Articles by Nadja I. Bork in JoVE
Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System Christiane Jungen1,2, Katharina Scherschel1,2, Nadja I. Bork2,3, Pawel Kuklik1, Christian Eickholt1, Helge Kniep1, Niklas Klatt1,2, Stephan Willems1,2, Viacheslav O. Nikolaev2,3, Christian Meyer1,2 1Department of Cardiology-Electrophysiology, cNEP (cardiac Neuro- and Electrophysiology research group), University Heart Center, University Hospital Hamburg-Eppendorf, 2DZHK (German Center for Cardiovascular Research), 3Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf Here, we present a protocol for the modulation of the intracardiac autonomic nervous system and the assessment of its influence on basic electrophysiology, arrhythmogenesis, and cAMP dynamics using an ex vivo Langendorff setup.
Other articles by Nadja I. Bork on PubMed
CGMP Signaling in the Cardiovascular System-The Role of Compartmentation and Its Live Cell Imaging International Journal of Molecular Sciences. | Pubmed ID: 29534460 The ubiquitous second messenger 3',5'-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time cGMP measurements with a specific focus on live cell imaging methods. We will also discuss currently accepted and emerging mechanisms of cGMP compartmentation in the cardiovascular system.