008 | Pubmed ID: 18279945 GU-rich RNA: Expanding CUGBP1 Function, Broadening MRNA Turnover Molecular Cell. Feb, 2008 | Pubmed ID: 18243108 AsSIRTing the DNA Damage Response Trends in Cell Biology. Feb, 2008 | Pubmed ID: 18215521 Posttranscriptional Gene Regulation by RNA-binding Proteins During Oxidative Stress: Implications for Cellular Senescence Biological Chemistry. Mar, 2008 | Pubmed ID: 18177264 RNA-binding Proteins HuR and PTB Promote the Translation of Hypoxia-inducible Factor 1alpha Molecular and Cellular Biology. Jan, 2008 | Pubmed ID: 17967866 Polyamines Modulate the Subcellular Localization of RNA-binding Protein HuR Through AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin Alpha1 The Biochemical Journal. Jan, 2008 | Pubmed ID: 17919121 Kinetic Analysis of Butyrate Transport in Human Colon Adenocarcinoma Cells Reveals Two Different Carrier-mediated Mechanisms The Biochemical Journal. Jan, 2008 | Pubmed ID: 17760565 AGEMAP: a Gene Expression Database for Aging in Mice PLoS Genetics. Nov, 2007 | Pubmed ID: 18081424 Polyamines Regulate the Stability of Activating Transcription Factor-2 MRNA Through RNA-binding Protein HuR in Intestinal Epithelial Cells Molecular Biology of the Cell. Nov, 2007 | Pubmed ID: 17804813 Elucidation of a C-rich Signature Motif in Target MRNAs of RNA-binding Protein TIAR Molecular and Cellular Biology. Oct, 2007 | Pubmed ID: 17682065 Analysis of Turnover and Translation Regulatory RNA-binding Protein Expression Through Binding to Cognate MRNAs Molecular and Cellular Biology. Sep, 2007 | Pubmed ID: 17620417 Posttranscriptional Orchestration of an Anti-apoptotic Program by HuR Cell Cycle (Georgetown, Tex.). Jun, 2007 | Pubmed ID: 17534146 Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression Molecular Cell. Feb, 2007 | Pubmed ID: 17317627 Esg1, Expressed Exclusively in Preimplantation Embryos, Germline, and Embryonic Stem Cells, is a Putative RNA-binding Protein with Broad RNA Targets Development, Growth & Differentiation. Aug, 2006 | Pubmed ID: 16872451 Differential Stability of Thymidylate Synthase 3'-untranslated Region Polymorphic Variants Regulated by AUF1 The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16787927 Egad, More Forms of Gene Regulation: the Gadd45a Story Cell Cycle (Georgetown, Tex.). Jul, 2006 | Pubmed ID: 16775423 Posttranscriptional Derepression of GADD45alpha by Genotoxic Stress Molecular Cell. Apr, 2006 | Pubmed ID: 16600875 Translational Control of Cytochrome C by RNA-binding Proteins TIA-1 and HuR Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16581801 En Masse Nascent Transcription Analysis to Elucidate Regulatory Transcription Factors Nucleic Acids Research. 2006 | Pubmed ID: 16540593 Translational Repression by RNA-binding Protein TIAR Molecular and Cellular Biology. Apr, 2006 | Pubmed ID: 16537914 HuR: Post-transcriptional Paths to Malignancy RNA Biology. Jan, 2005 | Pubmed ID: 17132932 Clean Western Blot Signals from Immunoprecipitated Samples Molecular and Cellular Probes. Dec, 2005 | Pubmed ID: 16146684 En Masse Analysis of Nascent Translation Using Microarrays BioTechniques. Jul, 2005 | Pubmed ID: 16060370 Antiapoptotic Function of RNA-binding Protein HuR Effected Through Prothymosin Alpha The EMBO Journal. May, 2005 | Pubmed ID: 15861128 Phosphorylation of P66Shc and Forkhead Proteins Mediates Abeta Toxicity The Journal of Cell Biology. Apr, 2005 | Pubmed ID: 15837797 Enhanced Proliferation of Cultured Human Vascular Smooth Muscle Cells Linked to Increased Function of RNA-binding Protein HuR The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15824116 Global Analysis of HuR-regulated Gene Expression in Colon Cancer Systems of Reducing Complexity Gene Expression. 2004 | Pubmed ID: 15473260 Prostaglandin A2-mediated Stabilization of P21 MRNA Through an ERK-dependent Pathway Requiring the RNA-binding Protein HuR The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15371446 AMP-activated Protein Kinase-regulated Phosphorylation and Acetylation of Importin Alpha1: Involvement in the Nuclear Import of RNA-binding Protein HuR The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15342649 Concurrent Versus Individual Binding of HuR and AUF1 to Common Labile Target MRNAs The EMBO Journal. Aug, 2004 | Pubmed ID: 15257295 Global MRNA Stabilization Preferentially Linked to Translational Repression During the Endoplasmic Reticulum Stress Response Molecular and Cellular Biology. Aug, 2004 | Pubmed ID: 15254244 Identification of a Target RNA Motif for RNA-binding Protein HuR Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14981256 Influence of the RNA-binding Protein HuR in PVHL-regulated P53 Expression in Renal Carcinoma Cells Molecular and Cellular Biology. Oct, 2003 | Pubmed ID: 14517280 HuR in the Mammalian Genotoxic Response: Post-transcriptional Multitasking Cell Cycle (Georgetown, Tex.). Sep-Oct, 2003 | Pubmed ID: 12963828 RNA-binding Protein HuR Enhances P53 Translation in Response to Ultraviolet Light Irradiation Proceedings of the National Academy of Sciences of the United States of America. Jul, 2003 | Pubmed ID: 12821781 An in Vitro Model of Caloric Restriction Experimental Gerontology. Jun, 2003 | Pubmed ID: 12814798 Increased AMP:ATP Ratio and AMP-activated Protein Kinase Activity During Cellular Senescence Linked to Reduced HuR Function The Journal of Biological Chemistry. Jul, 2003 | Pubmed ID: 12730239 Caveolin-induced Activation of the Phosphatidylinositol 3-kinase/Akt Pathway Increases Arsenite Cytotoxicity Molecular and Cellular Biology. Apr, 2003 | Pubmed ID: 12640124 Von Hippel-Lindau Protein-mediated Repression of Tumor Necrosis Factor Alpha Translation Revealed Through Use of CDNA Arrays Molecular and Cellular Biology. Apr, 2003 | Pubmed ID: 12640117 Functional Role of P21 During the Cellular Response to Stress Gene Expression. 1999 | Pubmed ID: 10440238 Измерение скорости оборота белка в стареющих и неделящихся культивируемых клетках с помощью метаболической маркировки и масс-спектрометрии Matthew Payea1, Myriam Gorospe1, Nathan Basisty2 1Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 2Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health JoVE 63835 Biochemistry
Измерение скорости оборота белка в стареющих и неделящихся культивируемых клетках с помощью метаболической маркировки и масс-спектрометрии Matthew Payea1, Myriam Gorospe1, Nathan Basisty2 1Laboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, 2Translational Gerontology Branch, National Institute on Aging Intramural Research Program, National Institutes of Health JoVE 63835 Biochemistry
